Motif ID: GTF2I.p2

Z-value: 1.531


Transcription factors associated with GTF2I.p2:

Gene SymbolEntrez IDGene Name
GTF2I 2969 general transcription factor II, i

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GTF2Ichr7_+_74072038-0.469.7e-03Click!


Activity profile for motif GTF2I.p2.

activity profile for motif GTF2I.p2


Sorted Z-values histogram for motif GTF2I.p2

Sorted Z-values for motif GTF2I.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2I.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51487070 11.366 NM_139277
NM_001207053
NM_001243126
NM_005046
KLK7



kallikrein-related peptidase 7



chr19_-_51472003 7.801 NM_001012964
NM_001012965
KLK6

kallikrein-related peptidase 6

chr19_-_51472816 6.602 NM_002774
KLK6
kallikrein-related peptidase 6
chr1_-_20812271 4.904 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr9_+_128509616 4.091 NM_006195
PBX3
pre-B-cell leukemia homeobox 3
chr19_+_35646006 3.665 FXYD5
FXYD domain containing ion transport regulator 5
chr19_-_41859519 3.430 TGFB1
transforming growth factor, beta 1
chr19_-_41859830 3.399 NM_000660
TGFB1
transforming growth factor, beta 1
chr11_-_123065836 3.371 CLMP
CXADR-like membrane protein
chr1_-_20812727 3.197 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr11_-_2160199 3.030 NM_000612
IGF2
insulin-like growth factor 2 (somatomedin A)
chr19_-_51504799 2.948 NM_007196
NM_144505
NM_144506
NM_144507
KLK8



kallikrein-related peptidase 8



chr6_-_30655078 2.806 NM_001134870
PPP1R18
protein phosphatase 1, regulatory subunit 18
chr19_-_41859332 2.738 TGFB1
transforming growth factor, beta 1
chr2_-_72374919 2.727 NM_019885
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr6_-_30654978 2.720 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr21_-_28217692 2.515 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr11_-_2159472 2.500 IGF2
insulin-like growth factor 2 (somatomedin A)
chr11_-_123065988 2.471 NM_024769
CLMP
CXADR-like membrane protein
chr19_-_41933255 2.426



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 208 entries
enrichment   p-value GO term description
2.37 4.27e-02 GO:0043588 skin development
1.91 1.87e-03 GO:0030100 regulation of endocytosis
1.89 1.13e-02 GO:0022612 gland morphogenesis
1.87 2.15e-02 GO:2000027 regulation of organ morphogenesis
1.75 2.78e-04 GO:0060627 regulation of vesicle-mediated transport
1.71 3.67e-03 GO:0010975 regulation of neuron projection development
1.70 1.00e-05 GO:0048732 gland development
1.70 6.37e-03 GO:0010959 regulation of metal ion transport
1.69 1.03e-04 GO:0030900 forebrain development
1.68 1.06e-03 GO:0031344 regulation of cell projection organization
1.66 3.05e-03 GO:0045165 cell fate commitment
1.65 1.46e-03 GO:0051272 positive regulation of cellular component movement
1.65 5.12e-03 GO:0034330 cell junction organization
1.65 2.59e-02 GO:0022604 regulation of cell morphogenesis
1.64 4.45e-02 GO:0007050 cell cycle arrest
1.63 3.37e-03 GO:0070482 response to oxygen levels
1.63 4.32e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.62 6.45e-07 GO:0051270 regulation of cellular component movement
1.62 8.25e-03 GO:0001666 response to hypoxia
1.61 7.93e-03 GO:0040017 positive regulation of locomotion

Gene overrepresentation in compartment category:

Showing 1 to 20 of 40 entries
enrichment   p-value GO term description
2.15 9.91e-03 GO:0042734 presynaptic membrane
1.82 1.69e-03 GO:0030027 lamellipodium
1.76 1.22e-02 GO:0014069 postsynaptic density
1.64 7.31e-03 GO:0030662 coated vesicle membrane
1.56 1.12e-03 GO:0030424 axon
1.56 1.24e-03 GO:0031252 cell leading edge
1.56 1.89e-03 GO:0043025 neuronal cell body
1.52 7.41e-03 GO:0044297 cell body
1.49 4.68e-07 GO:0043005 neuron projection
1.49 7.50e-05 GO:0044456 synapse part
1.48 1.31e-02 GO:0030425 dendrite
1.45 5.42e-06 GO:0045202 synapse
1.45 1.12e-03 GO:0012506 vesicle membrane
1.44 3.49e-04 GO:0044433 cytoplasmic vesicle part
1.44 3.16e-03 GO:0030659 cytoplasmic vesicle membrane
1.42 3.47e-03 GO:0015629 actin cytoskeleton
1.35 4.83e-05 GO:0030054 cell junction
1.35 6.40e-03 GO:0009986 cell surface
1.32 3.54e-02 GO:0031012 extracellular matrix
1.31 3.39e-06 GO:0042995 cell projection

Gene overrepresentation in function category:

Showing 1 to 19 of 19 entries
enrichment   p-value GO term description
1.56 2.34e-02 GO:0003714 transcription corepressor activity
1.43 2.11e-09 GO:0043565 sequence-specific DNA binding
1.39 2.75e-04 GO:0019904 protein domain specific binding
1.39 1.13e-02 GO:0016563 transcription activator activity
1.38 2.51e-02 GO:0022836 gated channel activity
1.36 3.43e-02 GO:0003779 actin binding
1.34 7.63e-03 GO:0004674 protein serine/threonine kinase activity
1.33 2.10e-08 GO:0030528 transcription regulator activity
1.33 3.38e-08 GO:0001071 nucleic acid binding transcription factor activity
1.33 3.38e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
1.33 2.34e-04 GO:0004672 protein kinase activity
1.31 5.72e-03 GO:0008092 cytoskeletal protein binding
1.30 1.48e-04 GO:0019899 enzyme binding
1.29 5.63e-04 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.26 1.37e-04 GO:0005102 receptor binding
1.25 6.66e-03 GO:0016301 kinase activity
1.23 4.27e-02 GO:0042802 identical protein binding
1.17 7.31e-29 GO:0005515 protein binding
1.08 1.62e-16 GO:0005488 binding