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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for ZNF8
Z-value: 0.33
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Transcription factors associated with ZNF8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF8 | hg19_v2_chr19_+_58790314_58790358 | 0.15 | 4.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_+_79258444 Show fit | 0.83 |
ENST00000261205.4
|
synaptotagmin I |
|
| chr12_+_79258547 Show fit | 0.81 |
ENST00000457153.2
|
synaptotagmin I |
|
| chr11_+_13690249 Show fit | 0.67 |
ENST00000532701.1
|
fatty acyl CoA reductase 1 |
|
| chr6_+_53659746 Show fit | 0.62 |
ENST00000370888.1
|
leucine rich repeat containing 1 |
|
| chr2_+_173600514 Show fit | 0.42 |
ENST00000264111.6
|
Rap guanine nucleotide exchange factor (GEF) 4 |
|
| chr2_+_173600565 Show fit | 0.41 |
ENST00000397081.3
|
Rap guanine nucleotide exchange factor (GEF) 4 |
|
| chr1_-_186344802 Show fit | 0.37 |
ENST00000451586.1
|
translocated promoter region, nuclear basket protein |
|
| chr19_+_37998031 Show fit | 0.36 |
ENST00000586138.1
ENST00000588578.1 ENST00000587986.1 |
zinc finger protein 793 |
|
| chr6_-_31763408 Show fit | 0.32 |
ENST00000444930.2
|
valyl-tRNA synthetase |
|
| chr2_+_169926047 Show fit | 0.31 |
ENST00000428522.1
ENST00000450153.1 ENST00000421653.1 |
dehydrogenase/reductase (SDR family) member 9 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF8
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.6 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.1 | 0.7 | GO:0046504 | ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503) |
| 0.1 | 0.7 | GO:0048388 | endosomal lumen acidification(GO:0048388) |
| 0.1 | 0.4 | GO:0031990 | mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) positive regulation of chromatin assembly or disassembly(GO:0045799) negative regulation of RNA export from nucleus(GO:0046832) |
| 0.1 | 0.3 | GO:0009440 | cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440) |
| 0.1 | 0.3 | GO:0006438 | valyl-tRNA aminoacylation(GO:0006438) |
| 0.0 | 0.3 | GO:0042904 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.1 | 0.2 | GO:0061114 | hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979) |
| 0.0 | 0.2 | GO:0030421 | defecation(GO:0030421) |
| 0.0 | 0.2 | GO:0039536 | negative regulation of RIG-I signaling pathway(GO:0039536) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.6 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.0 | 0.7 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 0.4 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
| 0.0 | 0.2 | GO:0000835 | ER ubiquitin ligase complex(GO:0000835) |
| 0.0 | 0.1 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.0 | 0.1 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.0 | 0.1 | GO:0016012 | sarcoglycan complex(GO:0016012) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.6 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.0 | 0.8 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.1 | 0.7 | GO:0080019 | fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019) |
| 0.1 | 0.7 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 0.0 | 0.4 | GO:0043495 | protein anchor(GO:0043495) |
| 0.1 | 0.3 | GO:0004832 | valine-tRNA ligase activity(GO:0004832) |
| 0.1 | 0.3 | GO:0004792 | thiosulfate sulfurtransferase activity(GO:0004792) |
| 0.0 | 0.3 | GO:0047035 | testosterone dehydrogenase (NAD+) activity(GO:0047035) |
| 0.0 | 0.2 | GO:0039552 | RIG-I binding(GO:0039552) |
| 0.0 | 0.2 | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.0 | 0.8 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 0.7 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |