Motif ID: EWSR1-FLI1.p2

Z-value: 0.619


Transcription factors associated with EWSR1-FLI1.p2:

fusion protein between EWSR1 and FLI1 in an oncogenic event

Gene SymbolEntrez IDGene Name
EWSR1 2130 Ewing sarcoma breakpoint region 1
FLI1 2313 Friend leukemia virus integration 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EWSR1chr22_+_296642160.301.1e-01Click!
FLI1chr11_+_128563772-0.251.8e-01Click!


Activity profile for motif EWSR1-FLI1.p2.

activity profile for motif EWSR1-FLI1.p2


Sorted Z-values histogram for motif EWSR1-FLI1.p2

Sorted Z-values for motif EWSR1-FLI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EWSR1-FLI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_37892786 1.658 NM_001163334
SYTL5
synaptotagmin-like 5
chr3_-_42307661 0.987 NM_000729
CCK
cholecystokinin
chr18_+_43405544 0.737 NM_213602
SIGLEC15
sialic acid binding Ig-like lectin 15
chrX_+_585078 0.644 NM_000451
NM_006883
SHOX

short stature homeobox

chrY_+_535078 0.636 NM_000451
NM_006883
SHOX

short stature homeobox

chr9_-_124990706 0.616 NM_001242333
LHX6
LIM homeobox 6
chr6_-_25832268 0.570 NM_005074
SLC17A1
solute carrier family 17 (sodium phosphate), member 1
chrX_-_109561427 0.534 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr20_+_43374487 0.514 NM_022358
KCNK15
potassium channel, subfamily K, member 15
chr6_+_116937641 0.510 NM_001010892
NM_001161664
RSPH4A

radial spoke head 4 homolog A (Chlamydomonas)

chr14_-_54423448 0.505 NM_001202
NM_130850
BMP4

bone morphogenetic protein 4

chr3_-_164914448 0.469 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chr2_-_99917638 0.467 NM_174898
LYG1
lysozyme G-like 1
chr20_+_42187634 0.457 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr8_+_133879202 0.456 NM_003235
TG
thyroglobulin
chr7_-_99527242 0.420 NM_181538
GJC3
gap junction protein, gamma 3, 30.2kDa
chrX_-_109561298 0.403 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr5_+_156887026 0.378 NM_001099287
NM_001172292
NIPAL4

NIPA-like domain containing 4

chrX_+_1401570 0.371 NM_001161530
NM_172247
CSF2RA

colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)

chr7_+_36429388 0.368 NM_018685
ANLN
anillin, actin binding protein
chrY_+_1351570 0.355 NM_001161530
NM_172247
CSF2RA

colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)

chr6_-_132272311 0.344 NM_001901
CTGF
connective tissue growth factor
chr17_-_10633645 0.342 NM_001004313
TMEM220
transmembrane protein 220
chr1_-_169680677 0.329 NM_000655
SELL
selectin L
chr9_-_124989755 0.326 NM_001242334
LHX6
LIM homeobox 6
chr7_-_99573637 0.323 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr11_+_73357222 0.313 NM_001130033
NM_021200
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr6_-_134497069 0.312 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr3_-_192445344 0.308 NM_004113
FGF12
fibroblast growth factor 12
chr6_-_134496833 0.303 SGK1
serum/glucocorticoid regulated kinase 1
chr15_-_79298001 0.284 NM_153815
RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1
chr12_+_85673884 0.280 NM_006982
ALX1
ALX homeobox 1
chr19_-_33716609 0.275 NM_019849
SLC7A10
solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10
chrX_-_109561314 0.273 NM_001025580
NM_015365
AMMECR1

Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1

chr12_+_93771607 0.262 NM_019094
NM_199040
NUDT4

NUDT4P1
nudix (nucleoside diphosphate linked moiety X)-type motif 4

nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene 1
chr2_-_105467912 0.261 LOC100506421
uncharacterized LOC100506421
chr12_-_9760481 0.261 NM_002258
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr19_-_48823331 0.258 NM_144577
CCDC114
coiled-coil domain containing 114
chr3_-_50378238 0.258 NM_001206957
NM_007182
NM_170714
RASSF1


Ras association (RalGDS/AF-6) domain family member 1


chr2_-_24307529 0.252 NM_004881
NM_147184
TP53I3

tumor protein p53 inducible protein 3

chr18_+_12948004 0.250 SEH1L
SEH1-like (S. cerevisiae)
chr11_+_60970983 0.249 NM_001079807
PGA3
PGA4
pepsinogen 3, group I (pepsinogen A)
pepsinogen 4, group I (pepsinogen A)
chr8_-_145559831 0.245 NM_031309
SCRT1
scratch homolog 1, zinc finger protein (Drosophila)
chr10_-_90611675 0.241 NM_144590
ANKRD22
ankyrin repeat domain 22
chr1_-_93257950 0.234 NM_005665
EVI5
ecotropic viral integration site 5
chr5_-_81046943 0.234 NM_012446
SSBP2
single-stranded DNA binding protein 2
chr17_+_2497233 0.233 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr12_+_56660913 0.231 COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr3_-_192126837 0.229 NM_021032
FGF12
fibroblast growth factor 12
chr12_+_56661026 0.224 NM_001099337
COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr12_+_56660548 0.204 NM_144576
COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr4_-_16900348 0.202 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr12_+_56660724 0.201 COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr9_+_125796845 0.196 NM_005294
GPR21
G protein-coupled receptor 21
chr4_-_16900028 0.195 LDB2
LIM domain binding 2
chr19_+_52901101 0.193 NM_032423
ZNF528
zinc finger protein 528
chr17_+_33448597 0.193 NM_017559
FNDC8
fibronectin type III domain containing 8
chr11_+_10476665 0.192 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr8_-_95487284 0.189 NM_001205262
NM_012415
RAD54B

RAD54 homolog B (S. cerevisiae)

chr11_+_10477480 0.188 NM_001025390
AMPD3
adenosine monophosphate deaminase 3
chr16_-_70719854 0.182 NM_138383
MTSS1L
metastasis suppressor 1-like
chr7_-_99766191 0.181 GAL3ST4
galactose-3-O-sulfotransferase 4
chr2_+_113816214 0.180 NM_173170
IL36RN
interleukin 36 receptor antagonist
chrX_-_148586666 0.178 NM_000202
NM_001166550
NM_006123
IDS


iduronate 2-sulfatase


chr19_-_14201230 0.177 NM_138352
SAMD1
sterile alpha motif domain containing 1
chr2_-_26541916 0.175 NM_001145168
NM_001145169
GPR113

G protein-coupled receptor 113

chr14_+_70346113 0.173 NM_001034852
NM_022137
SMOC1

SPARC related modular calcium binding 1

chr2_+_113816684 0.173 NM_012275
IL36RN
interleukin 36 receptor antagonist
chr7_+_143412938 0.173 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr4_-_57522469 0.167 NM_001145459
NM_139211
HOPX

HOP homeobox

chr18_+_12947972 0.162 NM_001013437
NM_031216
SEH1L

SEH1-like (S. cerevisiae)

chr1_-_223537400 0.160 NM_001037175
NM_017982
SUSD4

sushi domain containing 4

chr2_-_42991201 0.156 NM_148962
OXER1
oxoeicosanoid (OXE) receptor 1
chr5_+_150040402 0.155 NM_001122853
NM_133371
MYOZ3

myozenin 3

chr19_-_17958814 0.155 NM_000215
JAK3
Janus kinase 3
chr12_-_16759939 0.154 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chr16_-_2318412 0.152 NM_080594
RNPS1
RNA binding protein S1, serine-rich domain
chr10_+_104221158 0.151 NM_024789
TMEM180
transmembrane protein 180
chr1_-_11042093 0.151 NM_001170754
C1orf127
chromosome 1 open reading frame 127
chr1_+_154975201 0.143 NM_001252406
ZBTB7B
zinc finger and BTB domain containing 7B
chr13_+_47127383 0.140 LRCH1
leucine-rich repeats and calponin homology (CH) domain containing 1
chr13_-_28543290 0.138 NM_001265
CDX2
caudal type homeobox 2
chr7_-_99766238 0.136 NM_024637
GAL3ST4
galactose-3-O-sulfotransferase 4
chr11_+_17757494 0.136 NM_001112741
NM_004976
KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1

chr6_-_45983279 0.136 NM_016929
CLIC5
chloride intracellular channel 5
chr18_-_45935627 0.136 ZBTB7C
zinc finger and BTB domain containing 7C
chr1_-_31230594 0.135 LAPTM5
lysosomal protein transmembrane 5
chr12_+_46123495 0.132 NM_152641
ARID2
AT rich interactive domain 2 (ARID, RFX-like)
chr1_-_31230673 0.130 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chrX_+_154997396 0.130 NM_005840
SPRY3
sprouty homolog 3 (Drosophila)
chr4_-_96470114 0.127 UNC5C
unc-5 homolog C (C. elegans)
chr19_-_2015628 0.124 NM_017797
BTBD2
BTB (POZ) domain containing 2
chr19_-_39368889 0.124 NM_001195833
NM_198445
RINL

Ras and Rab interactor-like

chr18_+_12948010 0.123 SEH1L
SEH1-like (S. cerevisiae)
chr2_+_182756468 0.120 NM_001130445
NM_006751
SSFA2

sperm specific antigen 2

chrX_+_48644961 0.118 NM_002049
GATA1
GATA binding protein 1 (globin transcription factor 1)
chr17_-_63052816 0.118


chr4_-_16900256 0.117 LDB2
LIM domain binding 2
chr8_-_22550057 0.116 NM_001199881
EGR3
early growth response 3
chrX_-_153718984 0.115 NM_001142391
NM_001142392
NM_019848
SLC10A3


solute carrier family 10 (sodium/bile acid cotransporter family), member 3


chr17_-_63052707 0.115 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr16_+_67022487 0.114 NM_173815
CES4A
carboxylesterase 4A
chr7_+_94285620 0.114 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr19_-_17958773 0.112 JAK3
Janus kinase 3
chr10_+_70883930 0.110 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr14_+_23775970 0.109 NM_001199864
NM_004050
NM_001199839
BCL2L2-PABPN1
BCL2L2

BCL2L2-PABPN1 readthrough
BCL2-like 2

chr13_+_47127312 0.108 LRCH1
leucine-rich repeats and calponin homology (CH) domain containing 1
chr12_-_49351240 0.108 ARF3
ADP-ribosylation factor 3
chr10_-_102027337 0.107 NM_018294
CWF19L1
CWF19-like 1, cell cycle control (S. pombe)
chr4_+_110736636 0.107 NM_018983
NM_032993
GAR1

GAR1 ribonucleoprotein homolog (yeast)

chr5_-_81046858 0.107 SSBP2
single-stranded DNA binding protein 2
chr15_+_41523465 0.107 CHP
calcium binding protein P22
chr8_-_37823986 0.106 NM_000025
ADRB3
adrenergic, beta-3-, receptor
chr18_+_46065367 0.105 NM_001142397
NM_014772
CTIF

CBP80/20-dependent translation initiation factor

chrX_+_198060 0.103 NM_018390
PLCXD1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr13_+_47127295 0.102 NM_001164211
NM_001164213
NM_015116
LRCH1


leucine-rich repeats and calponin homology (CH) domain containing 1


chr12_-_117175844 0.102 C12orf49
chromosome 12 open reading frame 49
chr11_-_67407024 0.101 NM_005995
TBX10
T-box 10
chr1_-_26232643 0.100 NM_203401
STMN1
stathmin 1
chr10_+_70883943 0.100 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chrY_+_148060 0.099 NM_018390
PLCXD1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr10_+_70883987 0.099 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr19_+_13205956 0.098 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr1_+_186798031 0.098 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr1_-_26232890 0.097 NM_001145454
NM_005563
STMN1

stathmin 1

chr11_+_60989820 0.097 NM_001079808
PGA3
PGA4
pepsinogen 3, group I (pepsinogen A)
pepsinogen 4, group I (pepsinogen A)
chr2_+_149402321 0.096 EPC2
enhancer of polycomb homolog 2 (Drosophila)
chrX_-_153718937 0.096 SLC10A3
solute carrier family 10 (sodium/bile acid cotransporter family), member 3
chr12_-_49351263 0.096


chr10_+_70883977 0.093 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr8_-_27695543 0.092 PBK
PDZ binding kinase
chr17_+_635656 0.091 NM_024792
FAM57A
family with sequence similarity 57, member A
chr4_+_154125589 0.090 NM_015271
TRIM2
tripartite motif containing 2
chr2_+_149402559 0.090 NM_015630
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr1_+_154975041 0.089 NM_001252405
NM_015872
ZBTB7B

zinc finger and BTB domain containing 7B

chr11_+_101980736 0.089 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr1_+_167599329 0.089 NM_052862
RCSD1
RCSD domain containing 1
chr1_+_44412418 0.088 NM_014652
IPO13
importin 13
chr12_-_49351129 0.088 ARF3
ADP-ribosylation factor 3
chrX_+_152599544 0.088 NM_001080485
ZNF275
zinc finger protein 275
chr8_-_145701717 0.087 NM_003923
FOXH1
forkhead box H1
chr17_-_63052884 0.086 NM_006572
GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr12_+_49658865 0.086 TUBA1C
tubulin, alpha 1c
chr2_+_182756665 0.084 SSFA2
sperm specific antigen 2
chr4_-_85887543 0.083 NM_014991
WDFY3
WD repeat and FYVE domain containing 3
chr10_+_70883856 0.082 NM_001035260
NM_004896
VPS26A

vacuolar protein sorting 26 homolog A (S. pombe)

chr22_+_19467413 0.081 NM_001178010
NM_001178011
NM_003504
CDC45


cell division cycle 45 homolog (S. cerevisiae)


chr6_+_52284948 0.080 NM_018100
EFHC1
EF-hand domain (C-terminal) containing 1
chr5_-_142000899 0.079 NM_001144892
FGF1
fibroblast growth factor 1 (acidic)
chr3_+_170075494 0.079 SKIL
SKI-like oncogene
chr14_-_21566728 0.078 NM_016423
ZNF219
zinc finger protein 219
chr11_-_65488142 0.076 NM_032193
RNASEH2C
ribonuclease H2, subunit C
chr6_-_24719286 0.076 NM_030939
C6orf62
chromosome 6 open reading frame 62
chr15_-_68498373 0.075 NM_001031733
NM_033429
CALML4

calmodulin-like 4

chr9_+_115513050 0.074 NM_001012994
SNX30
sorting nexin family member 30
chr12_-_49351245 0.074 ARF3
ADP-ribosylation factor 3
chr8_-_27695288 0.074 NM_018492
PBK
PDZ binding kinase
chr7_+_94285736 0.071 PEG10
paternally expressed 10
chr1_-_152009406 0.070 S100A11
S100 calcium binding protein A11
chr17_-_40833840 0.068 NM_016602
CCR10
chemokine (C-C motif) receptor 10
chr19_+_8117645 0.067 NM_001201359
NM_005624
CCL25

chemokine (C-C motif) ligand 25

chr10_-_71892596 0.067 NM_001198696
NM_032797
AIFM2

apoptosis-inducing factor, mitochondrion-associated, 2

chr16_-_74734687 0.067 NM_001142497
NM_152649
MLKL

mixed lineage kinase domain-like

chr1_+_246887591 0.065 SCCPDH
saccharopine dehydrogenase (putative)
chr17_+_48133357 0.065 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr1_-_154193044 0.065 C1orf43
chromosome 1 open reading frame 43
chr9_-_130639939 0.065 NM_000476
AK1
adenylate kinase 1
chr12_-_49351297 0.064 ARF3
ADP-ribosylation factor 3
chr1_-_152009440 0.064 S100A11
S100 calcium binding protein A11
chr12_+_49658862 0.064 NM_032704
TUBA1C
tubulin, alpha 1c
chr18_+_10454542 0.063 APCDD1
adenomatosis polyposis coli down-regulated 1
chr16_+_69458489 0.061 NM_030579
CYB5B
cytochrome b5 type B (outer mitochondrial membrane)
chr19_+_16144929 0.061 FLJ25328
uncharacterized LOC148231
chr11_-_123065836 0.061 CLMP
CXADR-like membrane protein
chr19_+_1207129 0.060 EFNA2
ephrin-A2
chr11_+_71927818 0.060 NM_000803
NM_001113534
NM_001113535
NM_001113536
FOLR2



folate receptor 2 (fetal)



chr6_+_36916038 0.059 NM_001199159
PI16
peptidase inhibitor 16
chr17_+_18855477 0.059 NM_001042450
NM_152351
SLC5A10

solute carrier family 5 (sodium/glucose cotransporter), member 10

chr15_-_40599872 0.058 PLCB2
phospholipase C, beta 2
chr8_-_145701139 0.057 FOXH1
forkhead box H1
chr14_-_94595925 0.057 NM_032036
IFI27L2
interferon, alpha-inducible protein 27-like 2
chr17_+_48133331 0.057 NM_002204
NM_005501
ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr15_+_41523401 0.057 NM_007236
CHP
calcium binding protein P22
chr1_-_152009467 0.057 S100A11
S100 calcium binding protein A11
chr5_+_137673702 0.057 NM_016605
FAM53C
family with sequence similarity 53, member C
chr12_-_49351251 0.056 NM_001659
ARF3
ADP-ribosylation factor 3
chr12_-_42538432 0.056 NM_001099650
NM_173601
GXYLT1

glucoside xylosyltransferase 1

chr11_+_9685650 0.056 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr12_+_90103470 0.055 LOC338758
uncharacterized LOC338758
chrX_-_20284910 0.055 RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr1_-_27930101 0.054 NM_001029882
AHDC1
AT hook, DNA binding motif, containing 1
chr15_-_59041933 0.054 NM_001110
ADAM10
ADAM metallopeptidase domain 10
chr5_+_137673953 0.052 FAM53C
family with sequence similarity 53, member C
chr1_-_226926875 0.051 NM_002221
ITPKB
inositol-trisphosphate 3-kinase B
chr5_+_137673956 0.051 FAM53C
family with sequence similarity 53, member C
chr17_-_63052744 0.051 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr11_-_62474666 0.051 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr6_+_31590468 0.050


chr14_-_64009971 0.050 PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr11_-_65487910 0.049 RNASEH2C
ribonuclease H2, subunit C

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.91 2.04e-02 GO:0008201 heparin binding