Motif ID: ATF2.p2

Z-value: 0.756


Transcription factors associated with ATF2.p2:

Gene SymbolEntrez IDGene Name
ATF2 1386 activating transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ATF2chr2_-_1760328500.183.3e-01Click!


Activity profile for motif ATF2.p2.

activity profile for motif ATF2.p2


Sorted Z-values histogram for motif ATF2.p2

Sorted Z-values for motif ATF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_22634373 2.378 NM_001253854
NM_001253855
NM_012443
NM_172242
SPAG6



sperm associated antigen 6



chr3_+_158288952 2.039 NM_001130156
NM_001130157
NM_001195432
NM_001195433
NM_001195434
NM_022443
MLF1





myeloid leukemia factor 1





chr12_-_91505215 1.821 LUM
lumican
chr16_-_55867016 1.812 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr4_+_41700736 1.802 LIMCH1
LIM and calponin homology domains 1
chr6_-_29595746 1.753 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr16_-_55866972 1.719 CES1
carboxylesterase 1
chr12_+_7013896 1.695 NM_001135217
NM_006992
NM_201650
LRRC23


leucine rich repeat containing 23


chr12_-_91505541 1.597 NM_002345
LUM
lumican
chr2_-_135782246 1.520 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr13_-_20110884 1.498 NM_001141968
NM_130785
NM_199254
TPTE2


transmembrane phosphoinositide 3-phosphatase and tensin homolog 2


chr1_+_85527992 1.436 NM_145172
WDR63
WD repeat domain 63
chr7_+_116660263 1.291 ST7
suppression of tumorigenicity 7
chr19_+_45504686 1.289 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr5_+_94727047 1.251 NM_152548
FAM81B
family with sequence similarity 81, member B
chr17_+_53342356 1.239 HLF
hepatic leukemia factor
chr1_-_76076762 1.199 NM_001130058
NM_152697
SLC44A5

solute carrier family 44, member 5

chr19_+_50979656 1.193 NM_175063
NM_206538
C19orf63

chromosome 19 open reading frame 63

chr19_-_815243 1.170 LPPR3
lipid phosphate phosphatase-related protein type 3
chr1_+_183774214 1.169 RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr12_-_46121248 1.116 LOC400027
uncharacterized LOC400027
chr5_+_140165875 1.104 NM_018900
NM_031410
NM_031411
PCDHA1


protocadherin alpha 1


chrX_+_152240726 1.086 NM_001170944
NM_001242319
NM_032882
PNMA6C
PNMA6D
PNMA6A
paraneoplastic antigen like 6C
paraneoplastic antigen like 6D
paraneoplastic antigen like 6A
chr5_+_156696351 1.072 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr8_+_40010986 1.056 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr20_-_39317875 1.023 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr5_+_140254930 1.011 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chr19_+_50979788 1.007 C19orf63
chromosome 19 open reading frame 63
chr4_+_6784487 1.003 KIAA0232
KIAA0232
chr17_+_53342320 0.995 NM_002126
HLF
hepatic leukemia factor
chr6_+_39760148 0.964 NM_001201427
DAAM2
dishevelled associated activator of morphogenesis 2
chr5_+_36606456 0.929 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr10_+_95848811 0.914 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr8_+_99076749 0.856 NM_001170806
NM_173549
C8orf47

chromosome 8 open reading frame 47

chr4_+_6784462 0.855 KIAA0232
KIAA0232
chr5_+_36606667 0.836 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr20_+_18794369 0.836 NM_178483
C20orf79
chromosome 20 open reading frame 79
chr9_+_137967088 0.834 NM_014279
NM_006334
OLFM1

olfactomedin 1

chr7_+_30174343 0.826 NM_152793
C7orf41
chromosome 7 open reading frame 41
chr5_+_140247767 0.821 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr20_+_9288446 0.817 NM_000933
PLCB4
phospholipase C, beta 4
chr6_+_43211221 0.785 NM_032538
TTBK1
tau tubulin kinase 1
chr8_-_102803196 0.762 NCALD
neurocalcin delta
chr12_-_8043743 0.726 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr4_+_6784453 0.704 NM_001100590
NM_014743
KIAA0232

KIAA0232

chr1_+_104198301 0.685 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr2_-_27712520 0.663 NM_015662
IFT172
intraflagellar transport 172 homolog (Chlamydomonas)
chr20_+_58179601 0.636 NM_080672
PHACTR3
phosphatase and actin regulator 3
chr10_-_90967048 0.630 NM_003956
CH25H
cholesterol 25-hydroxylase
chr11_+_61447816 0.627 NM_006133
DAGLA
diacylglycerol lipase, alpha
chr4_-_70725792 0.615 NM_005420
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr7_+_89843133 0.604 NM_001040666
STEAP2
STEAP family member 2, metalloreductase
chr22_-_30867944 0.595 NM_174975
SEC14L3
SEC14-like 3 (S. cerevisiae)
chr12_-_31881949 0.594 AMN1
antagonist of mitotic exit network 1 homolog (S. cerevisiae)
chr8_-_102217907 0.594 NM_001042510
NM_016096
ZNF706

zinc finger protein 706

chr9_+_132251403 0.594 LOC100506190
uncharacterized LOC100506190
chr8_-_102217868 0.583 NM_001042511
ZNF706
zinc finger protein 706
chr3_+_238274 0.583 NM_001253387
NM_006614
CHL1

cell adhesion molecule with homology to L1CAM (close homolog of L1)

chr19_-_460995 0.583 NM_012435
SHC2
SHC (Src homology 2 domain containing) transforming protein 2
chr4_-_70518964 0.582 NM_001252274
NM_001252275
NM_006798
UGT2A1


UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus


chr3_+_69812961 0.579 NM_006722
MITF
microphthalmia-associated transcription factor
chr16_-_54962707 0.571 CRNDE
colorectal neoplasia differentially expressed (non-protein coding)
chr12_+_131438451 0.567 NM_198827
GPR133
G protein-coupled receptor 133
chr3_+_69812620 0.562 NM_001184967
MITF
microphthalmia-associated transcription factor
chr9_-_125027080 0.558 NM_033117
RBM18
RNA binding motif protein 18
chr19_-_5340700 0.545 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr4_-_23891608 0.531 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr12_-_31882006 0.521 NM_001113402
AMN1
antagonist of mitotic exit network 1 homolog (S. cerevisiae)
chr19_+_41594367 0.513 NM_000766
CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chr1_-_1293907 0.512 NM_032348
MXRA8
matrix-remodelling associated 8
chr14_+_21498344 0.510 NM_173846
TPPP2
tubulin polymerization-promoting protein family member 2
chr1_+_244214576 0.507 ZNF238
zinc finger protein 238
chr20_-_48530275 0.501 NM_001135773
SPATA2
spermatogenesis associated 2
chr14_+_93651295 0.495 NM_015676
NM_001098621
C14orf109

chromosome 14 open reading frame 109

chr9_-_125027017 0.495 RBM18
RNA binding motif protein 18
chr3_-_51937336 0.494 NM_152397
IQCF1
IQ motif containing F1
chr3_+_23987514 0.492 NM_001145425
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr17_-_77770776 0.492 NM_020649
CBX8
chromobox homolog 8
chr5_-_94417544 0.491 NM_001002796
MCTP1
multiple C2 domains, transmembrane 1
chr14_+_56585147 0.491 PELI2
pellino homolog 2 (Drosophila)
chr1_-_104238785 0.486 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr11_-_62474810 0.484 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr2_+_220071493 0.473 NM_138802
ZFAND2B
zinc finger, AN1-type domain 2B
chr4_+_85504056 0.472 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr14_+_56584854 0.469 NM_021255
PELI2
pellino homolog 2 (Drosophila)
chr9_+_126773851 0.467 NM_004789
LHX2
LIM homeobox 2
chr7_+_117120016 0.457 NM_000492
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr1_+_104159953 0.449 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr10_+_119000583 0.442 NM_003054
SLC18A2
solute carrier family 18 (vesicular monoamine), member 2
chr5_+_140514787 0.438 NM_015669
PCDHB5
protocadherin beta 5
chr1_+_244214552 0.436 NM_205768
ZNF238
zinc finger protein 238
chr17_+_685606 0.433 RNMTL1
RNA methyltransferase like 1
chr22_-_44258210 0.431 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr11_+_62104773 0.428 NM_001083926
NM_025080
ASRGL1

asparaginase like 1

chr19_+_8455265 0.426 RAB11B
RAB11B, member RAS oncogene family
chr14_-_77494974 0.426 NM_024496
IRF2BPL
interferon regulatory factor 2 binding protein-like
chr12_+_122150638 0.425 NM_001080825
TMEM120B
transmembrane protein 120B
chr20_+_58296264 0.424 NM_183244
NM_183246
PHACTR3

phosphatase and actin regulator 3

chr21_-_35828038 0.415 NM_001127670
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr2_-_98280326 0.415 ACTR1B
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr19_+_8455243 0.412 RAB11B
RAB11B, member RAS oncogene family
chr17_-_41984888 0.407 MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr2_-_25194772 0.405 NM_001198559
NM_016544
DNAJC27

DnaJ (Hsp40) homolog, subfamily C, member 27

chr11_-_8892909 0.401 ST5
suppression of tumorigenicity 5
chr7_-_25164902 0.399 NM_018947
CYCS
cytochrome c, somatic
chr2_-_98280538 0.398 NM_005735
ACTR1B
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr21_-_36421630 0.396 RUNX1
runt-related transcription factor 1
chr4_-_142054431 0.393 NM_020724
RNF150
ring finger protein 150
chr11_-_3818971 0.388 NM_005387
NM_016320
NM_139131
NM_139132
NUP98



nucleoporin 98kDa



chr11_-_111749810 0.384 FDXACB1
ferredoxin-fold anticodon binding domain containing 1
chr5_-_132948195 0.380 FSTL4
follistatin-like 4
chr4_+_170581212 0.378 NM_001243374
CLCN3
chloride channel 3
chr14_+_23352430 0.376 NM_173527
REM2
RAS (RAD and GEM)-like GTP binding 2
chr6_-_31671089 0.375 ABHD16A
abhydrolase domain containing 16A
chr11_+_18343794 0.372 NM_001142307
NM_005316
GTF2H1

general transcription factor IIH, polypeptide 1, 62kDa

chr6_-_132272311 0.370 NM_001901
CTGF
connective tissue growth factor
chr9_+_132251323 0.370 LOC100506190
uncharacterized LOC100506190
chr11_+_36317724 0.368 NM_001160167
PRR5L
proline rich 5 like
chr17_-_8151353 0.366 CTC1
CTS telomere maintenance complex component 1
chr16_-_755718 0.364 NM_153350
FBXL16
F-box and leucine-rich repeat protein 16
chr4_+_128802064 0.358 NM_001190801
PLK4
polo-like kinase 4
chr6_-_31671054 0.358 ABHD16A
abhydrolase domain containing 16A
chr6_-_31671120 0.356 NM_021160
ABHD16A
abhydrolase domain containing 16A
chr1_+_212782103 0.356 ATF3
activating transcription factor 3
chr13_-_52378230 0.352 NM_001031719
NM_024705
DHRS12

dehydrogenase/reductase (SDR family) member 12

chr22_+_31518923 0.351 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr3_-_100712248 0.350 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr4_+_128802015 0.350 NM_001190799
NM_014264
PLK4

polo-like kinase 4

chr19_+_6135650 0.347 NM_030924
ACSBG2
acyl-CoA synthetase bubblegum family member 2
chr5_-_121413967 0.346 LOX
lysyl oxidase
chr16_-_68057098 0.346 DDX28
DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
chr8_+_132916339 0.343 NM_015137
EFR3A
EFR3 homolog A (S. cerevisiae)
chr9_+_17578952 0.342 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr4_-_54424402 0.341 NM_032622
LNX1
ligand of numb-protein X 1
chr20_+_17207680 0.337 PCSK2
proprotein convertase subtilisin/kexin type 2
chr19_+_8455200 0.335 NM_004218
RAB11B
RAB11B, member RAS oncogene family
chr6_+_30908776 0.335 NM_080870
DPCR1
diffuse panbronchiolitis critical region 1
chr20_+_19915716 0.330 RIN2
Ras and Rab interactor 2
chr17_+_26800657 0.327 NM_001145975
NM_001145976
NM_003984
SLC13A2


solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2


chr1_+_29562947 0.325 NM_001195001
NM_005704
NM_133177
NM_133178
PTPRU



protein tyrosine phosphatase, receptor type, U



chr4_+_74702272 0.325 NM_002993
CXCL6
chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
chr5_-_54468833 0.323 NM_001145734
NM_001170402
NM_152623
CDC20B


cell division cycle 20 homolog B (S. cerevisiae)


chr13_+_32605436 0.322 NM_023037
FRY
furry homolog (Drosophila)
chrX_+_110339374 0.320 NM_002578
PAK3
p21 protein (Cdc42/Rac)-activated kinase 3
chr4_-_54424345 0.318 LNX1
ligand of numb-protein X 1
chr11_+_1463674 0.317 BRSK2
BR serine/threonine kinase 2
chr3_-_156877882 0.316 CCNL1
cyclin L1
chr22_+_50925212 0.316 NM_017584
MIOX
myo-inositol oxygenase
chr6_-_32908583 0.316 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr3_-_187463474 0.315 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr11_-_77184549 0.314 NM_001128620
NM_002576
PAK1

p21 protein (Cdc42/Rac)-activated kinase 1

chr12_+_54393876 0.311 NM_006897
HOXC9
homeobox C9
chr17_+_4643318 0.311 NM_001136046
NM_032265
ZMYND15

zinc finger, MYND-type containing 15

chr15_-_48470319 0.310 MYEF2
myelin expression factor 2
chr12_+_86268072 0.307 NM_006183
NTS
neurotensin
chr12_-_42877785 0.306 NM_001144882
NM_001144883
PRICKLE1

prickle homolog 1 (Drosophila)

chr17_+_42264300 0.305 NM_001076674
NM_024107
TMUB2

transmembrane and ubiquitin-like domain containing 2

chr11_-_62474869 0.305 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr4_-_38806410 0.302 NM_003263
TLR1
toll-like receptor 1
chr8_+_117778741 0.301 NM_032334
UTP23
UTP23, small subunit (SSU) processome component, homolog (yeast)
chr15_-_60884615 0.299 NM_134262
RORA
RAR-related orphan receptor A
chr2_-_43823099 0.299 NM_001083953
NM_022065
THADA

thyroid adenoma associated

chr17_+_72428228 0.299 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr2_+_132480063 0.298 NM_013310
C2orf27A
chromosome 2 open reading frame 27A
chr3_+_132318980 0.297 NM_178445
CCRL1
chemokine (C-C motif) receptor-like 1
chr13_-_45010937 0.296 TSC22D1
TSC22 domain family, member 1
chr10_+_35484829 0.293 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr17_-_42264023 0.293 C17orf65
chromosome 17 open reading frame 65
chr17_-_42264075 0.292 NM_178542
C17orf65
chromosome 17 open reading frame 65
chr5_-_153857782 0.292 HAND1
heart and neural crest derivatives expressed 1
chr6_-_47277640 0.292 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr11_-_3818736 0.291 NUP98
nucleoporin 98kDa
chr12_+_111843743 0.291 NM_005475
SH2B3
SH2B adaptor protein 3
chr17_-_80231240 0.290 CSNK1D
casein kinase 1, delta
chr17_+_73521744 0.290 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr9_-_126030854 0.290 NM_001171137
STRBP
spermatid perinuclear RNA binding protein
chr5_+_73109342 0.290 NM_001244364
RGNEF
190 kDa guanine nucleotide exchange factor
chr16_-_68057120 0.289 DDX28
DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
chr19_+_49122762 0.288 SPHK2
sphingosine kinase 2
chr19_-_47617008 0.287 NM_015168
ZC3H4
zinc finger CCCH-type containing 4
chr19_+_49122547 0.287 NM_001204158
NM_001243876
NM_020126
SPHK2


sphingosine kinase 2


chr8_+_117778764 0.285 UTP23
UTP23, small subunit (SSU) processome component, homolog (yeast)
chr1_+_40839368 0.283 NM_022733
SMAP2
small ArfGAP2
chr6_-_106773607 0.283 NM_004849
ATG5
ATG5 autophagy related 5 homolog (S. cerevisiae)
chr16_+_475605 0.283 RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr22_+_29449877 0.281 ZNRF3
zinc and ring finger 3
chr4_+_74606222 0.280 NM_000584
IL8
interleukin 8
chr9_-_126030792 0.279 NM_018387
STRBP
spermatid perinuclear RNA binding protein
chr19_+_49122789 0.279 NM_001204159
SPHK2
sphingosine kinase 2
chr1_+_201476283 0.277


chr21_-_36421586 0.277 NM_001754
RUNX1
runt-related transcription factor 1
chr2_-_97535669 0.277 NM_017789
SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr19_-_46389307 0.276 NM_015649
IRF2BP1
interferon regulatory factor 2 binding protein 1
chr5_-_121413906 0.276 LOX
lysyl oxidase
chr2_+_149632772 0.274 NM_004522
KIF5C
kinesin family member 5C
chr1_-_36915969 0.272 NM_145047
NM_206837
OSCP1

organic solute carrier partner 1

chr11_-_62474666 0.271 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr20_+_9049660 0.271 NM_001172646
PLCB4
phospholipase C, beta 4
chr17_+_685512 0.269 NM_018146
RNMTL1
RNA methyltransferase like 1
chr2_-_71357348 0.266 NM_032601
MCEE
methylmalonyl CoA epimerase

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.32 2.24e-02 GO:0060255 regulation of macromolecule metabolic process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.45 4.79e-03 GO:0004879 ligand-dependent nuclear receptor activity
1.64 5.92e-03 GO:0001071 nucleic acid binding transcription factor activity
1.64 5.92e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
4.32 1.50e-02 GO:0003707 steroid hormone receptor activity
1.09 2.27e-02 GO:0005488 binding
1.16 2.99e-02 GO:0005515 protein binding