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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for ZNF423

Z-value: 0.92

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Transcription factors associated with ZNF423

Gene Symbol Gene ID Gene Info
ZNF423
ENSG00000102935.7 zinc finger protein 423

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF423hg19_v2_chr16_-_49890016_49890046-0.725.9e-05Click!

Activity profile of ZNF423 motif

Sorted Z-values of ZNF423 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_11681023 4.31 ENST00000570904.1
ENST00000574701.1
LITAF
lipopolysaccharide-induced TNF factor
chr17_+_77020325 4.01 ENST00000311661.4
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr17_+_77020224 3.98 ENST00000339142.2
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr12_-_50101165 2.78 ENST00000352151.5
ENST00000335154.5
ENST00000293590.5
FMNL3
formin-like 3
chr16_-_11681316 2.76 ENST00000571688.1
LITAF
lipopolysaccharide-induced TNF factor
chr12_-_57522813 2.48 ENST00000556155.1
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr17_+_77020146 2.46 ENST00000579760.1
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr5_+_135385202 2.35 ENST00000514554.1
TGFBI
transforming growth factor, beta-induced, 68kDa
chr12_-_50101003 2.12 ENST00000550488.1
FMNL3
formin-like 3
chr6_-_143266297 2.11 ENST00000367603.2
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr8_-_80680078 2.08 ENST00000337919.5
ENST00000354724.3
HEY1
hes-related family bHLH transcription factor with YRPW motif 1
chr5_-_172756506 1.90 ENST00000265087.4
STC2
stanniocalcin 2
chr7_-_19184929 1.80 ENST00000275461.3
FERD3L
Fer3-like bHLH transcription factor
chr1_-_203055129 1.75 ENST00000241651.4
MYOG
myogenin (myogenic factor 4)
chr16_+_30675654 1.70 ENST00000287468.5
ENST00000395073.2
FBRS
fibrosin
chr10_-_121296045 1.59 ENST00000392865.1
RGS10
regulator of G-protein signaling 10
chr19_+_14544099 1.36 ENST00000242783.6
ENST00000586557.1
ENST00000590097.1
PKN1
protein kinase N1
chr21_-_18985230 1.34 ENST00000457956.1
ENST00000348354.6
BTG3
BTG family, member 3
chr10_-_100027943 1.34 ENST00000260702.3
LOXL4
lysyl oxidase-like 4
chr11_-_61062762 1.29 ENST00000335613.5
VWCE
von Willebrand factor C and EGF domains
chr7_-_23053693 1.27 ENST00000409763.1
ENST00000409923.1
FAM126A
family with sequence similarity 126, member A
chr4_+_74735102 1.27 ENST00000395761.3
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr22_-_37823468 1.18 ENST00000402918.2
ELFN2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chr21_-_18985158 1.17 ENST00000339775.6
BTG3
BTG family, member 3
chr7_-_23053719 1.10 ENST00000432176.2
ENST00000440481.1
FAM126A
family with sequence similarity 126, member A
chr16_+_27325202 1.09 ENST00000395762.2
ENST00000562142.1
ENST00000561742.1
ENST00000543915.2
ENST00000449195.1
ENST00000380922.3
ENST00000563002.1
IL4R
interleukin 4 receptor
chr11_-_61658853 1.04 ENST00000525588.1
ENST00000540820.1
FADS3
fatty acid desaturase 3
chr4_-_120548779 1.03 ENST00000264805.5
PDE5A
phosphodiesterase 5A, cGMP-specific
chr15_+_100106155 0.98 ENST00000557785.1
ENST00000558049.1
ENST00000449277.2
MEF2A
myocyte enhancer factor 2A
chr19_+_45582453 0.98 ENST00000591607.1
ENST00000591747.1
ENST00000270257.4
ENST00000391951.2
ENST00000587566.1
GEMIN7
MARK4
gem (nuclear organelle) associated protein 7
MAP/microtubule affinity-regulating kinase 4
chr11_-_61659006 0.98 ENST00000278829.2
FADS3
fatty acid desaturase 3
chrX_+_30265256 0.97 ENST00000397548.2
MAGEB1
melanoma antigen family B, 1
chr13_+_96743093 0.97 ENST00000376705.2
HS6ST3
heparan sulfate 6-O-sulfotransferase 3
chr22_+_35653445 0.93 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
HMGXB4
HMG box domain containing 4
chr15_+_100106244 0.90 ENST00000557942.1
MEF2A
myocyte enhancer factor 2A
chr6_-_32160622 0.76 ENST00000487761.1
ENST00000375040.3
GPSM3
G-protein signaling modulator 3
chr1_+_10459111 0.74 ENST00000541529.1
ENST00000270776.8
ENST00000483936.1
ENST00000538557.1
PGD
phosphogluconate dehydrogenase
chr7_-_100491854 0.71 ENST00000426415.1
ENST00000430554.1
ENST00000412389.1
ACHE
acetylcholinesterase (Yt blood group)
chr5_+_170736243 0.70 ENST00000296921.5
TLX3
T-cell leukemia homeobox 3
chr22_-_38484922 0.69 ENST00000428572.1
BAIAP2L2
BAI1-associated protein 2-like 2
chr19_-_4043154 0.67 ENST00000535853.1
AC016586.1
AC016586.1
chr15_-_75660919 0.67 ENST00000569482.1
ENST00000565683.1
ENST00000561615.1
ENST00000563622.1
ENST00000568374.1
ENST00000566256.1
ENST00000267978.5
MAN2C1
mannosidase, alpha, class 2C, member 1
chr17_+_7341586 0.67 ENST00000575235.1
FGF11
fibroblast growth factor 11
chr8_+_22423219 0.66 ENST00000523965.1
ENST00000521554.1
SORBS3
sorbin and SH3 domain containing 3
chr3_-_195808952 0.65 ENST00000540528.1
ENST00000392396.3
ENST00000535031.1
ENST00000420415.1
TFRC
transferrin receptor
chr3_-_195808980 0.65 ENST00000360110.4
TFRC
transferrin receptor
chr19_-_10450287 0.61 ENST00000589261.1
ENST00000590569.1
ENST00000589580.1
ENST00000589249.1
ICAM3
intercellular adhesion molecule 3
chr6_-_35480640 0.61 ENST00000428978.1
ENST00000322263.4
TULP1
tubby like protein 1
chr11_-_44972418 0.58 ENST00000525680.1
ENST00000528290.1
ENST00000530035.1
TP53I11
tumor protein p53 inducible protein 11
chrX_+_136648297 0.57 ENST00000287538.5
ZIC3
Zic family member 3
chr19_-_10450328 0.57 ENST00000160262.5
ICAM3
intercellular adhesion molecule 3
chr11_-_6495082 0.55 ENST00000536344.1
TRIM3
tripartite motif containing 3
chr9_+_112542572 0.53 ENST00000374530.3
PALM2-AKAP2
PALM2-AKAP2 readthrough
chr6_+_33589161 0.53 ENST00000605930.1
ITPR3
inositol 1,4,5-trisphosphate receptor, type 3
chr6_-_35480705 0.52 ENST00000229771.6
TULP1
tubby like protein 1
chr10_+_124913930 0.52 ENST00000368858.5
BUB3
BUB3 mitotic checkpoint protein
chr5_+_78407602 0.51 ENST00000274353.5
ENST00000524080.1
BHMT
betaine--homocysteine S-methyltransferase
chr15_-_66649010 0.50 ENST00000367709.4
ENST00000261881.4
TIPIN
TIMELESS interacting protein
chr9_+_116638562 0.50 ENST00000374126.5
ENST00000288466.7
ZNF618
zinc finger protein 618
chr10_+_124914285 0.50 ENST00000407911.2
BUB3
BUB3 mitotic checkpoint protein
chr10_+_124913793 0.50 ENST00000368865.4
ENST00000538238.1
ENST00000368859.2
BUB3
BUB3 mitotic checkpoint protein
chr11_-_6495101 0.49 ENST00000528227.1
ENST00000359518.3
ENST00000345851.3
ENST00000537602.1
TRIM3
tripartite motif containing 3
chr8_+_30241995 0.49 ENST00000397323.4
ENST00000339877.4
ENST00000320203.4
ENST00000287771.5
RBPMS
RNA binding protein with multiple splicing
chr2_-_120980939 0.46 ENST00000426077.2
TMEM185B
transmembrane protein 185B
chr19_-_10679644 0.46 ENST00000393599.2
CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr2_+_46769798 0.46 ENST00000238738.4
RHOQ
ras homolog family member Q
chr2_+_171785824 0.45 ENST00000452526.2
GORASP2
golgi reassembly stacking protein 2, 55kDa
chr4_-_20985632 0.45 ENST00000359001.5
KCNIP4
Kv channel interacting protein 4
chr6_-_31080336 0.45 ENST00000259870.3
C6orf15
chromosome 6 open reading frame 15
chr12_-_54779511 0.44 ENST00000551109.1
ENST00000546970.1
ZNF385A
zinc finger protein 385A
chr2_+_171785012 0.43 ENST00000234160.4
GORASP2
golgi reassembly stacking protein 2, 55kDa
chr8_+_22022653 0.42 ENST00000354870.5
ENST00000397816.3
ENST00000306349.8
BMP1
bone morphogenetic protein 1
chr19_-_15311713 0.42 ENST00000601011.1
ENST00000263388.2
NOTCH3
notch 3
chr10_+_85933494 0.42 ENST00000372126.3
C10orf99
chromosome 10 open reading frame 99
chr21_+_45432174 0.42 ENST00000380221.3
ENST00000291574.4
TRAPPC10
trafficking protein particle complex 10
chr11_-_64013663 0.41 ENST00000392210.2
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr6_+_30130969 0.41 ENST00000376694.4
TRIM15
tripartite motif containing 15
chr6_+_151186554 0.40 ENST00000367321.3
ENST00000367307.4
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr9_+_135037334 0.40 ENST00000393229.3
ENST00000360670.3
ENST00000393228.4
ENST00000372179.3
NTNG2
netrin G2
chr6_-_91296602 0.40 ENST00000369325.3
ENST00000369327.3
MAP3K7
mitogen-activated protein kinase kinase kinase 7
chr17_+_6347761 0.39 ENST00000250056.8
ENST00000571373.1
ENST00000570337.2
ENST00000572595.2
ENST00000576056.1
FAM64A
family with sequence similarity 64, member A
chr5_-_176057518 0.39 ENST00000393693.2
SNCB
synuclein, beta
chr17_+_6347729 0.39 ENST00000572447.1
FAM64A
family with sequence similarity 64, member A
chr8_+_22423168 0.39 ENST00000518912.1
ENST00000428103.1
SORBS3
sorbin and SH3 domain containing 3
chr8_+_30241934 0.39 ENST00000538486.1
RBPMS
RNA binding protein with multiple splicing
chr6_-_91296737 0.39 ENST00000369332.3
ENST00000369329.3
MAP3K7
mitogen-activated protein kinase kinase kinase 7
chrX_+_49028265 0.38 ENST00000376322.3
ENST00000376327.5
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr5_-_176057365 0.38 ENST00000310112.3
SNCB
synuclein, beta
chr19_-_38714847 0.38 ENST00000420980.2
ENST00000355526.4
DPF1
D4, zinc and double PHD fingers family 1
chr20_+_23016057 0.36 ENST00000255008.3
SSTR4
somatostatin receptor 4
chr8_+_22422749 0.33 ENST00000523900.1
SORBS3
sorbin and SH3 domain containing 3
chr1_-_33366931 0.32 ENST00000373463.3
ENST00000329151.5
TMEM54
transmembrane protein 54
chr4_+_152330390 0.31 ENST00000503146.1
ENST00000435205.1
FAM160A1
family with sequence similarity 160, member A1
chr19_-_56110859 0.31 ENST00000221665.3
ENST00000592585.1
FIZ1
FLT3-interacting zinc finger 1
chr9_-_130742792 0.30 ENST00000373095.1
FAM102A
family with sequence similarity 102, member A
chr11_-_1036706 0.29 ENST00000421673.2
MUC6
mucin 6, oligomeric mucus/gel-forming
chr6_+_151187074 0.29 ENST00000367308.4
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr2_+_12246664 0.29 ENST00000449986.1
AC096559.1
AC096559.1
chr20_+_43514315 0.29 ENST00000353703.4
YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
chr10_+_135340859 0.28 ENST00000252945.3
ENST00000421586.1
ENST00000418356.1
CYP2E1
cytochrome P450, family 2, subfamily E, polypeptide 1
chr22_-_43045574 0.28 ENST00000352397.5
CYB5R3
cytochrome b5 reductase 3
chr4_+_4388805 0.28 ENST00000504171.1
NSG1
Homo sapiens neuron specific gene family member 1 (NSG1), transcript variant 3, mRNA.
chr22_+_39853258 0.27 ENST00000341184.6
MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chrX_-_136113833 0.27 ENST00000298110.1
GPR101
G protein-coupled receptor 101
chr16_+_3014217 0.26 ENST00000572045.1
KREMEN2
kringle containing transmembrane protein 2
chr12_+_57522439 0.26 ENST00000338962.4
LRP1
low density lipoprotein receptor-related protein 1
chr14_-_77608121 0.26 ENST00000319374.4
ZDHHC22
zinc finger, DHHC-type containing 22
chr4_+_128982490 0.25 ENST00000394288.3
ENST00000432347.2
ENST00000264584.5
ENST00000441387.1
ENST00000427266.1
ENST00000354456.3
LARP1B
La ribonucleoprotein domain family, member 1B
chr16_+_333152 0.25 ENST00000219406.6
ENST00000404312.1
ENST00000456379.1
PDIA2
protein disulfide isomerase family A, member 2
chr10_-_75255724 0.25 ENST00000342558.3
ENST00000360663.5
ENST00000394829.2
ENST00000394828.2
ENST00000394822.2
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr10_-_75255668 0.24 ENST00000545874.1
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr9_-_131486367 0.23 ENST00000372663.4
ENST00000406904.2
ENST00000452105.1
ENST00000372672.2
ENST00000372667.5
ZDHHC12
zinc finger, DHHC-type containing 12
chr11_-_44971702 0.23 ENST00000533940.1
ENST00000533937.1
TP53I11
tumor protein p53 inducible protein 11
chr20_+_43514320 0.22 ENST00000372839.3
ENST00000428262.1
ENST00000445830.1
YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
chr7_-_5570229 0.22 ENST00000331789.5
ACTB
actin, beta
chr9_+_131549610 0.22 ENST00000223865.8
TBC1D13
TBC1 domain family, member 13
chr8_-_133493200 0.21 ENST00000388996.4
KCNQ3
potassium voltage-gated channel, KQT-like subfamily, member 3
chr11_-_62783303 0.21 ENST00000336232.2
ENST00000430500.2
SLC22A8
solute carrier family 22 (organic anion transporter), member 8
chr11_-_44972390 0.21 ENST00000395648.3
ENST00000531928.2
TP53I11
tumor protein p53 inducible protein 11
chr1_-_102462565 0.21 ENST00000370103.4
OLFM3
olfactomedin 3
chr1_+_26644441 0.20 ENST00000374213.2
CD52
CD52 molecule
chr19_+_41770269 0.18 ENST00000378215.4
HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr19_+_41770349 0.17 ENST00000602130.1
HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr1_+_55271736 0.17 ENST00000358193.3
ENST00000371273.3
C1orf177
chromosome 1 open reading frame 177
chr7_+_150748288 0.17 ENST00000490540.1
ASIC3
acid-sensing (proton-gated) ion channel 3
chr7_+_20370300 0.16 ENST00000537992.1
ITGB8
integrin, beta 8
chr1_-_165414414 0.15 ENST00000359842.5
RXRG
retinoid X receptor, gamma
chr19_-_4066890 0.15 ENST00000322357.4
ZBTB7A
zinc finger and BTB domain containing 7A
chr19_+_10531150 0.14 ENST00000352831.6
PDE4A
phosphodiesterase 4A, cAMP-specific
chr2_-_206950781 0.14 ENST00000403263.1
INO80D
INO80 complex subunit D
chr11_+_61595752 0.14 ENST00000521849.1
FADS2
fatty acid desaturase 2
chr2_+_135011731 0.13 ENST00000281923.2
MGAT5
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
chr7_+_20370746 0.13 ENST00000222573.4
ITGB8
integrin, beta 8
chr20_-_25062767 0.13 ENST00000429762.3
ENST00000444511.2
ENST00000376707.3
VSX1
visual system homeobox 1
chr21_-_45682099 0.12 ENST00000270172.3
ENST00000418993.1
DNMT3L
DNA (cytosine-5-)-methyltransferase 3-like
chr10_-_118032979 0.12 ENST00000355422.6
GFRA1
GDNF family receptor alpha 1
chr8_-_42234745 0.12 ENST00000220812.2
DKK4
dickkopf WNT signaling pathway inhibitor 4
chr12_+_7037461 0.11 ENST00000396684.2
ATN1
atrophin 1
chr8_+_22022223 0.11 ENST00000306385.5
BMP1
bone morphogenetic protein 1
chr4_+_128982430 0.11 ENST00000512292.1
ENST00000508819.1
LARP1B
La ribonucleoprotein domain family, member 1B
chr11_-_44972476 0.10 ENST00000527685.1
ENST00000308212.5
TP53I11
tumor protein p53 inducible protein 11
chr3_-_196439065 0.08 ENST00000399942.4
ENST00000409690.3
CEP19
centrosomal protein 19kDa
chr16_+_3014269 0.08 ENST00000575885.1
ENST00000571007.1
ENST00000319500.6
KREMEN2
kringle containing transmembrane protein 2
chr4_+_4388245 0.08 ENST00000433139.2
NSG1
Homo sapiens neuron specific gene family member 1 (NSG1), transcript variant 3, mRNA.
chr15_-_41522889 0.07 ENST00000458580.2
ENST00000314992.5
ENST00000558396.1
EXD1
exonuclease 3'-5' domain containing 1
chr16_+_71392616 0.04 ENST00000349553.5
ENST00000302628.4
ENST00000562305.1
CALB2
calbindin 2
chrX_+_106163626 0.04 ENST00000336803.1
CLDN2
claudin 2
chr19_+_55795493 0.02 ENST00000309383.1
BRSK1
BR serine/threonine kinase 1
chr9_-_35619539 0.01 ENST00000396757.1
CD72
CD72 molecule
chr9_-_39239171 0.01 ENST00000358144.2
CNTNAP3
contactin associated protein-like 3
chr12_+_7342441 0.01 ENST00000412720.2
ENST00000396637.3
PEX5
peroxisomal biogenesis factor 5
chr20_-_62475273 0.01 ENST00000596861.1
AL158091.1
Protein LOC100509861
chr17_-_79212825 0.00 ENST00000374769.2
ENTHD2
ENTH domain containing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF423

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 10.4 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.6 2.5 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.5 2.1 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.3 1.7 GO:1903862 regulation of muscle atrophy(GO:0014735) response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) positive regulation of oxidative phosphorylation(GO:1903862)
0.3 1.9 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005) ERK5 cascade(GO:0070375)
0.2 0.7 GO:0019521 pentose-phosphate shunt, oxidative branch(GO:0009051) aldonic acid metabolic process(GO:0019520) D-gluconate metabolic process(GO:0019521)
0.2 0.7 GO:0045212 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.2 1.4 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.2 1.8 GO:0033504 floor plate development(GO:0033504)
0.2 1.1 GO:1990834 negative regulation of T-helper 1 cell differentiation(GO:0045626) response to odorant(GO:1990834)
0.2 1.9 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.2 1.0 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.2 7.1 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.2 0.7 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.2 0.5 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
0.1 1.0 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.1 1.1 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.1 0.5 GO:0050916 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.1 0.6 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 0.4 GO:1902162 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.1 0.7 GO:0006013 mannose metabolic process(GO:0006013)
0.1 0.4 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.1 1.6 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.1 0.3 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.1 0.5 GO:0048478 replication fork protection(GO:0048478)
0.1 1.3 GO:0046852 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.1 0.4 GO:0072104 glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
0.1 0.9 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0 0.3 GO:0010193 response to ozone(GO:0010193)
0.0 0.8 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.5 GO:0048102 autophagic cell death(GO:0048102)
0.0 1.3 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.0 0.5 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.7 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 1.5 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 0.2 GO:0050968 iron chelate transport(GO:0015688) siderophore transport(GO:0015891) detection of chemical stimulus involved in sensory perception of pain(GO:0050968)
0.0 0.7 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.5 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 2.2 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636)
0.0 0.4 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 1.4 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 0.5 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.0 1.0 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.2 GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887)
0.0 0.3 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 5.2 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.1 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 0.1 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.0 0.4 GO:0034380 high-density lipoprotein particle assembly(GO:0034380)
0.0 0.5 GO:0051220 cytoplasmic sequestering of protein(GO:0051220)
0.0 0.2 GO:0060081 membrane hyperpolarization(GO:0060081)
0.0 2.1 GO:0002062 chondrocyte differentiation(GO:0002062)
0.0 2.4 GO:0042552 myelination(GO:0042552)
0.0 0.9 GO:0008333 endosome to lysosome transport(GO:0008333)
0.0 0.1 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.0 0.3 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.0 0.8 GO:0042417 dopamine metabolic process(GO:0042417)
0.0 0.3 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880)
0.0 0.4 GO:0050832 defense response to fungus(GO:0050832)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 7.1 GO:0098560 cytoplasmic side of early endosome membrane(GO:0098559) cytoplasmic side of late endosome membrane(GO:0098560)
0.5 1.5 GO:0033597 mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298)
0.1 1.0 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.1 0.3 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.1 0.9 GO:0016589 NURF complex(GO:0016589)
0.1 1.3 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 0.5 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 10.4 GO:0005581 collagen trimer(GO:0005581)
0.1 0.7 GO:0043083 synaptic cleft(GO:0043083)
0.1 0.5 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.8 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.7 GO:0071439 clathrin complex(GO:0071439)
0.0 0.5 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.5 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.2 GO:0098845 postsynaptic endosome(GO:0098845)
0.0 0.4 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.9 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.1 GO:1990923 PET complex(GO:1990923)
0.0 0.2 GO:0097433 dense body(GO:0097433)
0.0 1.1 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 2.1 GO:0005604 basement membrane(GO:0005604)
0.0 0.3 GO:0005833 hemoglobin complex(GO:0005833)
0.0 1.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.3 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 4.8 GO:0000790 nuclear chromatin(GO:0000790)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.1 GO:0035939 microsatellite binding(GO:0035939)
0.4 1.3 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.4 1.1 GO:0004913 interleukin-4 receptor activity(GO:0004913)
0.3 1.0 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.2 1.4 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.2 4.9 GO:0032794 GTPase activating protein binding(GO:0032794)
0.2 0.7 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.2 0.7 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.2 0.7 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.2 0.5 GO:0047150 betaine-homocysteine S-methyltransferase activity(GO:0047150)
0.2 0.5 GO:0032427 GBD domain binding(GO:0032427)
0.1 0.4 GO:0070052 collagen V binding(GO:0070052)
0.1 0.5 GO:0000822 inositol hexakisphosphate binding(GO:0000822) inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 0.9 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.1 7.1 GO:0050699 WW domain binding(GO:0050699)
0.1 12.7 GO:0005518 collagen binding(GO:0005518)
0.1 1.3 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 0.5 GO:0050815 phosphoserine binding(GO:0050815)
0.1 0.4 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 1.3 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.1 1.4 GO:0017166 vinculin binding(GO:0017166)
0.1 0.8 GO:1903136 cuprous ion binding(GO:1903136)
0.1 0.3 GO:0042954 apolipoprotein receptor activity(GO:0030226) lipoprotein transporter activity(GO:0042954)
0.1 1.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.5 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.3 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 2.0 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.7 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 0.2 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 1.0 GO:0047555 cGMP binding(GO:0030553) 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 1.7 GO:0070888 E-box binding(GO:0070888)
0.0 0.2 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 0.8 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.1 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 0.2 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 1.0 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.1 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 1.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.3 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 2.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.3 GO:0004935 adrenergic receptor activity(GO:0004935)
0.0 0.1 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 0.2 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.5 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.3 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 1.9 GO:0005179 hormone activity(GO:0005179)
0.0 0.2 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.4 GO:0019956 chemokine binding(GO:0019956)
0.0 1.5 GO:0043130 ubiquitin binding(GO:0043130)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.1 1.4 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 2.5 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.1 3.5 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 11.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.1 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.8 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.3 PID IL23 PATHWAY IL23-mediated signaling events
0.0 1.0 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.9 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 2.3 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.0 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.5 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.5 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.5 PID P73PATHWAY p73 transcription factor network
0.0 0.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.5 PID ATR PATHWAY ATR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.6 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 0.8 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.4 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 1.5 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 0.5 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.5 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 1.1 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 2.1 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 2.3 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 1.0 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.0 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.7 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 1.3 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 2.5 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 1.0 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.4 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.5 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell