Motif ID: GTF2A1,2.p2

Z-value: 1.586


Transcription factors associated with GTF2A1,2.p2:

Gene SymbolEntrez IDGene Name
GTF2A1 2957 general transcription factor IIA, 1, 19/37kDa
GTF2A2 2958 general transcription factor IIA, 2, 12kDa

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GTF2A2chr15_-_59949536-0.451.3e-02Click!
GTF2A1chr14_-_816872650.038.9e-01Click!


Activity profile for motif GTF2A1,2.p2.

activity profile for motif GTF2A1,2.p2


Sorted Z-values histogram for motif GTF2A1,2.p2

Sorted Z-values for motif GTF2A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2A1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_153013593 6.080 NM_006945
SPRR2D
small proline-rich protein 2D
chr15_-_74495093 5.642 NM_001199042
NM_022369
STRA6

stimulated by retinoic acid gene 6 homolog (mouse)

chr2_-_31440378 5.582 NM_001145122
CAPN14
calpain 14
chr12_+_53491417 5.158 NM_002178
IGFBP6
insulin-like growth factor binding protein 6
chr15_-_74495528 5.073 NM_001142618
STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr1_-_153044083 5.011 NM_001017418
SPRR2B
small proline-rich protein 2B
chr1_-_153067000 4.477 NM_001024209
SPRR2E
small proline-rich protein 2E
chr12_+_53491448 4.422 IGFBP6
insulin-like growth factor binding protein 6
chr7_-_41742666 4.291 NM_002192
INHBA
inhibin, beta A
chr7_+_100770378 3.964 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr10_-_5541401 3.790 NM_017422
CALML5
calmodulin-like 5
chr22_+_30792929 3.672 NM_001204204
NM_012429
NM_033382
SEC14L2


SEC14-like 2 (S. cerevisiae)


chr9_+_131191206 3.415 CERCAM
cerebral endothelial cell adhesion molecule
chr1_-_153085963 3.369 NM_001014450
SPRR2A
SPRR2F
small proline-rich protein 2A
small proline-rich protein 2F
chr19_-_43032525 3.206 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001205344
NM_001712
CEACAM1





carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)





chr8_-_23177481 3.132 LOXL2
lysyl oxidase-like 2
chr21_-_28217692 3.099 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr11_+_130318457 3.096 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr9_-_136242925 3.088 SURF4
surfeit 4
chr19_+_48828627 3.022 NM_001425
EMP3
epithelial membrane protein 3
chr19_-_51487070 3.010 NM_139277
NM_001207053
NM_001243126
NM_005046
KLK7



kallikrein-related peptidase 7



chr20_+_56285213 2.993


chr12_+_41086189 2.932 NM_001843
NM_175038
CNTN1

contactin 1

chr20_+_3776905 2.893 CDC25B
cell division cycle 25 homolog B (S. pombe)
chr4_-_47983430 2.805 NM_001142564
CNGA1
cyclic nucleotide gated channel alpha 1
chr3_+_100328432 2.720 NM_032787
GPR128
G protein-coupled receptor 128
chr12_+_13349601 2.719 NM_001423
EMP1
epithelial membrane protein 1
chr22_+_31487315 2.660 SMTN
smoothelin
chr12_-_76425207 2.602 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr9_-_33167166 2.493 B4GALT1
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
chr15_+_59908908 2.344 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr16_+_55515468 2.334 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr19_-_45909566 2.332 NM_001142502
PPP1R13L
protein phosphatase 1, regulatory subunit 13 like
chr20_-_56285576 2.332 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr5_-_39203061 2.321 FYB
FYN binding protein
chr2_+_75061234 2.261 HK2
hexokinase 2
chr20_-_56284945 2.256 NM_020182
PMEPA1
prostate transmembrane protein, androgen induced 1
chr19_+_17666381 2.225 GLT25D1
glycosyltransferase 25 domain containing 1
chr3_-_48130633 2.204 NM_001134364
NM_002375
NM_030885
MAP4


microtubule-associated protein 4


chr19_+_41725098 2.187 NM_001699
NM_021913
AXL

AXL receptor tyrosine kinase

chr3_-_48130283 2.169 MAP4
microtubule-associated protein 4
chr19_-_44031310 2.161 NM_014297
ETHE1
ethylmalonic encephalopathy 1
chr15_-_73661141 2.154 HCN4
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chr1_+_209859524 2.153 NM_001206741
NM_181755
HSD11B1

hydroxysteroid (11-beta) dehydrogenase 1

chr22_-_30685485 2.129 NM_001037666
GATSL3
GATS protein-like 3
chrX_+_149009940 2.111 NM_001166400
NM_001166401
NM_005364
MAGEA8


melanoma antigen family A, 8


chr17_-_80009237 2.042 RFNG
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr3_+_50304989 1.941 NM_001005914
NM_004636
SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

chr9_-_33167084 1.927 B4GALT1
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
chr21_-_28217272 1.925 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr2_+_28616360 1.906 FOSL2
FOS-like antigen 2
chr9_+_131182690 1.894 NM_016174
CERCAM
cerebral endothelial cell adhesion molecule
chr2_-_96781887 1.858 NM_000682
ADRA2B
adrenergic, alpha-2B-, receptor
chr19_-_46999149 1.851 NM_020709
PNMAL2
PNMA-like 2
chr3_-_42843217 1.843


chr14_+_75745480 1.839 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr9_+_116263706 1.796 NM_130795
RGS3
regulator of G-protein signaling 3
chr8_-_21998994 1.748 NM_025232
REEP4
receptor accessory protein 4
chr2_+_28616346 1.741 FOSL2
FOS-like antigen 2
chr17_+_48133331 1.732 NM_002204
NM_005501
ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr19_-_55660557 1.652 NM_001126132
NM_001126133
NM_003283
TNNT1


troponin T type 1 (skeletal, slow)


chr15_+_81071708 1.645 NM_018689
KIAA1199
KIAA1199
chr16_+_66637934 1.625 CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr20_+_3776385 1.617 NM_004358
NM_021872
NM_021873
CDC25B


cell division cycle 25 homolog B (S. pombe)


chr4_+_6695565 1.605 NM_005980
S100P
S100 calcium binding protein P
chr19_-_51504799 1.592 NM_007196
NM_144505
NM_144506
NM_144507
KLK8



kallikrein-related peptidase 8



chr17_+_40610875 1.587 ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr2_-_161056573 1.577 NM_000888
ITGB6
integrin, beta 6
chr11_-_117166247 1.576 NM_001207048
NM_001207049
BACE1

beta-site APP-cleaving enzyme 1

chr17_+_40610897 1.570 ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr15_-_74494780 1.562 STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr17_+_48133357 1.556 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr9_+_131644368 1.543 NM_001127245
NM_019594
LRRC8A

leucine rich repeat containing 8 family, member A

chr9_-_136242933 1.535 SURF4
surfeit 4
chr12_-_76425375 1.531 NM_007350
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr9_-_136344182 1.523 NM_001145099
NM_017585
SLC2A6

solute carrier family 2 (facilitated glucose transporter), member 6

chr16_+_23690212 1.517 PLK1
polo-like kinase 1
chr19_+_6739697 1.506 NM_004240
TRIP10
thyroid hormone receptor interactor 10
chr6_-_35696359 1.500 NM_001145775
FKBP5
FK506 binding protein 5
chr2_-_31637598 1.497 NM_000379
XDH
xanthine dehydrogenase
chr13_+_53035227 1.484 CKAP2
cytoskeleton associated protein 2
chr17_+_40610940 1.474 ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr7_-_99699426 1.470 NM_005916
MCM7
minichromosome maintenance complex component 7
chr3_-_149086884 1.459 TM4SF1
transmembrane 4 L six family member 1
chr6_+_106546736 1.458 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr1_-_24469571 1.446 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr2_+_28615695 1.444 FOSL2
FOS-like antigen 2
chr15_+_59908724 1.409 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr3_+_121796695 1.406 NM_006889
NM_176892
CD86

CD86 molecule

chr12_-_49504337 1.391 LMBR1L
limb region 1 homolog (mouse)-like
chr22_+_22758538 1.385


chr16_-_71264596 1.358 NM_001198542
NM_001198543
HYDIN

hydrocephalus inducing homolog (mouse)

chr10_-_129924467 1.355 NM_001145966
NM_002417
MKI67

antigen identified by monoclonal antibody Ki-67

chr15_+_39873276 1.339 NM_003246
THBS1
thrombospondin 1
chr1_-_168105620 1.322 NM_153832
GPR161
G protein-coupled receptor 161
chr12_-_8088629 1.301 NM_006931
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
chr9_+_131644427 1.294 LRRC8A
leucine rich repeat containing 8 family, member A
chr19_+_17666457 1.294 GLT25D1
glycosyltransferase 25 domain containing 1
chr16_+_3162555 1.289 NM_001042428
NM_003456
ZNF205

zinc finger protein 205

chr12_-_52715140 1.284 NM_002282
KRT83
keratin 83
chr19_+_48828820 1.283 EMP3
epithelial membrane protein 3
chr17_-_80009649 1.276 NM_002917
RFNG
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr17_+_40610857 1.251 NM_001130020
NM_001130021
NM_005177
ATP6V0A1


ATPase, H+ transporting, lysosomal V0 subunit a1


chr2_+_28615771 1.240 NM_005253
FOSL2
FOS-like antigen 2
chr11_+_66024746 1.229 NM_001134775
KLC2
kinesin light chain 2
chr1_+_17531619 1.229 NM_013358
PADI1
peptidyl arginine deiminase, type I
chr9_-_104145800 1.222 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr5_+_60933635 1.218 NM_173667
C5orf64
chromosome 5 open reading frame 64
chr7_-_143105897 1.199 NM_005232
EPHA1
EPH receptor A1
chr12_+_13349720 1.189 EMP1
epithelial membrane protein 1
chr17_+_40610899 1.184 ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr10_-_17659365 1.180 NM_014241
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr6_-_41130820 1.173 TREM2
triggering receptor expressed on myeloid cells 2
chrX_+_49832214 1.169 NM_000084
CLCN5
chloride channel 5
chr4_+_177241109 1.164 SPCS3
signal peptidase complex subunit 3 homolog (S. cerevisiae)
chrX_+_134555867 1.161 LINC00086
long intergenic non-protein coding RNA 86
chr1_-_24126891 1.160 NM_000403
GALE
UDP-galactose-4-epimerase
chr6_-_111888520 1.158 NM_001164283
TRAF3IP2
TRAF3 interacting protein 2
chrX_+_99899388 1.156 SRPX2
sushi-repeat containing protein, X-linked 2
chr19_-_7058644 1.153 NM_001164425
MBD3L3
methyl-CpG binding domain protein 3-like 3
chr9_-_136242969 1.152 NM_033161
SURF4
surfeit 4
chr9_-_136242818 1.148 SURF4
surfeit 4
chr15_-_74494851 1.133 STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chrX_-_132095422 1.125 NM_001077188
NM_147175
HS6ST2

heparan sulfate 6-O-sulfotransferase 2

chr20_-_35201677 1.124


chrX_-_106960268 1.124 NM_004089
TSC22D3
TSC22 domain family, member 3
chr1_-_155939051 1.123 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr21_+_39628663 1.120 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr19_-_11266451 1.119 NM_182513
SPC24
SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr11_-_64825992 1.102 NM_005468
NAALADL1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr7_+_74188308 1.101 NM_000265
NCF1
NCF1B
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
chr12_+_12509947 1.100 NM_058169
LOH12CR1
loss of heterozygosity, 12, chromosomal region 1
chr17_-_48278987 1.096 NM_000088
COL1A1
collagen, type I, alpha 1
chr20_+_59827452 1.096 NM_001794
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chrX_-_48327739 1.093 SLC38A5
solute carrier family 38, member 5
chr3_-_119812512 1.092 GSK3B
glycogen synthase kinase 3 beta
chr12_+_113796370 1.092 NM_001159727
NM_173542
PLBD2

phospholipase B domain containing 2

chr1_+_111770280 1.085 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr6_-_41130864 1.083 TREM2
triggering receptor expressed on myeloid cells 2
chr1_+_205473768 1.078 CDK18
cyclin-dependent kinase 18
chr6_+_26273143 1.078 NM_003525
HIST1H2BI
histone cluster 1, H2bi
chr5_-_134369841 1.057 NM_002653
PITX1
paired-like homeodomain 1
chr1_+_205473683 1.056 NM_002596
NM_212502
NM_212503
CDK18


cyclin-dependent kinase 18


chr16_-_4562979 1.052 C16orf5
chromosome 16 open reading frame 5
chr17_+_7210929 1.048 EIF5A
eukaryotic translation initiation factor 5A
chr3_+_121774208 1.043 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr15_-_76005179 1.042 NM_001897
CSPG4
chondroitin sulfate proteoglycan 4
chr15_-_63673918 1.038 CA12
carbonic anhydrase XII
chr8_+_128748476 1.037 MYC
v-myc myelocytomatosis viral oncogene homolog (avian)
chr1_+_24645914 1.037 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr22_+_25003610 1.032 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr19_+_46010685 1.030 NM_003370
VASP
vasodilator-stimulated phosphoprotein
chr5_-_134369571 1.029 PITX1
paired-like homeodomain 1
chr4_-_57547845 1.025 NM_001145460
NM_032495
NM_139212
HOPX


HOP homeobox


chr11_-_111782447 1.016 NM_001885
CRYAB
crystallin, alpha B
chr5_+_147443534 1.016 NM_001127698
NM_001127699
NM_006846
SPINK5


serine peptidase inhibitor, Kazal type 5


chr17_+_17206626 1.016 NM_020201
NT5M
5',3'-nucleotidase, mitochondrial
chr4_+_115519557 1.014 NM_001128174
UGT8
UDP glycosyltransferase 8
chr17_-_1389013 1.008 NM_001080950
MYO1C
myosin IC
chr19_+_42212525 1.005 NM_004363
CEACAM5
carcinoembryonic antigen-related cell adhesion molecule 5
chr14_+_24563369 1.001 NM_001018073
NM_004563
PCK2

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

chr3_-_197025411 0.999 NM_001098424
NM_001204386
NM_004087
DLG1


discs, large homolog 1 (Drosophila)


chr19_-_42192095 0.998 NM_006890
CEACAM7
carcinoembryonic antigen-related cell adhesion molecule 7
chr17_-_39092714 0.994 KRT23
keratin 23 (histone deacetylase inducible)
chr19_+_46010748 0.980 VASP
vasodilator-stimulated phosphoprotein
chrX_+_135251454 0.979 NM_001159704
FHL1
four and a half LIM domains 1
chr11_-_124310980 0.973 NM_012378
OR8B8
olfactory receptor, family 8, subfamily B, member 8
chr2_+_27301434 0.972 NM_007046
EMILIN1
elastin microfibril interfacer 1
chr1_+_107683548 0.972 NTNG1
netrin G1
chr15_+_55611132 0.972 NM_004855
PIGB
phosphatidylinositol glycan anchor biosynthesis, class B
chr1_+_32050510 0.968 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr13_+_111154013 0.965 COL4A2
collagen, type IV, alpha 2
chr16_+_23690234 0.965 PLK1
polo-like kinase 1
chr14_-_55658205 0.965 NM_001146015
NM_014750
DLGAP5

discs, large (Drosophila) homolog-associated protein 5

chr11_+_117049838 0.956 NM_001040455
SIDT2
SID1 transmembrane family, member 2
chr11_-_64646053 0.951 NM_006795
EHD1
EH-domain containing 1
chr3_-_50358855 0.950 HYAL2
hyaluronoglucosaminidase 2
chr17_-_26697293 0.947 VTN
vitronectin
chr20_+_43803539 0.942 NM_002638
PI3
peptidase inhibitor 3, skin-derived
chr1_-_153581415 0.937 S100A16
S100 calcium binding protein A16
chr1_-_204120909 0.936 ETNK2
ethanolamine kinase 2
chr2_-_50574891 0.934 NM_138735
NRXN1
neurexin 1
chr15_-_74659926 0.928 NM_000781
CYP11A1
cytochrome P450, family 11, subfamily A, polypeptide 1
chrX_+_99899162 0.925 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr11_+_61008643 0.923 NM_014224
PGA5
pepsinogen 5, group I (pepsinogen A)
chr2_+_74120132 0.923 ACTG2
actin, gamma 2, smooth muscle, enteric
chr1_+_84630014 0.921 NM_001242857
NM_001242858
NM_001242859
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr5_-_114938060 0.913 NM_021649
TICAM2
toll-like receptor adaptor molecule 2
chr2_-_9563584 0.912 ITGB1BP1
integrin beta 1 binding protein 1
chr19_-_39264144 0.911 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr11_+_66025070 0.905 NM_001134776
NM_001134774
NM_022822
KLC2


kinesin light chain 2


chr3_-_145878775 0.903 PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr2_-_208031570 0.903 KLF7
Kruppel-like factor 7 (ubiquitous)
chr5_-_177423242 0.895 NM_006261
PROP1
PROP paired-like homeobox 1
chr17_-_26697224 0.894 VTN
vitronectin
chr2_+_74120092 0.893 NM_001199893
NM_001615
ACTG2

actin, gamma 2, smooth muscle, enteric

chr9_-_95527002 0.891 NM_001003800
NM_015250
BICD2

bicaudal D homolog 2 (Drosophila)

chr3_-_99594915 0.890 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr12_+_130647002 0.879 NM_007197
FZD10
frizzled family receptor 10
chr12_+_113796374 0.875 PLBD2
phospholipase B domain containing 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.67 1.33e-06 GO:0009611 response to wounding
1.16 2.84e-06 GO:0065007 biological regulation
1.09 2.40e-05 GO:0009987 cellular process
1.26 2.41e-05 GO:0023052 signaling
2.12 4.61e-05 GO:0030029 actin filament-based process
1.76 5.01e-05 GO:0042060 wound healing
1.81 1.10e-04 GO:0007596 blood coagulation
1.81 1.10e-04 GO:0050817 coagulation
1.33 1.11e-04 GO:0006950 response to stress
1.75 1.33e-04 GO:0050878 regulation of body fluid levels
1.80 1.50e-04 GO:0007599 hemostasis
1.47 2.69e-04 GO:0002376 immune system process
1.26 3.91e-04 GO:0048856 anatomical structure development
1.18 5.86e-04 GO:0032501 multicellular organismal process
1.33 7.18e-04 GO:0065008 regulation of biological quality
2.08 1.02e-03 GO:0030036 actin cytoskeleton organization
1.27 1.72e-03 GO:0048731 system development
1.22 1.74e-03 GO:0032502 developmental process
1.48 2.73e-03 GO:0007154 cell communication
1.15 2.93e-03 GO:0050896 response to stimulus
1.23 4.46e-03 GO:0007275 multicellular organismal development
1.22 8.12e-03 GO:0007165 signal transduction
1.12 1.11e-02 GO:0050789 regulation of biological process
1.67 1.14e-02 GO:0007010 cytoskeleton organization
2.71 4.20e-02 GO:0002576 platelet degranulation
1.18 4.26e-02 GO:0051716 cellular response to stimulus
1.47 4.58e-02 GO:0006952 defense response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.45 2.29e-09 GO:0005576 extracellular region
1.56 2.33e-06 GO:0044421 extracellular region part
3.05 1.64e-05 GO:0001726 ruffle
2.27 1.05e-04 GO:0031252 cell leading edge
1.50 2.24e-03 GO:0005615 extracellular space
2.88 6.41e-03 GO:0031256 leading edge membrane
1.43 9.87e-03 GO:0042995 cell projection
1.66 1.61e-02 GO:0031012 extracellular matrix
1.71 2.38e-02 GO:0005578 proteinaceous extracellular matrix
6.46 3.34e-02 GO:0005952 cAMP-dependent protein kinase complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 2.91e-04 GO:0005515 protein binding
1.62 2.98e-03 GO:0008092 cytoskeletal protein binding
1.06 1.69e-02 GO:0005488 binding
1.70 4.35e-02 GO:0003779 actin binding