Motif ID: GAUUGUC

Z-value: 0.715


Mature miRNA associated with seed GAUUGUC:

NamemiRBase Accession
hsa-miR-219-5p MIMAT0000276
hsa-miR-4782-3p MIMAT0019945



Activity profile for motif GAUUGUC.

activity profile for motif GAUUGUC


Sorted Z-values histogram for motif GAUUGUC

Sorted Z-values for motif GAUUGUC



Network of associatons between targets according to the STRING database.



First level regulatory network of GAUUGUC

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_5914192 3.717 NM_004058
NM_080590
CAPS

calcyphosine

chr6_+_17281773 3.106 NM_001143942
RBM24
RNA binding motif protein 24
chr6_+_17282294 3.028 NM_001143941
RBM24
RNA binding motif protein 24
chr6_+_17282931 3.021 NM_153020
RBM24
RNA binding motif protein 24
chr1_-_207119707 2.437 NM_002644
PIGR
polymeric immunoglobulin receptor
chr7_-_131241321 2.037 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr4_+_75858205 1.780 NM_015393
PARM1
prostate androgen-regulated mucin-like protein 1
chr19_-_55691468 1.456 NM_003180
SYT5
synaptotagmin V
chr7_+_3340919 1.451 NM_152744
SDK1
sidekick cell adhesion molecule 1
chr1_+_244214552 1.372 NM_205768
ZNF238
zinc finger protein 238
chr5_+_50678957 1.321 NM_002202
ISL1
ISL LIM homeobox 1
chr14_+_74111577 1.272 NM_001201366
NM_031427
DNAL1

dynein, axonemal, light chain 1

chr1_+_244216506 1.203 NM_006352
ZNF238
zinc finger protein 238
chr15_-_60884615 0.974 NM_134262
RORA
RAR-related orphan receptor A
chr7_+_21467572 0.960 NM_003112
SP4
Sp4 transcription factor
chr19_-_14316980 0.955 NM_001008701
NM_014921
LPHN1

latrophilin 1

chr1_-_86043932 0.896 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr1_-_85930733 0.886 NM_012137
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr15_-_61521478 0.876 NM_134261
RORA
RAR-related orphan receptor A
chr1_-_115632047 0.841 NM_005725
TSPAN2
tetraspanin 2
chr1_+_180601121 0.833 NM_001135669
NM_004736
XPR1

xenotropic and polytropic retrovirus receptor 1

chr6_+_72926462 0.774 NM_001168410
RIMS1
regulating synaptic membrane exocytosis 1
chr13_+_100258886 0.748 NM_206808
CLYBL
citrate lyase beta like
chr15_-_60919642 0.706 NM_002943
NM_134260
RORA

RAR-related orphan receptor A

chr15_+_57668702 0.669 NM_001252335
NM_032866
CGNL1

cingulin-like 1

chr9_-_35749209 0.665 NM_020944
GBA2
glucosidase, beta (bile acid) 2
chr1_+_61547625 0.651 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr1_+_61542928 0.625 NM_001145511
NFIA
nuclear factor I/A
chr8_-_72268720 0.622 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr22_-_21088954 0.597 NM_002650
PI4KA
phosphatidylinositol 4-kinase, catalytic, alpha
chr6_+_72922513 0.593 NM_001168407
NM_001168408
RIMS1

regulating synaptic membrane exocytosis 1

chr17_+_68165660 0.582 NM_000891
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr2_+_24807345 0.568 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr6_+_143999058 0.555 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr12_-_56652118 0.549 NM_173595
ANKRD52
ankyrin repeat domain 52
chr6_+_72926144 0.541 NM_001168409
RIMS1
regulating synaptic membrane exocytosis 1
chr22_-_21213099 0.540 NM_058004
PI4KA
phosphatidylinositol 4-kinase, catalytic, alpha
chr6_+_43211221 0.530 NM_032538
TTBK1
tau tubulin kinase 1
chr15_+_89631380 0.516 NM_007011
NM_152924
ABHD2

abhydrolase domain containing 2

chr7_-_138665853 0.510 NM_001164665
NM_020910
KIAA1549

KIAA1549

chr16_+_69958900 0.499 NM_199424
WWP2
WW domain containing E3 ubiquitin protein ligase 2
chr17_+_31254927 0.498 NM_001033504
NM_015544
TMEM98

transmembrane protein 98

chr22_+_31518923 0.493 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr13_+_108870713 0.487 NM_032859
ABHD13
abhydrolase domain containing 13
chr6_+_143929316 0.481 NM_001100166
NM_014721
PHACTR2

phosphatase and actin regulator 2

chr8_-_72274466 0.476 NM_000503
EYA1
eyes absent homolog 1 (Drosophila)
chr2_-_148779172 0.472 NM_181742
ORC4
origin recognition complex, subunit 4
chr12_+_65004191 0.472 NM_178169
RASSF3
Ras association (RalGDS/AF-6) domain family member 3
chr4_-_23891608 0.468 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr21_+_44394634 0.461 NM_004571
PKNOX1
PBX/knotted 1 homeobox 1
chr1_+_61547388 0.443 NM_001145512
NFIA
nuclear factor I/A
chr9_+_115983807 0.441 NM_001859
SLC31A1
solute carrier family 31 (copper transporters), member 1
chr3_-_114343791 0.441 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr10_-_94050799 0.440 NM_014912
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr3_-_114343052 0.424 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr3_-_114478117 0.419 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr1_-_205782135 0.417 NM_173854
SLC41A1
solute carrier family 41, member 1
chr9_-_126030854 0.416 NM_001171137
STRBP
spermatid perinuclear RNA binding protein
chr15_+_85923739 0.412 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chr15_+_86220267 0.411 NM_144767
AKAP13
A kinase (PRKA) anchor protein 13
chr20_-_50418946 0.410 NM_020436
SALL4
sal-like 4 (Drosophila)
chr3_-_114102488 0.408 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr6_+_33387846 0.405 NM_006772
SYNGAP1
synaptic Ras GTPase activating protein 1
chr6_+_167412791 0.402 NM_007045
NM_194429
FGFR1OP

FGFR1 oncogene partner

chr14_+_64682671 0.393 NM_182910
SYNE2
spectrin repeat containing, nuclear envelope 2
chr9_-_126030792 0.389 NM_018387
STRBP
spermatid perinuclear RNA binding protein
chr3_+_185080835 0.388 NM_004721
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr6_+_73076431 0.382 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr2_-_148778262 0.379 NM_001190882
NM_001190879
NM_002552
NM_001190881
NM_181741
ORC4




origin recognition complex, subunit 4




chr14_+_73525187 0.379 NM_021239
RBM25
RNA binding motif protein 25
chr3_+_185000714 0.378 NM_001242314
NM_001242317
MAP3K13

mitogen-activated protein kinase kinase kinase 13

chr15_-_45670955 0.365 NM_001482
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr1_+_110082493 0.362 NM_031936
GPR61
G protein-coupled receptor 61
chr3_+_43328001 0.361 NM_001100594
NM_017719
SNRK

SNF related kinase

chr3_-_114790221 0.358 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr12_-_105629790 0.357 NM_001251904
NM_018171
APPL2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

chr12_-_42538432 0.355 NM_001099650
NM_173601
GXYLT1

glucoside xylosyltransferase 1

chr22_-_41842853 0.354 NM_016272
TOB2
transducer of ERBB2, 2
chr1_-_155532322 0.353 NM_018489
ASH1L
ash1 (absent, small, or homeotic)-like (Drosophila)
chr1_+_57110745 0.352 NM_006252
PRKAA2
protein kinase, AMP-activated, alpha 2 catalytic subunit
chr12_-_24715349 0.350 NM_152989
SOX5
SRY (sex determining region Y)-box 5
chr3_+_14989076 0.349 NM_003298
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr3_+_187871473 0.340 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr4_+_57775064 0.339 NM_001193508
REST
RE1-silencing transcription factor
chr13_-_26795927 0.334 NM_183043
RNF6
ring finger protein (C3H2C3 type) 6
chr14_+_64680858 0.334 NM_182913
SYNE2
spectrin repeat containing, nuclear envelope 2
chr3_+_187930720 0.334 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr4_+_108814419 0.329 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr13_-_26795821 0.326 NM_183044
RNF6
ring finger protein (C3H2C3 type) 6
chr9_-_125027080 0.322 NM_033117
RBM18
RNA binding motif protein 18
chr4_+_108745718 0.320 NM_001136258
SGMS2
sphingomyelin synthase 2
chr18_+_48556483 0.318 NM_005359
SMAD4
SMAD family member 4
chr10_-_94003002 0.300 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chrX_+_122993536 0.296 NM_001204401
NM_001167
XIAP

X-linked inhibitor of apoptosis

chr6_+_107811272 0.295 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr10_-_21814610 0.290 NM_207371
C10orf140
chromosome 10 open reading frame 140
chr5_+_112312392 0.285 NM_001242377
NM_152624
DCP2

DCP2 decapping enzyme homolog (S. cerevisiae)

chr16_-_87525317 0.284 NM_015144
ZCCHC14
zinc finger, CCHC domain containing 14
chr6_+_72596648 0.284 NM_014989
RIMS1
regulating synaptic membrane exocytosis 1
chr3_+_19189969 0.279 NM_144633
KCNH8
potassium voltage-gated channel, subfamily H (eag-related), member 8
chr6_-_119031230 0.279 NM_001178035
CEP85L
centrosomal protein 85kDa-like
chr11_-_130184459 0.278 NM_014155
ZBTB44
zinc finger and BTB domain containing 44
chr18_+_905296 0.270 NM_001117
ADCYAP1
adenylate cyclase activating polypeptide 1 (pituitary)
chr1_+_2985730 0.269 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr17_-_66287256 0.262 NM_001174166
NM_004694
SLC16A6

solute carrier family 16, member 6 (monocarboxylic acid transporter 7)

chr16_-_68482373 0.257 NM_018667
SMPD3
sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
chr1_+_65730423 0.255 NM_014787
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr10_+_115803805 0.255 NM_000684
ADRB1
adrenergic, beta-1-, receptor
chr14_+_64319607 0.254 NM_015180
NM_182914
SYNE2

spectrin repeat containing, nuclear envelope 2

chr4_+_30721865 0.250 NM_032456
NM_001173523
NM_002589
NM_032457
PCDH7



protocadherin 7



chr3_-_114866090 0.249 NM_015642
ZBTB20
zinc finger and BTB domain containing 20
chr5_-_74807448 0.243 NM_005713
NM_031361
COL4A3BP

collagen, type IV, alpha 3 (Goodpasture antigen) binding protein

chr7_+_94536926 0.236 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory subunit 9A

chr4_+_57774035 0.234 NM_005612
REST
RE1-silencing transcription factor
chr1_-_212004113 0.228 NM_014873
LPGAT1
lysophosphatidylglycerol acyltransferase 1
chr5_-_58334936 0.228 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr2_-_70994846 0.226 NM_001185054
ADD2
adducin 2 (beta)
chr5_-_74807805 0.222 NM_001130105
COL4A3BP
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
chr16_+_57126439 0.219 NM_152727
CPNE2
copine II
chr12_-_12419702 0.216 NM_002336
LRP6
low density lipoprotein receptor-related protein 6
chr12_-_23737507 0.214 NM_178010
SOX5
SRY (sex determining region Y)-box 5
chr15_+_52043738 0.209 NM_001142885
NM_014548
TMOD2

tropomodulin 2 (neuronal)

chr7_+_94539209 0.203 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chrX_+_16964730 0.195 NM_001080975
NM_004726
REPS2

RALBP1 associated Eps domain containing 2

chr9_-_127905715 0.195 NM_001144877
NM_173690
SCAI

suppressor of cancer cell invasion

chr1_+_167189948 0.192 NM_001198786
NM_002697
POU2F1

POU class 2 homeobox 1

chr7_+_155089483 0.188 NM_005542
NM_198336
NM_198337
INSIG1


insulin induced gene 1


chr15_+_57210823 0.185 NM_003205
NM_207036
NM_207037
NM_207038
TCF12



transcription factor 12



chr5_-_59783885 0.184 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr4_+_48343502 0.184 NM_020846
SLAIN2
SLAIN motif family, member 2
chr10_-_75173807 0.177 NM_001156
NM_004034
ANXA7

annexin A7

chr7_-_5463176 0.175 NM_001080495
TNRC18
trinucleotide repeat containing 18
chr5_+_78531848 0.172 NM_152405
JMY
junction mediating and regulatory protein, p53 cofactor
chr8_-_22550708 0.172 NM_004430
EGR3
early growth response 3
chr2_-_16847070 0.172 NM_030797
FAM49A
family with sequence similarity 49, member A
chr13_-_26796343 0.169 NM_005977
RNF6
ring finger protein (C3H2C3 type) 6
chr11_-_86666211 0.169 NM_012193
FZD4
frizzled family receptor 4
chr11_-_72852957 0.169 NM_014824
FCHSD2
FCH and double SH3 domains 2
chr3_-_128206704 0.168 NM_001145662
GATA2
GATA binding protein 2
chr11_+_9595183 0.165 NM_003390
WEE1
WEE1 homolog (S. pombe)
chr2_-_114514196 0.162 NM_025181
SLC35F5
solute carrier family 35, member F5
chr2_-_68547018 0.162 NM_001111101
NM_015463
CNRIP1

cannabinoid receptor interacting protein 1

chr1_+_167298280 0.159 NM_001198783
POU2F1
POU class 2 homeobox 1
chr5_+_142150291 0.155 NM_001135608
NM_015071
ARHGAP26

Rho GTPase activating protein 26

chr14_-_93799371 0.153 NM_001002860
NM_018167
BTBD7

BTB (POZ) domain containing 7

chr8_+_17013799 0.152 NM_016353
ZDHHC2
zinc finger, DHHC-type containing 2
chr12_+_72666462 0.146 NM_013381
TRHDE
thyrotropin-releasing hormone degrading enzyme
chr6_-_38607923 0.145 NM_001099272
NM_052893
BTBD9

BTB (POZ) domain containing 9

chr12_-_49449106 0.142 NM_003482
MLL2
myeloid/lymphoid or mixed-lineage leukemia 2
chr6_-_86352635 0.139 NM_001159673
SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr19_+_1285766 0.139 NM_001405
EFNA2
ephrin-A2
chr1_-_31230673 0.137 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chr15_+_64791618 0.136 NM_015042
ZNF609
zinc finger protein 609
chrX_-_54209639 0.135 NM_017848
NM_198456
FAM120C

family with sequence similarity 120C

chrX_-_135338640 0.133 NM_001173516
MAP7D3
MAP7 domain containing 3
chr16_+_75032874 0.133 NM_032268
ZNRF1
zinc and ring finger 1
chr4_-_170924911 0.131 NM_001009554
MFAP3L
microfibrillar-associated protein 3-like
chr15_+_65822738 0.124 NM_016395
PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr8_+_132916339 0.124 NM_015137
EFR3A
EFR3 homolog A (S. cerevisiae)
chr6_-_109703703 0.123 NM_001142401
NM_001142402
NM_001142403
NM_001142404
NM_006016
CD164




CD164 molecule, sialomucin




chr15_-_23932410 0.120 NM_002487
NDN
necdin homolog (mouse)
chr6_-_107435635 0.120 NM_001080450
BEND3
BEN domain containing 3
chr11_-_6255891 0.119 NM_001098794
NM_032127
FAM160A2

family with sequence similarity 160, member A2

chr11_+_86511490 0.116 NM_007173
PRSS23
protease, serine, 23
chr3_-_125094003 0.115 NM_021964
ZNF148
zinc finger protein 148
chr3_+_69812961 0.114 NM_006722
MITF
microphthalmia-associated transcription factor
chr16_+_69796237 0.114 NM_007014
NM_199423
WWP2

WW domain containing E3 ubiquitin protein ligase 2

chr2_-_70995113 0.114 NM_001185055
NM_001617
NM_017482
NM_017488
ADD2



adducin 2 (beta)



chr19_-_47617008 0.112 NM_015168
ZC3H4
zinc finger CCCH-type containing 4
chr12_+_72233486 0.112 NM_001146213
NM_001146214
NM_022771
TBC1D15


TBC1 domain family, member 15


chr8_+_61591239 0.110 NM_017780
CHD7
chromodomain helicase DNA binding protein 7
chr6_-_38563763 0.109 NM_001172418
NM_152733
BTBD9

BTB (POZ) domain containing 9

chr6_-_86352564 0.109 NM_001159674
NM_001253771
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr11_-_30038487 0.108 NM_002233
KCNA4
potassium voltage-gated channel, shaker-related subfamily, member 4
chr3_+_30647901 0.107 NM_001024847
NM_003242
TGFBR2

transforming growth factor, beta receptor II (70/80kDa)

chr2_-_60780404 0.106 NM_018014
NM_022893
NM_138559
BCL11A


B-cell CLL/lymphoma 11A (zinc finger protein)


chr5_-_56247915 0.106 NM_152622
MIER3
mesoderm induction early response 1, family member 3
chr6_-_118973019 0.106 NM_001042475
NM_206921
CEP85L

centrosomal protein 85kDa-like

chr4_+_38665587 0.104 NM_016531
KLF3
Kruppel-like factor 3 (basic)
chr2_-_198175494 0.102 NM_001195144
NM_153697
ANKRD44

ankyrin repeat domain 44

chr5_+_65440662 0.102 NM_139168
SREK1
splicing regulatory glutamine/lysine-rich protein 1
chr11_-_124806302 0.100 NM_152722
HEPACAM
hepatic and glial cell adhesion molecule
chr3_+_29322802 0.100 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr3_+_69788562 0.099 NM_198159
MITF
microphthalmia-associated transcription factor
chr12_+_94542239 0.098 NM_005761
PLXNC1
plexin C1
chr9_-_88714486 0.097 NM_016548
GOLM1
golgi membrane protein 1
chr3_-_169381417 0.096 NM_001205194
NM_004991
MECOM

MDS1 and EVI1 complex locus

chr6_-_86351156 0.096 NM_001159675
NM_001159676
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr1_+_29562947 0.094 NM_001195001
NM_005704
NM_133177
NM_133178
PTPRU



protein tyrosine phosphatase, receptor type, U



chr5_-_76934508 0.094 NM_032109
OTP
orthopedia homeobox
chr18_+_904943 0.093 NM_001099733
ADCYAP1
adenylate cyclase activating polypeptide 1 (pituitary)
chr1_-_42800623 0.091 NM_001198851
FOXJ3
forkhead box J3
chr1_+_178995055 0.091 NM_014864
FAM20B
family with sequence similarity 20, member B
chr3_+_69915374 0.090 NM_198177
MITF
microphthalmia-associated transcription factor
chr3_-_116164363 0.089 NM_002338
LSAMP
limbic system-associated membrane protein
chr3_+_69812620 0.089 NM_001184967
MITF
microphthalmia-associated transcription factor
chr3_-_18466759 0.088 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr4_-_170947428 0.087 NM_021647
MFAP3L
microfibrillar-associated protein 3-like
chr1_-_225840660 0.086 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr15_+_57511616 0.085 NM_207040
TCF12
transcription factor 12

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.80 3.20e-04 GO:0006357 regulation of transcription from RNA polymerase II promoter
2.02 7.45e-04 GO:0051252 regulation of RNA metabolic process
3.00 9.69e-04 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.21 1.49e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.89 1.63e-03 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.91 1.67e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.71 3.37e-03 GO:0080090 regulation of primary metabolic process
1.83 4.13e-03 GO:0051171 regulation of nitrogen compound metabolic process
3.00 4.66e-03 GO:0051254 positive regulation of RNA metabolic process
1.69 5.45e-03 GO:0031323 regulation of cellular metabolic process
2.97 5.45e-03 GO:0010628 positive regulation of gene expression
3.43 5.78e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.93 7.89e-03 GO:0006355 regulation of transcription, DNA-dependent
1.62 9.60e-03 GO:0019222 regulation of metabolic process
1.83 1.10e-02 GO:0010468 regulation of gene expression
11.18 1.42e-02 GO:0060021 palate development
1.67 2.18e-02 GO:0060255 regulation of macromolecule metabolic process
2.69 2.51e-02 GO:0010557 positive regulation of macromolecule biosynthetic process
1.37 4.66e-02 GO:0050794 regulation of cellular process
5.35 4.80e-02 GO:0051099 positive regulation of binding

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.50 9.80e-04 GO:0030528 transcription regulator activity
2.81 2.59e-03 GO:0043565 sequence-specific DNA binding
2.30 1.32e-02 GO:0001071 nucleic acid binding transcription factor activity
2.30 1.32e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.59 2.01e-02 GO:0003676 nucleic acid binding
1.74 2.38e-02 GO:0003677 DNA binding
1.17 3.51e-02 GO:0005488 binding