Motif ID: CEBPA,B_DDIT3.p2

Z-value: 0.765


Transcription factors associated with CEBPA,B_DDIT3.p2:

Gene SymbolEntrez IDGene Name
CEBPA 1050 CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB 1051 CCAAT/enhancer binding protein (C/EBP), beta
DDIT3 1649 DNA-damage-inducible transcript 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
DDIT3chr12_-_579142870.541.9e-03Click!
CEBPAchr19_-_33793429-0.125.4e-01Click!
CEBPBchr20_+_488073650.048.4e-01Click!


Activity profile for motif CEBPA,B_DDIT3.p2.

activity profile for motif CEBPA,B_DDIT3.p2


Sorted Z-values histogram for motif CEBPA,B_DDIT3.p2

Sorted Z-values for motif CEBPA,B_DDIT3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CEBPA,B_DDIT3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_52845862 4.269 NM_005555
KRT6B
keratin 6B
chr12_-_25102281 3.383 NM_001178091
NM_001178092
NM_005504
BCAT1


branched chain amino-acid transaminase 1, cytosolic


chr2_-_216300770 2.394 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr2_-_113594325 2.288 NM_000576
IL1B
interleukin 1, beta
chr12_-_25101993 2.217 BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr17_-_39092714 1.987 KRT23
keratin 23 (histone deacetylase inducible)
chr5_-_140012730 1.896 CD14
CD14 molecule
chr5_-_140013285 1.875 NM_001040021
NM_001174104
NM_001174105
CD14


CD14 molecule


chr12_-_25101923 1.500 BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr19_-_35992798 1.372 NM_001035516
DMKN
dermokine
chr5_-_147211141 1.351 SPINK1
serine peptidase inhibitor, Kazal type 1
chr1_+_150954498 1.271 NM_003568
ANXA9
annexin A9
chr4_-_10023094 1.202 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr11_-_102668892 0.986 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr1_-_230513390 0.968 NM_024554
PGBD5
piggyBac transposable element derived 5
chr12_-_53074172 0.961 NM_006121
KRT1
keratin 1
chr1_+_111770280 0.934 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr5_-_140013034 0.933 NM_000591
CD14
CD14 molecule
chr15_-_72598655 0.920 NM_001172685
CELF6
CUGBP, Elav-like family member 6
chrX_+_135251795 0.910 NM_001167819
FHL1
four and a half LIM domains 1
chr17_-_39768939 0.906 NM_005557
KRT16
keratin 16
chr8_-_6735438 0.903 NM_005218
DEFB1
defensin, beta 1
chr3_+_136676706 0.869 NM_144717
IL20RB
interleukin 20 receptor beta
chr14_+_62462540 0.837 NM_031914
SYT16
synaptotagmin XVI
chr19_-_44174497 0.823 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr10_-_92680784 0.805 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr19_+_1450208 0.767 APC2
adenomatosis polyposis coli 2
chr8_+_124194751 0.751 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr2_-_215896809 0.738 NM_015657
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr10_-_92681025 0.736 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr5_+_167956545 0.735


chr20_+_361938 0.727 TRIB3
tribbles homolog 3 (Drosophila)
chr9_+_116342939 0.719 NM_021106
RGS3
regulator of G-protein signaling 3
chr17_-_47925378 0.697 NM_001077503
NM_001077504
NM_001077505
NM_001077506
NM_170685
TAC4




tachykinin 4 (hemokinin)




chr12_+_5153084 0.668 NM_002234
KCNA5
potassium voltage-gated channel, shaker-related subfamily, member 5
chr8_+_124194873 0.653 FAM83A
family with sequence similarity 83, member A
chr11_-_121986800 0.650 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr3_+_12392993 0.623 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr11_+_62495942 0.615 NM_173810
TTC9C
tetratricopeptide repeat domain 9C
chr3_-_9595412 0.613 NM_198560
LHFPL4
lipoma HMGIC fusion partner-like 4
chr9_+_80911990 0.602 NM_021154
NM_058179
PSAT1

phosphoserine aminotransferase 1

chr16_+_3405888 0.591 NM_012368
OR2C1
olfactory receptor, family 2, subfamily C, member 1
chr19_-_49258646 0.586 NM_000148
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr21_-_47604360 0.581 NM_001142854
NM_032261
C21orf56

chromosome 21 open reading frame 56

chr5_-_147286064 0.539 NM_206966
C5orf46
chromosome 5 open reading frame 46
chr16_-_90076528 0.500 NM_024043
DBNDD1
dysbindin (dystrobrevin binding protein 1) domain containing 1
chr9_+_131185129 0.497 CERCAM
cerebral endothelial cell adhesion molecule
chr19_+_49078992 0.485 NM_004605
SULT2B1
sulfotransferase family, cytosolic, 2B, member 1
chr21_+_43619798 0.483 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr3_+_186330711 0.467 AHSG
alpha-2-HS-glycoprotein
chr14_-_68162419 0.464 NM_001252650
NM_016026
RDH11

retinol dehydrogenase 11 (all-trans/9-cis/11-cis)

chr16_-_21663962 0.460 NM_005849
IGSF6
immunoglobulin superfamily, member 6
chr11_-_102668822 0.456 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr5_-_151066445 0.447 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr11_-_66675334 0.436 NM_022172
PC
pyruvate carboxylase
chr8_-_130799133 0.428 NM_031415
GSDMC
gasdermin C
chr1_-_153521717 0.414 NM_002960
S100A3
S100 calcium binding protein A3
chr1_-_23342342 0.409 NM_001242521
LOC729059
uncharacterized LOC729059
chr13_+_32313678 0.399 NM_001166058
NM_130806
RXFP2

relaxin/insulin-like family peptide receptor 2

chr1_-_67519698 0.399 SLC35D1
solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1
chr9_-_77502635 0.397 NM_001177310
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr11_+_114167168 0.384 NNMT
nicotinamide N-methyltransferase
chrX_-_40506666 0.369 CXorf38
chromosome X open reading frame 38
chr8_-_17743062 0.366 FGL1
fibrinogen-like 1
chr12_-_49259549 0.364 NM_014470
RND1
Rho family GTPase 1
chrX_+_99899162 0.362 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr9_-_77502262 0.351 NM_001177311
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr15_-_34212523 0.349


chr7_-_83824216 0.347 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr9_-_77503009 0.346 NM_017662
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr1_+_84630374 0.341 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_-_116383692 0.333 NM_005599
NHLH2
nescient helix loop helix 2
chr9_+_116343169 0.333 RGS3
regulator of G-protein signaling 3
chr5_-_16738346 0.330 MYO10
myosin X
chr3_+_130569368 0.325 NM_001199180
NM_001199181
NM_001199182
ATP2C1


ATPase, Ca++ transporting, type 2C, member 1


chr13_-_24007822 0.317 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr11_+_114167197 0.314 NNMT
nicotinamide N-methyltransferase
chrX_-_138724851 0.313 NM_001171877
NM_001171878
NM_001171879
NM_005369
MCF2



MCF.2 cell line derived transforming sequence



chr4_+_40198526 0.313 NM_004310
RHOH
ras homolog gene family, member H
chr6_+_36644236 0.311 NM_001220777
NM_078467
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr6_+_151187310 0.308 NM_001242768
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr20_+_361675 0.308 TRIB3
tribbles homolog 3 (Drosophila)
chr3_+_186330844 0.305 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr7_+_75124298 0.302 NM_001099435
SPDYE5
speedy homolog E5 (Xenopus laevis)
chr17_-_77813049 0.301 NM_003655
CBX4
chromobox homolog 4
chr20_+_57766074 0.298 NM_178457
ZNF831
zinc finger protein 831
chr15_+_41245635 0.292 NM_001142776
NM_024111
CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr4_-_15940362 0.292 NM_005130
FGFBP1
fibroblast growth factor binding protein 1
chr5_-_22853435 0.287 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr12_-_6756533 0.284 NM_032489
ACRBP
acrosin binding protein
chr7_+_28338939 0.279 NM_182899
CREB5
cAMP responsive element binding protein 5
chr17_-_64225496 0.277 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr9_-_71590754 0.271


chr3_+_186330859 0.269 AHSG
alpha-2-HS-glycoprotein
chr20_+_54987167 0.268 NM_001164116
NM_001164114
NM_001164115
NM_020356
CASS4



Cas scaffolding protein family member 4



chr11_-_119187811 0.268 NM_006500
MCAM
melanoma cell adhesion molecule
chr4_-_71532341 0.265 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr5_-_16742336 0.264 MYO10
myosin X
chr7_-_107443631 0.264 NM_000111
SLC26A3
solute carrier family 26, member 3
chr5_-_151066492 0.264 NM_003118
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr4_-_123377471 0.263 NM_000586
IL2
interleukin 2
chrX_-_40506800 0.262 NM_144970
CXorf38
chromosome X open reading frame 38
chr2_+_210444154 0.262 MAP2
microtubule-associated protein 2
chr12_-_121736110 0.260 NM_006549
NM_153499
NM_153500
NM_172214
NM_172215
NM_172216
CAMKK2





calcium/calmodulin-dependent protein kinase kinase 2, beta





chr9_-_95055913 0.259 IARS
isoleucyl-tRNA synthetase
chr8_-_101661892 0.259 NM_152628
SNX31
sorting nexin 31
chr11_-_104972147 0.255 NM_001007232
NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CARD17
CASP1




caspase recruitment domain family, member 17
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr15_+_89182038 0.254 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr19_+_33864574 0.253 NM_001806
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr22_+_23054862 0.250 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr9_-_95055986 0.249 IARS
isoleucyl-tRNA synthetase
chr14_-_64194692 0.246 NM_030791
SGPP1
sphingosine-1-phosphate phosphatase 1
chr9_+_117085302 0.245 NM_000607
ORM1
orosomucoid 1
chr1_+_151630710 0.242 SNX27
sorting nexin family member 27
chr7_-_83270746 0.241 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr16_-_21663908 0.241 IGSF6
immunoglobulin superfamily, member 6
chr10_+_105005643 0.237 NM_001143909
LOC729020
rcRPE
chr6_-_52109226 0.236 NM_052872
IL17F
interleukin 17F
chr2_+_210444364 0.236 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr5_-_176836488 0.235 F12
coagulation factor XII (Hageman factor)
chr6_-_11779279 0.235 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr7_+_44040487 0.232 NM_175064
SPDYE1
speedy homolog E1 (Xenopus laevis)
chr6_-_49754899 0.228 NM_138733
PGK2
phosphoglycerate kinase 2
chr4_+_187187342 0.226 F11
coagulation factor XI
chr11_+_18287807 0.225 NM_000331
NM_001178006
NM_199161
SAA1


serum amyloid A1


chrX_-_13062720 0.221 NM_174901
FAM9C
family with sequence similarity 9, member C
chr6_-_41254392 0.220 NM_001242589
NM_001242590
NM_018643
TREM1


triggering receptor expressed on myeloid cells 1


chr1_+_196857143 0.218 NM_001201550
NM_001201551
NM_006684
CFHR4


complement factor H-related 4


chr5_-_77844975 0.218 LHFPL2
lipoma HMGIC fusion partner-like 2
chr9_-_95055966 0.217 NM_013417
IARS
isoleucyl-tRNA synthetase
chr6_-_42162693 0.216 NM_002098
GUCA1B
guanylate cyclase activator 1B (retina)
chr4_+_111397181 0.214 NM_001977
ENPEP
glutamyl aminopeptidase (aminopeptidase A)
chr12_+_107078476 0.211 NM_032491
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr18_-_67624159 0.209 NM_006566
CD226
CD226 molecule
chr9_-_95055989 0.206 NM_002161
IARS
isoleucyl-tRNA synthetase
chr12_-_54867372 0.205 NM_144594
GTSF1
gametocyte specific factor 1
chr12_+_56915587 0.204 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr12_-_50595303 0.204 NM_001243775
LIMA1
LIM domain and actin binding 1
chr9_+_110045516 0.204 NM_002874
RAD23B
RAD23 homolog B (S. cerevisiae)
chr14_+_32798478 0.202 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr12_-_68619535 0.200 NM_018402
IL26
interleukin 26
chr16_-_84651519 0.197 COTL1
coactosin-like 1 (Dictyostelium)
chr18_+_21032786 0.196 NM_003831
RIOK3
RIO kinase 3 (yeast)
chr12_+_54426831 0.196 NM_018953
HOXC5
homeobox C5
chr16_-_84651639 0.194 NM_021149
COTL1
coactosin-like 1 (Dictyostelium)
chr20_-_35885276 0.192 NM_001184731
NM_021081
GHRH

growth hormone releasing hormone

chr12_-_57914287 0.190 NM_001195053
NM_001195054
NM_001195055
NM_001195056
NM_001195057
NM_004083
DDIT3





DNA-damage-inducible transcript 3





chr7_+_123295860 0.189 NM_207163
LMOD2
leiomodin 2 (cardiac)
chr6_+_151187064 0.188 MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr2_+_113816684 0.185 NM_012275
IL36RN
interleukin 36 receptor antagonist
chr9_+_135937364 0.182 NM_001807
CEL
carboxyl ester lipase (bile salt-stimulated lipase)
chr19_+_11350282 0.180 NM_018687
C19orf80
chromosome 19 open reading frame 80
chr6_-_37225360 0.179 NM_145316
TMEM217
transmembrane protein 217
chrX_+_7137471 0.176 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chrX_-_105282714 0.175 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr19_+_48964505 0.172 NM_170720
KCNJ14
potassium inwardly-rectifying channel, subfamily J, member 14
chr14_-_60337350 0.170 NM_021136
RTN1
reticulon 1
chr12_+_113344811 0.170 OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr1_-_153283166 0.164 NM_052891
PGLYRP3
peptidoglycan recognition protein 3
chr19_+_56511090 0.164 NM_153447
NLRP5
NLR family, pyrin domain containing 5
chr19_-_39235113 0.161 NM_144691
CAPN12
calpain 12
chr10_-_1071797 0.157 NM_033261
IDI2
isopentenyl-diphosphate delta isomerase 2
chr1_-_67520028 0.156 NM_015139
SLC35D1
solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1
chr12_-_63546589 0.156 NM_000706
AVPR1A
arginine vasopressin receptor 1A
chr17_+_18647325 0.154 NM_031456
FBXW10
F-box and WD repeat domain containing 10
chr20_+_62795826 0.154 NM_004535
MYT1
myelin transcription factor 1
chr19_-_52391095 0.154 NM_001135590
NM_032679
ZNF577

zinc finger protein 577

chr15_-_55563091 0.154 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr1_+_26348308 0.153 EXTL1
exostoses (multiple)-like 1
chr18_+_22040592 0.151 NM_001143828
NM_001160166
NM_021624
HRH4


histamine receptor H4


chr9_+_137004913 0.151 NM_052821
WDR5
WD repeat domain 5
chr6_-_11111955 0.148 NM_207582
ERVFRD-1
endogenous retrovirus group FRD, member 1
chr1_+_11249344 0.148 NM_021146
ANGPTL7
angiopoietin-like 7
chr18_-_40857245 0.146 NM_020783
SYT4
synaptotagmin IV
chr17_-_15523017 0.143 NM_006382
CDRT1
CMT1A duplicated region transcript 1
chr16_-_28550227 0.142 NUPR1
nuclear protein, transcriptional regulator, 1
chr8_-_66701175 0.142 NM_002603
PDE7A
phosphodiesterase 7A
chr6_+_31895401 0.142 C2
complement component 2
chr13_-_30169584 0.141 SLC7A1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr4_+_187187117 0.140 NM_000128
F11
coagulation factor XI
chr3_+_9476506 0.140


chr3_-_129599220 0.140 NM_001017395
TMCC1
transmembrane and coiled-coil domain family 1
chr1_-_21501229 0.139 NM_001198803
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr12_-_57009361 0.139 BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr12_-_6756597 0.138 ACRBP
acrosin binding protein
chr19_+_6887576 0.138 NM_001974
EMR1
egf-like module containing, mucin-like, hormone receptor-like 1
chr5_-_176836535 0.138 NM_000505
F12
coagulation factor XII (Hageman factor)
chr21_-_31864274 0.137 NM_181609
KRTAP19-3
keratin associated protein 19-3
chr1_+_241815579 0.137 NM_144625
WDR64
WD repeat domain 64
chr20_+_34995443 0.137 NM_014902
DLGAP4
discs, large (Drosophila) homolog-associated protein 4
chr5_-_95748688 0.136 NM_001177876
PCSK1
proprotein convertase subtilisin/kexin type 1
chr9_+_125132823 0.135 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr2_-_74542149 0.132 NM_021196
SLC4A5
solute carrier family 4, sodium bicarbonate cotransporter, member 5
chr7_-_104567089 0.131 LOC723809
uncharacterized LOC723809
chr10_-_15197345 0.131 LOC100192204
peptidylprolyl isomerase A (cyclophilin A) pseudogene
chr10_+_135160843 0.131 NM_001145201
NM_145202
PRAP1

proline-rich acidic protein 1

chr4_-_2230957 0.128 NM_181808
POLN
polymerase (DNA directed) nu
chr4_-_70826712 0.127 NM_001891
CSN2
casein beta
chr1_-_13184325 0.126 NM_001136561
LOC440563
heterogeneous nuclear ribonucleoprotein C-like
chr8_+_22019167 0.124 NM_001172357
NM_001172410
NM_003018
SFTPC


surfactant protein C



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.62 2.41e-06 GO:0006955 immune response
2.15 9.97e-06 GO:0002376 immune system process
1.33 1.59e-03 GO:0050896 response to stimulus
2.06 2.06e-02 GO:0006952 defense response
3.12 3.28e-02 GO:0008202 steroid metabolic process
1.97 3.37e-02 GO:0051704 multi-organism process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.03 2.56e-10 GO:0005576 extracellular region
2.14 6.45e-04 GO:0005615 extracellular space
1.96 8.61e-04 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
7.59 2.67e-03 GO:0003823 antigen binding