Motif ID: ATF4.p2

Z-value: 1.736


Transcription factors associated with ATF4.p2:

Gene SymbolEntrez IDGene Name
ATF4 468 activating transcription factor 4 (tax-responsive enhancer element B67)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ATF4chr22_+_399165630.478.0e-03Click!


Activity profile for motif ATF4.p2.

activity profile for motif ATF4.p2


Sorted Z-values histogram for motif ATF4.p2

Sorted Z-values for motif ATF4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF4.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_68086633 17.676 ARG2
arginase, type II
chr2_-_216300770 12.166 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
 FN1





fibronectin 1





chr20_+_34203746 11.376 NM_003116
 SPAG4
sperm associated antigen 4
chr11_-_61584451 10.705 NM_013402
 FADS1
fatty acid desaturase 1
chr4_+_75310852 10.646 NM_001657
 AREG
amphiregulin
chr14_+_68086570 9.877 NM_001172
 ARG2
arginase, type II
chr7_+_5632435 9.861 NM_003088
 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr7_+_5632453 8.854 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr14_+_68086655 7.986 ARG2
arginase, type II
chr4_-_104119475 7.196 NM_001813
 CENPE
centromere protein E, 312kDa
chr19_+_16187266 6.875 TPM4
tropomyosin 4
chr19_+_16187306 6.302 TPM4
tropomyosin 4
chr17_+_41476351 6.279 NM_001661
 ARL4D
ADP-ribosylation factor-like 4D
chr4_+_75480628 6.151 NM_001657
 AREG
amphiregulin
chr21_-_45079327 6.053 NM_007031
 HSF2BP
heat shock transcription factor 2 binding protein
chr11_-_61584228 5.930 FADS1
fatty acid desaturase 1
chr16_-_46655262 5.904 SHCBP1
SHC SH2-domain binding protein 1
chr4_-_122744782 5.833 CCNA2
cyclin A2
chr16_-_46655303 5.623 NM_024745
 SHCBP1
SHC SH2-domain binding protein 1
chr6_+_86159738 5.556 NT5E
5'-nucleotidase, ecto (CD73)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 22 entries
enrichment   p-value GO term description
8.17 1.98e-02 GO:0051310 metaphase plate congression
3.59 1.68e-02 GO:0045185 maintenance of protein location
2.32 1.44e-02 GO:0007017 microtubule-based process
1.63 1.04e-03 GO:0051641 cellular localization
1.57 3.01e-02 GO:0051649 establishment of localization in cell
1.50 8.58e-03 GO:0006996 organelle organization
1.49 1.39e-05 GO:0044267 cellular protein metabolic process
1.43 1.66e-02 GO:0043412 macromolecule modification
1.43 2.61e-02 GO:0006464 protein modification process
1.38 2.04e-07 GO:0044260 cellular macromolecule metabolic process
1.38 7.03e-04 GO:0019538 protein metabolic process
1.38 3.58e-03 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.34 3.77e-02 GO:0071841 cellular component organization or biogenesis at cellular level
1.33 6.76e-03 GO:0034641 cellular nitrogen compound metabolic process
1.32 9.48e-06 GO:0043170 macromolecule metabolic process
1.32 9.95e-03 GO:0016043 cellular component organization
1.31 7.66e-03 GO:0071840 cellular component organization or biogenesis
1.31 1.57e-02 GO:0006807 nitrogen compound metabolic process
1.26 1.21e-05 GO:0044237 cellular metabolic process
1.26 1.45e-05 GO:0044238 primary metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 25 entries
enrichment   p-value GO term description
14.00 2.05e-02 GO:0005663 DNA replication factor C complex
2.64 1.74e-02 GO:0000793 condensed chromosome
1.95 2.51e-03 GO:0044427 chromosomal part
1.90 1.00e-03 GO:0005694 chromosome
1.50 1.82e-04 GO:0031981 nuclear lumen
1.47 2.20e-02 GO:0005654 nucleoplasm
1.44 1.05e-04 GO:0043233 organelle lumen
1.44 1.23e-04 GO:0031974 membrane-enclosed lumen
1.44 1.82e-04 GO:0070013 intracellular organelle lumen
1.44 2.52e-04 GO:0044428 nuclear part
1.36 1.22e-03 GO:0043228 non-membrane-bounded organelle
1.36 1.22e-03 GO:0043232 intracellular non-membrane-bounded organelle
1.36 1.97e-02 GO:0005829 cytosol
1.33 2.73e-09 GO:0044446 intracellular organelle part
1.33 5.88e-09 GO:0044422 organelle part
1.26 7.49e-06 GO:0044444 cytoplasmic part
1.25 1.26e-04 GO:0005634 nucleus
1.25 3.39e-02 GO:0032991 macromolecular complex
1.24 3.37e-10 GO:0005737 cytoplasm
1.21 3.64e-08 GO:0043231 intracellular membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
1.43 3.70e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.43 2.51e-02 GO:0005524 ATP binding
1.42 3.93e-02 GO:0030554 adenyl nucleotide binding
1.41 7.53e-03 GO:0017076 purine nucleotide binding
1.41 8.69e-03 GO:0032553 ribonucleotide binding
1.41 8.69e-03 GO:0032555 purine ribonucleotide binding
1.41 4.80e-02 GO:0032559 adenyl ribonucleotide binding
1.33 4.32e-02 GO:0000166 nucleotide binding
1.30 2.31e-12 GO:0005515 protein binding
1.13 1.88e-06 GO:0005488 binding