Motif ID: BPTF.p2

Z-value: 1.251


Transcription factors associated with BPTF.p2:

Gene SymbolEntrez IDGene Name
BPTF 2186 bromodomain PHD finger transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
BPTFchr17_+_659365900.422.1e-02Click!


Activity profile for motif BPTF.p2.

activity profile for motif BPTF.p2


Sorted Z-values histogram for motif BPTF.p2

Sorted Z-values for motif BPTF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of BPTF.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrY_+_22737610 5.207 NM_004681
EIF1AY
eukaryotic translation initiation factor 1A, Y-linked
chr11_+_125756954 3.177 NM_001134793
HYLS1
hydrolethalus syndrome 1
chr16_+_57728711 3.058 NM_032269
CCDC135
coiled-coil domain containing 135
chr11_+_101918168 3.019 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr19_+_47813074 2.713 NM_001736
C5AR1
complement component 5a receptor 1
chr13_+_50589389 2.486 NM_173605
NM_199464
TRIM13
KCNRG

tripartite motif containing 13
potassium channel regulator

chr11_+_73661363 2.431 NM_153614
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr5_-_159739482 2.243 NM_024565
CCNJL
cyclin J-like
chr3_+_151488214 2.215 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr18_+_61575203 2.194 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chrY_+_22917953 2.103 NM_001039567
RPS4Y2
ribosomal protein S4, Y-linked 2
chr2_-_119605758 2.066 NM_001426
EN1
engrailed homeobox 1
chr18_-_53089722 2.023 NM_001243233
TCF4
transcription factor 4
chr16_+_28699878 1.917 NM_001199142
EIF3C
eukaryotic translation initiation factor 3, subunit C
chr16_+_3559893 1.890 NM_024793
CLUAP1
clusterin associated protein 1
chr19_+_41620336 1.876 NM_000774
CYP2F1
cytochrome P450, family 2, subfamily F, polypeptide 1
chr17_-_33775761 1.853 NM_144682
SLFN13
schlafen family member 13
chr2_+_109403140 1.819 NM_144978
CCDC138
coiled-coil domain containing 138
chr7_-_16921596 1.799 NM_176813
AGR3
anterior gradient 3 homolog (Xenopus laevis)
chr5_-_35938736 1.736 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr7_+_94292816 1.733 PEG10
paternally expressed 10
chr10_+_63422718 1.730 NM_173554
C10orf107
chromosome 10 open reading frame 107
chr6_+_130758261 1.716 NM_052913
TMEM200A
transmembrane protein 200A
chr17_+_9479943 1.681 NM_001080556
NM_145054
WDR16

WD repeat domain 16

chr3_+_93698959 1.615 NM_001174150
NM_001174151
NM_144996
NM_182896
ARL13B



ADP-ribosylation factor-like 13B



chr6_+_163148163 1.611 NM_001080378
NM_152410
PACRG

PARK2 co-regulated

chr7_+_94292737 1.608 PEG10
paternally expressed 10
chr4_-_16085593 1.566 NM_001145847
NM_001145848
PROM1

prominin 1

chr12_-_111358353 1.552 NM_000432
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr10_+_97759847 1.506 NM_001001732
NM_001159747
CC2D2B

coiled-coil and C2 domain containing 2B

chrX_-_117119282 1.490 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chrY_+_2709630 1.410 RPS4Y1
ribosomal protein S4, Y-linked 1
chr11_-_102668822 1.391 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr13_-_20357125 1.390 NM_001042414
PSPC1
paraspeckle component 1
chr16_+_29827489 1.360 NM_024516
C16orf53
chromosome 16 open reading frame 53
chr11_-_115088628 1.333 CADM1
cell adhesion molecule 1
chr6_-_32805819 1.324 TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr3_-_46506342 1.311 NM_002343
LTF
lactotransferrin
chr4_+_72204769 1.308 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr16_+_3405888 1.304 NM_012368
OR2C1
olfactory receptor, family 2, subfamily C, member 1
chr9_+_34458810 1.262 NM_012144
DNAI1
dynein, axonemal, intermediate chain 1
chr9_+_131217433 1.248 NM_153436
ODF2
outer dense fiber of sperm tails 2
chr4_-_16085666 1.241 PROM1
prominin 1
chr2_-_135782246 1.235 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr21_-_35884503 1.226 KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr13_-_46756291 1.224 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr3_-_160101443 1.213 NM_001190242
IFT80
intraflagellar transport 80 homolog (Chlamydomonas)
chrY_+_2709596 1.173 NM_001008
RPS4Y1
ribosomal protein S4, Y-linked 1
chr8_+_18079176 1.151 NM_001160174
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr20_+_56725982 1.144 NM_178456
C20orf85
chromosome 20 open reading frame 85
chr16_-_28437663 1.142 NM_001199142
EIF3C
eukaryotic translation initiation factor 3, subunit C
chr7_+_158649200 1.135 NM_018051
WDR60
WD repeat domain 60
chr9_-_117156684 1.118 NM_030767
AKNA
AT-hook transcription factor
chr22_+_18632841 1.116 USP18
ubiquitin specific peptidase 18
chr3_-_196065243 1.105 NM_001204897
NM_001204898
NM_138461
TM4SF19


transmembrane 4 L six family member 19


chr12_+_118454505 1.092 NM_001130112
NM_001206801
NM_007370
NM_181578
RFC5



replication factor C (activator 1) 5, 36.5kDa



chr7_-_16844606 1.092 NM_006408
AGR2
anterior gradient 2 homolog (Xenopus laevis)
chr3_-_182880463 1.087 NM_014398
LAMP3
lysosomal-associated membrane protein 3
chr13_-_20356788 1.072 PSPC1
paraspeckle component 1
chr5_+_37379382 1.071 WDR70
WD repeat domain 70
chr5_+_37379392 1.070 NM_018034
WDR70
WD repeat domain 70
chr17_-_33446632 1.051 RAD51D
RAD51 homolog D (S. cerevisiae)
chr4_-_17806820 1.038 DCAF16
DDB1 and CUL4 associated factor 16
chr10_-_69597768 1.030 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr1_+_63249771 1.014 NM_032852
NM_178221
ATG4C

ATG4 autophagy related 4 homolog C (S. cerevisiae)

chr17_-_10633645 1.005 NM_001004313
TMEM220
transmembrane protein 220
chr1_-_27701302 1.002 NM_003665
NM_173452
FCN3

ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)

chr9_-_14086901 0.993 NFIB
nuclear factor I/B
chr19_-_55677919 0.977 NM_178837
C19orf51
chromosome 19 open reading frame 51
chrY_+_2803111 0.977 NM_001145276
ZFY
zinc finger protein, Y-linked
chr22_-_42343079 0.974 NM_001002876
NM_024053
CENPM

centromere protein M

chr9_-_3223007 0.974


chr12_-_57146081 0.969 NM_000946
PRIM1
primase, DNA, polypeptide 1 (49kDa)
chr3_-_9994057 0.962 NM_207351
PRRT3
proline-rich transmembrane protein 3
chrX_-_44202834 0.955 NM_025184
EFHC2
EF-hand domain (C-terminal) containing 2
chr6_+_52285804 0.944 NM_001172420
EFHC1
EF-hand domain (C-terminal) containing 1
chr16_-_74700775 0.932 NM_018124
RFWD3
ring finger and WD repeat domain 3
chr2_-_217540722 0.918 IGFBP5
insulin-like growth factor binding protein 5
chr19_-_48752921 0.916 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr6_-_79675672 0.915 PHIP
pleckstrin homology domain interacting protein
chr3_+_159557745 0.894 SCHIP1
schwannomin interacting protein 1
chr21_+_30400229 0.886 USP16
ubiquitin specific peptidase 16
chr6_-_32634287 0.883 NM_001243961
NM_002123
HLA-DQB1

major histocompatibility complex, class II, DQ beta 1

chr5_+_69345349 0.882 NM_000344
NM_022874
NM_017411
NM_022875
NM_022876
NM_022877
SMN1

SMN2



survival of motor neuron 1, telomeric

survival of motor neuron 2, centromeric



chr5_+_94727047 0.881 NM_152548
FAM81B
family with sequence similarity 81, member B
chr15_+_89787184 0.875 NM_001113378
NM_018193
FANCI

Fanconi anemia, complementation group I

chr19_+_58281049 0.871 ZNF586
zinc finger protein 586
chr16_+_78133163 0.869 NM_016373
NM_130791
NM_130844
WWOX


WW domain containing oxidoreductase


chr12_+_54943176 0.865 NM_000924
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr3_-_112693711 0.853 NM_138806
NM_138939
NM_138940
NM_170780
CD200R1



CD200 receptor 1



chr1_+_38022514 0.850 NM_003462
DNALI1
dynein, axonemal, light intermediate chain 1
chr1_-_216978708 0.845 NM_001243514
ESRRG
estrogen-related receptor gamma
chr1_-_217113007 0.843 NM_001243512
NM_001243513
NM_001243510
NM_001243511
ESRRG



estrogen-related receptor gamma



chr9_+_131218279 0.832 NM_001242352
NM_001242353
NM_001242354
NM_002540
NM_153432
NM_153435
NM_153439
ODF2






outer dense fiber of sperm tails 2






chr7_-_25268057 0.832 NM_022150
NPVF
neuropeptide VF precursor
chr7_+_48075107 0.808 NM_001100159
C7orf57
chromosome 7 open reading frame 57
chr19_+_58280996 0.802 NM_001077426
NM_001204814
NM_017652
ZNF586


zinc finger protein 586


chr12_+_110906203 0.797 NM_013300
C12orf24
chromosome 12 open reading frame 24
chr3_-_71180061 0.791 NM_001244815
FOXP1
forkhead box P1
chr3_-_64211111 0.791 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr12_-_123706393 0.789 NM_022782
MPHOSPH9
M-phase phosphoprotein 9
chr8_-_38008332 0.776 NM_000349
STAR
steroidogenic acute regulatory protein
chr7_-_21985421 0.774 NM_001127370
NM_001127371
NM_018719
CDCA7L


cell division cycle associated 7-like


chrY_+_14813159 0.763 NM_004654
USP9Y
ubiquitin specific peptidase 9, Y-linked
chr11_+_100862719 0.760 NM_032021
TMEM133
transmembrane protein 133
chr9_-_131418931 0.755 WDR34
WD repeat domain 34
chr8_+_101170231 0.747 NM_172218
SPAG1
sperm associated antigen 1
chr5_-_146833150 0.745 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr3_-_126327397 0.740 NM_001039783
TXNRD3NB
thioredoxin reductase 3 neighbor
chr12_-_86230158 0.739 NM_005447
RASSF9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr3_+_63638343 0.738 NM_001080537
SNTN
sentan, cilia apical structure protein
chrX_-_15332680 0.735 NM_001012428
ASB11
ankyrin repeat and SOCS box containing 11
chr12_-_122107559 0.735 NM_173855
MORN3
MORN repeat containing 3
chr2_+_97001506 0.726 NCAPH
non-SMC condensin I complex, subunit H
chr12_+_111051831 0.725 NM_001082537
NM_001082538
NM_001173976
NM_024549
NM_001173975
TCTN1




tectonic family member 1




chr6_-_24358279 0.724 NM_016356
DCDC2
doublecortin domain containing 2
chr1_+_151630710 0.718 SNX27
sorting nexin family member 27
chr1_-_161207879 0.716 NM_001077469
NM_001077470
NM_001077471
NM_001077472
NM_001077473
NM_001077474
NM_001077475
NM_001077476
NM_001077477
NM_001077478
NM_001077479
NM_001077480
NM_001077481
NM_001077482
NM_005122
NR1I3














nuclear receptor subfamily 1, group I, member 3














chr13_-_20357043 0.714 PSPC1
paraspeckle component 1
chr20_-_35407693 0.712 KIAA0889
KIAA0889
chr8_+_26435920 0.711 NM_001244604
DPYSL2
dihydropyrimidinase-like 2
chr17_-_56606534 0.710 SEPT4
septin 4
chr6_-_24383519 0.707 NM_001195610
DCDC2
doublecortin domain containing 2
chr6_+_44310396 0.706 NM_145026
SPATS1
spermatogenesis associated, serine-rich 1
chr17_+_67498391 0.703 MAP2K6
mitogen-activated protein kinase kinase 6
chr3_+_97158453 0.702 NM_173655
EPHA6
EPH receptor A6
chr1_-_173962050 0.687 NM_172071
RC3H1
ring finger and CCCH-type domains 1
chr16_-_87799495 0.686 KLHDC4
kelch domain containing 4
chr15_+_89787226 0.684 FANCI
Fanconi anemia, complementation group I
chr20_-_33265088 0.684 NM_080476
PIGU
phosphatidylinositol glycan anchor biosynthesis, class U
chr7_+_55433396 0.679 LANCL2
LanC lantibiotic synthetase component C-like 2 (bacterial)
chr3_+_46395224 0.677 NM_001123041
NM_001123396
CCR2

chemokine (C-C motif) receptor 2

chr17_-_73874634 0.675 NM_033452
TRIM47
tripartite motif containing 47
chr17_+_1633754 0.675 WDR81
WD repeat domain 81
chr4_+_77610610 0.672 SHROOM3
shroom family member 3
chr14_-_55650348 0.670 DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr18_-_53303129 0.670 NM_001243226
TCF4
transcription factor 4
chr1_-_1677430 0.666 NM_001199787
NM_182838
SLC35E2B
SLC35E2

solute carrier family 35, member E2B
solute carrier family 35, member E2

chr12_-_85306539 0.662 SLC6A15
solute carrier family 6 (neutral amino acid transporter), member 15
chr4_-_38806410 0.653 NM_003263
TLR1
toll-like receptor 1
chr19_-_40023449 0.652 NM_152361
EID2B
EP300 interacting inhibitor of differentiation 2B
chrX_-_48056198 0.649 NM_021015
NM_175723
SSX5

synovial sarcoma, X breakpoint 5

chr5_-_75013209 0.643 NM_001099271
POC5
POC5 centriolar protein homolog (Chlamydomonas)
chr18_-_53255734 0.639 NM_001083962
NM_001243230
NM_003199
TCF4


transcription factor 4


chr12_-_113658826 0.638 NM_138451
IQCD
IQ motif containing D
chr12_+_34175412 0.638 ALG10
asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog (S. pombe)
chr14_+_62584120 0.637 FLJ43390
uncharacterized LOC646113
chr2_-_86565205 0.636 NM_001164730
REEP1
receptor accessory protein 1
chr16_-_87799540 0.635 NM_001184854
NM_001184856
NM_017566
KLHDC4


kelch domain containing 4


chr8_+_144731829 0.632 NM_014789
ZNF623
zinc finger protein 623
chr16_+_28943259 0.632 NM_001178098
NM_001770
CD19

CD19 molecule

chr6_-_119470336 0.625 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr19_+_35168558 0.624 NM_001012320
NM_018443
ZNF302

zinc finger protein 302

chr7_-_112726143 0.624 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chr7_-_122339186 0.623 NM_139175
RNF133
ring finger protein 133
chr10_-_25304865 0.622 NM_145010
ENKUR
enkurin, TRPC channel interacting protein
chr4_+_174292100 0.620 SAP30
Sin3A-associated protein, 30kDa
chrX_-_114252132 0.619 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr20_+_9198036 0.618 NM_182797
PLCB4
phospholipase C, beta 4
chr1_+_84768333 0.615 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr3_-_52737599 0.615 NM_152932
GLT8D1
glycosyltransferase 8 domain containing 1
chr9_+_131580719 0.610 NM_004435
ENDOG
endonuclease G
chr12_-_71551778 0.604 NM_004616
TSPAN8
tetraspanin 8
chr17_-_33446863 0.602 NM_001142571
NM_002878
NM_133629
RAD51D


RAD51 homolog D (S. cerevisiae)


chr3_+_159557649 0.598 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr2_+_97001463 0.596 NM_015341
NCAPH
non-SMC condensin I complex, subunit H
chr14_-_55658205 0.591 NM_001146015
NM_014750
DLGAP5

discs, large (Drosophila) homolog-associated protein 5

chr5_-_96143573 0.589 ERAP1
endoplasmic reticulum aminopeptidase 1
chr7_+_114055048 0.589 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chrX_-_117251302 0.582 NM_001168301
KLHL13
kelch-like 13 (Drosophila)
chr4_-_110723127 0.581 CFI
complement factor I
chr11_-_102668892 0.578 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr6_-_155777036 0.578 NM_015718
NOX3
NADPH oxidase 3
chr4_+_17578838 0.576 NM_015907
LAP3
leucine aminopeptidase 3
chr8_-_72274466 0.576 NM_000503
EYA1
eyes absent homolog 1 (Drosophila)
chr21_-_40817658 0.573 LCA5L
Leber congenital amaurosis 5-like
chr12_-_16759939 0.570 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chr6_+_42749562 0.570 KIAA0240
KIAA0240
chr17_-_67311773 0.570 NM_018672
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chr3_-_189840225 0.570 NM_001134418
LEPREL1
leprecan-like 1
chr6_+_159309618 0.569 NM_001195032
C6orf99
chromosome 6 open reading frame 99
chr12_-_42877413 0.565 NM_001144881
PRICKLE1
prickle homolog 1 (Drosophila)
chr15_+_59397276 0.563 NM_004701
CCNB2
cyclin B2
chrX_-_80457440 0.562 NM_030763
HMGN5
high mobility group nucleosome binding domain 5
chr9_-_27573841 0.558 NM_145005
C9orf72
chromosome 9 open reading frame 72
chr9_-_35079751 0.555 NM_004629
FANCG
Fanconi anemia, complementation group G
chr12_-_24103842 0.554 SOX5
SRY (sex determining region Y)-box 5
chr7_-_87856282 0.552 NM_198901
SRI
sorcin
chr3_+_186739643 0.550 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr8_-_110661007 0.549 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chrX_-_24045302 0.544 NM_030624
KLHL15
kelch-like 15 (Drosophila)
chr2_+_29038862 0.543 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr3_+_171561138 0.541 NM_001164436
TMEM212
transmembrane protein 212
chr6_-_10838712 0.540 NM_001242385
NM_001242957
NM_005906
MAK


