Motif ID: FOSL2.p2

Z-value: 1.796


Transcription factors associated with FOSL2.p2:

Gene SymbolEntrez IDGene Name
FOSL2 2355 FOS-like antigen 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOSL2chr2_+_286163600.783.2e-07Click!


Activity profile for motif FOSL2.p2.

activity profile for motif FOSL2.p2


Sorted Z-values histogram for motif FOSL2.p2

Sorted Z-values for motif FOSL2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOSL2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_39768939 14.104 NM_005557
KRT16
keratin 16
chr18_+_21452981 13.567 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr1_+_150480584 13.386 ECM1
extracellular matrix protein 1
chr19_-_51472816 11.053 NM_002774
KLK6
kallikrein-related peptidase 6
chr19_-_36019194 10.409 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr1_+_150480486 9.992 NM_001202858
NM_004425
NM_022664
ECM1


extracellular matrix protein 1


chr2_-_216259197 8.865 FN1
fibronectin 1
chr1_+_152956563 8.821 NM_001199828
NM_005987
SPRR1A

small proline-rich protein 1A

chr21_+_41029253 8.615 NM_006057
NM_033170
NM_033171
NM_033172
NM_033173
B3GALT5




UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5




chr2_+_113875469 7.562 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr1_+_32043745 7.158 NM_001204415
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr11_-_65667858 7.119 FOSL1
FOS-like antigen 1
chr6_+_74405764 6.914 CD109
CD109 molecule
chr12_+_13349720 6.735 EMP1
epithelial membrane protein 1
chr1_-_153521717 6.588 NM_002960
S100A3
S100 calcium binding protein A3
chr20_+_33759773 6.549 NM_006404
PROCR
protein C receptor, endothelial
chr7_+_48128225 6.398 NM_181597
UPP1
uridine phosphorylase 1
chr6_+_74405933 6.269 CD109
CD109 molecule
chr12_+_13349601 6.175 NM_001423
EMP1
epithelial membrane protein 1
chr6_+_74405505 6.073 NM_001159587
NM_001159588
NM_133493
CD109


CD109 molecule


chr2_-_31440378 6.039 NM_001145122
CAPN14
calpain 14
chr6_+_74405909 5.888 CD109
CD109 molecule
chr13_-_60325073 5.757


chr4_+_169013687 5.482 NM_007193
ANXA10
annexin A10
chr1_-_17308072 5.428 NM_001135247
NM_017459
MFAP2

microfibrillar-associated protein 2

chr19_-_19049790 5.289 NM_001145724
HOMER3
homer homolog 3 (Drosophila)
chr11_-_65667809 5.249 FOSL1
FOS-like antigen 1
chr19_-_11688441 5.209 ACP5
acid phosphatase 5, tartrate resistant
chrX_+_99899162 5.053 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr9_+_140119643 4.932 NM_199001
C9orf169
chromosome 9 open reading frame 169
chr6_+_74405856 4.900 CD109
CD109 molecule
chr10_+_118187381 4.856 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr6_-_35696359 4.835 NM_001145775
FKBP5
FK506 binding protein 5
chr21_+_30517897 4.796 C21orf7
chromosome 21 open reading frame 7
chr18_+_61442611 4.688 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr13_+_78109808 4.557 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr1_-_153067000 4.485 NM_001024209
SPRR2E
small proline-rich protein 2E
chr11_-_65667860 4.390 NM_005438
FOSL1
FOS-like antigen 1
chr10_+_17270257 4.373 NM_003380
VIM
vimentin
chr19_-_11688484 4.369 ACP5
acid phosphatase 5, tartrate resistant
chr9_+_131191206 4.215 CERCAM
cerebral endothelial cell adhesion molecule
chr1_+_152974222 4.176 NM_001097589
NM_005416
SPRR3

small proline-rich protein 3

chr19_-_44174497 4.142 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr8_-_42623928 4.052 NM_001199279
NM_004198
CHRNA6

cholinergic receptor, nicotinic, alpha 6

chrX_+_99899388 4.050 SRPX2
sushi-repeat containing protein, X-linked 2
chr19_-_51537996 4.023 NM_019598
NM_145894
NM_145895
KLK12


kallikrein-related peptidase 12


chr1_-_153348057 3.915 NM_005621
S100A12
S100 calcium binding protein A12
chr12_-_54813002 3.831 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr1_-_153029987 3.818 NM_005988
SPRR2A
small proline-rich protein 2A
chr19_-_11688508 3.817 NM_001611
ACP5
acid phosphatase 5, tartrate resistant
chrX_-_15683153 3.816 NM_020665
TMEM27
transmembrane protein 27
chr11_-_6341708 3.814 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr3_-_48632592 3.754 NM_000094
COL7A1
collagen, type VII, alpha 1
chr22_+_22758538 3.726


chr10_+_17270469 3.664 VIM
vimentin
chr15_+_74165967 3.566 NM_153356
TBC1D21
TBC1 domain family, member 21
chr15_-_80263460 3.456 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr17_+_74381186 3.440 NM_001142602
SPHK1
sphingosine kinase 1
chr17_+_74381419 3.430 SPHK1
sphingosine kinase 1
chr1_+_26606621 3.378 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr2_-_85641128 3.321 CAPG
capping protein (actin filament), gelsolin-like
chr17_-_40575117 3.293 NM_012232
PTRF
polymerase I and transcript release factor
chr1_-_26197743 3.243 NM_178422
PAQR7
progestin and adipoQ receptor family member VII
chr11_-_2162340 3.225 NM_001127598
IGF2
insulin-like growth factor 2 (somatomedin A)
chr11_+_12308446 3.223 NM_032867
MICALCL
MICAL C-terminal like
chr19_+_11200037 3.201 NM_000527
NM_001195798
NM_001195799
NM_001195800
NM_001195802
NM_001195803
LDLR





low density lipoprotein receptor





chr19_+_39279849 3.145 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr19_-_35992798 3.112 NM_001035516
DMKN
dermokine
chr8_+_10530146 3.093 NM_001040032
C8orf74
chromosome 8 open reading frame 74
chr8_-_125580745 3.031 MTSS1
metastasis suppressor 1
chr1_-_154943001 3.026 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr19_-_36004553 2.949 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine






chr11_+_706607 2.922 EPS8L2
EPS8-like 2
chr11_-_71159442 2.915 NM_001163817
NM_001360
DHCR7

7-dehydrocholesterol reductase

chr1_+_86889768 2.877 NM_006536
CLCA2
chloride channel accessory 2
chr21_+_30452872 2.859 NM_020152
C21orf7
chromosome 21 open reading frame 7
chr20_+_43343523 2.848 WISP2
WNT1 inducible signaling pathway protein 2
chr15_+_67458492 2.838 NM_001145104
SMAD3
SMAD family member 3
chr2_-_85641153 2.821 CAPG
capping protein (actin filament), gelsolin-like
chr12_-_91505541 2.806 NM_002345
LUM
lumican
chr1_-_28520379 2.799 NM_001164721
NM_001164722
PTAFR

platelet-activating factor receptor

chr3_-_12800739 2.793 NM_018306
TMEM40
transmembrane protein 40
chr17_-_39538635 2.791 NM_021013
KRT34
keratin 34
chr4_-_39033981 2.764 NM_024943
TMEM156
transmembrane protein 156
chr19_-_51523272 2.761 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr19_-_51568323 2.748 NM_015596
KLK13
kallikrein-related peptidase 13
chr17_+_74380943 2.742 SPHK1
sphingosine kinase 1
chr12_-_10021932 2.738 CLEC2B
C-type lectin domain family 2, member B
chr4_-_159092509 2.731 FAM198B
family with sequence similarity 198, member B
chr20_-_1309809 2.708 NM_080489
SDCBP2
syndecan binding protein (syntenin) 2
chr19_-_44174271 2.688 PLAUR
plasminogen activator, urokinase receptor
chr12_-_54812936 2.655 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr19_-_39264144 2.634 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr11_-_71159371 2.631 DHCR7
7-dehydrocholesterol reductase
chr9_-_130341265 2.618 NM_001035534
FAM129B
family with sequence similarity 129, member B
chr7_+_26331611 2.601 SNX10
sorting nexin 10
chr7_-_107643330 2.598 NM_002291
LAMB1
laminin, beta 1
chr6_-_30712294 2.572 NM_003897
IER3
immediate early response 3
chr9_+_103191795 2.538 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr7_+_143078457 2.452 ZYX
zyxin
chr9_+_35673852 2.450 NM_001216
CA9
carbonic anhydrase IX
chr12_+_107974633 2.416 NM_001017523
BTBD11
BTB (POZ) domain containing 11
chr1_-_204120909 2.397 ETNK2
ethanolamine kinase 2
chr19_-_44285407 2.372 NM_002250
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr7_+_143078399 2.360 ZYX
zyxin
chr19_-_44285012 2.327 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr7_-_158611301 2.301 ESYT2
extended synaptotagmin-like protein 2
chr6_+_106546736 2.280 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr7_+_143078447 2.278 ZYX
zyxin
chr7_+_143078444 2.264 ZYX
zyxin
chr4_+_69313166 2.250 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr12_-_48152180 2.248 NM_001098532
NM_006105
RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3

chr3_+_188889762 2.245 NM_198485
TPRG1
tumor protein p63 regulated 1
chr1_+_154378044 2.235 IL6R
interleukin 6 receptor
chr7_+_143078395 2.233 ZYX
zyxin
chr1_-_27816667 2.211 WASF2
WAS protein family, member 2
chr12_-_48152860 2.202 NM_001098531
RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chr16_+_58534045 2.194 NM_001242833
NM_001242834
NM_001242835
NM_001242836
NDRG4



NDRG family member 4



chr1_+_154377847 2.193 IL6R
interleukin 6 receptor
chr8_-_30515665 2.181 NM_002095
GTF2E2
general transcription factor IIE, polypeptide 2, beta 34kDa
chr17_-_41622727 2.173 ETV4
ets variant 4
chr21_-_28217272 2.157 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr7_+_143078358 2.144 NM_001010972
NM_003461
ZYX

zyxin

chr11_-_5537815 2.121 NM_145053
UBQLNL
ubiquilin-like
chr16_-_30124829 2.118 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr12_-_49259549 2.061 NM_014470
RND1
Rho family GTPase 1
chr2_+_158114109 2.046 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr8_-_21998994 2.033 NM_025232
REEP4
receptor accessory protein 4
chr1_-_179112178 2.018 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr14_+_55221505 2.014 NM_001161577
SAMD4A
sterile alpha motif domain containing 4A
chr13_+_109248499 2.005 NM_015011
MYO16
myosin XVI
chr6_+_32121228 1.999 NM_138717
PPT2
palmitoyl-protein thioesterase 2
chr20_+_43343884 1.999 NM_003881
WISP2
WNT1 inducible signaling pathway protein 2
chr17_-_33390676 1.991 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chrX_-_153599719 1.982 FLNA
filamin A, alpha
chrX_-_106960268 1.973 NM_004089
TSC22D3
TSC22 domain family, member 3
chr11_-_102668892 1.966 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr19_+_6531009 1.962 NM_003811
TNFSF9
tumor necrosis factor (ligand) superfamily, member 9
chr11_-_102668822 1.937 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr1_+_3388170 1.928 ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr11_+_62649160 1.907 SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr1_+_155006281 1.883 NM_001143687
NM_152494
DCST1

DC-STAMP domain containing 1

chr1_+_154377668 1.874 NM_000565
NM_001206866
NM_181359
IL6R


interleukin 6 receptor


chr3_+_188664939 1.872 TPRG1
tumor protein p63 regulated 1
chr12_-_54813010 1.853 NM_002205
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr14_-_91710851 1.830 NM_001177676
GPR68
G protein-coupled receptor 68
chr4_+_74606222 1.829 NM_000584
IL8
interleukin 8
chr20_+_44637539 1.822 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr15_+_67418053 1.816 NM_001145102
SMAD3
SMAD family member 3
chr19_+_11200124 1.815 LDLR
low density lipoprotein receptor
chr2_+_87755059 1.807 LINC00152
long intergenic non-protein coding RNA 152
chr11_+_2924504 1.803 SLC22A18
solute carrier family 22, member 18
chr19_-_16045669 1.794 NM_001128932
NM_021187
CYP4F11

cytochrome P450, family 4, subfamily F, polypeptide 11

chr1_+_26606586 1.778 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr7_+_134233848 1.770 NM_001080538
AKR1B15
aldo-keto reductase family 1, member B15
chr12_+_7023490 1.769 NM_001975
ENO2
enolase 2 (gamma, neuronal)
chr9_-_99064385 1.768 NM_000197
HSD17B3
hydroxysteroid (17-beta) dehydrogenase 3
chr15_-_56209305 1.739 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr12_-_52845862 1.732 NM_005555
KRT6B
keratin 6B
chr18_+_61144143 1.725 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr7_-_1199785 1.725 ZFAND2A
zinc finger, AN1-type domain 2A
chr9_+_4985082 1.724 JAK2
Janus kinase 2
chr1_+_183155173 1.719 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr7_+_134212343 1.714 NM_020299
AKR1B10
aldo-keto reductase family 1, member B10 (aldose reductase)
chr1_+_183155361 1.701 LAMC2
laminin, gamma 2
chr1_-_159923961 1.699 NM_001146172
NM_001146173
NM_033438
SLAMF9


SLAM family member 9


chr8_+_22210311 1.699 PIWIL2
piwi-like 2 (Drosophila)
chr19_-_6670598 1.695 NM_003807
NM_172014
TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr2_+_87754991 1.689 LINC00152
long intergenic non-protein coding RNA 152
chr7_-_1199813 1.680 ZFAND2A
zinc finger, AN1-type domain 2A
chr11_+_706103 1.676 NM_022772
EPS8L2
EPS8-like 2
chr7_+_129932973 1.675 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr1_-_244006471 1.662 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr2_+_90077732 1.651


chr17_-_43502992 1.646 NM_199282
ARHGAP27
Rho GTPase activating protein 27
chr7_-_93519990 1.645 NM_006528
TFPI2
tissue factor pathway inhibitor 2
chr7_+_1577118 1.608 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr15_+_81071708 1.601 NM_018689
KIAA1199
KIAA1199
chr20_-_34195409 1.595 FER1L4
fer-1-like 4 (C. elegans) pseudogene
chr6_-_117150197 1.588 NM_148963
GPRC6A
G protein-coupled receptor, family C, group 6, member A
chr12_-_8043743 1.579 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr12_-_91505215 1.558 LUM
lumican
chr9_+_4839763 1.557 RCL1
RNA terminal phosphate cyclase-like 1
chr4_+_84457390 1.554 NM_032717
AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr18_+_268147 1.553


chr1_-_209824641 1.548 NM_001017402
LAMB3
laminin, beta 3
chr2_+_169923531 1.546 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr1_+_84647342 1.542 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr11_-_67448684 1.538 NM_001031615
ALDH3B2
aldehyde dehydrogenase 3 family, member B2
chr20_-_633808 1.499 SRXN1
sulfiredoxin 1
chr1_+_32050510 1.476 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr20_+_43344005 1.476 WISP2
WNT1 inducible signaling pathway protein 2
chr4_+_84457256 1.473 AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr7_+_26331493 1.460 NM_001199835
NM_013322
SNX10

sorting nexin 10

chr19_-_6670078 1.459 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr2_-_165697927 1.455 NM_014900
COBLL1
COBL-like 1
chr2_-_163099877 1.452 NM_004460
FAP
fibroblast activation protein, alpha
chr1_+_15944017 1.451 DDI2
DNA-damage inducible 1 homolog 2 (S. cerevisiae)
chr2_-_71062904 1.448 NM_015717
CD207
CD207 molecule, langerin
chr6_+_29794743 1.440 NM_002127
HLA-G
major histocompatibility complex, class I, G

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.64 1.08e-05 GO:0002376 immune system process
1.31 3.23e-04 GO:0007165 signal transduction
1.27 5.87e-04 GO:0051716 cellular response to stimulus
2.79 6.39e-04 GO:0002237 response to molecule of bacterial origin
1.87 6.44e-04 GO:0006928 cellular component movement
2.87 8.90e-04 GO:0032496 response to lipopolysaccharide
1.37 2.30e-03 GO:0042221 response to chemical stimulus
1.45 2.35e-03 GO:0023051 regulation of signaling
1.59 3.24e-03 GO:0032879 regulation of localization
1.41 3.49e-03 GO:0048583 regulation of response to stimulus
1.19 3.64e-03 GO:0050896 response to stimulus
1.26 4.27e-03 GO:0023052 signaling
1.59 4.47e-03 GO:0042127 regulation of cell proliferation
2.21 4.79e-03 GO:0009617 response to bacterium
2.18 6.60e-03 GO:0030334 regulation of cell migration
1.79 8.83e-03 GO:0010647 positive regulation of cell communication
2.16 9.04e-03 GO:2000145 regulation of cell motility
1.54 9.42e-03 GO:0010646 regulation of cell communication
1.48 9.78e-03 GO:0010033 response to organic substance
1.78 1.09e-02 GO:0023056 positive regulation of signaling
1.88 1.43e-02 GO:0051707 response to other organism
2.07 1.51e-02 GO:0040012 regulation of locomotion
3.74 1.63e-02 GO:0002761 regulation of myeloid leukocyte differentiation
2.08 2.22e-02 GO:0010740 positive regulation of intracellular protein kinase cascade
1.77 2.59e-02 GO:0001775 cell activation
1.88 2.61e-02 GO:0010627 regulation of intracellular protein kinase cascade
1.76 2.97e-02 GO:0009967 positive regulation of signal transduction
1.43 3.52e-02 GO:0009966 regulation of signal transduction

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.37 2.31e-04 GO:0044459 plasma membrane part
1.21 8.12e-03 GO:0005886 plasma membrane
1.21 9.46e-03 GO:0071944 cell periphery
1.46 1.74e-02 GO:0044421 extracellular region part
1.29 4.13e-02 GO:0005576 extracellular region
2.67 4.13e-02 GO:0001726 ruffle

Nothing significant found in function category.