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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for ZNF384
Z-value: 0.91
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Transcription factors associated with ZNF384
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF384 | hg19_v2_chr12_-_6798616_6798684 | -0.35 | 9.1e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_9046503 Show fit | 3.84 |
ENST00000512942.2
|
RP11-10A14.5 |
|
| chr7_+_150211918 Show fit | 1.63 |
ENST00000313543.4
|
GTPase, IMAP family member 7 |
|
| chr8_-_6836156 Show fit | 1.57 |
ENST00000382679.2
|
defensin, alpha 1 |
|
| chr12_-_47473557 Show fit | 1.55 |
ENST00000321382.3
|
adhesion molecule with Ig-like domain 2 |
|
| chr3_-_18466026 Show fit | 1.50 |
ENST00000417717.2
|
SATB homeobox 1 |
|
| chr3_-_64211112 Show fit | 1.31 |
ENST00000295902.6
|
prickle homolog 2 (Drosophila) |
|
| chr6_+_132891461 Show fit | 1.29 |
ENST00000275198.1
|
trace amine associated receptor 6 |
|
| chr3_+_8543393 Show fit | 1.27 |
ENST00000157600.3
ENST00000415597.1 ENST00000535732.1 |
LIM and cysteine-rich domains 1 |
|
| chr12_-_47473425 Show fit | 1.27 |
ENST00000550413.1
|
adhesion molecule with Ig-like domain 2 |
|
| chr4_-_186696425 Show fit | 1.23 |
ENST00000430503.1
ENST00000319454.6 ENST00000450341.1 |
sorbin and SH3 domain containing 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF384
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 3.0 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.1 | 2.5 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.0 | 2.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 2.3 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.0 | 2.1 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
| 0.0 | 2.0 | GO:0007224 | smoothened signaling pathway(GO:0007224) |
| 0.1 | 1.9 | GO:0072189 | ureter development(GO:0072189) |
| 0.2 | 1.7 | GO:2000546 | positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546) |
| 0.5 | 1.6 | GO:0035915 | pore formation in membrane of other organism(GO:0035915) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.4 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 3.3 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 3.1 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 2.5 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 2.3 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 2.2 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 2.2 | GO:0031674 | I band(GO:0031674) |
| 0.1 | 1.7 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 1.7 | GO:0016514 | SWI/SNF complex(GO:0016514) |
| 0.0 | 1.7 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.2 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 2.3 | GO:0016505 | peptidase activator activity involved in apoptotic process(GO:0016505) |
| 0.1 | 2.0 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.1 | 2.0 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 1.7 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.1 | 1.6 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
| 0.1 | 1.6 | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity(GO:0008970) |
| 0.0 | 1.5 | GO:0019210 | kinase inhibitor activity(GO:0019210) |
| 0.1 | 1.4 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.0 | 1.4 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 2.1 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 1.9 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 1.8 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 1.4 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 1.1 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 0.9 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 0.8 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 0.7 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 0.7 | PID IL3 PATHWAY | IL3-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 2.5 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 2.1 | REACTOME DEFENSINS | Genes involved in Defensins |
| 0.0 | 1.9 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 1.7 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 1.6 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.1 | 1.6 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.1 | 1.6 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 1.4 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.0 | 1.4 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |