Motif ID: E2F1..5.p2

Z-value: 4.691


Transcription factors associated with E2F1..5.p2:

Gene SymbolEntrez IDGene Name
E2F1 1869 E2F transcription factor 1
E2F2 1870 E2F transcription factor 2
E2F3 1871 E2F transcription factor 3
E2F4 1874 E2F transcription factor 4, p107/p130-binding
E2F5 1875 E2F transcription factor 5, p130-binding

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
E2F2chr1_-_238577110.659.1e-05Click!
E2F1chr20_-_322740700.542.3e-03Click!
E2F3chr6_+_204020400.242.1e-01Click!
E2F5chr8_+_860999090.067.6e-01Click!
E2F4chr16_+_67226098,
chr16_+_67226027
0.038.7e-01Click!


Activity profile for motif E2F1..5.p2.

activity profile for motif E2F1..5.p2


Sorted Z-values histogram for motif E2F1..5.p2

Sorted Z-values for motif E2F1..5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F1..5.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_4909447 37.022 NM_001048201
UHRF1
ubiquitin-like with PHD and ring finger domains 1
chr10_+_96305521 24.420 NM_018063
HELLS
helicase, lymphoid-specific
chr9_-_99180661 21.258 NM_153695
ZNF367
zinc finger protein 367
chr2_+_10262853 16.276 NM_001034
RRM2
ribonucleotide reductase M2
chr10_+_62538088 15.886 NM_001170406
NM_001170407
NM_001786
NM_033379
CDK1



cyclin-dependent kinase 1



chr2_-_136633934 15.697 MCM6
minichromosome maintenance complex component 6
chr10_+_62538250 15.623 CDK1
cyclin-dependent kinase 1
chr2_+_10262694 15.063 NM_001165931
RRM2
ribonucleotide reductase M2
chr17_+_38444130 14.366 CDC6
cell division cycle 6 homolog (S. cerevisiae)
chr22_+_35796104 14.243 NM_006739
MCM5
minichromosome maintenance complex component 5
chr12_-_77459198 14.236 NM_203394
E2F7
E2F transcription factor 7
chr22_+_35796154 13.585 MCM5
minichromosome maintenance complex component 5
chr11_-_118966103 13.408 H2AFX
H2A histone family, member X
chr11_-_118966175 13.051 NM_002105
H2AFX
H2A histone family, member X
chr3_+_127317271 12.736 MCM2
minichromosome maintenance complex component 2
chr19_+_4910339 12.591 NM_013282
UHRF1
ubiquitin-like with PHD and ring finger domains 1
chr3_+_127317212 12.560 NM_004526
MCM2
minichromosome maintenance complex component 2
chr3_+_127317274 12.497 MCM2
minichromosome maintenance complex component 2
chr17_+_38444134 12.382 NM_001254
CDC6
cell division cycle 6 homolog (S. cerevisiae)
chr22_+_35796294 12.150 MCM5
minichromosome maintenance complex component 5

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 140 entries
enrichment   p-value GO term description
11.84 4.07e-07 GO:0071897 DNA biosynthetic process
10.65 7.22e-03 GO:0000731 DNA synthesis involved in DNA repair
8.62 5.76e-10 GO:0006271 DNA strand elongation involved in DNA replication
8.52 2.54e-06 GO:0000083 regulation of transcription involved in G1/S phase of mitotic cell cycle
8.52 4.79e-02 GO:0006301 postreplication repair
8.05 2.80e-09 GO:0022616 DNA strand elongation
7.89 1.82e-04 GO:0007062 sister chromatid cohesion
7.75 1.14e-05 GO:0006270 DNA-dependent DNA replication initiation
7.48 3.60e-04 GO:0032201 telomere maintenance via semi-conservative replication
7.10 6.75e-04 GO:0000722 telomere maintenance via recombination
7.10 6.75e-04 GO:0006298 mismatch repair
7.10 6.75e-04 GO:2000104 negative regulation of DNA-dependent DNA replication
7.10 1.11e-02 GO:0006297 nucleotide-excision repair, DNA gap filling
6.79 3.01e-04 GO:0090329 regulation of DNA-dependent DNA replication
6.73 4.85e-03 GO:0051225 spindle assembly
6.51 5.21e-04 GO:0031055 chromatin remodeling at centromere
6.09 1.66e-13 GO:0006261 DNA-dependent DNA replication
6.09 1.36e-02 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus
6.09 1.36e-02 GO:0016444 somatic cell DNA recombination
6.01 1.41e-03 GO:0006312 mitotic recombination

Gene overrepresentation in compartment category:

Showing 1 to 20 of 54 entries
enrichment   p-value GO term description
12.43 2.74e-05 GO:0042555 MCM complex
9.47 3.63e-03 GO:0005721 centromeric heterochromatin
9.47 3.63e-03 GO:0035098 ESC/E(Z) complex
7.10 3.32e-02 GO:0032300 mismatch repair complex
6.73 8.67e-04 GO:0031519 PcG protein complex
5.85 3.79e-02 GO:0030894 replisome
5.85 3.79e-02 GO:0043601 nuclear replisome
5.76 4.43e-06 GO:0005657 replication fork
5.17 3.35e-02 GO:0043596 nuclear replication fork
4.52 4.60e-04 GO:0000792 heterochromatin
3.81 2.15e-03 GO:0016605 PML body
3.62 8.39e-03 GO:0000794 condensed nuclear chromosome
3.44 4.27e-03 GO:0000922 spindle pole
3.31 2.40e-02 GO:0000123 histone acetyltransferase complex
3.27 7.49e-07 GO:0000793 condensed chromosome
3.26 1.42e-08 GO:0044454 nuclear chromosome part
3.25 8.83e-11 GO:0000228 nuclear chromosome
3.14 8.61e-03 GO:0000779 condensed chromosome, centromeric region
3.00 1.96e-05 GO:0000775 chromosome, centromeric region
2.95 2.04e-02 GO:0000790 nuclear chromatin

Gene overrepresentation in function category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
11.84 5.86e-03 GO:0032135 DNA insertion or deletion binding
8.12 7.32e-04 GO:0030983 mismatched DNA binding
7.10 4.64e-02 GO:0000217 DNA secondary structure binding
5.46 3.27e-03 GO:0003887 DNA-directed DNA polymerase activity
5.39 1.30e-03 GO:0034061 DNA polymerase activity
4.44 3.46e-04 GO:0003684 damaged DNA binding
4.11 2.50e-02 GO:0019205 nucleobase, nucleoside, nucleotide kinase activity
3.65 3.48e-04 GO:0042393 histone binding
3.61 3.13e-03 GO:0008094 DNA-dependent ATPase activity
3.49 1.81e-02 GO:0003697 single-stranded DNA binding
3.14 1.20e-02 GO:0003729 mRNA binding
2.74 1.37e-03 GO:0003690 double-stranded DNA binding
2.60 1.48e-04 GO:0003682 chromatin binding
2.46 1.17e-03 GO:0043566 structure-specific DNA binding
1.94 3.29e-02 GO:0008134 transcription factor binding
1.64 1.20e-03 GO:0003723 RNA binding
1.55 4.61e-10 GO:0000166 nucleotide binding
1.46 6.13e-04 GO:0030554 adenyl nucleotide binding
1.46 7.16e-04 GO:0032559 adenyl ribonucleotide binding
1.45 2.41e-10 GO:0003676 nucleic acid binding