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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for ZNF35

Z-value: 0.31

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Transcription factors associated with ZNF35

Gene Symbol Gene ID Gene Info
ZNF35
ENSG00000169981.6 zinc finger protein 35

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF35hg19_v2_chr3_+_44690211_44690267-0.038.9e-01Click!

Activity profile of ZNF35 motif

Sorted Z-values of ZNF35 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_61869748 0.95 ENST00000357977.5
NFIA
nuclear factor I/A
chr10_-_131762105 0.76 ENST00000368648.3
ENST00000355311.5
EBF3
early B-cell factor 3
chr8_-_95274536 0.50 ENST00000297596.2
ENST00000396194.2
GEM
GTP binding protein overexpressed in skeletal muscle
chr2_-_191878162 0.46 ENST00000540176.1
STAT1
signal transducer and activator of transcription 1, 91kDa
chr12_+_79258444 0.41 ENST00000261205.4
SYT1
synaptotagmin I
chr5_+_139027877 0.36 ENST00000302517.3
CXXC5
CXXC finger protein 5
chr21_+_17792672 0.33 ENST00000602620.1
LINC00478
long intergenic non-protein coding RNA 478
chr5_+_139028510 0.33 ENST00000502336.1
ENST00000520967.1
ENST00000511048.1
CXXC5
CXXC finger protein 5
chr12_+_51318513 0.32 ENST00000332160.4
METTL7A
methyltransferase like 7A
chr9_+_130853715 0.31 ENST00000373066.5
ENST00000432073.2
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr13_-_41240717 0.28 ENST00000379561.5
FOXO1
forkhead box O1
chr15_+_35270552 0.28 ENST00000391457.2
AC114546.1
HCG37415; PRO1914; Uncharacterized protein
chr15_+_96876340 0.27 ENST00000453270.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr17_-_295730 0.23 ENST00000329099.4
FAM101B
family with sequence similarity 101, member B
chr1_+_214161272 0.18 ENST00000498508.2
ENST00000366958.4
PROX1
prospero homeobox 1
chr4_+_129730947 0.18 ENST00000452328.2
ENST00000504089.1
PHF17
jade family PHD finger 1
chr3_-_58523010 0.17 ENST00000459701.2
ENST00000302819.5
ACOX2
acyl-CoA oxidase 2, branched chain
chr14_+_76776957 0.17 ENST00000512784.1
ESRRB
estrogen-related receptor beta
chr17_-_58042075 0.14 ENST00000305783.8
ENST00000589113.1
ENST00000442346.2
RNFT1
ring finger protein, transmembrane 1
chr7_+_27282319 0.14 ENST00000222761.3
EVX1
even-skipped homeobox 1
chr12_+_25205446 0.13 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
LRMP
lymphoid-restricted membrane protein
chr7_+_74072288 0.13 ENST00000443166.1
GTF2I
general transcription factor IIi
chr10_+_74653330 0.12 ENST00000334011.5
OIT3
oncoprotein induced transcript 3
chr2_+_177015122 0.12 ENST00000468418.3
HOXD3
homeobox D3
chr14_-_92198403 0.11 ENST00000553329.1
ENST00000256343.3
CATSPERB
catsper channel auxiliary subunit beta
chr3_+_141105705 0.11 ENST00000513258.1
ZBTB38
zinc finger and BTB domain containing 38
chr9_+_42671887 0.11 ENST00000456520.1
ENST00000377391.3
CBWD7
COBW domain containing 7
chr1_-_169599353 0.10 ENST00000367793.2
ENST00000367794.2
ENST00000367792.2
ENST00000367791.2
ENST00000367788.2
SELP
selectin P (granule membrane protein 140kDa, antigen CD62)
chr8_-_145754428 0.10 ENST00000527462.1
ENST00000313465.5
ENST00000524821.1
C8orf82
chromosome 8 open reading frame 82
chr18_+_39535152 0.09 ENST00000262039.4
ENST00000398870.3
ENST00000586545.1
PIK3C3
phosphatidylinositol 3-kinase, catalytic subunit type 3
chr17_-_42295870 0.09 ENST00000526094.1
ENST00000529383.1
ENST00000530828.1
UBTF
upstream binding transcription factor, RNA polymerase I
chr6_-_133084580 0.08 ENST00000525270.1
ENST00000530536.1
ENST00000524919.1
VNN2
vanin 2
chr4_+_88754069 0.07 ENST00000395102.4
ENST00000497649.2
MEPE
matrix extracellular phosphoglycoprotein
chr12_-_11091862 0.07 ENST00000537503.1
TAS2R14
taste receptor, type 2, member 14
