Motif ID: ESR1.p2

Z-value: 0.818


Transcription factors associated with ESR1.p2:

Gene SymbolEntrez IDGene Name
ESR1 2099 estrogen receptor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ESR1chr6_+_1521286850.374.4e-02Click!


Activity profile for motif ESR1.p2.

activity profile for motif ESR1.p2


Sorted Z-values histogram for motif ESR1.p2

Sorted Z-values for motif ESR1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESR1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_17982753 2.848 NM_000453
SLC5A5
solute carrier family 5 (sodium iodide symporter), member 5
chr13_+_25254548 1.779 NM_001185085
NM_001676
ATP12A

ATPase, H+/K+ transporting, nongastric, alpha polypeptide

chr4_-_16085666 1.706 PROM1
prominin 1
chr4_-_16085593 1.586 NM_001145847
NM_001145848
PROM1

prominin 1

chr22_+_39853316 1.484 NM_002409
MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr16_-_67427335 1.465 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chrX_+_152240726 1.170 NM_001170944
NM_001242319
NM_032882
PNMA6C
PNMA6D
PNMA6A
paraneoplastic antigen like 6C
paraneoplastic antigen like 6D
paraneoplastic antigen like 6A
chr11_-_63381840 1.161 PLA2G16
phospholipase A2, group XVI
chr17_+_72732958 1.160 NM_001163989
RAB37
RAB37, member RAS oncogene family
chr11_-_46867788 1.151 CKAP5
cytoskeleton associated protein 5
chr5_-_157002705 1.149


chr17_+_72733350 1.126 NM_001006638
NM_001163990
RAB37

RAB37, member RAS oncogene family

chr11_-_63381485 1.118 PLA2G16
phospholipase A2, group XVI
chr11_-_63381940 1.117 NM_001128203
PLA2G16
phospholipase A2, group XVI
chr11_-_63381907 1.102 NM_007069
PLA2G16
phospholipase A2, group XVI
chr4_-_16085309 1.071 PROM1
prominin 1
chr19_-_3047632 0.990 NM_001144761
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr2_+_71162995 0.936 NM_001692
ATP6V1B1
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
chr20_-_25038501 0.922 NM_001252675
NM_001252677
NM_032501
ACSS1


acyl-CoA synthetase short-chain family member 1


chr16_+_810764 0.920 NM_005823
NM_001177355
MSLN

mesothelin

chr1_+_25944610 0.886 MAN1C1
mannosidase, alpha, class 1C, member 1
chr19_+_50706868 0.868 NM_001077186
NM_001145809
NM_024729
MYH14


myosin, heavy chain 14, non-muscle


chr16_+_811049 0.866 NM_013404
MSLN
mesothelin
chr18_+_55711388 0.859 NM_001144967
NM_001243960
NM_015277
NEDD4L


neural precursor cell expressed, developmentally down-regulated 4-like


chr22_-_19929447 0.786 TXNRD2
thioredoxin reductase 2
chr6_+_24495166 0.780 NM_001080
NM_170740
ALDH5A1

aldehyde dehydrogenase 5 family, member A1

chr16_-_75590107 0.766 NM_001077416
NM_001077418
NM_001077419
TMEM231


transmembrane protein 231


chr6_+_148663953 0.748 SASH1
SAM and SH3 domain containing 1
chr8_-_110704019 0.740 NM_001099743
NM_001099744
SYBU

syntabulin (syntaxin-interacting)

chr9_-_99382073 0.729 NM_003671
NM_033331
CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

chr4_-_16077740 0.725 NM_001145849
NM_001145850
NM_001145851
NM_001145852
NM_006017
PROM1




prominin 1




chr1_+_228871109 0.714 RHOU
ras homolog gene family, member U
chr3_-_50383009 0.711 NM_015896
ZMYND10
zinc finger, MYND-type containing 10
chr9_+_90112419 0.709 DAPK1
death-associated protein kinase 1
chr22_-_19929333 0.709 NM_006440
TXNRD2
thioredoxin reductase 2
chr13_-_26625164 0.706 NM_001007538
SHISA2
shisa homolog 2 (Xenopus laevis)
chr14_-_21493910 0.705 NM_016250
NM_201535
NM_201536
NM_201537
NDRG2



NDRG family member 2



chr2_+_106682111 0.692 NM_032411
C2orf40
chromosome 2 open reading frame 40
chr22_-_19137795 0.691 NM_005315
GSC2
goosecoid homeobox 2
chr19_-_15090349 0.686 SLC1A6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr14_+_96505566 0.663 NM_001252507
C14orf132
chromosome 14 open reading frame 132
chr14_-_21493858 0.661 NDRG2
NDRG family member 2
chr19_-_36705982 0.661 NM_001042474
ZNF565
zinc finger protein 565
chr17_+_62075710 0.655 NM_001164257
NM_001191029
NM_001191030
NM_001191031
C17orf72



chromosome 17 open reading frame 72



chr15_+_60296506 0.652 FOXB1
forkhead box B1
chr1_+_62660473 0.632 NM_001164835
NM_019079
L1TD1

LINE-1 type transposase domain containing 1

chrX_-_71525763 0.631 NM_001144885
NM_001144887
CITED1

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1

chr16_+_58549382 0.629 NM_001160305
NM_024860
SETD6

SET domain containing 6

chr10_+_102891060 0.620 NM_001195517
NM_005521
TLX1

T-cell leukemia homeobox 1

chr10_-_131909061 0.618 LOC387723
uncharacterized LOC387723
chr15_-_65715385 0.617 NM_020962
IGDCC4
immunoglobulin superfamily, DCC subclass, member 4
chr19_-_7990974 0.617 NM_206833
CTXN1
cortexin 1
chr22_-_19929250 0.617 TXNRD2
thioredoxin reductase 2
chr19_-_18717467 0.603 CRLF1
cytokine receptor-like factor 1
chr19_-_18717631 0.603 NM_004750
CRLF1
cytokine receptor-like factor 1
chr9_+_90112754 0.594 NM_004938
DAPK1
death-associated protein kinase 1
chr19_+_51152634 0.592 NM_001195076
C19orf81
chromosome 19 open reading frame 81
chr16_-_52580805 0.589 NM_001080430
TOX3
TOX high mobility group box family member 3
chr6_-_31846751 0.587 SLC44A4
solute carrier family 44, member 4
chr17_+_79651052 0.584


chr1_+_110230417 0.582 NM_000561
NM_146421
GSTM1

glutathione S-transferase mu 1

chr19_+_51815095 0.581 NM_001101372
IGLON5
IgLON family member 5
chr9_-_140083034 0.581 NM_013366
ANAPC2
anaphase promoting complex subunit 2
chr5_-_16617085 0.581 NM_001034850
FAM134B
family with sequence similarity 134, member B
chr19_-_18717577 0.579 CRLF1
cytokine receptor-like factor 1
chr6_-_31846766 0.578 SLC44A4
solute carrier family 44, member 4
chr14_+_79745653 0.566 NM_001105250
NM_138970
NRXN3

neurexin 3

chr7_+_128828712 0.560 NM_005631
SMO
smoothened, frizzled family receptor
chr19_+_10531128 0.557 NM_001111307
PDE4A
phosphodiesterase 4A, cAMP-specific
chr7_+_94139331 0.554 CASD1
CAS1 domain containing 1
chr7_+_94138991 0.545 NM_022900
CASD1
CAS1 domain containing 1
chr19_-_45826232 0.543 NM_001824
CKM
creatine kinase, muscle
chr3_-_13114547 0.542 NM_001134382
IQSEC1
IQ motif and Sec7 domain 1
chr6_+_148663728 0.542 NM_015278
SASH1
SAM and SH3 domain containing 1
chr7_+_44143945 0.529 NM_001129
AEBP1
AE binding protein 1
chr15_+_41062158 0.527 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr12_+_52345437 0.526 NM_004302
NM_020328
ACVR1B

activin A receptor, type IB

chr1_+_217804665 0.526 NM_138796
SPATA17
spermatogenesis associated 17
chr6_-_31846816 0.518 NM_001178044
NM_025257
SLC44A4

solute carrier family 44, member 4

chr11_-_82611358 0.511 NM_005040
NM_199418
PRCP

prolylcarboxypeptidase (angiotensinase C)

chr17_-_43045612 0.510 NM_006688
C1QL1
complement component 1, q subcomponent-like 1
chr1_-_146696896 0.507 FMO5
flavin containing monooxygenase 5
chr19_-_36705556 0.506 NM_152477
ZNF565
zinc finger protein 565
chr4_-_25864430 0.506 NM_015187
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr5_+_110559647 0.503 NM_001744
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr19_-_41388656 0.500 NM_000764
NM_030589
CYP2A7

cytochrome P450, family 2, subfamily A, polypeptide 7

chr3_+_113666544 0.498 NM_173570
ZDHHC23
zinc finger, DHHC-type containing 23
chr4_-_101111606 0.496 NM_145244
DDIT4L
DNA-damage-inducible transcript 4-like
chr9_-_35748875 0.495 GBA2
glucosidase, beta (bile acid) 2
chr19_-_45826131 0.491 CKM
creatine kinase, muscle
chr1_+_159750756 0.485 NM_017823
DUSP23
dual specificity phosphatase 23
chr13_+_113622758 0.484 MCF2L
MCF.2 cell line derived transforming sequence-like
chr6_-_154831652 0.482 CNKSR3
CNKSR family member 3
chr3_-_122512526 0.481 NM_024610
HSPBAP1
HSPB (heat shock 27kDa) associated protein 1
chr19_-_49576120 0.480 NM_031886
KCNA7
potassium voltage-gated channel, shaker-related subfamily, member 7
chr9_-_136150629 0.474 NM_020469
ABO
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
chr11_+_1874199 0.467 NM_002339
LSP1
lymphocyte-specific protein 1
chr9_-_140082983 0.467 ANAPC2
anaphase promoting complex subunit 2
chr9_+_137533713 0.465 COL5A1
collagen, type V, alpha 1
chr6_-_154831788 0.464 CNKSR3
CNKSR family member 3
chr9_-_35749144 0.461 GBA2
glucosidase, beta (bile acid) 2
chr5_-_1112106 0.461 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr8_-_61193882 0.459 NM_004056
CA8
carbonic anhydrase VIII
chr6_+_88117689 0.457 NM_001031743
C6orf165
chromosome 6 open reading frame 165
chr18_+_55711746 0.457 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr19_-_7293876 0.457 NM_000208
NM_001079817
INSR

insulin receptor

chr6_+_33422319 0.447 NM_152735
ZBTB9
zinc finger and BTB domain containing 9
chr12_-_133532847 0.445 NM_183238
NM_001164715
ZNF605

zinc finger protein 605

chr12_+_120427476 0.443 NM_207311
CCDC64
coiled-coil domain containing 64
chr2_+_39893021 0.439 NM_152390
TMEM178
transmembrane protein 178
chr7_+_106685007 0.434 NM_002736
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr15_-_52587851 0.432 NM_018728
MYO5C
myosin VC
chr10_+_12391471 0.430 NM_020397
NM_153498
CAMK1D

calcium/calmodulin-dependent protein kinase ID

chr2_-_175869910 0.429 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr6_-_154831704 0.429 NM_173515
CNKSR3
CNKSR family member 3
chr9_-_139922595 0.426 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr19_+_54041332 0.424 NM_001079906
NM_001253798
NM_001253799
ZNF331


zinc finger protein 331


chr7_+_44144002 0.419 AEBP1
AE binding protein 1
chr10_+_119000583 0.416 NM_003054
SLC18A2
solute carrier family 18 (vesicular monoamine), member 2
chr10_-_100027943 0.412 NM_032211
LOXL4
lysyl oxidase-like 4
chr8_-_102217907 0.410 NM_001042510
NM_016096
ZNF706

zinc finger protein 706

chr5_-_137368682 0.408 FAM13B
family with sequence similarity 13, member B
chr6_-_6007632 0.407 NM_016588
NRN1
neuritin 1
chr19_+_1491000 0.407 NM_138393
REEP6
receptor accessory protein 6
chr20_+_48429249 0.407 NM_015266
SLC9A8
solute carrier family 9 (sodium/hydrogen exchanger), member 8
chr19_+_36705503 0.405 NM_001099638
NM_001099639
NM_007145
ZNF146


zinc finger protein 146


chr19_+_54057898 0.403 NM_001253801
ZNF331
zinc finger protein 331
chr12_-_63328857 0.403 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr15_-_75248925 0.400 RPP25
ribonuclease P/MRP 25kDa subunit
chr20_+_48429375 0.399 SLC9A8
solute carrier family 9 (sodium/hydrogen exchanger), member 8
chr4_+_156588811 0.398 NM_001130684
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr6_+_148664124 0.396 SASH1
SAM and SH3 domain containing 1
chrX_-_21676416 0.396 NM_153270
KLHL34
kelch-like 34 (Drosophila)
chrX_-_48693934 0.395 NM_013271
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr21_-_43373938 0.393 NM_015500
C2CD2
C2 calcium-dependent domain containing 2
chr3_-_46505077 0.393 NM_001199149
LTF
lactotransferrin
chr9_-_21994414 0.392 NM_058195
CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr15_+_81426605 0.390 NM_173528
C15orf26
chromosome 15 open reading frame 26
chr8_-_101322180 0.387 RNF19A
ring finger protein 19A
chr15_-_93616308 0.387 RGMA
RGM domain family, member A
chr1_-_160068617 0.386 NM_001206665
IGSF8
immunoglobulin superfamily, member 8
chr19_+_13205956 0.385 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr1_+_110198873 0.385 GSTM2
GSTM4
glutathione S-transferase mu 2 (muscle)
glutathione S-transferase mu 4
chr9_-_21994329 0.384 CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr6_+_29894105 0.379


chr5_-_101631965 0.377 NM_180991
SLCO4C1
solute carrier organic anion transporter family, member 4C1
chr18_+_77724575 0.377 NM_001136180
HSBP1L1
heat shock factor binding protein 1-like 1
chr19_+_54042041 0.374 NM_001253800
ZNF331
zinc finger protein 331
chr13_+_113741668 0.372 MCF2L
MCF.2 cell line derived transforming sequence-like
chr1_-_40254131 0.369 BMP8B
bone morphogenetic protein 8b
chr5_-_7851255 0.368 NM_001089584
C5orf49
chromosome 5 open reading frame 49
chr5_-_137368778 0.368 NM_001101800
NM_001101801
NM_016603
FAM13B


family with sequence similarity 13, member B


chr1_+_245133628 0.366 NM_001143943
EFCAB2
EF-hand calcium binding domain 2
chr19_+_10527448 0.366 NM_001243121
PDE4A
phosphodiesterase 4A, cAMP-specific
chr2_-_99552677 0.365 NM_207362
C2orf55
chromosome 2 open reading frame 55
chr8_+_98881277 0.359 NM_002380
NM_030583
MATN2

matrilin 2

chr12_-_50297575 0.358 NM_012306
FAIM2
Fas apoptotic inhibitory molecule 2
chr6_+_33168602 0.356 NM_001077516
NM_006979
SLC39A7

solute carrier family 39 (zinc transporter), member 7

chr19_+_49617631 0.354 LIN7B
lin-7 homolog B (C. elegans)
chr1_-_11107295 0.350 NM_006610
NM_139208
MASP2

mannan-binding lectin serine peptidase 2

chr11_+_61522860 0.350 NM_013279
C11orf9
chromosome 11 open reading frame 9
chr2_-_233415266 0.350 TIGD1
tigger transposable element derived 1
chr15_-_93616358 0.348 NM_001166286
RGMA
RGM domain family, member A
chr19_+_54058493 0.347 NM_001079907
ZNF331
zinc finger protein 331
chr9_-_140083010 0.346 ANAPC2
anaphase promoting complex subunit 2
chr9_-_89562103 0.346 NM_002048
GAS1
growth arrest-specific 1
chr19_+_49617611 0.342 NM_022165
LIN7B
lin-7 homolog B (C. elegans)
chr20_+_31870940 0.342 NM_033197
BPIFB1
BPI fold containing family B, member 1
chr16_+_71660063 0.341 NM_001017967
NM_052858
MARVELD3

MARVEL domain containing 3

chr1_+_245133283 0.341 EFCAB2
EF-hand calcium binding domain 2
chr12_+_56660724 0.341 COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr20_-_3219835 0.339 NM_001174089
SLC4A11
solute carrier family 4, sodium borate transporter, member 11
chr10_-_13043570 0.339 NM_031455
CCDC3
coiled-coil domain containing 3
chr1_+_1567556 0.338 NM_006983
MMP23B
matrix metallopeptidase 23B
chr12_-_6982448 0.336 NM_001146316
NM_032641
SPSB2

splA/ryanodine receptor domain and SOCS box containing 2

chr19_+_42829760 0.335 NM_001410
MEGF8
multiple EGF-like-domains 8
chr22_-_43116796 0.335 NM_017436
A4GALT
alpha 1,4-galactosyltransferase
chr11_-_67771527 0.332 NM_030930
UNC93B1
unc-93 homolog B1 (C. elegans)
chrX_-_2847351 0.331 NM_001669
ARSD
arylsulfatase D
chr5_-_137475076 0.328 NM_003551
NME5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chr5_-_54529424 0.328 NM_021147
CCNO
cyclin O
chr9_-_139922705 0.327 NM_001606
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr17_-_40540359 0.327 NM_213662
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr12_+_56660548 0.325 NM_144576
COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr9_+_130830595 0.323 SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr1_-_157108132 0.321 ETV3
ets variant 3
chr2_-_233415206 0.319 NM_145702
TIGD1
tigger transposable element derived 1
chr12_+_56661026 0.317 NM_001099337
COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr12_+_121647936 0.315 P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr16_+_70148213 0.314 PDPR
pyruvate dehydrogenase phosphatase regulatory subunit
chr9_-_22009270 0.312 NM_004936
NM_078487
CDKN2B

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

chr4_+_156587861 0.312 NM_000856
NM_001130682
NM_001130686
NM_001130687
NM_001130683
NM_001130685
GUCY1A3





guanylate cyclase 1, soluble, alpha 3





chr9_+_130830447 0.311 NM_001006641
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr19_+_840963 0.311 PRTN3
proteinase 3
chr21_+_43639930 0.307 NM_207174
ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr15_-_64126081 0.304 HERC1
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
chr11_+_1889902 0.304 NM_001013253
LSP1
lymphocyte-specific protein 1
chr11_+_6411637 0.303 NM_000543
NM_001007593
SMPD1

sphingomyelin phosphodiesterase 1, acid lysosomal

chr14_+_105953256 0.303 NM_001311
CRIP1
cysteine-rich protein 1 (intestinal)
chr6_-_11044354 0.301 NM_017770
ELOVL2
ELOVL fatty acid elongase 2

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.09 6.19e-06 GO:0005622 intracellular
1.10 8.85e-06 GO:0044424 intracellular part
1.11 8.20e-05 GO:0043229 intracellular organelle
1.11 9.66e-05 GO:0043226 organelle
1.12 1.10e-04 GO:0043231 intracellular membrane-bounded organelle
1.12 1.40e-04 GO:0043227 membrane-bounded organelle
5.72 1.77e-04 GO:0033116 ER-Golgi intermediate compartment membrane
1.12 5.60e-04 GO:0005737 cytoplasm
1.15 2.35e-03 GO:0044444 cytoplasmic part
1.41 1.35e-02 GO:0005794 Golgi apparatus
1.04 2.93e-02 GO:0044464 cell part
1.04 3.01e-02 GO:0005623 cell

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.07 4.88e-03 GO:0005488 binding
1.18 2.57e-02 GO:0043169 cation binding
1.18 3.28e-02 GO:0043167 ion binding
1.18 4.88e-02 GO:0046872 metal ion binding