Motif ID: BACH2.p2

Z-value: 0.986


Transcription factors associated with BACH2.p2:

Gene SymbolEntrez IDGene Name
BACH2 60468 BTB and CNC homology 1, basic leucine zipper transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
BACH2chr6_-_91006460-0.441.5e-02Click!


Activity profile for motif BACH2.p2.

activity profile for motif BACH2.p2


Sorted Z-values histogram for motif BACH2.p2

Sorted Z-values for motif BACH2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of BACH2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_21452981 5.561 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr11_-_102668822 5.455 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr11_-_102668892 5.420 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr1_+_150480584 5.362 ECM1
extracellular matrix protein 1
chr1_+_150480486 5.031 NM_001202858
NM_004425
NM_022664
ECM1


extracellular matrix protein 1


chr19_-_51472816 4.887 NM_002774
KLK6
kallikrein-related peptidase 6
chr11_-_102826433 4.599 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr1_+_32043745 4.327 NM_001204415
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr19_-_36019194 4.222 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr2_+_113875469 4.034 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr17_-_39768939 3.952 NM_005557
KRT16
keratin 16
chr6_+_74405764 3.725 CD109
CD109 molecule
chr6_+_74405505 3.479 NM_001159587
NM_001159588
NM_133493
CD109


CD109 molecule


chr1_+_152956563 3.452 NM_001199828
NM_005987
SPRR1A

small proline-rich protein 1A

chr6_+_74405909 3.452 CD109
CD109 molecule
chr1_-_153521717 3.436 NM_002960
S100A3
S100 calcium binding protein A3
chr6_+_74405933 3.376 CD109
CD109 molecule
chr6_+_74405856 3.333 CD109
CD109 molecule
chr3_-_48632592 3.307 NM_000094
COL7A1
collagen, type VII, alpha 1
chr15_-_80263460 3.033 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr11_-_65667858 2.996 FOSL1
FOS-like antigen 1
chr21_+_41029253 2.838 NM_006057
NM_033170
NM_033171
NM_033172
NM_033173
B3GALT5




UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5




chr11_-_6341708 2.828 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr7_-_107643330 2.738 NM_002291
LAMB1
laminin, beta 1
chr7_+_48128225 2.630 NM_181597
UPP1
uridine phosphorylase 1
chr1_+_153003677 2.570 NM_003125
SPRR1B
small proline-rich protein 1B
chr9_+_140119643 2.537 NM_199001
C9orf169
chromosome 9 open reading frame 169
chr11_+_12308446 2.532 NM_032867
MICALCL
MICAL C-terminal like
chr21_+_30517897 2.521 C21orf7
chromosome 21 open reading frame 7
chr1_-_153085963 2.278 NM_001014450
SPRR2A
SPRR2F
small proline-rich protein 2A
small proline-rich protein 2F
chr9_-_99064385 2.207 NM_000197
HSD17B3
hydroxysteroid (17-beta) dehydrogenase 3
chr11_-_65667809 2.112 FOSL1
FOS-like antigen 1
chr1_-_17308072 2.107 NM_001135247
NM_017459
MFAP2

microfibrillar-associated protein 2

chr17_-_33390676 2.067 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chr1_+_183155361 2.063 LAMC2
laminin, gamma 2
chr18_+_61442611 2.026 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr19_-_44285407 1.963 NM_002250
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr1_-_162381805 1.946 NM_053282
SH2D1B
SH2 domain containing 1B
chr17_-_76921205 1.919 TIMP2
TIMP metallopeptidase inhibitor 2
chr20_-_1309809 1.887 NM_080489
SDCBP2
syndecan binding protein (syntenin) 2
chr19_-_35992798 1.865 NM_001035516
DMKN
dermokine
chr10_+_17270257 1.808 NM_003380
VIM
vimentin
chr19_-_36004553 1.787 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine






chr1_+_152974222 1.780 NM_001097589
NM_005416
SPRR3

small proline-rich protein 3

chr1_+_183155393 1.759 LAMC2
laminin, gamma 2
chr11_-_118134956 1.758 MPZL2
myelin protein zero-like 2
chr1_-_204121144 1.758 NM_018208
ETNK2
ethanolamine kinase 2
chr19_-_44285012 1.724 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr13_-_60325073 1.680


chr10_+_17270469 1.642 VIM
vimentin
chr7_+_134233848 1.633 NM_001080538
AKR1B15
aldo-keto reductase family 1, member B15
chr21_+_30452872 1.631 NM_020152
C21orf7
chromosome 21 open reading frame 7
chr15_+_89182038 1.614 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr6_+_47666288 1.611 NM_153838
GPR115
G protein-coupled receptor 115
chr1_+_183155173 1.609 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chrX_+_99899162 1.573 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr20_+_44637539 1.563 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr11_+_2924504 1.561 SLC22A18
solute carrier family 22, member 18
chr7_+_143078457 1.523 ZYX
zyxin
chr4_+_169013687 1.513 NM_007193
ANXA10
annexin A10
chr2_-_85641128 1.502 CAPG
capping protein (actin filament), gelsolin-like
chr3_+_100238063 1.496 TMEM45A
transmembrane protein 45A
chr1_+_40627066 1.482 RLF
rearranged L-myc fusion
chr4_-_39033981 1.458 NM_024943
TMEM156
transmembrane protein 156
chr12_+_107974633 1.451 NM_001017523
BTBD11
BTB (POZ) domain containing 11
chr1_-_153029987 1.438 NM_005988
SPRR2A
small proline-rich protein 2A
chr7_+_143078447 1.429 ZYX
zyxin
chr6_-_30654978 1.398 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr18_+_56338678 1.394 MALT1
mucosa associated lymphoid tissue lymphoma translocation gene 1
chr3_-_12800739 1.382 NM_018306
TMEM40
transmembrane protein 40
chr11_-_118135197 1.381 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chr7_+_143078395 1.381 ZYX
zyxin
chr7_+_143078444 1.380 ZYX
zyxin
chr11_-_65667860 1.361 NM_005438
FOSL1
FOS-like antigen 1
chr12_+_7023490 1.352 NM_001975
ENO2
enolase 2 (gamma, neuronal)
chr19_-_43969723 1.349 NM_014400
LYPD3
LY6/PLAUR domain containing 3
chr7_+_143078399 1.347 ZYX
zyxin
chr16_-_30124829 1.339 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr11_-_118134986 1.333 MPZL2
myelin protein zero-like 2
chr2_+_48541767 1.325 NM_002158
FOXN2
forkhead box N2
chr1_-_27816667 1.292 WASF2
WAS protein family, member 2
chr19_-_51537996 1.278 NM_019598
NM_145894
NM_145895
KLK12


kallikrein-related peptidase 12


chr19_+_39279849 1.272 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr7_+_143078358 1.271 NM_001010972
NM_003461
ZYX

zyxin

chr8_-_30515665 1.251 NM_002095
GTF2E2
general transcription factor IIE, polypeptide 2, beta 34kDa
chr19_-_44174497 1.251 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr19_-_39264144 1.243 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr17_+_74381419 1.239 SPHK1
sphingosine kinase 1
chr17_+_73717515 1.238 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr11_+_706607 1.237 EPS8L2
EPS8-like 2
chr1_-_153067000 1.225 NM_001024209
SPRR2E
small proline-rich protein 2E
chr1_+_26606621 1.221 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr17_+_74381186 1.188 NM_001142602
SPHK1
sphingosine kinase 1
chr19_-_51523272 1.185 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr3_-_98241357 1.174 CLDND1
claudin domain containing 1
chr17_-_39538635 1.157 NM_021013
KRT34
keratin 34
chr6_+_32121228 1.154 NM_138717
PPT2
palmitoyl-protein thioesterase 2
chr6_-_30655078 1.140 NM_001134870
PPP1R18
protein phosphatase 1, regulatory subunit 18
chr1_-_28520379 1.135 NM_001164721
NM_001164722
PTAFR

platelet-activating factor receptor

chr6_-_84140854 1.125 NM_002395
ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr12_-_39299335 1.084 NM_153634
CPNE8
copine VIII
chr8_-_68658577 1.076 NM_020361
CPA6
carboxypeptidase A6
chr15_+_90728118 1.072 NM_020210
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr17_-_48278874 1.069 COL1A1
collagen, type I, alpha 1
chr7_-_158611301 1.052 ESYT2
extended synaptotagmin-like protein 2
chr1_-_154943001 1.040 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr1_-_156675237 1.036 NM_001878
NM_001199723
CRABP2

cellular retinoic acid binding protein 2

chr4_-_80329354 1.019 NM_033214
GK2
glycerol kinase 2
chr19_-_51568323 1.008 NM_015596
KLK13
kallikrein-related peptidase 13
chr17_-_76921453 0.994 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr18_+_268147 0.993


chr7_+_1577118 0.961 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr6_-_111927473 0.957 NM_001164281
NM_147686
TRAF3IP2

TRAF3 interacting protein 2

chr16_-_2908105 0.955 NM_022119
PRSS22
protease, serine, 22
chr19_-_44174271 0.951 PLAUR
plasminogen activator, urokinase receptor
chr1_+_26606586 0.950 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr2_-_31352489 0.949 NM_001253827
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr22_+_31478845 0.942 NM_001207017
SMTN
smoothelin
chr1_+_55007927 0.940 ACOT11
acyl-CoA thioesterase 11
chr1_-_211848820 0.938 NM_001204182
NM_001204183
NM_002497
NEK2


NIMA (never in mitosis gene a)-related kinase 2


chr6_-_150346599 0.933 NM_130900
RAET1L
retinoic acid early transcript 1L
chr17_-_43502992 0.933 NM_199282
ARHGAP27
Rho GTPase activating protein 27
chr2_-_31637598 0.930 NM_000379
XDH
xanthine dehydrogenase
chr2_-_65593866 0.928 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr16_+_67311412 0.918 NM_015432
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr13_-_60587298 0.916 NM_030932
DIAPH3
diaphanous homolog 3 (Drosophila)
chr7_+_143058794 0.906 ZYX
zyxin
chr9_-_123688352 0.901 TRAF1
TNF receptor-associated factor 1
chr8_+_7752198 0.898 NM_004942
DEFB4A
defensin, beta 4A
chr1_+_154377668 0.898 NM_000565
NM_001206866
NM_181359
IL6R


interleukin 6 receptor


chr15_+_44829373 0.896 EIF3J
eukaryotic translation initiation factor 3, subunit J
chr22_+_22758538 0.888


chr9_+_103191795 0.871 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr8_-_42623928 0.866 NM_001199279
NM_004198
CHRNA6

cholinergic receptor, nicotinic, alpha 6

chr1_-_27816542 0.859 WASF2
WAS protein family, member 2
chr1_-_209824641 0.853 NM_001017402
LAMB3
laminin, beta 3
chr18_+_56338617 0.846 NM_006785
NM_173844
MALT1

mucosa associated lymphoid tissue lymphoma translocation gene 1

chr10_-_129691202 0.845 NM_152311
CLRN3
clarin 3
chr22_+_20861884 0.845 NM_001003891
NM_015889
MED15

mediator complex subunit 15

chr1_+_3388170 0.839 ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr5_-_141061798 0.833 NM_022481
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr9_+_4985082 0.832 JAK2
Janus kinase 2
chr1_+_40627055 0.829 RLF
rearranged L-myc fusion
chrX_-_129244422 0.826 ELF4
E74-like factor 4 (ets domain transcription factor)
chr18_+_61254533 0.822 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr17_+_7482938 0.821 CD68
CD68 molecule
chr17_+_74380943 0.820 SPHK1
sphingosine kinase 1
chr6_-_111927059 0.816 TRAF3IP2
TRAF3 interacting protein 2
chr8_-_125579395 0.812 MTSS1
metastasis suppressor 1
chr1_+_154377847 0.811 IL6R
interleukin 6 receptor
chr8_+_22210311 0.810 PIWIL2
piwi-like 2 (Drosophila)
chr22_+_20861886 0.808 MED15
mediator complex subunit 15
chr2_-_85641153 0.808 CAPG
capping protein (actin filament), gelsolin-like
chr22_+_20861875 0.803 MED15
mediator complex subunit 15
chr1_-_225616556 0.797 NM_194442
LBR
lamin B receptor
chr3_+_154797644 0.794 NM_007287
MME
membrane metallo-endopeptidase
chr6_+_30875962 0.794 NM_001517
GTF2H4
general transcription factor IIH, polypeptide 4, 52kDa
chr7_-_75623888 0.793 TMEM120A
transmembrane protein 120A
chr22_+_20861964 0.792 MED15
mediator complex subunit 15
chr2_+_220492286 0.791 NM_005070
NM_201574
SLC4A3

solute carrier family 4, anion exchanger, member 3

chr18_+_21693316 0.786 TTC39C
tetratricopeptide repeat domain 39C
chr1_-_27816676 0.777 NM_001201404
NM_006990
WASF2

WAS protein family, member 2

chrY_+_15016775 0.776 DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr6_-_84140744 0.769 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr19_-_3969734 0.763 NM_001348
DAPK3
death-associated protein kinase 3
chr5_-_141061749 0.762 ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr6_-_35888816 0.761 SRPK1
SRSF protein kinase 1
chr12_-_48152180 0.755 NM_001098532
NM_006105
RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3

chr1_-_17307107 0.754 NM_001135248
NM_002403
MFAP2

microfibrillar-associated protein 2

chr1_-_95007139 0.752 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr17_+_79651072 0.748 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr6_+_106959729 0.743 NM_001624
AIM1
absent in melanoma 1
chr1_+_154378044 0.742 IL6R
interleukin 6 receptor
chr12_-_48152860 0.740 NM_001098531
RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chr11_-_2950593 0.739 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr2_+_169926084 0.726 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr16_+_67312057 0.719 NM_001129727
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr20_+_43030005 0.719 HNF4A
hepatocyte nuclear factor 4, alpha
chr8_+_22844918 0.716 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr3_+_160394946 0.708 NM_025047
ARL14
ADP-ribosylation factor-like 14
chr17_+_79650961 0.707 NM_004712
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr10_+_5238756 0.700 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr19_-_46405854 0.692 NM_001012643
MYPOP
Myb-related transcription factor, partner of profilin
chr4_-_159092509 0.692 FAM198B
family with sequence similarity 198, member B
chr17_+_9745847 0.686 GLP2R
glucagon-like peptide 2 receptor
chrX_-_129244471 0.685 NM_001421
ELF4
E74-like factor 4 (ets domain transcription factor)
chr10_-_48806862 0.682 NM_001042357
NM_001042389
PTPN20B
PTPN20A
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20A
chr5_+_147648374 0.675 NM_001040129
SPINK13
serine peptidase inhibitor, Kazal type 13 (putative)
chr17_+_7482804 0.673 NM_001251
NM_001040059
CD68

CD68 molecule

chr9_+_4985243 0.672 NM_004972
JAK2
Janus kinase 2
chr10_+_118187381 0.668 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr6_+_44195008 0.665 SLC29A1
solute carrier family 29 (nucleoside transporters), member 1
chr1_+_40627031 0.665 NM_012421
RLF
rearranged L-myc fusion
chr6_-_84140758 0.661 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr8_-_42065193 0.660 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr17_+_79651035 0.658 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr11_-_47207425 0.652 NM_001184975
PACSIN3
protein kinase C and casein kinase substrate in neurons 3
chr17_+_75372164 0.651 NM_001113494
SEPT9
septin 9
chr22_-_44708730 0.650 NM_001099294
KIAA1644
KIAA1644
chr7_-_1177821 0.644 NM_001134395
NM_001134396
NM_032350
C7orf50


chromosome 7 open reading frame 50



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
10.59 3.55e-03 GO:0042098 T cell proliferation
1.84 4.26e-03 GO:0032879 regulation of localization
1.67 9.10e-03 GO:0035556 intracellular signal transduction
11.02 1.53e-02 GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
7.35 1.54e-02 GO:0007044 cell-substrate junction assembly
1.37 1.73e-02 GO:0007165 signal transduction
1.34 2.33e-02 GO:0023052 signaling
2.04 2.46e-02 GO:0050878 regulation of body fluid levels
2.84 3.28e-02 GO:0008544 epidermis development
1.31 4.71e-02 GO:0051716 cellular response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.56 6.81e-03 GO:0005856 cytoskeleton
7.35 3.46e-02 GO:0001533 cornified envelope
4.08 4.57e-02 GO:0000502 proteasome complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.88 3.20e-02 GO:0005198 structural molecule activity