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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for ZNF8

Z-value: 0.33

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Transcription factors associated with ZNF8

Gene Symbol Gene ID Gene Info
ZNF8
ENSG00000083842.8 zinc finger protein 8
ZNF8
ENSG00000273439.1 zinc finger protein 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF8hg19_v2_chr19_+_58790314_587903580.154.6e-01Click!

Activity profile of ZNF8 motif

Sorted Z-values of ZNF8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_79258444 0.83 ENST00000261205.4
SYT1
synaptotagmin I
chr12_+_79258547 0.81 ENST00000457153.2
SYT1
synaptotagmin I
chr11_+_13690249 0.67 ENST00000532701.1
FAR1
fatty acyl CoA reductase 1
chr6_+_53659746 0.62 ENST00000370888.1
LRRC1
leucine rich repeat containing 1
chr2_+_173600514 0.42 ENST00000264111.6
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr2_+_173600565 0.41 ENST00000397081.3
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr1_-_186344802 0.37 ENST00000451586.1
TPR
translocated promoter region, nuclear basket protein
chr19_+_37998031 0.36 ENST00000586138.1
ENST00000588578.1
ENST00000587986.1
ZNF793
zinc finger protein 793
chr6_-_31763408 0.32 ENST00000444930.2
VARS
valyl-tRNA synthetase
chr2_+_169926047 0.31 ENST00000428522.1
ENST00000450153.1
ENST00000421653.1
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr5_+_138677515 0.27 ENST00000265192.4
ENST00000511706.1
PAIP2
poly(A) binding protein interacting protein 2
chr4_+_170541678 0.25 ENST00000360642.3
ENST00000512813.1
CLCN3
chloride channel, voltage-sensitive 3
chr4_+_170541835 0.24 ENST00000504131.2
CLCN3
chloride channel, voltage-sensitive 3
chr17_+_34136459 0.24 ENST00000588240.1
ENST00000590273.1
ENST00000588441.1
ENST00000587272.1
ENST00000592237.1
ENST00000311979.3
TAF15
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
chr5_-_93447333 0.21 ENST00000395965.3
ENST00000505869.1
ENST00000509163.1
FAM172A
family with sequence similarity 172, member A
chr1_-_246670519 0.21 ENST00000388985.4
ENST00000490107.1
SMYD3
SET and MYND domain containing 3
chr17_+_75181292 0.20 ENST00000431431.2
SEC14L1
SEC14-like 1 (S. cerevisiae)
chr13_+_45563721 0.20 ENST00000361121.2
GPALPP1
GPALPP motifs containing 1
chr1_+_214161272 0.20 ENST00000498508.2
ENST00000366958.4
PROX1
prospero homeobox 1
chrX_+_102631248 0.19 ENST00000361298.4
ENST00000372645.3
ENST00000372635.1
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr5_+_10353780 0.18 ENST00000449913.2
ENST00000503788.1
ENST00000274140.5
MARCH6
membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
chr4_+_170541660 0.17 ENST00000513761.1
ENST00000347613.4
CLCN3
chloride channel, voltage-sensitive 3
chr14_+_105941118 0.16 ENST00000550577.1
ENST00000538259.2
CRIP2
cysteine-rich protein 2
chr22_-_37415475 0.15 ENST00000403892.3
ENST00000249042.3
ENST00000438203.1
TST
thiosulfate sulfurtransferase (rhodanese)
chr2_-_240322643 0.13 ENST00000345617.3
HDAC4
histone deacetylase 4
chr2_+_87144738 0.13 ENST00000559485.1
RGPD1
RANBP2-like and GRIP domain containing 1
chr4_+_186347388 0.12 ENST00000511138.1
ENST00000511581.1
C4orf47
chromosome 4 open reading frame 47
chr11_+_46402583 0.12 ENST00000359803.3
MDK
midkine (neurite growth-promoting factor 2)
chr1_+_6615241 0.11 ENST00000333172.6
ENST00000328191.4
ENST00000351136.3
TAS1R1
taste receptor, type 1, member 1
chr6_+_106959718 0.11 ENST00000369066.3
AIM1
absent in melanoma 1
chr4_-_52904425 0.10 ENST00000535450.1
SGCB
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
chr22_+_30163340 0.10 ENST00000330029.6
ENST00000401406.3
UQCR10
ubiquinol-cytochrome c reductase, complex III subunit X
chr19_-_18392422 0.10 ENST00000252818.3
JUND
jun D proto-oncogene
chr17_+_48624450 0.10 ENST00000006658.6
ENST00000356488.4
ENST00000393244.3
SPATA20
spermatogenesis associated 20
chr1_+_70671363 0.10 ENST00000370951.1
ENST00000370950.3
ENST00000405432.1
ENST00000454435.2
SRSF11
serine/arginine-rich splicing factor 11
chr7_+_1748798 0.09 ENST00000561626.1
ELFN1
extracellular leucine-rich repeat and fibronectin type III domain containing 1
chr6_-_26056695 0.08 ENST00000343677.2
HIST1H1C
histone cluster 1, H1c
chr1_-_70671216 0.08 ENST00000370952.3
LRRC40
leucine rich repeat containing 40
chr10_+_135192695 0.08 ENST00000368539.4
ENST00000278060.5
ENST00000357296.3
PAOX
polyamine oxidase (exo-N4-amino)
chr3_-_46759314 0.08 ENST00000315170.7
PRSS50
protease, serine, 50
chr16_+_29973351 0.08 ENST00000602948.1
ENST00000279396.6
ENST00000575829.2
ENST00000561899.2
TMEM219
transmembrane protein 219
chr12_-_74686314 0.07 ENST00000551210.1
ENST00000515416.2
ENST00000549905.1
RP11-81H3.2
RP11-81H3.2
chr6_-_116601044 0.07 ENST00000368608.3
TSPYL1
TSPY-like 1
chr1_-_235292250 0.07 ENST00000366607.4
TOMM20
translocase of outer mitochondrial membrane 20 homolog (yeast)
chr11_+_46402482 0.06 ENST00000441869.1
MDK
midkine (neurite growth-promoting factor 2)
chr22_+_37415776 0.06 ENST00000341116.3
ENST00000429360.2
ENST00000404393.1
MPST
mercaptopyruvate sulfurtransferase
chr10_-_13043697 0.06 ENST00000378825.3
CCDC3
coiled-coil domain containing 3
chr11_+_13690200 0.05 ENST00000354817.3
FAR1
fatty acyl CoA reductase 1
chr1_-_55266926 0.05 ENST00000371276.4
TTC22
tetratricopeptide repeat domain 22
chr9_+_96026230 0.05 ENST00000448251.1
WNK2
WNK lysine deficient protein kinase 2
chr22_+_37415676 0.04 ENST00000401419.3
MPST
mercaptopyruvate sulfurtransferase
chr1_+_186344883 0.04 ENST00000367470.3
C1orf27
chromosome 1 open reading frame 27
chr4_-_186347099 0.04 ENST00000505357.1
ENST00000264689.6
UFSP2
UFM1-specific peptidase 2
chr5_+_102455968 0.04 ENST00000358359.3
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr7_-_74489609 0.04 ENST00000329959.4
ENST00000503250.2
ENST00000543840.1
WBSCR16
Williams-Beuren syndrome chromosome region 16
chr16_+_21964662 0.04 ENST00000561553.1
ENST00000565331.1
UQCRC2
ubiquinol-cytochrome c reductase core protein II
chr22_+_37415728 0.04 ENST00000404802.3
MPST
mercaptopyruvate sulfurtransferase
chr19_+_35739782 0.04 ENST00000347609.4
LSR
lipolysis stimulated lipoprotein receptor
chr19_+_35739897 0.04 ENST00000605618.1
ENST00000427250.1
ENST00000601623.1
LSR
lipolysis stimulated lipoprotein receptor
chr22_+_37415700 0.04 ENST00000397129.1
MPST
mercaptopyruvate sulfurtransferase
chr1_+_186344945 0.03 ENST00000419367.3
ENST00000287859.6
C1orf27
chromosome 1 open reading frame 27
chr10_+_1034646 0.03 ENST00000360059.5
ENST00000545048.1
GTPBP4
GTP binding protein 4
chr2_+_172290707 0.03 ENST00000375255.3
ENST00000539783.1
DCAF17
DDB1 and CUL4 associated factor 17
chr9_-_32552551 0.02 ENST00000360538.2
ENST00000379858.1
TOPORS
topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
chr10_+_1034338 0.02 ENST00000360803.4
ENST00000538293.1
GTPBP4
GTP binding protein 4
chr1_-_100715372 0.02 ENST00000370131.3
ENST00000370132.4
DBT
dihydrolipoamide branched chain transacylase E2
chr2_+_198365122 0.01 ENST00000604458.1
HSPE1-MOB4
HSPE1-MOB4 readthrough
chr16_-_53537105 0.00 ENST00000568596.1
ENST00000570004.1
ENST00000564497.1
ENST00000300245.4
ENST00000394657.7
AKTIP
AKT interacting protein
chr13_+_21750780 0.00 ENST00000309594.4
MRP63
mitochondrial ribosomal protein 63
chr13_-_21750659 0.00 ENST00000400018.3
ENST00000314759.5
SKA3
spindle and kinetochore associated complex subunit 3
chr22_-_30162924 0.00 ENST00000344318.3
ENST00000397781.3
ZMAT5
zinc finger, matrin-type 5

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.1 0.7 GO:0046504 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.1 0.4 GO:0031990 mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) positive regulation of chromatin assembly or disassembly(GO:0045799) negative regulation of RNA export from nucleus(GO:0046832)
0.1 0.7 GO:0048388 endosomal lumen acidification(GO:0048388)
0.1 0.3 GO:0009440 cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440)
0.1 0.2 GO:0061114 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 0.3 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.0 0.2 GO:0030421 defecation(GO:0030421)
0.0 0.3 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.1 GO:0050917 sensory perception of umami taste(GO:0050917)
0.0 0.1 GO:0035927 RNA import into mitochondrion(GO:0035927)
0.0 0.1 GO:0009447 putrescine catabolic process(GO:0009447)
0.0 0.2 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 0.1 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.0 0.0 GO:0033341 regulation of collagen binding(GO:0033341)
0.0 0.1 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.1 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.7 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.2 GO:0000835 ER ubiquitin ligase complex(GO:0000835)
0.0 0.4 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.1 GO:0035976 AP1 complex(GO:0035976)
0.0 0.1 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 0.7 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.1 0.7 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 0.3 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.1 0.3 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.0 0.2 GO:0039552 RIG-I binding(GO:0039552)
0.0 0.3 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0 0.1 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 0.2 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.1 GO:0052901 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.0 0.8 GO:0030552 cAMP binding(GO:0030552)
0.0 0.4 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.2 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 SIG CD40PATHWAYMAP Genes related to CD40 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.7 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.8 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling