Motif ID: EGR1..3.p2

Z-value: 1.886


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
EGR1 1958 early growth response 1
EGR2 1959 early growth response 2 (Krox-20 homolog, Drosophila)
EGR3 1960 early growth response 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EGR1chr5_+_137801166-0.431.7e-02Click!
EGR3chr8_-_22550057,
chr8_-_22549901
0.125.2e-01Click!
EGR2chr10_-_64576074,
chr10_-_64576123
-0.048.5e-01Click!


Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_39853316 5.506 NM_002409
MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr16_+_84178864 5.149 NM_178452
DNAAF1
dynein, axonemal, assembly factor 1
chr1_+_205538164 4.974 MFSD4
major facilitator superfamily domain containing 4
chr7_-_51384458 4.877 NM_015198
COBL
cordon-bleu homolog (mouse)
chr22_+_39853534 4.806 MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chrX_+_16964730 4.607 NM_001080975
NM_004726
REPS2

RALBP1 associated Eps domain containing 2

chr19_+_708766 4.517 NM_001040134
NM_002579
PALM

paralemmin

chr1_+_205538111 4.468 NM_181644
MFSD4
major facilitator superfamily domain containing 4
chr5_+_56111379 4.285 MAP3K1
mitogen-activated protein kinase kinase kinase 1
chr10_+_45869667 4.174 ALOX5
arachidonate 5-lipoxygenase
chr19_-_815243 4.029 LPPR3
lipid phosphate phosphatase-related protein type 3
chr8_+_17354562 4.000 NM_001008539
SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr15_-_27018160 3.999 GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr11_-_46867788 3.986 CKAP5
cytoskeleton associated protein 5
chr3_+_58223415 3.972 ABHD6
abhydrolase domain containing 6
chr3_+_113666544 3.953 NM_173570
ZDHHC23
zinc finger, DHHC-type containing 23
chr17_+_36861398 3.858 MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr18_-_45935627 3.851 ZBTB7C
zinc finger and BTB domain containing 7C
chr2_-_99552677 3.846 NM_207362
C2orf55
chromosome 2 open reading frame 55
chr11_+_2466171 3.828 NM_000218
KCNQ1
potassium voltage-gated channel, KQT-like subfamily, member 1
chr16_+_67465019 3.777 NM_000196
HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr7_-_51384331 3.764 COBL
cordon-bleu homolog (mouse)
chr2_+_132285469 3.559 NM_138770
CCDC74A
coiled-coil domain containing 74A
chr5_-_137368778 3.554 NM_001101800
NM_001101801
NM_016603
FAM13B


family with sequence similarity 13, member B


chr16_-_66959418 3.539 NM_001128850
NM_004165
RRAD

Ras-related associated with diabetes

chr15_-_27018108 3.530 GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr2_-_130902568 3.437 NM_207310
CCDC74B
coiled-coil domain containing 74B
chr6_+_19837599 3.433 NM_001546
ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr12_+_50355278 3.414 NM_001651
AQP5
aquaporin 5
chr13_-_37494370 3.236 NM_001127217
NM_005905
SMAD9

SMAD family member 9

chr11_-_119076888 3.099 CCDC153
coiled-coil domain containing 153
chr22_+_29279573 3.043 NM_001206998
ZNRF3
zinc and ring finger 3
chr6_+_135502477 3.019 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr4_+_72052354 2.957 NM_001098484
NM_001134742
SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr2_+_121103670 2.932 NM_002193
INHBB
inhibin, beta B
chr13_+_21141207 2.894 NM_006531
NM_175605
IFT88

intraflagellar transport 88 homolog (Chlamydomonas)

chr4_-_25864430 2.838 NM_015187
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr1_-_223537400 2.813 NM_001037175
NM_017982
SUSD4

sushi domain containing 4

chr1_+_118148506 2.805 NM_017709
FAM46C
family with sequence similarity 46, member C
chr10_+_45869611 2.786 NM_000698
ALOX5
arachidonate 5-lipoxygenase
chr1_+_118148668 2.784 FAM46C
family with sequence similarity 46, member C
chr6_+_36164528 2.780 NM_015695
BRPF3
bromodomain and PHD finger containing, 3
chr11_+_45907198 2.730 MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr19_-_3028901 2.657 NM_003260
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr4_-_105412466 2.575 NM_025212
CXXC4
CXXC finger protein 4
chr15_-_45480160 2.555 SHF
Src homology 2 domain containing F
chr3_+_58223228 2.491 NM_020676
ABHD6
abhydrolase domain containing 6
chr15_-_27018216 2.366 NM_000814
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr7_-_131241321 2.361 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr19_-_7990974 2.344 NM_206833
CTXN1
cortexin 1
chr16_+_810764 2.343 NM_005823
NM_001177355
MSLN

mesothelin

chr3_+_42544094 2.341 NM_001251883
NM_001251884
NM_001251885
NM_004624
VIPR1



vasoactive intestinal peptide receptor 1



chr3_-_183979074 2.289 NM_033259
CAMK2N2
calcium/calmodulin-dependent protein kinase II inhibitor 2
chr2_+_105471745 2.288 NM_006236
POU3F3
POU class 3 homeobox 3
chr5_-_137368682 2.283 FAM13B
family with sequence similarity 13, member B
chr7_+_90225607 2.275 CDK14
cyclin-dependent kinase 14
chr3_+_42544131 2.274 VIPR1
vasoactive intestinal peptide receptor 1
chr1_+_38259458 2.242 NM_001031740
NM_001113482
MANEAL

mannosidase, endo-alpha-like

chr16_-_54962707 2.178 CRNDE
colorectal neoplasia differentially expressed (non-protein coding)
chr6_+_84743250 2.177 NM_138409
MRAP2
melanocortin 2 receptor accessory protein 2
chr17_-_63557615 2.169 NM_004655
AXIN2
axin 2
chr12_+_104458235 2.147 NM_013320
HCFC2
host cell factor C2
chr20_-_39317875 2.146 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr4_+_1005609 2.145 NM_001004356
NM_001004358
FGFRL1

fibroblast growth factor receptor-like 1

chr19_+_13105970 2.126 NM_002501
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr19_-_6110561 2.118 NM_000635
NM_134433
RFX2

regulatory factor X, 2 (influences HLA class II expression)

chr10_+_12391728 2.100 CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr4_-_16085309 2.093 PROM1
prominin 1
chr10_+_115803805 2.093 NM_000684
ADRB1
adrenergic, beta-1-, receptor
chr1_-_23751126 2.077 NM_003196
TCEA3
transcription elongation factor A (SII), 3
chr5_-_101631965 2.075 NM_180991
SLCO4C1
solute carrier organic anion transporter family, member 4C1
chr19_+_8274179 2.032 NM_024552
CERS4
ceramide synthase 4
chr19_-_821913 1.987 NM_024888
LPPR3
lipid phosphate phosphatase-related protein type 3
chr7_-_117513527 1.973 NM_033427
CTTNBP2
cortactin binding protein 2
chr14_-_95786095 1.957 NM_024734
CLMN
calmin (calponin-like, transmembrane)
chr10_+_12391708 1.933 CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr7_-_117513466 1.919 CTTNBP2
cortactin binding protein 2
chr7_+_106685007 1.895 NM_002736
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr9_-_86432546 1.891 NM_001135953
NM_025211
GKAP1

G kinase anchoring protein 1

chr2_-_239148545 1.866 HES6
hairy and enhancer of split 6 (Drosophila)
chr20_-_61569265 1.856 NM_022105
NM_033081
NM_080797
DIDO1


death inducer-obliterator 1


chr1_+_60280462 1.846 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr22_-_31503484 1.845 NM_080430
SELM
selenoprotein M
chr6_-_79787887 1.843 PHIP
pleckstrin homology domain interacting protein
chr10_+_94608224 1.814 NM_019053
EXOC6
exocyst complex component 6
chr7_+_152161119 1.811 LOC100128822
uncharacterized LOC100128822
chr12_+_121148213 1.804 UNC119B
unc-119 homolog B (C. elegans)
chr13_+_21141283 1.782 IFT88
intraflagellar transport 88 homolog (Chlamydomonas)
chr17_-_56065474 1.776 VEZF1
vascular endothelial zinc finger 1
chr3_-_45267804 1.772 NM_015444
TMEM158
transmembrane protein 158 (gene/pseudogene)
chr6_+_18155535 1.752 NM_153042
KDM1B
lysine (K)-specific demethylase 1B
chr22_+_39745757 1.751 NM_004711
NM_145731
SYNGR1

synaptogyrin 1

chr15_-_93632161 1.748 NM_020211
RGMA
RGM domain family, member A
chr11_+_45907046 1.739 NM_005456
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr19_-_6110491 1.736 RFX2
regulatory factor X, 2 (influences HLA class II expression)
chr16_+_69600110 1.721 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr15_+_31619043 1.705 NM_015995
KLF13
Kruppel-like factor 13
chr7_+_116593554 1.705 ST7
suppression of tumorigenicity 7
chr11_-_110583120 1.703 NM_020809
ARHGAP20
Rho GTPase activating protein 20
chr16_-_1968230 1.688 NM_001009606
HS3ST6
heparan sulfate (glucosamine) 3-O-sulfotransferase 6
chr4_-_7044664 1.679 NM_153376
CCDC96
coiled-coil domain containing 96
chr11_-_110582887 1.678 ARHGAP20
Rho GTPase activating protein 20
chr1_-_22469414 1.660 NM_030761
WNT4
wingless-type MMTV integration site family, member 4
chr17_+_14204326 1.642 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr22_-_41593466 1.628


chr19_-_821966 1.625 LPPR3
lipid phosphate phosphatase-related protein type 3
chr16_-_67427335 1.625 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr2_+_149402321 1.625 EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr5_+_76506705 1.610 NM_001029851
NM_001029852
NM_001029853
NM_001029854
NM_003719
PDE8B




phosphodiesterase 8B




chr9_+_34458810 1.609 NM_012144
DNAI1
dynein, axonemal, intermediate chain 1
chr1_+_3569098 1.602 NM_001204184
NM_001204185
NM_001204186
NM_001204187
NM_001204188
NM_005427
TP73





tumor protein p73





chr8_+_16884745 1.601 NM_181723
EFHA2
EF-hand domain family, member A2
chr5_-_114632240 1.599 NM_001040440
CCDC112
coiled-coil domain containing 112
chr8_+_17014006 1.593 ZDHHC2
zinc finger, DHHC-type containing 2
chr3_+_129158949 1.585 NM_018262
NM_052985
NM_052989
NM_052990
IFT122



intraflagellar transport 122 homolog (Chlamydomonas)



chr16_-_28074776 1.572 NM_001109763
GSG1L
GSG1-like
chr20_-_61569227 1.564 DIDO1
death inducer-obliterator 1
chr13_-_114018365 1.558 NM_024719
GRTP1
growth hormone regulated TBC protein 1
chr11_-_110582772 1.540 ARHGAP20
Rho GTPase activating protein 20
chr2_-_202316227 1.524 NM_015049
TRAK2
trafficking protein, kinesin binding 2
chr9_+_134269509 1.524 PRRC2B
proline-rich coiled-coil 2B
chr5_+_172483285 1.523 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chr20_+_36531548 1.522 VSTM2L
V-set and transmembrane domain containing 2 like
chr9_-_139907614 1.515 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr6_-_79787784 1.509 PHIP
pleckstrin homology domain interacting protein
chr17_+_65822206 1.501 BPTF
bromodomain PHD finger transcription factor
chr17_+_7788094 1.501 NM_001005271
CHD3
chromodomain helicase DNA binding protein 3
chr2_+_10183630 1.488 NM_003597
NM_001177716
KLF11

Kruppel-like factor 11

chr3_-_53079959 1.486 SFMBT1
Scm-like with four mbt domains 1
chr11_-_95522640 1.476 FAM76B
family with sequence similarity 76, member B
chr1_-_24104743 1.474 LOC100506963
uncharacterized LOC100506963
chr10_-_123357503 1.468 NM_000141
NM_001144917
NM_001144918
NM_001144919
NM_022970
FGFR2




fibroblast growth factor receptor 2




chr16_-_54320328 1.467 IRX3
iroquois homeobox 3
chr16_+_29817426 1.457 MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr3_+_129159075 1.444 IFT122
intraflagellar transport 122 homolog (Chlamydomonas)
chr11_-_236324 1.431 NM_001017524
NM_012239
SIRT3

sirtuin 3

chr17_-_74137370 1.424 NM_001454
FOXJ1
forkhead box J1
chr2_+_97481977 1.423 NM_017623
NM_199078
CNNM3

cyclin M3

chr3_+_129159089 1.422 IFT122
intraflagellar transport 122 homolog (Chlamydomonas)
chr9_-_130661781 1.412 ST6GALNAC6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chrX_-_132548994 1.406 NM_001448
GPC4
glypican 4
chr14_-_99947080 1.404 SETD3
SET domain containing 3
chr1_+_38022514 1.403 NM_003462
DNALI1
dynein, axonemal, light intermediate chain 1
chr5_-_81046943 1.400 NM_012446
SSBP2
single-stranded DNA binding protein 2
chr19_-_18717577 1.393 CRLF1
cytokine receptor-like factor 1
chr16_-_755718 1.386 NM_153350
FBXL16
F-box and leucine-rich repeat protein 16
chr3_+_129159138 1.363 IFT122
intraflagellar transport 122 homolog (Chlamydomonas)
chr17_-_56065596 1.361 NM_007146
VEZF1
vascular endothelial zinc finger 1
chr2_-_190445466 1.359 SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr11_+_101918168 1.358 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr6_-_134495944 1.348 SGK1
serum/glucocorticoid regulated kinase 1
chr6_+_135502445 1.341 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr20_+_36531498 1.332 NM_080607
VSTM2L
V-set and transmembrane domain containing 2 like
chr8_-_17271015 1.330 NM_004686
MTMR7
myotubularin related protein 7
chr19_-_55691468 1.325 NM_003180
SYT5
synaptotagmin V
chr16_+_29817810 1.324 NM_001042539
NM_002383
MAZ

MYC-associated zinc finger protein (purine-binding transcription factor)

chr1_+_236305831 1.321 NM_003272
GPR137B
G protein-coupled receptor 137B
chr9_+_96338671 1.321 NM_005392
PHF2
PHD finger protein 2
chr3_+_129159150 1.315 IFT122
intraflagellar transport 122 homolog (Chlamydomonas)
chr10_-_13043570 1.306 NM_031455
CCDC3
coiled-coil domain containing 3
chr14_-_100625931 1.304 NM_206918
DEGS2
delta(4)-desaturase, sphingolipid 2
chr8_-_17270800 1.302 MTMR7
myotubularin related protein 7
chr3_-_197686837 1.301 NM_032263
IQCG
IQ motif containing G
chr14_-_21566497 1.301 ZNF219
zinc finger protein 219
chr18_-_53255734 1.298 NM_001083962
NM_001243230
NM_003199
TCF4


transcription factor 4


chr2_-_73460326 1.297 NM_032319
PRADC1
protease-associated domain containing 1
chr16_-_57570455 1.295 NM_033212
CCDC102A
coiled-coil domain containing 102A
chr2_-_242576382 1.291 THAP4
THAP domain containing 4
chr14_+_105953531 1.287 CRIP1
cysteine-rich protein 1 (intestinal)
chr14_+_105953256 1.284 NM_001311
CRIP1
cysteine-rich protein 1 (intestinal)
chr1_-_167906277 1.280 NM_001143674
NM_015415
BRP44

brain protein 44

chr19_-_1863425 1.277 KLF16
Kruppel-like factor 16
chr3_+_53529030 1.276 NM_000720
NM_001128839
NM_001128840
CACNA1D


calcium channel, voltage-dependent, L type, alpha 1D subunit


chr7_+_139877154 1.262 LOC100134229
uncharacterized LOC100134229
chr19_+_45504686 1.257 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr4_-_74124305 1.247


chr6_+_24495166 1.243 NM_001080
NM_170740
ALDH5A1

aldehyde dehydrogenase 5 family, member A1

chr1_-_32801606 1.240 NM_023009
MARCKSL1
MARCKS-like 1
chr2_-_222436996 1.237 NM_004438
EPHA4
EPH receptor A4
chr17_-_79008372 1.235 FLJ90757
uncharacterized LOC440465
chr2_-_242576527 1.232 THAP4
THAP domain containing 4
chr14_+_105331581 1.230 NM_001112726
NM_015005
KIAA0284

KIAA0284

chrX_+_9432980 1.223 NM_005647
TBL1X
transducin (beta)-like 1X-linked
chr7_-_152132924 1.218 MLL3
myeloid/lymphoid or mixed-lineage leukemia 3
chr17_+_65822242 1.217 BPTF
bromodomain PHD finger transcription factor
chr1_-_48937791 1.212 NM_019073
SPATA6
spermatogenesis associated 6
chr7_+_33168851 1.212 NM_001033604
NM_001033605
NM_014451
NM_198428
BBS9



Bardet-Biedl syndrome 9



chr19_+_860615 1.211 CFD
complement factor D (adipsin)
chr1_+_183441612 1.203 SMG7
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr4_+_1006251 1.199 NM_021923
FGFRL1
fibroblast growth factor receptor-like 1
chr5_-_179498995 1.196 NM_018434
RNF130
ring finger protein 130
chr19_+_41305041 1.196 NM_080732
EGLN2
egl nine homolog 2 (C. elegans)
chr1_+_114472438 1.192 HIPK1
homeodomain interacting protein kinase 1
chr9_-_130661886 1.188 ST6GALNAC6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr17_-_63557764 1.182 AXIN2
axin 2
chr16_-_3930713 1.181 CREBBP
CREB binding protein
chr14_+_100259445 1.180 NM_001008707
NM_004434
EML1

echinoderm microtubule associated protein like 1

chr12_-_29936685 1.178 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr2_+_42275017 1.176 NM_138370
PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr20_-_50384861 1.174 ATP9A
ATPase, class II, type 9A

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.65 1.56e-17 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.39 1.23e-16 GO:0051252 regulation of RNA metabolic process
1.36 1.25e-15 GO:0010468 regulation of gene expression
1.38 1.83e-14 GO:0006355 regulation of transcription, DNA-dependent
1.35 7.92e-14 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.33 1.01e-13 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.34 3.78e-13 GO:0010556 regulation of macromolecule biosynthetic process
1.31 2.25e-12 GO:0009889 regulation of biosynthetic process
1.31 2.80e-12 GO:0051171 regulation of nitrogen compound metabolic process
1.31 3.17e-12 GO:0031326 regulation of cellular biosynthetic process
1.23 3.40e-12 GO:0044260 cellular macromolecule metabolic process
1.43 6.37e-12 GO:0007399 nervous system development
1.90 2.93e-11 GO:0016568 chromatin modification
1.64 1.00e-10 GO:0010628 positive regulation of gene expression
1.25 1.58e-10 GO:0060255 regulation of macromolecule metabolic process
1.16 2.11e-10 GO:0044237 cellular metabolic process
1.09 2.39e-10 GO:0009987 cellular process
1.24 4.35e-10 GO:0031323 regulation of cellular metabolic process
1.62 5.45e-10 GO:0051254 positive regulation of RNA metabolic process
1.22 7.06e-10 GO:0019222 regulation of metabolic process
1.24 9.50e-10 GO:0080090 regulation of primary metabolic process
1.35 1.22e-09 GO:0006464 protein modification process
1.63 1.32e-09 GO:0045893 positive regulation of transcription, DNA-dependent
1.33 9.41e-09 GO:0043412 macromolecule modification
1.54 1.29e-08 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.53 1.57e-08 GO:0051173 positive regulation of nitrogen compound metabolic process
1.18 2.72e-08 GO:0043170 macromolecule metabolic process
1.14 4.57e-08 GO:0050794 regulation of cellular process
2.10 1.31e-07 GO:0016570 histone modification
1.66 1.78e-07 GO:0006325 chromatin organization
1.58 2.16e-07 GO:0010629 negative regulation of gene expression
2.07 3.52e-07 GO:0016569 covalent chromatin modification
1.60 4.38e-07 GO:0051253 negative regulation of RNA metabolic process
1.60 5.74e-07 GO:0045892 negative regulation of transcription, DNA-dependent
1.12 7.89e-07 GO:0050789 regulation of biological process
1.50 8.17e-07 GO:0010557 positive regulation of macromolecule biosynthetic process
1.63 1.06e-06 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.44 2.13e-06 GO:0022008 neurogenesis
1.45 2.22e-06 GO:0031328 positive regulation of cellular biosynthetic process
1.25 2.41e-06 GO:0044267 cellular protein metabolic process
1.45 2.46e-06 GO:0009891 positive regulation of biosynthetic process
1.50 3.93e-06 GO:0031327 negative regulation of cellular biosynthetic process
1.52 4.35e-06 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.44 4.45e-06 GO:0006351 transcription, DNA-dependent
1.49 4.53e-06 GO:0009890 negative regulation of biosynthetic process
1.22 4.91e-06 GO:0048731 system development
1.19 5.11e-06 GO:0032502 developmental process
1.20 5.71e-06 GO:0007275 multicellular organismal development
1.52 5.81e-06 GO:0051276 chromosome organization
1.51 5.99e-06 GO:0010558 negative regulation of macromolecule biosynthetic process
1.23 6.05e-06 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.11 6.19e-06 GO:0065007 biological regulation
1.12 6.54e-06 GO:0008152 metabolic process
1.37 7.66e-06 GO:0010604 positive regulation of macromolecule metabolic process
1.29 8.40e-06 GO:0016070 RNA metabolic process
1.52 8.98e-06 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.43 1.29e-05 GO:0048699 generation of neurons
1.51 1.40e-05 GO:0051172 negative regulation of nitrogen compound metabolic process
1.20 2.66e-05 GO:0048856 anatomical structure development
1.64 3.70e-05 GO:0009792 embryo development ending in birth or egg hatching
1.20 4.53e-05 GO:0034641 cellular nitrogen compound metabolic process
1.22 6.28e-05 GO:0071842 cellular component organization at cellular level
1.30 7.99e-05 GO:0009653 anatomical structure morphogenesis
1.45 8.03e-05 GO:0009790 embryo development
1.28 8.14e-05 GO:0023051 regulation of signaling
1.61 8.67e-05 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.24 9.22e-05 GO:0090304 nucleic acid metabolic process
1.33 9.47e-05 GO:0009893 positive regulation of metabolic process
1.19 1.12e-04 GO:0006807 nitrogen compound metabolic process
1.62 1.42e-04 GO:0043009 chordate embryonic development
1.71 2.01e-04 GO:0035295 tube development
1.23 2.58e-04 GO:0048523 negative regulation of cellular process
1.38 2.65e-04 GO:0050793 regulation of developmental process
1.22 3.03e-04 GO:0048519 negative regulation of biological process
1.32 3.56e-04 GO:0031325 positive regulation of cellular metabolic process
1.31 4.35e-04 GO:0051641 cellular localization
1.11 4.42e-04 GO:0044238 primary metabolic process
1.46 5.24e-04 GO:0009887 organ morphogenesis
1.35 5.50e-04 GO:0009892 negative regulation of metabolic process
1.36 6.44e-04 GO:0010605 negative regulation of macromolecule metabolic process
1.32 7.58e-04 GO:0051649 establishment of localization in cell
1.17 7.77e-04 GO:0016043 cellular component organization
1.74 7.98e-04 GO:0002009 morphogenesis of an epithelium
1.20 8.49e-04 GO:0071841 cellular component organization or biogenesis at cellular level
1.53 9.24e-04 GO:0032583 regulation of gene-specific transcription
1.21 9.75e-04 GO:0048522 positive regulation of cellular process
1.35 9.97e-04 GO:0032774 RNA biosynthetic process
1.58 1.01e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.41 1.44e-03 GO:0030182 neuron differentiation
1.39 1.48e-03 GO:2000026 regulation of multicellular organismal development
1.58 1.72e-03 GO:0007389 pattern specification process
1.41 2.42e-03 GO:0007167 enzyme linked receptor protein signaling pathway
1.19 2.67e-03 GO:0048518 positive regulation of biological process
1.40 2.79e-03 GO:0045595 regulation of cell differentiation
1.42 2.84e-03 GO:0030030 cell projection organization
1.34 3.38e-03 GO:0031324 negative regulation of cellular metabolic process
1.37 3.88e-03 GO:0046907 intracellular transport
1.85 4.05e-03 GO:0048562 embryonic organ morphogenesis
2.04 4.23e-03 GO:0010720 positive regulation of cell development
1.16 4.83e-03 GO:0071840 cellular component organization or biogenesis
1.17 4.93e-03 GO:0019538 protein metabolic process
1.85 5.29e-03 GO:0060562 epithelial tube morphogenesis
1.21 5.63e-03 GO:0048869 cellular developmental process
1.21 6.81e-03 GO:0030154 cell differentiation
1.57 7.66e-03 GO:0060284 regulation of cell development
1.53 7.68e-03 GO:0048598 embryonic morphogenesis
1.75 9.05e-03 GO:0035239 tube morphogenesis
1.26 9.35e-03 GO:0009966 regulation of signal transduction
1.55 9.59e-03 GO:0070647 protein modification by small protein conjugation or removal
1.66 1.00e-02 GO:0048568 embryonic organ development
1.22 1.34e-02 GO:0010467 gene expression
2.18 1.46e-02 GO:0022612 gland morphogenesis
2.11 1.77e-02 GO:0018205 peptidyl-lysine modification
1.29 1.82e-02 GO:0010646 regulation of cell communication
1.58 1.99e-02 GO:0032446 protein modification by small protein conjugation
1.43 2.10e-02 GO:0000904 cell morphogenesis involved in differentiation
2.09 2.48e-02 GO:0055123 digestive system development
1.55 2.52e-02 GO:0048729 tissue morphogenesis
1.42 2.59e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.82 2.80e-02 GO:0016055 Wnt receptor signaling pathway
1.90 2.89e-02 GO:0060541 respiratory system development
1.53 3.09e-02 GO:0001501 skeletal system development
1.38 3.13e-02 GO:0000902 cell morphogenesis
2.14 3.24e-02 GO:0048565 digestive tract development
1.85 3.29e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.22 3.29e-02 GO:0006996 organelle organization
1.42 3.37e-02 GO:0007417 central nervous system development
1.61 3.51e-02 GO:0003002 regionalization
1.84 4.22e-02 GO:0022604 regulation of cell morphogenesis
2.28 4.50e-02 GO:0016202 regulation of striated muscle tissue development
1.14 4.74e-02 GO:0051179 localization
1.30 4.79e-02 GO:0048468 cell development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.13 2.10e-29 GO:0044424 intracellular part
1.13 2.30e-28 GO:0005622 intracellular
1.18 1.94e-27 GO:0043227 membrane-bounded organelle
1.27 3.08e-27 GO:0005634 nucleus
1.18 7.77e-27 GO:0043231 intracellular membrane-bounded organelle
1.16 1.79e-26 GO:0043226 organelle
1.16 6.11e-26 GO:0043229 intracellular organelle
1.05 2.26e-10 GO:0005623 cell
1.05 3.24e-10 GO:0044464 cell part
1.30 2.75e-09 GO:0044428 nuclear part
1.38 1.05e-08 GO:0005654 nucleoplasm
1.31 1.39e-08 GO:0031981 nuclear lumen
1.51 2.94e-08 GO:0044451 nucleoplasm part
1.10 3.40e-07 GO:0005737 cytoplasm
1.24 6.61e-06 GO:0070013 intracellular organelle lumen
1.23 7.52e-06 GO:0043233 organelle lumen
1.23 9.74e-06 GO:0031974 membrane-enclosed lumen
2.21 6.32e-05 GO:0016585 chromatin remodeling complex
1.12 6.45e-05 GO:0044446 intracellular organelle part
1.12 1.82e-04 GO:0044422 organelle part
1.64 9.71e-04 GO:0005667 transcription factor complex
1.48 1.87e-03 GO:0045202 synapse
2.05 8.04e-03 GO:0014069 postsynaptic density
1.14 2.11e-02 GO:0043234 protein complex
1.48 3.08e-02 GO:0044456 synapse part
3.68 4.64e-02 GO:0010494 stress granule

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 1.59e-20 GO:0005488 binding
1.18 3.80e-18 GO:0005515 protein binding
1.37 1.89e-16 GO:0003677 DNA binding
1.30 5.13e-16 GO:0003676 nucleic acid binding
1.58 1.65e-15 GO:0030528 transcription regulator activity
1.49 2.22e-10 GO:0001071 nucleic acid binding transcription factor activity
1.49 2.22e-10 GO:0003700 sequence-specific DNA binding transcription factor activity
1.91 5.56e-10 GO:0008134 transcription factor binding
1.57 1.30e-09 GO:0043565 sequence-specific DNA binding
2.02 2.91e-08 GO:0010843 promoter binding
1.29 3.47e-08 GO:0008270 zinc ion binding
1.99 4.29e-08 GO:0000975 regulatory region DNA binding
1.99 4.29e-08 GO:0001067 regulatory region nucleic acid binding
1.99 4.29e-08 GO:0044212 transcription regulatory region DNA binding
1.25 8.37e-07 GO:0000166 nucleotide binding
1.72 1.36e-06 GO:0016563 transcription activator activity
1.74 3.43e-05 GO:0003702 RNA polymerase II transcription factor activity
1.22 7.04e-05 GO:0046914 transition metal ion binding
1.62 2.03e-04 GO:0016564 transcription repressor activity
1.15 2.13e-04 GO:0046872 metal ion binding
1.15 3.26e-04 GO:0043169 cation binding
1.15 4.05e-04 GO:0043167 ion binding
1.46 2.64e-03 GO:0019904 protein domain specific binding
1.21 2.80e-03 GO:0017076 purine nucleotide binding
1.50 3.12e-03 GO:0003712 transcription cofactor activity
1.49 3.60e-03 GO:0000988 protein binding transcription factor activity
1.49 3.60e-03 GO:0000989 transcription factor binding transcription factor activity
1.21 4.61e-03 GO:0032553 ribonucleotide binding
1.21 4.61e-03 GO:0032555 purine ribonucleotide binding
1.21 5.39e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.33 8.36e-03 GO:0019899 enzyme binding
1.61 1.43e-02 GO:0003713 transcription coactivator activity
1.96 1.76e-02 GO:0003704 specific RNA polymerase II transcription factor activity
2.40 1.97e-02 GO:0046332 SMAD binding
1.21 2.21e-02 GO:0030554 adenyl nucleotide binding
1.30 2.63e-02 GO:0016301 kinase activity
1.21 4.09e-02 GO:0032559 adenyl ribonucleotide binding