Motif ID: ADNP_IRX_SIX_ZHX.p2

Z-value: 0.913


Transcription factors associated with ADNP_IRX_SIX_ZHX.p2:

Gene SymbolEntrez IDGene Name
ADNP 23394 activity-dependent neuroprotector homeobox
IRX4 50805 iroquois homeobox 4
IRX5 10265 iroquois homeobox 5
SIX2 10736 SIX homeobox 2
SIX5 147912 SIX homeobox 5
ZHX1 11244 zinc fingers and homeoboxes 1
ZHX2 22882 zinc fingers and homeoboxes 2
ZHX3 23051 zinc fingers and homeoboxes 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZHX3chr20_-_39946119-0.651.0e-04Click!
IRX5chr16_+_549651100.469.9e-03Click!
SIX2chr2_-_452365210.421.9e-02Click!
IRX4chr5_-_1882764-0.402.8e-02Click!
ZHX1chr8_-_124286489-0.365.0e-02Click!
ZHX2chr8_+_123793988,
chr8_+_123794043
0.355.5e-02Click!
SIX5chr19_-_46272496-0.086.6e-01Click!
ADNPchr20_-_495474510.048.4e-01Click!


Activity profile for motif ADNP_IRX_SIX_ZHX.p2.

activity profile for motif ADNP_IRX_SIX_ZHX.p2


Sorted Z-values histogram for motif ADNP_IRX_SIX_ZHX.p2

Sorted Z-values for motif ADNP_IRX_SIX_ZHX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ADNP_IRX_SIX_ZHX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_-_7921068 4.894 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr20_+_31823801 4.326 NM_001243193
NM_016583
NM_130852
BPIFA1


BPI fold containing family A, member 1


chr20_+_31870940 4.081 NM_033197
BPIFB1
BPI fold containing family B, member 1
chr3_+_361365 4.014 NM_001253388
CHL1
cell adhesion molecule with homology to L1CAM (close homolog of L1)
chr4_+_70861647 3.482 NM_001009181
NM_003154
STATH

statherin

chr9_-_3223007 3.399


chr16_-_21314371 3.028 NM_001014444
NM_001888
CRYM

crystallin, mu

chr12_+_20963637 2.906 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr13_+_36050885 2.689 NM_001204197
NBEA
neurobeachin
chr4_-_70518964 2.545 NM_001252274
NM_001252275
NM_006798
UGT2A1


UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus


chr8_-_72268720 2.408 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr7_+_114055048 2.356 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr9_-_75567915 2.327 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr20_-_21494663 2.225 NM_002509
NKX2-2
NK2 homeobox 2
chr18_-_45663667 2.065 NM_001039360
ZBTB7C
zinc finger and BTB domain containing 7C
chr1_+_61869699 2.001 NFIA
nuclear factor I/A
chr1_-_217250230 1.999 NM_001243507
NM_001243509
ESRRG

estrogen-related receptor gamma

chr5_+_156696351 1.975 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr1_-_183622447 1.935 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr8_-_110655418 1.919 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr11_+_71900601 1.829 NM_016724
NM_016725
FOLR1

folate receptor 1 (adult)

chr11_+_71900958 1.828 NM_000802
FOLR1
folate receptor 1 (adult)
chr8_+_17396285 1.784 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr20_+_9288446 1.778 NM_000933
PLCB4
phospholipase C, beta 4
chr11_-_114466471 1.778 NM_001077639
NM_017678
FAM55D

family with sequence similarity 55, member D

chr8_-_110693233 1.751 NM_001099745
NM_001099746
SYBU

syntabulin (syntaxin-interacting)

chr3_-_183273407 1.673 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr18_-_53089722 1.630 NM_001243233
TCF4
transcription factor 4
chr9_-_14086901 1.624 NFIB
nuclear factor I/B
chr11_-_114466397 1.584 FAM55D
family with sequence similarity 55, member D
chrX_+_119029799 1.472 NM_001008534
NM_001008535
NM_178813
AKAP14


A kinase (PRKA) anchor protein 14


chr6_-_33041266 1.470 NM_033554
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr6_-_76203256 1.460 NM_015687
FILIP1
filamin A interacting protein 1
chr16_+_82068958 1.460 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr7_+_107110501 1.459 NM_005295
GPR22
G protein-coupled receptor 22
chr16_+_82068910 1.456 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr16_+_82068830 1.441 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr4_-_16085309 1.432 PROM1
prominin 1
chr5_-_160279045 1.419 NM_025153
ATP10B
ATPase, class V, type 10B
chr3_+_69812961 1.416 NM_006722
MITF
microphthalmia-associated transcription factor
chr21_+_25801042 1.410 FLJ42200
FLJ42200 protein
chr3_-_114478117 1.407 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr1_+_244214552 1.367 NM_205768
ZNF238
zinc finger protein 238
chr7_-_25268057 1.360 NM_022150
NPVF
neuropeptide VF precursor
chr11_+_101918168 1.331 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr5_-_41213513 1.323 NM_000065
C6
complement component 6
chr22_+_22735202 1.312


chr6_-_32908583 1.309 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr14_+_74035762 1.294 NM_006821
ACOT2
acyl-CoA thioesterase 2
chr12_-_71551564 1.278 TSPAN8
tetraspanin 8
chr3_+_151488214 1.255 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr17_+_72667255 1.233 NM_175738
RAB37
RAB37, member RAS oncogene family
chr8_-_102803196 1.228 NCALD
neurocalcin delta
chr3_+_132316080 1.218 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr6_-_25874439 1.209 NM_001098486
NM_006632
SLC17A3

solute carrier family 17 (sodium phosphate), member 3

chrX_+_102965836 1.202 NM_182541
TMEM31
transmembrane protein 31
chr17_-_34328607 1.176 CCL14-CCL15
CCL14-CCL15 readthrough
chr6_-_76782204 1.168 NM_001563
IMPG1
interphotoreceptor matrix proteoglycan 1
chr20_+_9198036 1.161 NM_182797
PLCB4
phospholipase C, beta 4
chr4_+_41700736 1.156 LIMCH1
LIM and calponin homology domains 1
chr11_-_102651321 1.152 NM_002425
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr11_-_108464344 1.147 NM_015065
EXPH5
exophilin 5
chr11_-_64727608 1.143 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr12_-_4488707 1.121 NM_020638
FGF23
fibroblast growth factor 23
chr9_-_215892 1.117 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr3_+_238274 1.108 NM_001253387
NM_006614
CHL1

cell adhesion molecule with homology to L1CAM (close homolog of L1)

chr3_-_112359277 1.100 CCDC80
coiled-coil domain containing 80
chr5_+_140602914 1.079 NM_018934
PCDHB14
protocadherin beta 14
chr17_-_34328530 1.070 CCL14-CCL15
CCL15
CCL14-CCL15 readthrough
chemokine (C-C motif) ligand 15
chr6_-_119252887 1.057 NM_017696
MCM9
minichromosome maintenance complex component 9
chr4_-_17806820 1.053 DCAF16
DDB1 and CUL4 associated factor 16
chr1_+_79115476 1.050 NM_006417
IFI44
interferon-induced protein 44
chr2_-_211018294 1.020 C2orf67
chromosome 2 open reading frame 67
chr5_-_42811959 1.017 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr5_+_139505519 1.007 NM_001007189
IGIP
IgA-inducing protein homolog (Bos taurus)
chr18_+_61575203 0.985 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr11_+_111789600 0.981 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr6_-_32497925 0.970 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr8_-_102803438 0.967 NM_032041
NCALD
neurocalcin delta
chrM_+_9725 0.966


chr6_+_159070994 0.965 NM_001009991
NM_001242384
NM_001242394
NM_001242395
SYTL3



synaptotagmin-like 3



chr10_+_49609641 0.961 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr3_+_181430075 0.952 SOX2
SRY (sex determining region Y)-box 2
chr1_+_167298382 0.940 POU2F1
POU class 2 homeobox 1
chr9_-_117156684 0.931 NM_030767
AKNA
AT-hook transcription factor
chr6_-_79675672 0.921 PHIP
pleckstrin homology domain interacting protein
chr20_+_5987897 0.920 NM_001127458
CRLS1
cardiolipin synthase 1
chr3_+_113616317 0.920 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr4_-_100356449 0.917 NM_000673
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chrX_-_117119282 0.906 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr13_+_24144402 0.905 NM_001204459
NM_148957
TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr4_-_100273831 0.903 NM_000669
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chrX_-_132162297 0.892 NM_031907
USP26
ubiquitin specific peptidase 26
chr9_-_124989755 0.885 NM_001242334
LHX6
LIM homeobox 6
chr6_-_165723074 0.868 NM_144980
C6orf118
chromosome 6 open reading frame 118
chr3_-_112358510 0.863 CCDC80
coiled-coil domain containing 80
chr6_+_46761093 0.859 NM_005588
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr5_-_75008245 0.857 NM_152408
POC5
POC5 centriolar protein homolog (Chlamydomonas)
chr15_+_34261088 0.853 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chr6_-_29012951 0.848 NM_030903
OR2W1
olfactory receptor, family 2, subfamily W, member 1
chr1_+_244214576 0.848 ZNF238
zinc finger protein 238
chr5_-_168271852 0.842


chr1_+_244515936 0.835 NM_001012970
C1orf100
chromosome 1 open reading frame 100
chr17_+_41158741 0.832 NM_005533
IFI35
interferon-induced protein 35
chr1_-_150738255 0.828 CTSS
cathepsin S
chr4_+_41614911 0.822 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr6_-_49712055 0.817 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chr8_-_10512616 0.813 NM_178857
RP1L1
retinitis pigmentosa 1-like 1
chr1_+_54359859 0.812 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr19_+_13134782 0.807 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr4_+_72204769 0.807 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr2_+_179184970 0.803 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr1_-_150738232 0.801 CTSS
cathepsin S
chr2_+_162272892 0.800 TBR1
T-box, brain, 1
chr2_+_172864803 0.794 NM_199227
METAP1D
methionyl aminopeptidase type 1D (mitochondrial)
chr17_-_10421858 0.792 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr4_-_123542165 0.788 NM_001207006
NM_021803
IL21

interleukin 21

chr3_-_112358758 0.778 CCDC80
coiled-coil domain containing 80
chr1_-_157670280 0.775 NM_052939
FCRL3
Fc receptor-like 3
chr1_-_42776760 0.767


chr5_-_41261539 0.765 NM_001115131
C6
complement component 6
chr7_+_102987970 0.764 NM_001204453
NM_002803
PSMC2

proteasome (prosome, macropain) 26S subunit, ATPase, 2

chr3_+_69812620 0.759 NM_001184967
MITF
microphthalmia-associated transcription factor
chr3_+_46395224 0.758 NM_001123041
NM_001123396
CCR2

chemokine (C-C motif) receptor 2

chr12_+_41831484 0.749 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr3_+_149192479 0.744 TM4SF4
transmembrane 4 L six family member 4
chr10_-_17171789 0.744 NM_001081
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr13_+_43355685 0.741 NM_182508
C13orf30
chromosome 13 open reading frame 30
chr10_-_42863435 0.736 LOC441666
zinc finger protein 91 pseudogene
chr2_-_69180011 0.721 NM_182536
GKN2
gastrokine 2
chr5_-_124080773 0.713 NM_020747
ZNF608
zinc finger protein 608
chr1_+_18807423 0.712 NM_152375
KLHDC7A
kelch domain containing 7A
chr12_+_113587547 0.709 NM_001144872
CCDC42B
coiled-coil domain containing 42B
chr15_-_37391893 0.708 MEIS2
Meis homeobox 2
chr16_-_49315682 0.707 NM_004352
CBLN1
cerebellin 1 precursor
chr6_+_52285804 0.696 NM_001172420
EFHC1
EF-hand domain (C-terminal) containing 1
chr2_+_159651828 0.691 NM_001017920
DAPL1
death associated protein-like 1
chr18_-_53177999 0.690 NM_001243231
TCF4
transcription factor 4
chr12_-_10562744 0.685 NM_001199805
KLRC4-KLRK1
KLRC4-KLRK1 readthrough
chr1_-_247921707 0.674 NM_012353
OR1C1
olfactory receptor, family 1, subfamily C, member 1
chr10_+_83637442 0.674 NM_001165973
NRG3
neuregulin 3
chr1_+_171283372 0.673 NM_002022
FMO4
flavin containing monooxygenase 4
chr9_+_2015218 0.672 NM_003070
NM_139045
SMARCA2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

chr11_-_115088628 0.669 CADM1
cell adhesion molecule 1
chr7_-_16921596 0.665 NM_176813
AGR3
anterior gradient 3 homolog (Xenopus laevis)
chrX_-_15332680 0.663 NM_001012428
ASB11
ankyrin repeat and SOCS box containing 11
chr3_+_149192367 0.662 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr11_+_36317724 0.660 NM_001160167
PRR5L
proline rich 5 like
chr3_-_120401401 0.658 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr12_-_31882006 0.655 NM_001113402
AMN1
antagonist of mitotic exit network 1 homolog (S. cerevisiae)
chr22_-_37098620 0.651 NM_006078
CACNG2
calcium channel, voltage-dependent, gamma subunit 2
chr6_-_32634287 0.651 NM_001243961
NM_002123
HLA-DQB1

