Motif ID: EN1,2.p2

Z-value: 0.760


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EN2chr7_+_155250705-0.086.8e-01Click!
EN1chr2_-_1196057580.048.3e-01Click!


Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_171154387 1.980 NM_001460
 FMO2
flavin containing monooxygenase 2 (non-functional)
chr8_+_7738725 1.425 NM_001081551
 DEFB103A
DEFB103B
defensin, beta 103A
defensin, beta 103B
chr19_-_51472816 1.274 NM_002774
 KLK6
kallikrein-related peptidase 6
chr11_-_121986800 1.124 NM_001001786
 BLID
BH3-like motif containing, cell death inducer
chr7_+_80267922 1.079 CD36
CD36 molecule (thrombospondin receptor)
chr2_-_216259197 1.040 FN1
fibronectin 1
chr2_-_216241321 0.906 FN1
fibronectin 1
chr7_+_80267972 0.857 CD36
CD36 molecule (thrombospondin receptor)
chr6_-_76782204 0.850 NM_001563
 IMPG1
interphotoreceptor matrix proteoglycan 1
chr4_+_70916158 0.813 NM_002159
 HTN1
histatin 1
chr17_+_56232493 0.797 NM_012374
 OR4D1
olfactory receptor, family 4, subfamily D, member 1
chr1_-_205391180 0.795 NM_001001552
NM_001199050
NM_001199051
NM_001199052
 LEMD1



LEM domain containing 1



chr20_-_23967431 0.767 NM_178312
 GGTLC1
gamma-glutamyltransferase light chain 1
chr17_+_39411635 0.739 NM_030975
 KRTAP9-9
keratin associated protein 9-9
chr8_+_7738908 0.732 NM_018661
 DEFB103B
defensin, beta 103B
chr4_-_46996423 0.718 NM_000809
 GABRA4
gamma-aminobutyric acid (GABA) A receptor, alpha 4
chr5_-_77844975 0.697 LHFPL2
lipoma HMGIC fusion partner-like 2
chr1_+_86934525 0.650 NM_001285
 CLCA1
chloride channel accessory 1
chr1_+_32050510 0.636 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr5_-_22853730 0.631 NM_004061
 CDH12
cadherin 12, type 2 (N-cadherin 2)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 25 entries
enrichment   p-value GO term description
4.04 2.58e-03 GO:0060337 type I interferon-mediated signaling pathway
4.04 2.58e-03 GO:0071357 cellular response to type I interferon
3.97 3.25e-03 GO:0034340 response to type I interferon
3.16 1.40e-02 GO:0007586 digestion
2.76 2.87e-03 GO:0009615 response to virus
2.53 1.57e-03 GO:0071345 cellular response to cytokine stimulus
2.47 1.25e-02 GO:0019221 cytokine-mediated signaling pathway
2.23 1.99e-04 GO:0045087 innate immune response
2.16 1.00e-02 GO:0034097 response to cytokine stimulus
2.12 3.47e-02 GO:0006954 inflammatory response
2.11 9.22e-09 GO:0006955 immune response
1.99 1.60e-07 GO:0006952 defense response
1.98 9.26e-03 GO:0051707 response to other organism
1.84 5.94e-06 GO:0009611 response to wounding
1.81 4.84e-02 GO:0007596 blood coagulation
1.81 4.84e-02 GO:0050817 coagulation
1.80 5.86e-08 GO:0002376 immune system process
1.79 2.03e-02 GO:0050878 regulation of body fluid levels
1.75 3.09e-02 GO:0042060 wound healing
1.59 2.30e-02 GO:0070887 cellular response to chemical stimulus

Gene overrepresentation in compartment category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
7.82 1.51e-02 GO:0001518 voltage-gated sodium channel complex
7.30 5.91e-03 GO:0034706 sodium channel complex
2.49 2.06e-02 GO:0009897 external side of plasma membrane
1.97 3.72e-08 GO:0005615 extracellular space
1.96 1.13e-10 GO:0044421 extracellular region part
1.81 2.35e-17 GO:0005576 extracellular region
1.58 1.06e-04 GO:0005887 integral to plasma membrane
1.56 1.61e-04 GO:0031226 intrinsic to plasma membrane
1.51 1.90e-07 GO:0044459 plasma membrane part
1.34 1.41e-07 GO:0005886 plasma membrane
1.33 2.14e-07 GO:0071944 cell periphery
1.20 8.30e-05 GO:0044425 membrane part
1.20 1.55e-03 GO:0031224 intrinsic to membrane
1.19 5.92e-03 GO:0016021 integral to membrane
1.13 2.83e-02 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
12.51 4.29e-02 GO:0032052 bile acid binding
3.37 2.62e-02 GO:0005496 steroid binding
2.34 8.43e-03 GO:0005125 cytokine activity
1.96 1.88e-03 GO:0015267 channel activity
1.96 2.02e-03 GO:0022803 passive transmembrane transporter activity
1.90 8.46e-03 GO:0022838 substrate-specific channel activity
1.89 1.21e-02 GO:0005216 ion channel activity
1.62 4.48e-04 GO:0005102 receptor binding
1.57 6.93e-03 GO:0022857 transmembrane transporter activity