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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for ZNF524
Z-value: 1.33
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Transcription factors associated with ZNF524
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF524 | hg19_v2_chr19_+_56111680_56111735 | 0.33 | 1.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_48757278 Show fit | 6.28 |
ENST00000404752.1
ENST00000406226.1 |
stonin 1 |
|
| chr9_-_77703115 Show fit | 4.73 |
ENST00000361092.4
ENST00000376808.4 |
nicotinamide riboside kinase 1 |
|
| chr9_-_77703056 Show fit | 4.58 |
ENST00000376811.1
|
nicotinamide riboside kinase 1 |
|
| chr2_+_112656048 Show fit | 4.58 |
ENST00000295408.4
|
c-mer proto-oncogene tyrosine kinase |
|
| chr2_+_112656176 Show fit | 4.57 |
ENST00000421804.2
ENST00000409780.1 |
c-mer proto-oncogene tyrosine kinase |
|
| chr16_+_55542910 Show fit | 3.36 |
ENST00000262134.5
|
lysophosphatidylcholine acyltransferase 2 |
|
| chr14_-_54420133 Show fit | 3.34 |
ENST00000559501.1
ENST00000558984.1 |
bone morphogenetic protein 4 |
|
| chr1_-_92371839 Show fit | 3.19 |
ENST00000370399.2
|
transforming growth factor, beta receptor III |
|
| chr1_-_100231349 Show fit | 3.09 |
ENST00000287474.5
ENST00000414213.1 |
ferric-chelate reductase 1 |
|
| chr14_-_105420241 Show fit | 3.08 |
ENST00000557457.1
|
AHNAK nucleoprotein 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF524
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 9.2 | GO:0097350 | neutrophil clearance(GO:0097350) |
| 0.0 | 4.3 | GO:0031424 | keratinization(GO:0031424) |
| 0.1 | 4.2 | GO:0009435 | NAD biosynthetic process(GO:0009435) |
| 0.2 | 3.7 | GO:0009650 | UV protection(GO:0009650) |
| 0.5 | 3.6 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.8 | 3.4 | GO:0006663 | platelet activating factor biosynthetic process(GO:0006663) |
| 0.6 | 3.4 | GO:1904381 | Golgi apparatus mannose trimming(GO:1904381) |
| 1.1 | 3.3 | GO:0061149 | apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007) |
| 0.8 | 3.2 | GO:0007181 | transforming growth factor beta receptor complex assembly(GO:0007181) |
| 0.1 | 3.1 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.0 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 4.9 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 4.8 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.2 | 4.5 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 4.1 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 3.8 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 3.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.9 | 3.5 | GO:0031251 | PAN complex(GO:0031251) |
| 0.1 | 3.4 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 3.3 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.2 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 2.3 | 9.3 | GO:0050262 | ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769) |
| 0.3 | 4.2 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.2 | 3.6 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.2 | 3.6 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 1.1 | 3.4 | GO:0047192 | 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192) |
| 0.3 | 3.4 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.6 | 3.3 | GO:0000293 | ferric-chelate reductase activity(GO:0000293) |
| 0.3 | 3.2 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
| 0.2 | 3.1 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.1 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 5.2 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 2.6 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 2.4 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 1.9 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 1.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.7 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 1.3 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.2 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.1 | 4.2 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.2 | 4.1 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.1 | 3.6 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 3.2 | REACTOME ACYL CHAIN REMODELLING OF PC | Genes involved in Acyl chain remodelling of PC |
| 0.1 | 2.9 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 2.9 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.0 | 2.9 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 2.8 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 2.6 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |