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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for ZNF274

Z-value: 0.33

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Transcription factors associated with ZNF274

Gene Symbol Gene ID Gene Info
ZNF274
ENSG00000171606.13 zinc finger protein 274

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF274hg19_v2_chr19_+_58694396_586944850.116.1e-01Click!

Activity profile of ZNF274 motif

Sorted Z-values of ZNF274 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_113344755 0.69 ENST00000550883.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr16_-_80603558 0.69 ENST00000567317.1
RP11-18F14.1
RP11-18F14.1
chr22_+_24038593 0.50 ENST00000452208.1
RGL4
ral guanine nucleotide dissociation stimulator-like 4
chr12_-_89920030 0.45 ENST00000413530.1
ENST00000547474.1
GALNT4
POC1B-GALNT4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
POC1B-GALNT4 readthrough
chr12_-_89919965 0.44 ENST00000548729.1
POC1B-GALNT4
POC1B-GALNT4 readthrough
chr6_+_31553978 0.43 ENST00000376096.1
ENST00000376099.1
ENST00000376110.3
LST1
leukocyte specific transcript 1
chr16_+_29818857 0.38 ENST00000567444.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr15_+_89164520 0.35 ENST00000332810.3
AEN
apoptosis enhancing nuclease
chr6_+_31553901 0.34 ENST00000418507.2
ENST00000438075.2
ENST00000376100.3
ENST00000376111.4
LST1
leukocyte specific transcript 1
chr19_+_40195101 0.34 ENST00000360675.3
ENST00000601802.1
LGALS14
lectin, galactoside-binding, soluble, 14
chr19_+_40194946 0.34 ENST00000392052.3
LGALS14
lectin, galactoside-binding, soluble, 14
chr4_+_15704573 0.31 ENST00000265016.4
BST1
bone marrow stromal cell antigen 1
chr18_+_9885760 0.30 ENST00000536353.2
ENST00000584255.1
TXNDC2
thioredoxin domain containing 2 (spermatozoa)
chr16_+_29819096 0.28 ENST00000568411.1
ENST00000563012.1
ENST00000562557.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr4_+_15704679 0.26 ENST00000382346.3
BST1
bone marrow stromal cell antigen 1
chr20_-_1638360 0.24 ENST00000216927.4
ENST00000344103.4
SIRPG
signal-regulatory protein gamma
chrX_+_52920336 0.24 ENST00000452154.2
FAM156B
family with sequence similarity 156, member B
chr20_-_1638408 0.24 ENST00000303415.3
ENST00000381583.2
SIRPG
signal-regulatory protein gamma
chr3_+_50284321 0.23 ENST00000451956.1
GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr11_+_55653396 0.20 ENST00000244891.3
TRIM51
tripartite motif-containing 51
chr16_+_29819372 0.20 ENST00000568544.1
ENST00000569978.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr18_+_9885961 0.19 ENST00000306084.6
TXNDC2
thioredoxin domain containing 2 (spermatozoa)
chr16_+_31470143 0.19 ENST00000457010.2
ENST00000563544.1
ARMC5
armadillo repeat containing 5
chr16_+_31470179 0.18 ENST00000538189.1
ENST00000268314.4
ARMC5
armadillo repeat containing 5
chr18_+_9103957 0.17 ENST00000400033.1
NDUFV2
NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
chr19_+_6887571 0.14 ENST00000250572.8
ENST00000381407.5
ENST00000312053.4
ENST00000450315.3
ENST00000381404.4
EMR1
egf-like module containing, mucin-like, hormone receptor-like 1
chr1_+_45205498 0.13 ENST00000372218.4
KIF2C
kinesin family member 2C
chr16_+_29819446 0.13 ENST00000568282.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr2_+_11864458 0.12 ENST00000396098.1
ENST00000396099.1
ENST00000425416.2
LPIN1
lipin 1
chr1_+_45205478 0.12 ENST00000452259.1
ENST00000372224.4
KIF2C
kinesin family member 2C
chr12_+_50135327 0.12 ENST00000549966.1
ENST00000547832.1
ENST00000547187.1
ENST00000548894.1
ENST00000546914.1
ENST00000552699.1
ENST00000267115.5
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr6_+_30687978 0.11 ENST00000327892.8
ENST00000435534.1
TUBB
tubulin, beta class I
chr14_-_24047965 0.09 ENST00000397118.3
ENST00000356300.4
JPH4
junctophilin 4
chr17_-_41132410 0.09 ENST00000409446.3
ENST00000453594.1
ENST00000409399.1
ENST00000421990.2
PTGES3L
PTGES3L-AARSD1
prostaglandin E synthase 3 (cytosolic)-like
PTGES3L-AARSD1 readthrough
chr6_-_32784687 0.09 ENST00000447394.1
ENST00000438763.2
HLA-DOB
major histocompatibility complex, class II, DO beta
chr7_+_30791743 0.09 ENST00000013222.5
ENST00000409539.1
INMT
indolethylamine N-methyltransferase
chr10_-_29811456 0.09 ENST00000535393.1
SVIL
supervillin
chr22_+_39353527 0.09 ENST00000249116.2
APOBEC3A
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
chr3_+_102153859 0.07 ENST00000306176.1
ENST00000466937.1
ZPLD1
zona pellucida-like domain containing 1
chr19_+_46498704 0.07 ENST00000595358.1
ENST00000594672.1
ENST00000536603.1
CCDC61
coiled-coil domain containing 61
chr19_+_41949054 0.05 ENST00000378187.2
C19orf69
chromosome 19 open reading frame 69
chr18_+_9885934 0.05 ENST00000357775.5
TXNDC2
thioredoxin domain containing 2 (spermatozoa)
chr5_-_173043591 0.05 ENST00000285908.5
ENST00000480951.1
ENST00000311086.4
BOD1
biorientation of chromosomes in cell division 1
chr11_-_10590118 0.04 ENST00000529598.1
LYVE1
lymphatic vessel endothelial hyaluronan receptor 1
chr19_+_4153598 0.04 ENST00000078445.2
ENST00000252587.3
ENST00000595923.1
ENST00000602257.1
ENST00000602147.1
CREB3L3
cAMP responsive element binding protein 3-like 3
chr20_+_60174827 0.04 ENST00000543233.1
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr19_+_7584088 0.04 ENST00000394341.2
ZNF358
zinc finger protein 358
chr6_+_36165133 0.03 ENST00000446974.1
ENST00000454960.1
BRPF3
bromodomain and PHD finger containing, 3
chr19_-_19774473 0.03 ENST00000357324.6
ATP13A1
ATPase type 13A1
chr1_-_114414316 0.02 ENST00000528414.1
ENST00000538253.1
ENST00000460620.1
ENST00000420377.2
ENST00000525799.1
ENST00000359785.5
PTPN22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
chr4_-_121993673 0.02 ENST00000379692.4
NDNF
neuron-derived neurotrophic factor
chr12_+_109273806 0.02 ENST00000228476.3
ENST00000547768.1
DAO
D-amino-acid oxidase
chr19_+_6135646 0.01 ENST00000588304.1
ENST00000588485.1
ENST00000588722.1
ENST00000591403.1
ENST00000586696.1
ENST00000589401.1
ENST00000252669.5
ACSBG2
acyl-CoA synthetase bubblegum family member 2
chr17_+_41132564 0.01 ENST00000361677.1
ENST00000589705.1
RUNDC1
RUN domain containing 1
chr8_-_4852218 0.00 ENST00000400186.3
ENST00000602723.1
CSMD1
CUB and Sushi multiple domains 1
chr1_+_47533160 0.00 ENST00000334194.3
CYP4Z1
cytochrome P450, family 4, subfamily Z, polypeptide 1

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF274

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 GO:0070234 positive regulation of T cell apoptotic process(GO:0070234)
0.0 0.1 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.0 0.5 GO:0006662 glycerol ether metabolic process(GO:0006662)
0.0 0.2 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0 0.1 GO:0031438 negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 0.1 GO:0006642 triglyceride mobilization(GO:0006642)
0.0 0.6 GO:0002691 regulation of cellular extravasation(GO:0002691)
0.0 0.1 GO:0070383 DNA cytosine deamination(GO:0070383)
0.0 0.2 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.0 0.1 GO:2001256 regulation of store-operated calcium entry(GO:2001256)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.2 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.0 0.6 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.1 GO:0030314 junctional membrane complex(GO:0030314)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0050135 NAD(P)+ nucleosidase activity(GO:0050135)
0.1 0.7 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 0.5 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.2 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 0.1 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.0 0.1 GO:0008172 S-methyltransferase activity(GO:0008172)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID S1P S1P4 PATHWAY S1P4 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.2 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway