Motif ID: EGR1..3.p2

Z-value: 1.886


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
EGR1 1958 early growth response 1
EGR2 1959 early growth response 2 (Krox-20 homolog, Drosophila)
EGR3 1960 early growth response 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EGR1chr5_+_137801166-0.431.7e-02Click!
EGR3chr8_-_22550057,
chr8_-_22549901		0.125.2e-01Click!
EGR2chr10_-_64576074,
chr10_-_64576123		-0.048.5e-01Click!


Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_+_39853316 5.506 NM_002409
 MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr16_+_84178864 5.149 NM_178452
 DNAAF1
dynein, axonemal, assembly factor 1
chr1_+_205538164 4.974 MFSD4
major facilitator superfamily domain containing 4
chr7_-_51384458 4.877 NM_015198
 COBL
cordon-bleu homolog (mouse)
chr22_+_39853534 4.806 MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chrX_+_16964730 4.607 NM_001080975
NM_004726
 REPS2

RALBP1 associated Eps domain containing 2

chr19_+_708766 4.517 NM_001040134
NM_002579
 PALM

paralemmin

chr1_+_205538111 4.468 NM_181644
 MFSD4
major facilitator superfamily domain containing 4
chr5_+_56111379 4.285 MAP3K1
mitogen-activated protein kinase kinase kinase 1
chr10_+_45869667 4.174 ALOX5
arachidonate 5-lipoxygenase
chr19_-_815243 4.029 LPPR3
lipid phosphate phosphatase-related protein type 3
chr8_+_17354562 4.000 NM_001008539
 SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr15_-_27018160 3.999 GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr11_-_46867788 3.986 CKAP5
cytoskeleton associated protein 5
chr3_+_58223415 3.972 ABHD6
abhydrolase domain containing 6
chr3_+_113666544 3.953 NM_173570
 ZDHHC23
zinc finger, DHHC-type containing 23
chr17_+_36861398 3.858 MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr18_-_45935627 3.851 ZBTB7C
zinc finger and BTB domain containing 7C
chr2_-_99552677 3.846 NM_207362
 C2orf55
chromosome 2 open reading frame 55
chr11_+_2466171 3.828 NM_000218
 KCNQ1
potassium voltage-gated channel, KQT-like subfamily, member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 132 entries
enrichment   p-value GO term description
2.28 4.50e-02 GO:0016202 regulation of striated muscle tissue development
2.18 1.46e-02 GO:0022612 gland morphogenesis
2.14 3.24e-02 GO:0048565 digestive tract development
2.11 1.77e-02 GO:0018205 peptidyl-lysine modification
2.10 1.31e-07 GO:0016570 histone modification
2.09 2.48e-02 GO:0055123 digestive system development
2.07 3.52e-07 GO:0016569 covalent chromatin modification
2.04 4.23e-03 GO:0010720 positive regulation of cell development
1.90 2.93e-11 GO:0016568 chromatin modification
1.90 2.89e-02 GO:0060541 respiratory system development
1.85 4.05e-03 GO:0048562 embryonic organ morphogenesis
1.85 5.29e-03 GO:0060562 epithelial tube morphogenesis
1.85 3.29e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.84 4.22e-02 GO:0022604 regulation of cell morphogenesis
1.82 2.80e-02 GO:0016055 Wnt receptor signaling pathway
1.75 9.05e-03 GO:0035239 tube morphogenesis
1.74 7.98e-04 GO:0002009 morphogenesis of an epithelium
1.71 2.01e-04 GO:0035295 tube development
1.66 1.78e-07 GO:0006325 chromatin organization
1.66 1.00e-02 GO:0048568 embryonic organ development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 26 entries
enrichment   p-value GO term description
3.68 4.64e-02 GO:0010494 stress granule
2.21 6.32e-05 GO:0016585 chromatin remodeling complex
2.05 8.04e-03 GO:0014069 postsynaptic density
1.64 9.71e-04 GO:0005667 transcription factor complex
1.51 2.94e-08 GO:0044451 nucleoplasm part
1.48 1.87e-03 GO:0045202 synapse
1.48 3.08e-02 GO:0044456 synapse part
1.38 1.05e-08 GO:0005654 nucleoplasm
1.31 1.39e-08 GO:0031981 nuclear lumen
1.30 2.75e-09 GO:0044428 nuclear part
1.27 3.08e-27 GO:0005634 nucleus
1.24 6.61e-06 GO:0070013 intracellular organelle lumen
1.23 7.52e-06 GO:0043233 organelle lumen
1.23 9.74e-06 GO:0031974 membrane-enclosed lumen
1.18 1.94e-27 GO:0043227 membrane-bounded organelle
1.18 7.77e-27 GO:0043231 intracellular membrane-bounded organelle
1.16 1.79e-26 GO:0043226 organelle
1.16 6.11e-26 GO:0043229 intracellular organelle
1.14 2.11e-02 GO:0043234 protein complex
1.13 2.10e-29 GO:0044424 intracellular part

Gene overrepresentation in function category:

Showing 1 to 20 of 37 entries
enrichment   p-value GO term description
2.40 1.97e-02 GO:0046332 SMAD binding
2.02 2.91e-08 GO:0010843 promoter binding
1.99 4.29e-08 GO:0000975 regulatory region DNA binding
1.99 4.29e-08 GO:0001067 regulatory region nucleic acid binding
1.99 4.29e-08 GO:0044212 transcription regulatory region DNA binding
1.96 1.76e-02 GO:0003704 specific RNA polymerase II transcription factor activity
1.91 5.56e-10 GO:0008134 transcription factor binding
1.74 3.43e-05 GO:0003702 RNA polymerase II transcription factor activity
1.72 1.36e-06 GO:0016563 transcription activator activity
1.62 2.03e-04 GO:0016564 transcription repressor activity
1.61 1.43e-02 GO:0003713 transcription coactivator activity
1.58 1.65e-15 GO:0030528 transcription regulator activity
1.57 1.30e-09 GO:0043565 sequence-specific DNA binding
1.50 3.12e-03 GO:0003712 transcription cofactor activity
1.49 2.22e-10 GO:0001071 nucleic acid binding transcription factor activity
1.49 2.22e-10 GO:0003700 sequence-specific DNA binding transcription factor activity
1.49 3.60e-03 GO:0000988 protein binding transcription factor activity
1.49 3.60e-03 GO:0000989 transcription factor binding transcription factor activity
1.46 2.64e-03 GO:0019904 protein domain specific binding
1.37 1.89e-16 GO:0003677 DNA binding