chr13_-_47471155 0.07 ENST00000543956.1
ENST00000542664.1
HTR2A
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
chr4_+_88754113 0.06 ENST00000560249.1
ENST00000540395.1
ENST00000511670.1
ENST00000361056.3
MEPE
matrix extracellular phosphoglycoprotein
chrM_+_4431 0.06 ENST00000361453.3
MT-ND2
mitochondrially encoded NADH dehydrogenase 2
chr3_+_69985734 0.05 ENST00000314557.6
ENST00000394351.3
MITF
microphthalmia-associated transcription factor
chr3_-_49066811 0.05 ENST00000442157.1
ENST00000326739.4
IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr3_+_10157276 0.04 ENST00000530758.1
ENST00000256463.6
BRK1
BRICK1, SCAR/WAVE actin-nucleating complex subunit
chr17_-_63557759 0.04 ENST00000307078.5
AXIN2
axin 2
chr7_-_87342564 0.04 ENST00000265724.3
ENST00000416177.1
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr8_-_116680833 0.03 ENST00000220888.5
TRPS1
trichorhinophalangeal syndrome I
chr7_+_80231466 0.03 ENST00000309881.7
ENST00000534394.1
CD36
CD36 molecule (thrombospondin receptor)
chr13_-_36429763 0.02 ENST00000379893.1
DCLK1
doublecortin-like kinase 1
chr12_+_25205666 0.02 ENST00000547044.1
LRMP
lymphoid-restricted membrane protein
chr4_+_78804393 0.02 ENST00000502384.1
MRPL1
mitochondrial ribosomal protein L1
chr4_-_89744365 0.02 ENST00000513837.1
ENST00000503556.1
FAM13A
family with sequence similarity 13, member A
chr3_+_29323043 0.02 ENST00000452462.1
ENST00000456853.1
RBMS3
RNA binding motif, single stranded interacting protein 3
chr21_+_35552978 0.02 ENST00000428914.2
ENST00000609062.1
ENST00000609947.1
LINC00310
long intergenic non-protein coding RNA 310
chrX_-_138724677 0.02 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
MCF2
MCF.2 cell line derived transforming sequence
chr1_+_220701456 0.01 ENST00000366918.4
ENST00000402574.1
MARK1
MAP/microtubule affinity-regulating kinase 1
chr3_+_69985792 0.01 ENST00000531774.1
MITF
microphthalmia-associated transcription factor
chr7_+_123488124 0.01 ENST00000476325.1
HYAL4
hyaluronoglucosaminidase 4
chr3_+_141106458 0.01 ENST00000509883.1
ZBTB38
zinc finger and BTB domain containing 38
chr1_-_161008697 0.01 ENST00000318289.10
ENST00000368023.3
ENST00000368024.1
ENST00000423014.2
TSTD1
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF35

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.1 0.5 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 0.5 GO:0072308 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.1 0.3 GO:0009956 radial pattern formation(GO:0009956)
0.1 0.2 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 0.3 GO:1902617 response to fluoride(GO:1902617)
0.1 0.2 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.1 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0 0.9 GO:0072189 ureter development(GO:0072189)
0.0 0.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.3 GO:0015866 ADP transport(GO:0015866)
0.0 0.1 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.2 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.1 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.1 GO:0036128 CatSper complex(GO:0036128)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 0.5 GO:0051233 spindle midzone(GO:0051233)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.2 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.3 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.1 GO:0042806 fucose binding(GO:0042806)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.1 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.0 0.0 GO:0003938 IMP dehydrogenase activity(GO:0003938)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 1.1 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.4 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle