Motif ID: AIRE.p2

Z-value: 0.639


Transcription factors associated with AIRE.p2:

Gene SymbolEntrez IDGene Name
AIRE 326 autoimmune regulator

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
AIREchr21_+_457101470.355.9e-02Click!


Activity profile for motif AIRE.p2.

activity profile for motif AIRE.p2


Sorted Z-values histogram for motif AIRE.p2

Sorted Z-values for motif AIRE.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AIRE.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_216241321 1.831 FN1
fibronectin 1
chr1_+_84630575 1.185 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr6_-_46703429 1.044 NM_001168357
PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr19_-_49865638 0.845 NM_003598
TEAD2
TEA domain family member 2
chr4_-_103245468 0.814 NM_001135148
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr11_-_64727608 0.740 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr19_-_14785626 0.657 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr1_-_144997110 0.628 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr11_+_7110164 0.615 NM_014469
RBMXL2
RNA binding motif protein, X-linked-like 2
chr19_-_39826676 0.604 NM_004877
GMFG
glia maturation factor, gamma
chr3_+_189507448 0.568 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr1_-_17308072 0.556 NM_001135247
NM_017459
MFAP2

microfibrillar-associated protein 2

chr16_-_58328879 0.530 NM_001080492
PRSS54
protease, serine, 54
chr14_-_60632019 0.516 DHRS7
dehydrogenase/reductase (SDR family) member 7
chr11_-_59612925 0.505 NM_005142
GIF
gastric intrinsic factor (vitamin B synthesis)
chr15_-_50411405 0.498 NM_024837
ATP8B4
ATPase, class I, type 8B, member 4
chr17_+_41006094 0.496 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr18_-_61311465 0.489 NM_002974
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr1_+_84609941 0.469 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr4_+_70146216 0.443 NM_001207004
NM_053039
UGT2B28

UDP glucuronosyltransferase 2 family, polypeptide B28

chr15_-_99789585 0.423 NM_001040655
NM_001040656
NM_001040657
NM_001040658
NM_001040659
NM_001040660
NM_022905
TTC23






tetratricopeptide repeat domain 23






chr10_-_101841593 0.417 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr19_+_52873169 0.408 NM_001145434
ZNF880
zinc finger protein 880
chr4_-_139163222 0.406 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr6_+_31683084 0.399 NM_021246
LY6G6D
lymphocyte antigen 6 complex, locus G6D
chr2_-_85637486 0.399 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr15_+_59908908 0.394 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr4_-_74847669 0.393 NM_002619
PF4
platelet factor 4
chr2_-_31637598 0.388 NM_000379
XDH
xanthine dehydrogenase
chr5_-_177207465 0.386 NM_173663
FAM153A
family with sequence similarity 153, member A
chr7_+_76054251 0.381 NM_001110354
ZP3
zona pellucida glycoprotein 3 (sperm receptor)
chr12_-_10282680 0.380 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr4_-_70080448 0.377 NM_001073
UGT2B11
UGT2B10
UDP glucuronosyltransferase 2 family, polypeptide B11
UDP glucuronosyltransferase 2 family, polypeptide B10
chr11_+_129979330 0.377 APLP2
amyloid beta (A4) precursor-like protein 2
chr19_-_23869939 0.367 NM_138330
ZNF675
zinc finger protein 675
chr15_+_59908724 0.361 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chrM_-_9203 0.357


chr14_-_60632058 0.322 NM_016029
DHRS7
dehydrogenase/reductase (SDR family) member 7
chr9_-_21305311 0.303 NM_002169
IFNA5
interferon, alpha 5
chr5_+_173472692 0.296 NM_015980
HMP19
HMP19 protein
chr10_-_48390873 0.293 NM_002900
RBP3
retinol binding protein 3, interstitial
chr17_+_41003184 0.282 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr17_+_61086897 0.282 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr4_-_185139018 0.280 NM_153343
ENPP6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr5_-_147162056 0.276 JAKMIP2
janus kinase and microtubule interacting protein 2
chrX_-_2882288 0.276 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr9_+_42717233 0.274 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr19_+_1026271 0.273 NM_004368
NM_201277
CNN2

calponin 2

chr19_-_43421944 0.271 NM_002782
NM_001031850
PSG6

pregnancy specific beta-1-glycoprotein 6

chr17_-_40021616 0.254 NM_018143
KLHL11
kelch-like 11 (Drosophila)
chrX_-_70128560 0.253 NM_001003811
NM_031276
TEX11

testis expressed 11

chr1_-_182357871 0.251 GLUL
glutamate-ammonia ligase
chrM_+_9217 0.249


chr12_-_91452130 0.249 NM_007035
KERA
keratocan
chr4_+_74270832 0.248 ALB
albumin
chr12_+_101988746 0.245 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr17_+_31318881 0.244 NM_173847
SPACA3
sperm acrosome associated 3
chr9_-_70178814 0.244 NM_001126334
FOXD4L5
forkhead box D4-like 5
chr6_+_31973358 0.241 NM_000500
NM_001128590
CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2

chr19_+_18208596 0.239 NM_015016
MAST3
microtubule associated serine/threonine kinase 3
chr22_+_36649116 0.238 NM_001136540
NM_001136541
NM_003661
NM_145343
APOL1



apolipoprotein L, 1



chr1_-_153348057 0.237 NM_005621
S100A12
S100 calcium binding protein A12
chrM_+_8857 0.231


chr12_+_21168629 0.231 NM_001009562
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr9_-_70429730 0.230 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr14_+_95078713 0.227 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr5_-_39203061 0.226 FYB
FYN binding protein
chr12_+_85430098 0.226 NM_001079910
LRRIQ1
leucine-rich repeats and IQ motif containing 1
chr8_+_39771327 0.226 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr4_-_69111333 0.225 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr10_+_123748688 0.225 NM_206861
NM_206862
TACC2

transforming, acidic coiled-coil containing protein 2

chrM_+_9182 0.224


chr2_-_32490688 0.223 NM_001199139
NM_021209
NLRC4

NLR family, CARD domain containing 4

chr5_+_176811431 0.222 NM_001167579
NM_003052
SLC34A1

solute carrier family 34 (sodium phosphate), member 1

chr6_+_27292539 0.222 NM_032030
FKSG83
FKSG83
chr17_-_50237342 0.218 NM_001082534
CA10
carbonic anhydrase X
chr12_-_53600999 0.217 NM_000889
ITGB7
integrin, beta 7
chr11_+_57365026 0.213 NM_000062
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr1_+_154955840 0.212 FLAD1
FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
chr9_+_118916069 0.211 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr1_+_948846 0.203 NM_005101
ISG15
ISG15 ubiquitin-like modifier
chr22_+_36649172 0.203 APOL1
apolipoprotein L, 1
chr7_-_102283237 0.203 NM_001114403
UPK3BL
uroplakin 3B-like
chr1_-_109618568 0.201 NM_005645
TAF13
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
chr12_-_67072881 0.201 NM_001178074
NM_021150
GRIP1

glutamate receptor interacting protein 1

chr19_-_13617037 0.199 NM_000068
NM_001127221
NM_001127222
NM_001174080
NM_023035
CACNA1A




calcium channel, voltage-dependent, P/Q type, alpha 1A subunit




chr12_-_8815479 0.198 MFAP5
microfibrillar associated protein 5
chr2_-_122042767 0.197 NM_014553
TFCP2L1
transcription factor CP2-like 1
chr2_+_201980873 0.196 NM_001127184
NM_001202516
NM_001202517
NM_001202519
NM_003879
CFLAR




CASP8 and FADD-like apoptosis regulator




chr19_-_51334747 0.196 NM_017509
NM_138563
NM_138564
KLK15


kallikrein-related peptidase 15


chr13_-_33859835 0.195 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr12_-_25102281 0.195 NM_001178091
NM_001178092
NM_005504
BCAT1


branched chain amino-acid transaminase 1, cytosolic


chr12_+_56915587 0.195 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr20_-_34195409 0.195 FER1L4
fer-1-like 4 (C. elegans) pseudogene
chr12_-_67072752 0.194 GRIP1
glutamate receptor interacting protein 1
chr5_-_39394423 0.193 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr2_-_31637553 0.193 XDH
xanthine dehydrogenase
chrY_+_27768241 0.186 NM_001003894
NM_001003895
NM_004680
NM_170723
CDY1B

CDY1

chromodomain protein, Y-linked, 1B

chromodomain protein, Y-linked, 1

chr5_-_64777703 0.185 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr17_+_72581056 0.184 NM_152460
C17orf77
chromosome 17 open reading frame 77
chr1_-_7973286 0.184 UTS2
urotensin 2
chr17_-_50237160 0.181 NM_001082533
CA10
carbonic anhydrase X
chr3_-_14583587 0.179 NM_001080423
GRIP2
glutamate receptor interacting protein 2
chr15_-_20747113 0.178 NM_001145004
GOLGA6L6
golgin A6 family-like 6
chr17_-_34207308 0.178 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr5_+_166711842 0.177 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr5_-_997408 0.176 NM_001242737
LOC100506688
uncharacterized LOC100506688
chr1_+_181002560 0.174 NM_001194999
NM_001195000
NM_001195035
NM_001531
MR1



major histocompatibility complex, class I-related



chr15_+_22736245 0.172 NM_001001413
GOLGA6L1
golgin A6 family-like 1
chrY_-_26194115 0.172 NM_001003894
NM_001003895
NM_004680
NM_170723
CDY1B

CDY1

chromodomain protein, Y-linked, 1B

chromodomain protein, Y-linked, 1

chr3_-_138478184 0.171 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
chrM_+_9725 0.169


chr7_+_112120907 0.169 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr10_+_7745341 0.166 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr17_-_50236950 0.164 CA10
carbonic anhydrase X
chr20_-_42939737 0.163 NM_001080472
FITM2
fat storage-inducing transmembrane protein 2
chr13_-_48987017 0.161 LPAR6
lysophosphatidic acid receptor 6
chr17_+_7942351 0.160 NM_001039130
NM_001039131
NM_001141
ALOX15B


arachidonate 15-lipoxygenase, type B


chr20_+_3776385 0.159 NM_004358
NM_021872
NM_021873
CDC25B


cell division cycle 25 homolog B (S. pombe)


chr19_-_55628780 0.155 NM_017607
PPP1R12C
protein phosphatase 1, regulatory subunit 12C
chr4_-_159093523 0.153 FAM198B
family with sequence similarity 198, member B
chr8_+_7353367 0.153 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr6_+_4890225 0.152 NM_001143971
CDYL
chromodomain protein, Y-like
chr19_-_6591012 0.148 CD70
CD70 molecule
chr4_+_646965 0.148 NM_001145292
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr5_+_72469022 0.147 NM_153217
TMEM174
transmembrane protein 174
chr4_-_90759446 0.145 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr1_-_89591685 0.144 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr14_+_39734475 0.142 NM_203354
CTAGE5
CTAGE family, member 5
chr19_+_21264952 0.142 NM_182515
ZNF714
zinc finger protein 714
chr4_+_187148624 0.140 NM_000892
KLKB1
kallikrein B, plasma (Fletcher factor) 1
chr22_-_24951842 0.140 C22orf13
chromosome 22 open reading frame 13
chr15_+_45248902 0.140 NM_152448
C15orf43
chromosome 15 open reading frame 43
chr5_-_77844975 0.138 LHFPL2
lipoma HMGIC fusion partner-like 2
chr19_+_52266640 0.136 NM_001462
FPR2
formyl peptide receptor 2
chr19_+_2867332 0.135 NM_024967
ZNF556
zinc finger protein 556
chr1_+_15783222 0.135 NM_033440
CELA2A
chymotrypsin-like elastase family, member 2A
chr7_-_64467006 0.134 NM_001007253
ERV3-1
endogenous retrovirus group 3, member 1
chr10_-_56560947 0.134 NM_001142763
NM_001142764
NM_001142765
NM_001142766
NM_001142767
NM_001142768
NM_001142769
NM_001142770
NM_001142771
NM_001142772
NM_001142773
NM_033056
PCDH15











protocadherin-related 15











chr6_+_32132379 0.133 NM_030652
EGFL8
EGF-like-domain, multiple 8
chr12_-_57009361 0.129 BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr8_-_7673137 0.129 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr14_-_106725232 0.129 ZCWPW2
IGHV3-23
IGKV3-20
IGK@
zinc finger, CW type with PWWP domain 2
immunoglobulin heavy variable 3-23
immunoglobulin kappa variable 3-20
immunoglobulin kappa locus
chr2_-_214015053 0.128 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr1_-_21377387 0.128 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr2_+_233404436 0.128 NM_005199
CHRNG
cholinergic receptor, nicotinic, gamma
chr4_+_69962191 0.127 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr2_+_218989997 0.127 NM_001168298
CXCR2
chemokine (C-X-C motif) receptor 2
chr4_+_74606222 0.126 NM_000584
IL8
interleukin 8
chr11_-_107729913 0.126 NM_017515
SLC35F2
solute carrier family 35, member F2
chr3_-_87325611 0.126 NM_000306
NM_001122757
POU1F1

POU class 1 homeobox 1

chr10_+_29577989 0.126 NM_032517
LYZL1
lysozyme-like 1
chr13_-_48987247 0.125 LPAR6
lysophosphatidic acid receptor 6
chr1_+_154955769 0.124 NM_001184891
NM_001184892
NM_025207
NM_201398
FLAD1



FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)



chr16_+_14294186 0.124 MKL2
MKL/myocardin-like 2
chr7_-_45151297 0.123 NM_004749
NM_030900
NM_199122
TBRG4


transforming growth factor beta regulator 4


chr15_+_58430394 0.123 NM_020980
AQP9
aquaporin 9
chr19_-_46526555 0.123 NM_005091
PGLYRP1
peptidoglycan recognition protein 1
chr9_-_104147261 0.122 NM_001701
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr5_+_173472737 0.122 HMP19
HMP19 protein
chr17_+_42422665 0.121 GRN
granulin
chr6_-_33756905 0.121 NM_181336
LEMD2
LEM domain containing 2
chr19_-_12834628 0.120 NM_001136195
TNPO2
transportin 2
chr16_-_11680756 0.120 NM_001136472
NM_001136473
LITAF

lipopolysaccharide-induced TNF factor

chr4_+_70916158 0.120 NM_002159
HTN1
histatin 1
chr12_+_8332789 0.119 FAM66C
family with sequence similarity 66, member C
chr6_+_42897236 0.119 CNPY3
canopy 3 homolog (zebrafish)
chr4_-_65275000 0.119 NM_001010874
TECRL
trans-2,3-enoyl-CoA reductase-like
chr7_+_76109826 0.119 NM_001102596
DTX2
deltex homolog 2 (Drosophila)
chr4_-_39033981 0.118 NM_024943
TMEM156
transmembrane protein 156
chr5_+_140529619 0.117 NM_018939
PCDHB6
protocadherin beta 6
chr19_+_24097656 0.117 NM_001244038
ZNF726
zinc finger protein 726
chr4_-_156787377 0.117 NM_017419
ACCN5
amiloride-sensitive cation channel 5, intestinal
chr1_+_152974222 0.116 NM_001097589
NM_005416
SPRR3

small proline-rich protein 3

chr19_+_55174425 0.115 LILRB4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
chr12_+_32832272 0.112 DNM1L
dynamin 1-like
chr6_+_42897184 0.112 CNPY3
canopy 3 homolog (zebrafish)
chr19_+_22235278 0.111 ZNF257
zinc finger protein 257
chr10_+_7745284 0.109 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr6_+_121756744 0.109 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr19_+_50879681 0.109 NM_007121
NR1H2
nuclear receptor subfamily 1, group H, member 2
chr20_-_3766905 0.109 NM_001810
CENPB
centromere protein B, 80kDa
chr10_+_5005453 0.107 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr12_+_50794591 0.107 NM_001170803
NM_001170804
NM_001170808
NM_052879
NM_199188
NM_199190
LARP4





La ribonucleoprotein domain family, member 4





chr15_+_55611405 0.105 PIGB
phosphatidylinositol glycan anchor biosynthesis, class B
chr19_+_22235253 0.104 NM_033468
ZNF257
zinc finger protein 257
chr17_-_38859976 0.104 NM_019016
KRT24
keratin 24
chr12_-_89920038 0.104 NM_001199781
NM_001199782
NM_172240
POC1B-GALNT4

POC1B
POC1B-GALNT4 readthrough

POC1 centriolar protein homolog B (Chlamydomonas)
chr11_+_114166534 0.103 NM_006169
NNMT
nicotinamide N-methyltransferase
chr1_-_160313353 0.103 NM_001098398
NM_004371
COPA

coatomer protein complex, subunit alpha

chr3_-_186262114 0.103 NM_017541
CRYGS
crystallin, gamma S
chr11_+_112832089 0.101 NCAM1
neural cell adhesion molecule 1
chr18_+_29171729 0.101 NM_000371
TTR
transthyretin
chr12_-_11175169 0.101 NM_176888
TAS2R19
taste receptor, type 2, member 19
chr8_+_29952921 0.099 NM_001128208
NM_015344
LEPROTL1

leptin receptor overlapping transcript-like 1

chr2_+_216176678 0.099 NM_004044
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr15_+_74165967 0.099 NM_153356
TBC1D21
TBC1 domain family, member 21
chr2_+_190539203 0.099 ANKAR
ankyrin and armadillo repeat containing
chr21_+_37536838 0.099 NM_005128
DOPEY2
dopey family member 2
chr11_+_122709205 0.098 NM_019604
CRTAM
cytotoxic and regulatory T cell molecule

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.16 3.58e-04 GO:0006952 defense response
1.84 2.42e-03 GO:0002376 immune system process
2.11 2.80e-03 GO:0006955 immune response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.66 5.10e-05 GO:0005576 extracellular region
1.68 4.29e-02 GO:0044421 extracellular region part

Nothing significant found in function category.