Project
Inflammatory response time course, HUVEC (Wada et al., 2009)
Navigation
Downloads
Results for ZNF711_TFAP2A_TFAP2D
Z-value: 2.11
Motif logo
Transcription factors associated with ZNF711_TFAP2A_TFAP2D
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000147180.12 | zinc finger protein 711 | |
| ENSG00000137203.6 | transcription factor AP-2 alpha | |
| ENSG00000008197.4 | transcription factor AP-2 delta |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF711 | hg19_v2_chrX_+_84498989_84499003, hg19_v2_chrX_+_84499038_84499078 | 0.53 | 6.0e-03 | Click! |
| TFAP2D | hg19_v2_chr6_+_50681541_50681541 | -0.30 | 1.5e-01 | Click! |
| TFAP2A | hg19_v2_chr6_-_10415218_10415274 | 0.29 | 1.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_156588350 Show fit | 15.94 |
ENST00000296518.7
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr1_+_25944341 Show fit | 15.86 |
ENST00000263979.3
|
mannosidase, alpha, class 1C, member 1 |
|
| chr4_+_156588806 Show fit | 13.14 |
ENST00000513574.1
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr4_+_156588249 Show fit | 9.47 |
ENST00000393832.3
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr17_-_42276574 Show fit | 8.44 |
ENST00000589805.1
|
ataxin 7-like 3 |
|
| chr9_+_139606983 Show fit | 8.04 |
ENST00000371692.4
|
family with sequence similarity 69, member B |
|
| chr6_-_84419101 Show fit | 7.79 |
ENST00000520302.1
ENST00000520213.1 ENST00000439399.2 ENST00000428679.2 ENST00000437520.1 |
synaptosomal-associated protein, 91kDa |
|
| chr9_-_140196703 Show fit | 7.76 |
ENST00000356628.2
|
NOTCH-regulated ankyrin repeat protein |
|
| chr2_+_112656048 Show fit | 7.42 |
ENST00000295408.4
|
c-mer proto-oncogene tyrosine kinase |
|
| chr4_+_156588115 Show fit | 7.39 |
ENST00000455639.2
|
guanylate cyclase 1, soluble, alpha 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF711_TFAP2A_TFAP2D
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.0 | 54.3 | GO:0052565 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 3.8 | 23.0 | GO:1904381 | Golgi apparatus mannose trimming(GO:1904381) |
| 0.6 | 19.0 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.6 | 17.6 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.2 | 16.7 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 1.5 | 15.1 | GO:0097350 | neutrophil clearance(GO:0097350) |
| 2.4 | 14.2 | GO:0061441 | renal artery morphogenesis(GO:0061441) |
| 0.6 | 13.9 | GO:0072189 | ureter development(GO:0072189) |
| 0.3 | 13.7 | GO:0033173 | calcineurin-NFAT signaling cascade(GO:0033173) |
| 0.3 | 13.6 | GO:0032784 | regulation of DNA-templated transcription, elongation(GO:0032784) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 55.4 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.6 | 33.5 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.2 | 29.2 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 26.5 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.4 | 23.6 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 22.8 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.3 | 20.8 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 1.6 | 17.2 | GO:0097443 | sorting endosome(GO:0097443) |
| 1.0 | 16.0 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.1 | 16.0 | GO:0030018 | Z disc(GO:0030018) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 55.4 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.1 | 48.1 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 37.0 | GO:0005509 | calcium ion binding(GO:0005509) |
| 2.3 | 25.3 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.7 | 22.5 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 2.3 | 21.1 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
| 1.0 | 17.3 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 1.2 | 16.1 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.2 | 15.0 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.4 | 14.1 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 34.0 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.3 | 21.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 1.1 | 20.5 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.3 | 17.3 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.3 | 17.1 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.3 | 16.8 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 16.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 16.0 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.4 | 15.9 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 14.0 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 52.6 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.5 | 22.0 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.3 | 21.7 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.2 | 19.0 | REACTOME TRANS GOLGI NETWORK VESICLE BUDDING | Genes involved in trans-Golgi Network Vesicle Budding |
| 0.9 | 18.8 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.5 | 17.8 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.2 | 16.2 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.6 | 15.0 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.2 | 14.3 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 13.6 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |