Motif ID: AAGGUGC

Z-value: 0.637


Mature miRNA associated with seed AAGGUGC:

NamemiRBase Accession
hsa-miR-18a MIMAT0000072
hsa-miR-18b MIMAT0001412
hsa-miR-4735-3p MIMAT0019861



Activity profile for motif AAGGUGC.

activity profile for motif AAGGUGC


Sorted Z-values histogram for motif AAGGUGC

Sorted Z-values for motif AAGGUGC



Network of associatons between targets according to the STRING database.



First level regulatory network of AAGGUGC

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_132272311 3.110 NM_001901
CTGF
connective tissue growth factor
chr6_+_112408673 2.558 NM_001033564
C6orf225
chromosome 6 open reading frame 225
chr13_+_43355685 2.497 NM_182508
C13orf30
chromosome 13 open reading frame 30
chr4_+_55523906 2.132 NM_000222
NM_001093772
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr6_+_39760148 1.443 NM_001201427
DAAM2
dishevelled associated activator of morphogenesis 2
chr6_+_39760772 1.313 NM_015345
DAAM2
dishevelled associated activator of morphogenesis 2
chr15_-_61521478 1.203 NM_134261
RORA
RAR-related orphan receptor A
chr11_-_108464344 1.178 NM_015065
EXPH5
exophilin 5
chr15_-_60884615 1.116 NM_134262
RORA
RAR-related orphan receptor A
chr12_+_12764755 0.944 NM_001310
CREBL2
cAMP responsive element binding protein-like 2
chr15_-_60919642 0.941 NM_002943
NM_134260
RORA

RAR-related orphan receptor A

chr12_+_104458235 0.920 NM_013320
HCFC2
host cell factor C2
chr9_-_35563895 0.850 NM_001099951
NM_001164310
FAM166B

family with sequence similarity 166, member B

chr2_+_63277191 0.829 NM_001199770
OTX1
orthodenticle homeobox 1
chr5_-_73937248 0.781 NM_003633
ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr2_+_63277936 0.765 NM_014562
OTX1
orthodenticle homeobox 1
chr1_+_87794150 0.764 NM_006769
LMO4
LIM domain only 4
chr9_-_74383301 0.675 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr9_+_96338671 0.617 NM_005392
PHF2
PHD finger protein 2
chr11_-_130184459 0.607 NM_014155
ZBTB44
zinc finger and BTB domain containing 44
chr1_+_40839368 0.603 NM_022733
SMAP2
small ArfGAP2
chr2_+_12856813 0.596 NM_021643
TRIB2
tribbles homolog 2 (Drosophila)
chr21_-_36421586 0.594 NM_001754
RUNX1
runt-related transcription factor 1
chr1_-_204329043 0.584 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr1_+_40859016 0.558 NM_001198979
SMAP2
small ArfGAP2
chr2_+_24807345 0.546 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr22_-_30867944 0.514 NM_174975
SEC14L3
SEC14-like 3 (S. cerevisiae)
chr13_-_77601296 0.504 NM_012158
FBXL3
F-box and leucine-rich repeat protein 3
chr13_-_26625164 0.475 NM_001007538
SHISA2
shisa homolog 2 (Xenopus laevis)
chr9_+_34458810 0.463 NM_012144
DNAI1
dynein, axonemal, intermediate chain 1
chr1_+_40840304 0.460 NM_001198978
SMAP2
small ArfGAP2
chr1_+_40862471 0.459 NM_001198980
SMAP2
small ArfGAP2
chr5_+_56110899 0.459 NM_005921
MAP3K1
mitogen-activated protein kinase kinase kinase 1
chr1_+_162467594 0.452 NM_144624
NM_175866
UHMK1

U2AF homology motif (UHM) kinase 1

chr6_+_19837599 0.451 NM_001546
ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr4_-_147866963 0.449 NM_031956
TTC29
tetratricopeptide repeat domain 29
chr16_+_69599868 0.437 NM_001113178
NM_006599
NM_138713
NM_138714
NM_173214
NM_173215
NFAT5





nuclear factor of activated T-cells 5, tonicity-responsive





chr12_-_56652118 0.436 NM_173595
ANKRD52
ankyrin repeat domain 52
chr17_-_27621163 0.433 NM_020772
NUFIP2
nuclear fragile X mental retardation protein interacting protein 2
chr1_+_162466963 0.408 NM_001184763
UHMK1
U2AF homology motif (UHM) kinase 1
chr5_+_122424840 0.402 NM_001136239
PRDM6
PR domain containing 6
chr8_+_104152876 0.401 NM_001024372
NM_024812
BAALC

brain and acute leukemia, cytoplasmic

chr3_+_108308336 0.394 NM_014648
DZIP3
DAZ interacting protein 3, zinc finger
chr6_+_52285804 0.383 NM_001172420
EFHC1
EF-hand domain (C-terminal) containing 1
chr3_+_187930720 0.376 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr7_+_105603656 0.366 NM_152750
CDHR3
cadherin-related family member 3
chr3_+_187871473 0.361 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr17_+_68165660 0.355 NM_000891
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr20_+_30865435 0.350 NM_004798
KIF3B
kinesin family member 3B
chr18_-_45456925 0.346 NM_005901
SMAD2
SMAD family member 2
chr19_-_23578226 0.329 NM_003430
ZNF91
zinc finger protein 91
chr18_-_45457454 0.328 NM_001003652
NM_001135937
SMAD2

SMAD family member 2

chr6_+_52284948 0.327 NM_018100
EFHC1
EF-hand domain (C-terminal) containing 1
chr11_-_72852957 0.324 NM_014824
FCHSD2
FCH and double SH3 domains 2
chr13_+_24734788 0.324 NM_001166271
NM_153023
SPATA13

spermatogenesis associated 13

chr4_+_154125589 0.314 NM_015271
TRIM2
tripartite motif containing 2
chr6_+_122720685 0.311 NM_001135564
NM_001243094
NM_004506
HSF2


heat shock transcription factor 2


chr22_+_40440664 0.310 NM_001024843
TNRC6B
trinucleotide repeat containing 6B
chr12_+_11802726 0.302 NM_001987
ETV6
ets variant 6
chr16_+_71879893 0.301 NM_001137675
ATXN1L
ataxin 1-like
chr4_-_125633716 0.292 NM_001167882
NM_020337
ANKRD50

ankyrin repeat domain 50

chr10_+_111767685 0.290 NM_001121
NM_016824
ADD3

adducin 3 (gamma)

chr4_+_154074269 0.289 NM_001130067
TRIM2
tripartite motif containing 2
chr2_+_233561997 0.286 NM_001103146
NM_001103147
NM_001103148
NM_015575
GIGYF2



GRB10 interacting GYF protein 2



chr9_-_138987096 0.285 NM_144653
NACC2
NACC family member 2, BEN and BTB (POZ) domain containing
chr11_+_108093558 0.285 NM_000051
ATM
ataxia telangiectasia mutated
chr7_+_66386129 0.283 NM_017994
C7orf42
chromosome 7 open reading frame 42
chr4_-_186697065 0.283 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr6_+_150690027 0.282 NM_001164694
NM_001164695
NM_203395
IYD


iodotyrosine deiodinase


chr20_+_60697471 0.274 NM_144703
LSM14B
LSM14B, SCD6 homolog B (S. cerevisiae)
chr2_+_85198176 0.270 NM_020122
KCMF1
potassium channel modulatory factor 1
chr6_-_119031230 0.269 NM_001178035
CEP85L
centrosomal protein 85kDa-like
chr1_-_70820363 0.259 NM_030816
ANKRD13C
ankyrin repeat domain 13C
chr10_+_106113513 0.258 NM_001008723
CCDC147
coiled-coil domain containing 147
chr7_+_94536926 0.256 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory subunit 9A

chr5_-_180288275 0.246 NM_001172638
NM_152283
ZFP62

zinc finger protein 62 homolog (mouse)

chr4_-_186578122 0.245 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr4_-_186877869 0.245 NM_021069
SORBS2
sorbin and SH3 domain containing 2
chrX_+_150565655 0.243 NM_001017980
VMA21
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr2_-_26101301 0.239 NM_018263
ASXL2
additional sex combs like 2 (Drosophila)
chr4_-_83931973 0.239 NM_001115008
NM_194282
LIN54

lin-54 homolog (C. elegans)

chr16_+_3550916 0.235 NM_015041
CLUAP1
clusterin associated protein 1
chr17_+_27717942 0.233 NM_020791
NM_025142
TAOK1

TAO kinase 1

chr2_+_36583369 0.231 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr7_+_94539209 0.231 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr16_+_3559893 0.230 NM_024793
CLUAP1
clusterin associated protein 1
chr1_+_26737232 0.225 NM_024674
LIN28A
lin-28 homolog A (C. elegans)
chr2_+_61292999 0.222 NM_001129993
KIAA1841
KIAA1841
chr7_-_100286869 0.221 NM_022574
GIGYF1
GRB10 interacting GYF protein 1
chr16_-_57219951 0.220 NM_024946
FAM192A
family with sequence similarity 192, member A
chr3_+_105085553 0.219 NM_001243280
NM_001243281
NM_001243283
NM_001627
ALCAM



activated leukocyte cell adhesion molecule



chr3_-_120401401 0.218 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr20_+_49348050 0.217 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr6_-_37665631 0.215 NM_153487
MDGA1
MAM domain containing glycosylphosphatidylinositol anchor 1
chr4_-_185395616 0.203 NM_002199
IRF2
interferon regulatory factor 2
chr3_+_43328001 0.199 NM_001100594
NM_017719
SNRK

SNF related kinase

chr3_-_148939784 0.195 NM_000096
CP
ceruloplasmin (ferroxidase)
chr5_-_160279045 0.195 NM_025153
ATP10B
ATPase, class V, type 10B
chr14_-_31889736 0.195 NM_015473
HEATR5A
HEAT repeat containing 5A
chr7_-_64451413 0.191 NM_015852
ZNF117
zinc finger protein 117
chr12_+_56661026 0.191 NM_001099337
COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr20_+_51588945 0.190 NM_173485
TSHZ2
teashirt zinc finger homeobox 2
chr1_+_167189948 0.190 NM_001198786
NM_002697
POU2F1

POU class 2 homeobox 1

chr3_+_171561138 0.190 NM_001164436
TMEM212
transmembrane protein 212
chrX_+_108780235 0.186 NM_001242618
NXT2
nuclear transport factor 2-like export factor 2
chr5_-_58334936 0.185 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr12_+_56660548 0.183 NM_144576
COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr1_+_167298280 0.178 NM_001198783
POU2F1
POU class 2 homeobox 1
chrX_+_108779009 0.176 NM_018698
NXT2
nuclear transport factor 2-like export factor 2
chr12_+_69864065 0.176 NM_001042555
NM_006654
FRS2

fibroblast growth factor receptor substrate 2

chr20_+_51801821 0.174 NM_001193421
TSHZ2
teashirt zinc finger homeobox 2
chr2_-_202316227 0.168 NM_015049
TRAK2
trafficking protein, kinesin binding 2
chr1_+_172502012 0.166 NM_014283
C1orf9
chromosome 1 open reading frame 9
chr6_-_16761600 0.163 NM_000332
NM_001128164
ATXN1

ataxin 1

chr3_-_169899519 0.162 NM_024947
PHC3
polyhomeotic homolog 3 (Drosophila)
chr5_-_59783885 0.162 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_+_40834571 0.161 NM_003632
CNTNAP1
contactin associated protein 1
chr4_-_83933961 0.160 NM_001115007
LIN54
lin-54 homolog (C. elegans)
chr15_+_73344824 0.157 NM_001172623
NM_001172624
NM_002499
NEO1


neogenin 1


chr5_+_140514787 0.155 NM_015669
PCDHB5
protocadherin beta 5
chr14_-_95623665 0.153 NM_177438
DICER1
dicer 1, ribonuclease type III
chr21_-_36260972 0.153 NM_001001890
NM_001122607
RUNX1

runt-related transcription factor 1

chr20_+_278200 0.152 NM_033089
ZCCHC3
zinc finger, CCHC domain containing 3
chrX_+_108780058 0.149 NM_001242617
NXT2
nuclear transport factor 2-like export factor 2
chr1_+_172502291 0.148 NM_016227
C1orf9
chromosome 1 open reading frame 9
chr11_-_69519105 0.147 NM_005117
FGF19
fibroblast growth factor 19
chr17_-_7382943 0.146 NM_001128833
ZBTB4
zinc finger and BTB domain containing 4
chr4_+_108814419 0.145 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr2_-_55459406 0.143 NM_152385
C2orf63
chromosome 2 open reading frame 63
chr1_-_23521221 0.142 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr4_+_108745718 0.139 NM_001136258
SGMS2
sphingomyelin synthase 2
chrX_-_24045302 0.138 NM_030624
KLHL15
kelch-like 15 (Drosophila)
chr8_-_145701717 0.137 NM_003923
FOXH1
forkhead box H1
chr2_-_55459698 0.137 NM_001135598
C2orf63
chromosome 2 open reading frame 63
chrX_-_108868250 0.137 NM_012282
KCNE1L
KCNE1-like
chr7_+_75831194 0.136 NM_001110199
SRRM3
serine/arginine repetitive matrix 3
chrX_-_19688991 0.136 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr20_-_4982133 0.134 NM_005116
SLC23A2
solute carrier family 23 (nucleobase transporters), member 2
chr16_-_66730466 0.133 NM_178818
NM_181521
CMTM4

CKLF-like MARVEL transmembrane domain containing 4

chr11_-_79151694 0.132 NM_001098816
ODZ4
odz, odd Oz/ten-m homolog 4 (Drosophila)
chr19_-_22018940 0.130 NM_003423
ZNF43
zinc finger protein 43
chr10_+_111765725 0.128 NM_019903
ADD3
adducin 3 (gamma)
chr7_+_90893735 0.127 NM_003505
FZD1
frizzled family receptor 1
chr18_+_55888750 0.124 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr16_+_22217369 0.124 NM_013302
EEF2K
eukaryotic elongation factor-2 kinase
chr12_-_15374290 0.123 NM_001190726
NM_032918
RERG

RAS-like, estrogen-regulated, growth inhibitor

chr4_-_186732047 0.123 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr3_-_64211111 0.122 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr7_+_21467572 0.121 NM_003112
SP4
Sp4 transcription factor
chr6_-_86352635 0.121 NM_001159673
SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr1_+_180601121 0.120 NM_001135669
NM_004736
XPR1

xenotropic and polytropic retrovirus receptor 1

chr3_+_107241782 0.119 NM_001142568
NM_020235
BBX

bobby sox homolog (Drosophila)

chr19_-_7293876 0.119 NM_000208
NM_001079817
INSR

insulin receptor

chrX_-_19905665 0.118 NM_031892
SH3KBP1
SH3-domain kinase binding protein 1
chr6_-_24358279 0.117 NM_016356
DCDC2
doublecortin domain containing 2
chr6_-_107435635 0.117 NM_001080450
BEND3
BEN domain containing 3
chr1_-_213189087 0.115 NM_144567
ANGEL2
angel homolog 2 (Drosophila)
chr9_+_125703111 0.113 NM_012197
RABGAP1
RAB GTPase activating protein 1
chr11_+_109964086 0.111 NM_033390
ZC3H12C
zinc finger CCCH-type containing 12C
chr1_-_55681024 0.110 NM_015306
USP24
ubiquitin specific peptidase 24
chr1_-_89530890 0.109 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible
chr5_+_140625146 0.107 NM_018935
PCDHB15
protocadherin beta 15
chrX_+_77166178 0.107 NM_000052
ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr5_+_141488314 0.107 NM_030571
NDFIP1
Nedd4 family interacting protein 1
chr8_+_144731829 0.106 NM_014789
ZNF623
zinc finger protein 623
chr3_-_15900928 0.106 NM_015199
ANKRD28
ankyrin repeat domain 28
chr16_+_28996146 0.105 NM_001014989
LAT
linker for activation of T cells
chr6_+_26368405 0.105 NM_001197246
BTN3A2
butyrophilin, subfamily 3, member A2
chr19_+_58341661 0.105 NM_001204818
LOC100293516
zinc finger protein
chr6_+_47624222 0.104 NM_153839
GPR111
G protein-coupled receptor 111
chr5_+_31799030 0.104 NM_178140
PDZD2
PDZ domain containing 2
chr7_-_152133071 0.104 NM_170606
MLL3
myeloid/lymphoid or mixed-lineage leukemia 3
chr21_-_18985224 0.104 NM_001130914
NM_006806
BTG3

