Motif ID: GUCAGUU

Z-value: 0.607


Mature miRNA associated with seed GUCAGUU:

NamemiRBase Accession
hsa-miR-223 MIMAT0000280



Activity profile for motif GUCAGUU.

activity profile for motif GUCAGUU


Sorted Z-values histogram for motif GUCAGUU

Sorted Z-values for motif GUCAGUU



Network of associatons between targets according to the STRING database.



First level regulatory network of GUCAGUU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_63638343 2.571 NM_001080537
SNTN
sentan, cilia apical structure protein
chr1_+_205538111 1.185 NM_181644
MFSD4
major facilitator superfamily domain containing 4
chr17_+_53342320 1.163 NM_002126
HLF
hepatic leukemia factor
chr16_+_19467771 1.081 NM_024780
TMC5
transmembrane channel-like 5
chr1_+_61547625 0.949 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr20_-_39317875 0.940 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr15_-_68498373 0.905 NM_001031733
NM_033429
CALML4

calmodulin-like 4

chr1_+_61542928 0.884 NM_001145511
NFIA
nuclear factor I/A
chr1_-_183622447 0.878 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr16_+_19422056 0.874 NM_001105248
NM_001105249
TMC5

transmembrane channel-like 5

chr1_+_118148506 0.810 NM_017709
FAM46C
family with sequence similarity 46, member C
chr8_+_17354562 0.798 NM_001008539
SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr11_+_73357222 0.795 NM_001130033
NM_021200
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr13_+_24734788 0.777 NM_001166271
NM_153023
SPATA13

spermatogenesis associated 13

chr11_+_73358593 0.761 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr11_+_73359734 0.761 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr1_+_61547388 0.755 NM_001145512
NFIA
nuclear factor I/A
chr5_+_140186658 0.699 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr5_+_140254930 0.698 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chr5_+_140213968 0.689 NM_018910
NM_031852
PCDHA7

protocadherin alpha 7

chr1_+_78956727 0.674 NM_000959
NM_001039585
PTGFR

prostaglandin F receptor (FP)

chr5_+_140220811 0.667 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr14_+_67999915 0.663 NM_020715
PLEKHH1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr4_+_72052354 0.653 NM_001098484
NM_001134742
SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr1_-_46598250 0.642 NM_003629
NM_001114172
PIK3R3

phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

chr8_+_17396285 0.642 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr5_-_41261539 0.629 NM_001115131
C6
complement component 6
chr17_+_4981721 0.607 NM_153018
ZFP3
zinc finger protein 3 homolog (mouse)
chr15_+_82555101 0.593 NM_001008226
FAM154B
family with sequence similarity 154, member B
chr5_-_41213513 0.589 NM_000065
C6
complement component 6
chr11_-_34535302 0.573 NM_001243080
NM_001422
ELF5

E74-like factor 5 (ets domain transcription factor)

chr11_-_33891361 0.568 NM_001142316
LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_-_33891485 0.568 NM_001142315
LMO2
LIM domain only 2 (rhombotin-like 1)
chr1_+_20512577 0.559 NM_152376
UBXN10
UBX domain protein 10
chr20_-_4982133 0.553 NM_005116
SLC23A2
solute carrier family 23 (nucleobase transporters), member 2
chr14_-_93673360 0.546 NM_032490
C14orf142
chromosome 14 open reading frame 142
chr2_-_86564632 0.546 NM_001164731
NM_001164732
NM_022912
REEP1


receptor accessory protein 1


chr5_+_140247767 0.545 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr11_-_34533117 0.536 NM_001243081
NM_198381
ELF5

E74-like factor 5 (ets domain transcription factor)

chr6_-_46138584 0.523 NM_021572
ENPP5
ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)
chr2_-_86565205 0.523 NM_001164730
REEP1
receptor accessory protein 1
chr3_-_37034609 0.513 NM_014805
EPM2AIP1
EPM2A (laforin) interacting protein 1
chr1_-_109969058 0.500 NM_001199772
NM_002790
NM_001199773
NM_001199774
PSMA5



proteasome (prosome, macropain) subunit, alpha type, 5



chr1_-_92351613 0.497 NM_001195683
NM_003243
TGFBR3

transforming growth factor, beta receptor III

chr8_-_102217907 0.452 NM_001042510
NM_016096
ZNF706

zinc finger protein 706

chr6_+_36164528 0.452 NM_015695
BRPF3
bromodomain and PHD finger containing, 3
chr1_+_244214552 0.451 NM_205768
ZNF238
zinc finger protein 238
chr3_+_93698959 0.449 NM_001174150
NM_001174151
NM_144996
NM_182896
ARL13B



ADP-ribosylation factor-like 13B



chr5_+_140165875 0.439 NM_018900
NM_031410
NM_031411
PCDHA1


protocadherin alpha 1


chr7_-_105319608 0.439 NM_138495
ATXN7L1
ataxin 7-like 1
chr11_-_33913835 0.434 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr4_+_85504056 0.432 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr8_-_102217868 0.431 NM_001042511
ZNF706
zinc finger protein 706
chr4_+_187112635 0.413 NM_207352
CYP4V2
cytochrome P450, family 4, subfamily V, polypeptide 2
chr10_-_123356158 0.398 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr1_+_244216506 0.395 NM_006352
ZNF238
zinc finger protein 238
chr1_-_92371558 0.394 NM_001195684
TGFBR3
transforming growth factor, beta receptor III
chr5_-_55290601 0.387 NM_001190981
NM_002184
NM_175767
IL6ST


interleukin 6 signal transducer (gp130, oncostatin M receptor)


chr7_-_25164902 0.381 NM_018947
CYCS
cytochrome c, somatic
chr5_+_140207562 0.374 NM_018909
NM_031848
NM_031849
PCDHA6


protocadherin alpha 6


chrX_-_112066353 0.373 NM_001113490
AMOT
angiomotin
chr12_-_90049818 0.373 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chrX_+_53449804 0.364 NM_144968
NM_001031745
RIBC1

RIB43A domain with coiled-coils 1

chr2_-_178483677 0.363 NM_152275
TTC30A
tetratricopeptide repeat domain 30A
chr22_+_39853316 0.359 NM_002409
MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr8_+_104152876 0.354 NM_001024372
NM_024812
BAALC

brain and acute leukemia, cytoplasmic

chr5_+_140345746 0.336 NM_018899
PCDHAC2
protocadherin alpha subfamily C, 2
chr22_-_17680485 0.325 NM_177405
CECR1
cat eye syndrome chromosome region, candidate 1
chr22_-_17690778 0.321 NM_017424
CECR1
cat eye syndrome chromosome region, candidate 1
chr20_-_4990913 0.314 NM_203327
SLC23A2
solute carrier family 23 (nucleobase transporters), member 2
chr5_+_140180782 0.313 NM_018906
NM_031497
PCDHA3

protocadherin alpha 3

chr4_-_146100793 0.310 NM_001102653
OTUD4
OTU domain containing 4
chr22_+_39883228 0.309 NM_001098270
MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr3_+_119421865 0.303 NM_033364
C3orf15
chromosome 3 open reading frame 15
chr9_+_137967088 0.299 NM_014279
NM_006334
OLFM1

olfactomedin 1

chr11_+_45907046 0.298 NM_005456
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr7_-_130080823 0.294 NM_018718
CEP41
centrosomal protein 41kDa
chr2_-_211035913 0.290 NM_152519
C2orf67
chromosome 2 open reading frame 67
chr5_+_140261792 0.289 NM_018904
NM_031865
PCDHA13

protocadherin alpha 13

chr10_-_123353771 0.288 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr6_-_79787939 0.287 NM_017934
PHIP
pleckstrin homology domain interacting protein
chr11_-_6494985 0.281 NM_001248007
NM_006458
NM_033278
TRIM3


tripartite motif containing 3


chr5_+_140235594 0.279 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr1_+_180601121 0.271 NM_001135669
NM_004736
XPR1

xenotropic and polytropic retrovirus receptor 1

chr4_+_72204769 0.269 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr18_-_47721165 0.269 NM_001080467
MYO5B
myosin VB
chr12_+_20963637 0.268 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chrX_-_112084006 0.266 NM_133265
AMOT
angiomotin
chr13_+_33160537 0.261 NM_015032
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr2_+_149632772 0.260 NM_004522
KIF5C
kinesin family member 5C
chr14_-_94856926 0.259 NM_001002235
NM_001002236
NM_001127700
NM_001127701
NM_001127702
NM_001127703
NM_001127704
NM_001127705
NM_001127706
NM_001127707
SERPINA1









serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1









chrX_+_77166178 0.255 NM_000052
ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr2_+_102770401 0.253 NM_000877
IL1R1
interleukin 1 receptor, type I
chr7_+_94536926 0.253 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory subunit 9A

chr10_-_116418056 0.252 NM_002313
ABLIM1
actin binding LIM protein 1
chr13_+_108870713 0.251 NM_032859
ABHD13
abhydrolase domain containing 13
chr6_-_97345760 0.250 NM_014165
NDUFAF4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4
chr9_-_130742803 0.248 NM_001035254
FAM102A
family with sequence similarity 102, member A
chr22_-_39548448 0.247 NM_175709
CBX7
chromobox homolog 7
chr14_-_94855120 0.246 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr2_+_45878912 0.246 NM_005400
PRKCE
protein kinase C, epsilon
chr2_+_42396392 0.245 NM_001145076
NM_019063
EML4

echinoderm microtubule associated protein like 4

chr10_-_116444374 0.244 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr2_-_175351755 0.243 NM_001033045
NM_152529
GPR155