male germ cell-associated kinase


chr5_+_139027907 0.534 CXXC5
CXXC finger protein 5
chr14_-_81405883 0.532 NM_152446
CEP128
centrosomal protein 128kDa
chr7_+_141695678 0.532 NM_004668
MGAM
maltase-glucoamylase (alpha-glucosidase)
chr3_+_158787040 0.532 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr16_+_53479685 0.529 RBL2
retinoblastoma-like 2 (p130)
chr22_-_50971007 0.529 NM_001014440
ODF3B
outer dense fiber of sperm tails 3B

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.36 1.17e-07 GO:0090304 nucleic acid metabolic process
1.30 1.16e-06 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.27 1.34e-06 GO:0034641 cellular nitrogen compound metabolic process
1.26 2.34e-06 GO:0006807 nitrogen compound metabolic process
1.36 1.24e-05 GO:0016070 RNA metabolic process
1.20 1.97e-05 GO:0044260 cellular macromolecule metabolic process
1.55 2.49e-05 GO:0022402 cell cycle process
1.59 4.93e-05 GO:0022403 cell cycle phase
1.62 1.24e-04 GO:0000278 mitotic cell cycle
1.14 4.27e-04 GO:0044237 cellular metabolic process
1.31 4.48e-04 GO:0010467 gene expression
1.43 4.67e-04 GO:0007049 cell cycle
1.16 1.42e-03 GO:0043170 macromolecule metabolic process
1.07 1.68e-03 GO:0009987 cellular process
2.46 8.90e-03 GO:0000236 mitotic prometaphase
1.50 9.66e-03 GO:0051276 chromosome organization
1.67 1.29e-02 GO:0010564 regulation of cell cycle process
1.11 1.29e-02 GO:0008152 metabolic process
1.71 1.66e-02 GO:0051325 interphase
1.71 1.77e-02 GO:0051329 interphase of mitotic cell cycle
1.11 2.72e-02 GO:0044238 primary metabolic process
1.63 3.02e-02 GO:0016568 chromatin modification
1.69 3.54e-02 GO:0000087 M phase of mitotic cell cycle

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.28 1.41e-19 GO:0005634 nucleus
1.16 5.65e-15 GO:0043231 intracellular membrane-bounded organelle
1.16 9.07e-15 GO:0043227 membrane-bounded organelle
1.43 1.83e-12 GO:0044428 nuclear part
1.10 1.36e-11 GO:0044424 intracellular part
1.10 3.91e-11 GO:0005622 intracellular
1.12 1.30e-10 GO:0043229 intracellular organelle
1.12 2.66e-10 GO:0043226 organelle
1.42 1.28e-09 GO:0031981 nuclear lumen
1.44 2.03e-07 GO:0005654 nucleoplasm
1.29 1.78e-05 GO:0070013 intracellular organelle lumen
1.28 2.06e-05 GO:0043233 organelle lumen
1.27 3.27e-05 GO:0031974 membrane-enclosed lumen
1.50 1.78e-04 GO:0044451 nucleoplasm part
1.49 4.76e-03 GO:0005694 chromosome

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.22 7.30e-05 GO:0003676 nucleic acid binding
1.07 1.08e-04 GO:0005488 binding
1.23 1.38e-02 GO:0008270 zinc ion binding
1.21 2.03e-02 GO:0046914 transition metal ion binding
1.20 2.98e-02 GO:0003677 DNA binding