BTG family, member 3

chr2_+_205410465 0.103 NM_057177
NM_152526
NM_205863
PARD3B


par-3 partitioning defective 3 homolog B (C. elegans)


chr1_-_109506016 0.102 NM_001048210
NM_015127
CLCC1

AKNAD1
chloride channel CLIC-like 1

AKNA domain containing 1
chr6_-_86352564 0.101 NM_001159674
NM_001253771
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr6_-_24383519 0.100 NM_001195610
DCDC2
doublecortin domain containing 2
chr6_+_80340971 0.100 NM_031469
SH3BGRL2
SH3 domain binding glutamic acid-rich protein like 2
chr6_+_138188352 0.100 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr2_-_27886443 0.100 NM_014860
SUPT7L
suppressor of Ty 7 (S. cerevisiae)-like
chr19_-_20748540 0.099 NM_001159293
ZNF737
zinc finger protein 737
chr5_+_153825497 0.097 NM_001131062
NM_001131063
NM_024632
SAP30L


SAP30-like


chr1_+_227751218 0.095 NM_178549
ZNF678
zinc finger protein 678
chr10_+_38299525 0.095 NM_006954
NM_006974
ZNF33A

zinc finger protein 33A

chr1_-_202777545 0.095 NM_006618
KDM5B
lysine (K)-specific demethylase 5B
chr2_-_96874569 0.094 NM_020151
STARD7
StAR-related lipid transfer (START) domain containing 7
chr4_+_157997181 0.094 NM_000824
NM_001166061
NM_001166060
GLRB


glycine receptor, beta


chr11_+_118307072 0.093 NM_001197104
NM_005933
MLL

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)

chr3_-_13114547 0.092 NM_001134382
IQSEC1
IQ motif and Sec7 domain 1
chr19_-_19774501 0.092 NM_020410
ATP13A1
ATPase type 13A1
chr1_-_247242111 0.092 NM_001204220
NM_033213
ZNF670-ZNF695
ZNF670

ZNF670-ZNF695 readthrough
zinc finger protein 670

chrX_-_19817907 0.092 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr1_+_145438437 0.091 NM_006472
TXNIP
thioredoxin interacting protein
chr4_-_186732208 0.091 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr16_+_28996369 0.090 NM_001014987
NM_001014988
NM_014387
LAT


linker for activation of T cells


chr1_+_70820485 0.090 NM_001031693
NM_001036645
NM_001036646
HHLA3


HERV-H LTR-associating 3


chr17_+_26698986 0.089 NM_015077
SARM1
sterile alpha and TIR motif containing 1
chr18_+_55711388 0.089 NM_001144967
NM_001243960
NM_015277
NEDD4L


neural precursor cell expressed, developmentally down-regulated 4-like


chr20_-_1165116 0.088 NM_018354
TMEM74B
transmembrane protein 74B
chr9_+_120466453 0.088 NM_138554
TLR4
toll-like receptor 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.83 1.01e-05 GO:0010468 regulation of gene expression
1.84 1.17e-05 GO:0010556 regulation of macromolecule biosynthetic process
1.79 1.46e-05 GO:0009889 regulation of biosynthetic process
1.83 3.50e-05 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.77 3.80e-05 GO:0031326 regulation of cellular biosynthetic process
1.60 3.08e-04 GO:0080090 regulation of primary metabolic process
1.59 3.29e-04 GO:0031323 regulation of cellular metabolic process
1.81 3.80e-04 GO:0006355 regulation of transcription, DNA-dependent
1.79 3.98e-04 GO:0051252 regulation of RNA metabolic process
1.59 1.06e-03 GO:0060255 regulation of macromolecule metabolic process
1.68 1.28e-03 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.50 3.82e-03 GO:0019222 regulation of metabolic process
1.63 4.33e-03 GO:0051171 regulation of nitrogen compound metabolic process
4.87 4.97e-02 GO:0040029 regulation of gene expression, epigenetic

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.45 7.58e-06 GO:0005634 nucleus
1.22 6.51e-03 GO:0043231 intracellular membrane-bounded organelle
1.22 7.09e-03 GO:0043227 membrane-bounded organelle
1.15 2.32e-02 GO:0044424 intracellular part
1.18 4.14e-02 GO:0043229 intracellular organelle
1.18 4.74e-02 GO:0043226 organelle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.89 8.79e-06 GO:0008270 zinc ion binding
1.75 9.66e-05 GO:0046914 transition metal ion binding
1.50 5.31e-04 GO:0046872 metal ion binding
1.48 9.31e-04 GO:0043169 cation binding
1.48 1.05e-03 GO:0043167 ion binding
1.48 8.61e-03 GO:0003676 nucleic acid binding
1.58 1.59e-02 GO:0003677 DNA binding