major histocompatibility complex, class II, DQ beta 1

chr10_+_114154522 0.649 ACSL5
acyl-CoA synthetase long-chain family member 5
chr5_+_59784004 0.643 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr1_+_167298280 0.642 NM_001198783
POU2F1
POU class 2 homeobox 1
chr4_+_81256873 0.636 NM_001206997
NM_152770
C4orf22

chromosome 4 open reading frame 22

chr16_+_53133063 0.636 CHD9
chromodomain helicase DNA binding protein 9
chr10_+_15001437 0.636 NM_001080836
MEIG1
meiosis expressed gene 1 homolog (mouse)
chr6_-_31845446 0.626 NM_001178045
SLC44A4
solute carrier family 44, member 4
chr12_+_86268072 0.626 NM_006183
NTS
neurotensin
chr6_-_132272311 0.624 NM_001901
CTGF
connective tissue growth factor
chr3_-_150920946 0.618 NM_013308
GPR171
G protein-coupled receptor 171
chr2_+_103035148 0.617 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr3_+_2280512 0.604 NM_001206955
CNTN4
contactin 4
chr3_+_132318980 0.598 NM_178445
CCRL1
chemokine (C-C motif) receptor-like 1
chr19_+_21579884 0.593 NM_001076678
NM_145326
NM_175910
ZNF493


zinc finger protein 493


chr2_+_71162995 0.593 NM_001692
ATP6V1B1
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
chr3_+_181429711 0.587 NM_003106
SOX2
SRY (sex determining region Y)-box 2
chr7_-_100026284 0.587 NM_017984
ZCWPW1
zinc finger, CW type with PWWP domain 1
chr6_+_131958441 0.585 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr8_-_102803178 0.578 NCALD
neurocalcin delta
chr11_+_60197061 0.577 NM_023945
MS4A5
membrane-spanning 4-domains, subfamily A, member 5
chr11_-_26593667 0.577 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr10_+_695887 0.577 C10orf108
chromosome 10 open reading frame 108
chr12_-_16760935 0.576 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr12_+_12223872 0.575 NM_138723
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr18_-_53303129 0.574 NM_001243226
TCF4
transcription factor 4
chr3_-_151058439 0.571 NM_176876
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr5_-_159827042 0.569 NM_022090
C5orf54
chromosome 5 open reading frame 54
chr16_+_22217369 0.566 NM_013302
EEF2K
eukaryotic elongation factor-2 kinase
chr14_-_90085325 0.566 NM_001085471
FOXN3
forkhead box N3
chrX_-_15333726 0.564 NM_001201583
NM_080873
ASB11

ankyrin repeat and SOCS box containing 11

chr13_-_30424795 0.563 NM_007106
UBL3
ubiquitin-like 3
chr12_-_25706177 0.561 NM_152590
NM_001145728
NM_001145729
IFLTD1


intermediate filament tail domain containing 1


chr13_+_33590477 0.558 NM_004795
KL
klotho
chr11_-_85425790 0.555 NM_032379
SYTL2
synaptotagmin-like 2
chr11_+_65271145 0.555


chr5_+_61874561 0.553 NM_181506
LRRC70
leucine rich repeat containing 70
chr4_-_16085593 0.553 NM_001145847
NM_001145848
PROM1

prominin 1

chr7_-_130080823 0.553 NM_018718
CEP41
centrosomal protein 41kDa
chr6_-_22297729 0.545 NM_000948
PRL
prolactin
chr11_-_84634219 0.544 DLG2
discs, large homolog 2 (Drosophila)
chr1_+_61547388 0.544 NM_001145512
NFIA
nuclear factor I/A
chr3_-_112359251 0.543 CCDC80
coiled-coil domain containing 80
chr13_-_70682458 0.542 NM_020866
KLHL1
kelch-like 1 (Drosophila)
chr13_-_36050758 0.541 NM_005584
MAB21L1
mab-21-like 1 (C. elegans)
chr1_+_109255555 0.541 NM_001144937
FNDC7
fibronectin type III domain containing 7
chr8_+_18079176 0.540 NM_001160174
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr3_-_194072004 0.540 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chrX_-_52386015 0.540 NM_001079538
XAGE2B
XAGE2
X antigen family, member 2B
X antigen family, member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.62 4.58e-02 GO:0006955 immune response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.33 6.81e-03 GO:0044459 plasma membrane part

Nothing significant found in function category.