Motif ID: AGCUUAU

Z-value: 0.312


Mature miRNA associated with seed AGCUUAU:

NamemiRBase Accession
hsa-miR-21 MIMAT0000076
hsa-miR-590-5p MIMAT0003258



Activity profile for motif AGCUUAU.

activity profile for motif AGCUUAU


Sorted Z-values histogram for motif AGCUUAU

Sorted Z-values for motif AGCUUAU



Network of associatons between targets according to the STRING database.



First level regulatory network of AGCUUAU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_36050885 0.514 NM_001204197
NBEA
neurobeachin
chr13_+_35516390 0.424 NM_015678
NBEA
neurobeachin
chr3_+_238274 0.308 NM_001253387
NM_006614
CHL1

cell adhesion molecule with homology to L1CAM (close homolog of L1)

chr2_-_55459406 0.263 NM_152385
C2orf63
chromosome 2 open reading frame 63
chr2_-_55459698 0.260 NM_001135598
C2orf63
chromosome 2 open reading frame 63
chr5_+_125695787 0.255 NM_001146319
GRAMD3
GRAM domain containing 3
chr3_+_181429711 0.244 NM_003106
SOX2
SRY (sex determining region Y)-box 2
chr2_-_19558371 0.243 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr5_+_125758818 0.230 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr1_+_61547625 0.228 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr1_+_61542928 0.224 NM_001145511
NFIA
nuclear factor I/A
chr5_+_125800786 0.222 NM_001146322
GRAMD3
GRAM domain containing 3
chr7_-_139876718 0.221 NM_030647
JHDM1D
jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)
chrX_-_24045302 0.203 NM_030624
KLHL15
kelch-like 15 (Drosophila)
chr3_+_186739643 0.199 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr11_-_79151694 0.188 NM_001098816
ODZ4
odz, odd Oz/ten-m homolog 4 (Drosophila)
chr1_+_61547388 0.186 NM_001145512
NFIA
nuclear factor I/A
chr3_+_186648273 0.182 NM_173216
NM_173217
ST6GAL1

ST6 beta-galactosamide alpha-2,6-sialyltranferase 1

chr16_+_69599868 0.177 NM_001113178
NM_006599
NM_138713
NM_138714
NM_173214
NM_173215
NFAT5





nuclear factor of activated T-cells 5, tonicity-responsive





chr11_-_115375065 0.176 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr9_+_133971862 0.175 NM_001185095
NM_001185096
NM_031426
AIF1L


allograft inflammatory factor 1-like


chr2_-_71454200 0.171 NM_020459
PAIP2B
poly(A) binding protein interacting protein 2B
chr5_-_38595506 0.170 NM_002310
LIFR
leukemia inhibitory factor receptor alpha
chr7_+_114055048 0.168 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr1_-_153895450 0.167 NM_020699
GATAD2B
GATA zinc finger domain containing 2B
chr10_+_72163860 0.164 NM_004096
EIF4EBP2
eukaryotic translation initiation factor 4E binding protein 2
chr4_+_86851425 0.159 NM_031305
ARHGAP24
Rho GTPase activating protein 24
chr4_+_86396251 0.156 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr5_+_67584251 0.153 NM_181524
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr5_-_38556682 0.151 NM_001127671
LIFR
leukemia inhibitory factor receptor alpha
chr16_+_57392694 0.150 NM_002990
CCL22
chemokine (C-C motif) ligand 22
chr5_+_67511578 0.147 NM_181523
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr5_+_67586466 0.146 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr16_+_4382224 0.142 NM_032575
GLIS2
GLIS family zinc finger 2
chr4_-_140060601 0.137 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr1_+_118148506 0.134 NM_017709
FAM46C
family with sequence similarity 46, member C
chr18_-_29523087 0.130 NM_014939
TRAPPC8
trafficking protein particle complex 8
chr7_+_101460881 0.128 NM_181552
CUX1
cut-like homeobox 1
chr13_+_73633097 0.128 NM_001730
KLF5
Kruppel-like factor 5 (intestinal)
chr9_-_14398981 0.127 NM_001190738
NFIB
nuclear factor I/B
chr1_-_207224298 0.127 NM_018566
YOD1
YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae)
chr12_+_12764755 0.127 NM_001310
CREBL2
cAMP responsive element binding protein-like 2
chr18_-_72921280 0.125 NM_175907
ZADH2
zinc binding alcohol dehydrogenase domain containing 2
chr11_-_63536112 0.124 NM_001144936
C11orf95
chromosome 11 open reading frame 95
chr2_-_60780404 0.124 NM_018014
NM_022893
NM_138559
BCL11A


B-cell CLL/lymphoma 11A (zinc finger protein)


chr6_+_36562089 0.121 NM_003017
SRSF3
serine/arginine-rich splicing factor 3
chr5_+_67588395 0.118 NM_001242466
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr9_-_14314036 0.116 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr2_-_218808705 0.115 NM_022648
TNS1
tensin 1
chr7_-_91875296 0.110 NM_194455
NM_194456
KRIT1

KRIT1, ankyrin repeat containing

chr4_+_86699846 0.109 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr5_+_56110899 0.108 NM_005921
MAP3K1
mitogen-activated protein kinase kinase kinase 1
chr4_-_140005464 0.107 NM_006874
ELF2
E74-like factor 2 (ets domain transcription factor)
chrX_-_20284708 0.103 NM_004586
RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr7_-_91875108 0.103 NM_004912
NM_001013406
NM_194454
KRIT1


KRIT1, ankyrin repeat containing


chr3_-_18466759 0.102 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr13_-_41706587 0.102 NM_152903
KBTBD6
kelch repeat and BTB (POZ) domain containing 6
chr8_-_57123858 0.102 NM_001114634
NM_001114635
NM_002655
PLAG1


pleiomorphic adenoma gene 1


chr1_-_36851484 0.101 NM_032017
STK40
serine/threonine kinase 40
chr2_+_66662516 0.101 NM_002398
MEIS1
Meis homeobox 1
chr1_-_40367539 0.099 NM_001033081
NM_001033082
NM_005376
MYCL1


v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)


chr20_+_278200 0.099 NM_033089
ZCCHC3
zinc finger, CCHC domain containing 3
chr4_-_89744154 0.098 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr6_+_148663728 0.096 NM_015278
SASH1
SAM and SH3 domain containing 1
chr2_-_48132656 0.094 NM_001190274
FBXO11
F-box protein 11
chr8_+_9413439 0.093 NM_003747
TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr16_-_4897265 0.089 NM_032569
GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr2_+_148602569 0.087 NM_001616
ACVR2A
activin A receptor, type IIA
chr7_-_44924946 0.087 NM_033224
PURB
purine-rich element binding protein B
chr4_-_87374282 0.086 NM_002753
MAPK10
mitogen-activated protein kinase 10
chr7_+_8008416 0.086 NM_138426
GLCCI1
glucocorticoid induced transcript 1
chr2_-_180129245 0.086 NM_178123
SESTD1
SEC14 and spectrin domains 1
chr9_-_98270321 0.085 NM_001083604
NM_001083605
PTCH1

patched 1

chr4_+_26321307 0.085 NM_005349
NM_203283
RBPJ

recombination signal binding protein for immunoglobulin kappa J region

chr4_-_87028805 0.084 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr11_-_1593149 0.084 NM_004420
DUSP8
dual specificity phosphatase 8
chr1_-_245027808 0.082 NM_004501
NM_031844
HNRNPU

heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)

chr7_+_11013453 0.081 NM_014660
PHF14
PHD finger protein 14
chr9_-_98269686 0.081 NM_001083606
PTCH1
patched 1
chrX_+_35937850 0.080 NM_152632
CXorf22
chromosome X open reading frame 22
chr3_-_52719514 0.076 NM_018313
PBRM1
polybromo 1
chr4_+_38665587 0.075 NM_016531
KLF3
Kruppel-like factor 3 (basic)
chr2_+_86947387 0.074 NM_022780
RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr18_+_67956136 0.074 NM_004232
SOCS6
suppressor of cytokine signaling 6
chr6_+_4021500 0.074 NM_003913
PRPF4B
PRP4 pre-mRNA processing factor 4 homolog B (yeast)
chr4_+_113152838 0.071 NM_001128426
NM_018569
AP1AR

adaptor-related protein complex 1 associated regulatory protein

chr12_+_122459791 0.067 NM_001024808
NM_020993
BCL7A

B-cell CLL/lymphoma 7A

chr8_-_119964059 0.067 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr3_-_52713728 0.066 NM_018165
NM_181042
PBRM1

polybromo 1

chr4_-_87281374 0.066 NM_138980
NM_138982
MAPK10

mitogen-activated protein kinase 10

chrX_+_123095555 0.065 NM_001042750
NM_001042751
NM_006603
STAG2


stromal antigen 2


chr11_+_64889699 0.064 NM_004927
MRPL49
mitochondrial ribosomal protein L49
chr17_+_60556247 0.063 NM_001112707
NM_006852
TLK2

tousled-like kinase 2

chr5_+_31799030 0.063 NM_178140
PDZD2
PDZ domain containing 2
chr9_-_98270830 0.063 NM_000264
PTCH1
patched 1
chr11_-_129062092 0.063 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr2_-_48115846 0.062 NM_025133
FBXO11
F-box protein 11
chr3_+_29322802 0.062 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr15_-_50978983 0.062 NM_017672
TRPM7
transient receptor potential cation channel, subfamily M, member 7
chr7_+_20370724 0.062 NM_002214
ITGB8
integrin, beta 8
chr4_+_81952118 0.062 NM_001201
BMP3
bone morphogenetic protein 3
chr5_-_89770432 0.062 NM_203406
MBLAC2
metallo-beta-lactamase domain containing 2
chr9_-_98269480 0.061 NM_001083607
PTCH1
patched 1
chr15_-_49338496 0.060 NM_001193489
NM_014701
SECISBP2L

SECIS binding protein 2-like

chr12_+_53845884 0.059 NM_001098620
NM_001128911
NM_001128912
NM_001128913
NM_001128914
NM_005016
NM_031989
PCBP2






poly(rC) binding protein 2






chr8_+_87354958 0.059 NM_007013
WWP1
WW domain containing E3 ubiquitin protein ligase 1
chr4_+_26322184 0.057 NM_015874
NM_203284
RBPJ

recombination signal binding protein for immunoglobulin kappa J region

chr9_-_98279246 0.055 NM_001083602
NM_001083603
PTCH1

patched 1

chr10_-_94050799 0.055 NM_014912
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr8_+_98881277 0.054 NM_002380
NM_030583
MATN2

matrilin 2

chr13_-_36944289 0.054 NM_001142294
SPG20
spastic paraplegia 20 (Troyer syndrome)
chr3_-_18480203 0.053 NM_001131010
SATB1
SATB homeobox 1
chr2_-_239197091 0.053 NM_022817
PER2
period homolog 2 (Drosophila)
chrX_-_131623994 0.052 NM_001170704
MBNL3
muscleblind-like 3 (Drosophila)
chr10_-_94003002 0.051 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr2_+_45878912 0.049 NM_005400
PRKCE
protein kinase C, epsilon
chr10_-_14816895 0.049 NM_031453
FAM107B
family with sequence similarity 107, member B
chrX_-_131547536 0.047 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr6_+_32939371 0.047 NM_001199455
BRD2
bromodomain containing 2
chr2_+_65283485 0.047 NM_015147
CEP68
centrosomal protein 68kDa
chr7_-_156685875 0.046 NM_022458
LMBR1
limb region 1 homolog (mouse)
chr1_+_65210724 0.045 NM_018211
RAVER2
ribonucleoprotein, PTB-binding 2
chr20_-_52199635 0.045 NM_006526
ZNF217
zinc finger protein 217
chr2_-_198650008 0.045 NM_033030
BOLL
bol, boule-like (Drosophila)
chr7_+_101459092 0.044 NM_001202543
NM_001202544
NM_001202545
NM_001913
NM_181500
NM_001202546
CUX1





cut-like homeobox 1





chr2_-_198650937 0.043 NM_197970
BOLL
bol, boule-like (Drosophila)
chr17_-_40540491 0.039 NM_003150
NM_139276
STAT3

signal transducer and activator of transcription 3 (acute-phase response factor)

chr19_+_14491920 0.038 NM_001025160
NM_001784
NM_078481
CD97


CD97 molecule


chr8_+_61591239 0.038 NM_017780
CHD7
chromodomain helicase DNA binding protein 7
chr8_+_75736771 0.037 NM_015886
PI15
peptidase inhibitor 15
chr11_-_128894008 0.037 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr6_-_116575170 0.036 NM_021648
TSPYL4
TSPY-like 4
chr8_-_75233461 0.036 NM_020647
JPH1
junctophilin 1
chr12_-_12419702 0.036 NM_002336
LRP6
low density lipoprotein receptor-related protein 6
chr6_-_46922533 0.036 NM_015234
GPR116
G protein-coupled receptor 116
chr5_+_60628085 0.035 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr7_-_30029904 0.033 NM_001145514
SCRN1
secernin 1
chr17_+_59477169 0.032 NM_005994
TBX2
T-box 2
chr12_-_45270157 0.032 NM_001145108
NM_006159
NELL2

NEL-like 2 (chicken)

chr20_-_49547451 0.032 NM_015339
NM_181442
ADNP

activity-dependent neuroprotector homeobox

chr11_+_120207617 0.031 NM_001198665
NM_015313
ARHGEF12

Rho guanine nucleotide exchange factor (GEF) 12

chr2_-_201936389 0.031 NM_173822
FAM126B
family with sequence similarity 126, member B
chr6_+_119215240 0.031 NM_014034
ASF1A
ASF1 anti-silencing function 1 homolog A (S. cerevisiae)
chr3_+_88188261 0.031 NM_018293
ZNF654
zinc finger protein 654
chr7_-_30029284 0.031 NM_001145515
NM_014766
NM_001145513
SCRN1


secernin 1


chr6_-_109330190 0.031 NM_001199934
SESN1
sestrin 1
chr14_-_92506284 0.031 NM_004239
TRIP11
thyroid hormone receptor interactor 11
chr13_-_36920777 0.030 NM_001142295
SPG20
spastic paraplegia 20 (Troyer syndrome)
chr1_+_222791151 0.030 NM_198551
MIA3
melanoma inhibitory activity family, member 3
chrX_-_131573638 0.030 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr13_-_36920603 0.029 NM_001142296
NM_015087
SPG20

spastic paraplegia 20 (Troyer syndrome)

chr1_-_115053758 0.029 NM_015906
NM_033020
TRIM33

tripartite motif containing 33

chr12_-_40013842 0.029 NM_005164
ABCD2
ATP-binding cassette, sub-family D (ALD), member 2
chr22_+_39101806 0.028 NM_004286
GTPBP1
GTP binding protein 1
chr17_+_38278789 0.028 NM_001012241
MSL1
male-specific lethal 1 homolog (Drosophila)
chr6_-_159466019 0.028 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr2_-_213403280 0.028 NM_001042599
NM_005235
ERBB4

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

chr2_+_170683900 0.027 NM_172070
UBR3
ubiquitin protein ligase E3 component n-recognin 3 (putative)
chr10_-_75910525 0.027 NM_012095
NM_207012
AP3M1

adaptor-related protein complex 3, mu 1 subunit

chr1_-_19282773 0.026 NM_001136265
IFFO2
intermediate filament family orphan 2
chr12_-_45270632 0.026 NM_001145107
NELL2
NEL-like 2 (chicken)
chr3_+_10183318 0.025 NM_000551
NM_198156
VHL

von Hippel-Lindau tumor suppressor

chr1_+_36273786 0.024 NM_017629
EIF2C4
eukaryotic translation initiation factor 2C, 4
chr4_+_153864134 0.024 NM_033393
FHDC1
FH2 domain containing 1
chr13_-_110959441 0.023 NM_001845
COL4A1
collagen, type IV, alpha 1
chr19_-_58662144 0.023 NM_024620
ZNF329
zinc finger protein 329
chr12_+_27397077 0.023 NM_015000
STK38L
serine/threonine kinase 38 like
chr1_-_47134039 0.023 NM_001042546
NM_022745
ATPAF1

ATP synthase mitochondrial F1 complex assembly factor 1

chr6_-_46889620 0.023 NM_001098518
GPR116
G protein-coupled receptor 116
chr4_-_129209983 0.023 NM_006320
PGRMC2
progesterone receptor membrane component 2
chr12_+_65563339 0.022 NM_001167614
NM_014319
LEMD3

LEM domain containing 3

chr6_+_32938658 0.021 NM_001113182
BRD2
bromodomain containing 2
chr15_-_42840992 0.020 NM_153260
LRRC57
leucine rich repeat containing 57
chr10_+_112631552 0.020 NM_001199492
NM_014456
NM_145341
PDCD4


programmed cell death 4 (neoplastic transformation inhibitor)


chr5_+_139493689 0.020 NM_005859
PURA
purine-rich element binding protein A
chr17_+_30264039 0.020 NM_015355
SUZ12
suppressor of zeste 12 homolog (Drosophila)
chr10_-_101989342 0.019 NM_001278
CHUK
conserved helix-loop-helix ubiquitous kinase
chr15_+_49715374 0.019 NM_002009
FGF7
fibroblast growth factor 7
chr6_-_109415514 0.019 NM_014454
SESN1
sestrin 1
chr12_-_45269340 0.018 NM_001145109
NELL2
NEL-like 2 (chicken)
chr18_-_47721165 0.018 NM_001080467
MYO5B
myosin VB
chr12_+_48516428 0.018 NM_001166687
NM_001166688
PFKM

phosphofructokinase, muscle

chr17_+_61627818 0.018 NM_005828
DCAF7
DDB1 and CUL4 associated factor 7
chr9_+_115513050 0.017 NM_001012994
SNX30
sorting nexin family member 30
chr13_+_20532906 0.016 NM_001190965
ZMYM2
zinc finger, MYM-type 2
chr15_+_59279849 0.015 NM_017610
RNF111
ring finger protein 111
chr16_-_47007567 0.015 NM_005880
DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr12_-_121342050 0.015 NM_139015
SPPL3
signal peptide peptidase-like 3
chr5_-_32313069 0.015 NM_001040446
MTMR12
myotubularin related protein 12
chr6_+_32936400 0.015 NM_005104
BRD2
bromodomain containing 2
chr12_+_85673884 0.014 NM_006982
ALX1
ALX homeobox 1
chr4_-_111544206 0.014 NM_000325
PITX2
paired-like homeodomain 2
chr9_+_115142188 0.014 NM_001195822
NM_032303
HSDL2

hydroxysteroid dehydrogenase like 2

chr6_-_134373618 0.014 NM_145176
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chr11_+_107992252 0.013 NM_000019
ACAT1
acetyl-CoA acetyltransferase 1
chr13_+_20532788 0.013 NM_003453
NM_197968
NM_001190964
ZMYM2


zinc finger, MYM-type 2


chr10_+_6130936 0.013 NM_032905
RBM17
RNA binding motif protein 17
chr3_+_43328001 0.012 NM_001100594
NM_017719
SNRK

SNF related kinase

chrX_+_114524291 0.012 NM_016383
LUZP4
leucine zipper protein 4
chr5_-_150080597 0.012 NM_018047
RBM22
RNA binding motif protein 22

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.45 4.58e-03 GO:0050794 regulation of cellular process
1.63 7.13e-03 GO:0044260 cellular macromolecule metabolic process
1.41 1.02e-02 GO:0050789 regulation of biological process
1.71 2.83e-02 GO:0060255 regulation of macromolecule metabolic process
1.83 4.19e-02 GO:0010468 regulation of gene expression

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.49 2.79e-03 GO:0005634 nucleus
1.81 2.97e-02 GO:0044428 nuclear part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.44 2.74e-04 GO:0005515 protein binding
2.56 2.45e-03 GO:0001071 nucleic acid binding transcription factor activity
2.56 2.45e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
3.40 6.32e-03 GO:0004674 protein serine/threonine kinase activity
1.63 2.18e-02 GO:0003676 nucleic acid binding
2.66 2.57e-02 GO:0043565 sequence-specific DNA binding
25.88 2.89e-02 GO:0090079 translation regulator activity, nucleic acid binding
1.18 3.47e-02 GO:0005488 binding