G protein-coupled receptor 155

chr16_+_5008317 0.241 NM_014692
SEC14L5
SEC14-like 5 (S. cerevisiae)
chr14_-_78083109 0.241 NM_004863
SPTLC2
serine palmitoyltransferase, long chain base subunit 2
chr20_-_3149070 0.238 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr21_+_30396911 0.231 NM_001001992
NM_001032410
NM_006447
USP16


ubiquitin specific peptidase 16


chr10_-_116286661 0.229 NM_006720
ABLIM1
actin binding LIM protein 1
chr12_+_72233486 0.227 NM_001146213
NM_001146214
NM_022771
TBC1D15


TBC1 domain family, member 15


chr3_-_113160318 0.226 NM_001164496
NM_018338
WDR52

WD repeat domain 52

chr3_-_93692898 0.226 NM_000313
PROS1
protein S (alpha)
chr1_-_217262946 0.225 NM_001243506
NM_206594
NM_206595
ESRRG


estrogen-related receptor gamma


chr11_+_45868956 0.224 NM_021117
CRY2
cryptochrome 2 (photolyase-like)
chr7_+_94539209 0.224 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr7_-_152133071 0.223 NM_170606
MLL3
myeloid/lymphoid or mixed-lineage leukemia 3
chr9_-_125693778 0.221 NM_020924
ZBTB26
zinc finger and BTB domain containing 26
chr7_-_105516923 0.220 NM_020725
NM_152749
ATXN7L1

ataxin 7-like 1

chr11_+_3876919 0.219 NM_003156
STIM1
stromal interaction molecule 1
chr20_+_51588945 0.216 NM_173485
TSHZ2
teashirt zinc finger homeobox 2
chr9_+_132934685 0.214 NM_014286
NCS1
neuronal calcium sensor 1
chr1_+_162466963 0.213 NM_001184763
UHMK1
U2AF homology motif (UHM) kinase 1
chr9_-_130712866 0.213 NM_203305
FAM102A
family with sequence similarity 102, member A
chr1_-_217311095 0.212 NM_001134285
ESRRG
estrogen-related receptor gamma
chr1_-_245027808 0.211 NM_004501
NM_031844
HNRNPU

heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)

chr11_+_45868668 0.211 NM_001127457
CRY2
cryptochrome 2 (photolyase-like)
chr1_-_77685076 0.211 NM_005482
PIGK
phosphatidylinositol glycan anchor biosynthesis, class K
chr10_-_94050799 0.211 NM_014912
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr1_+_162467594 0.210 NM_144624
NM_175866
UHMK1

U2AF homology motif (UHM) kinase 1

chr1_-_204329043 0.207 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr3_+_169755733 0.206 NM_014373
GPR160
G protein-coupled receptor 160
chr1_-_216896640 0.205 NM_001243515
NM_001243518
NM_001243519
NM_001438
ESRRG



estrogen-related receptor gamma



chr16_+_14164879 0.204 NM_014048
MKL2
MKL/myocardin-like 2
chr16_-_87525317 0.203 NM_015144
ZCCHC14
zinc finger, CCHC domain containing 14
chr9_-_127703294 0.201 NM_002077
GOLGA1
golgin A1
chr6_+_138483024 0.200 NM_020340
KIAA1244
KIAA1244
chr8_+_81398416 0.198 NM_001105539
NM_023929
ZBTB10

zinc finger and BTB domain containing 10

chr1_+_18434236 0.197 NM_032880
IGSF21
immunoglobin superfamily, member 21
chr1_-_226595796 0.197 NM_001618
PARP1
poly (ADP-ribose) polymerase 1
chr1_-_207095198 0.197 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr3_-_148939784 0.196 NM_000096
CP
ceruloplasmin (ferroxidase)
chr8_+_94767071 0.196 NM_001142301
NM_153704
TMEM67

transmembrane protein 67

chr5_-_88199868 0.196 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr19_+_15783827 0.194 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr15_-_40398286 0.192 NM_001003942
NM_001003943
BMF

Bcl2 modifying factor

chr15_-_40398573 0.191 NM_033503
BMF
Bcl2 modifying factor
chr2_+_148602569 0.191 NM_001616
ACVR2A
activin A receptor, type IIA
chr20_+_51801821 0.190 NM_001193421
TSHZ2
teashirt zinc finger homeobox 2
chr12_-_15374290 0.187 NM_001190726
NM_032918
RERG

RAS-like, estrogen-regulated, growth inhibitor

chr12_+_111843743 0.184 NM_005475
SH2B3
SH2B adaptor protein 3
chr10_-_123357503 0.184 NM_000141
NM_001144917
NM_001144918
NM_001144919
NM_022970
FGFR2




fibroblast growth factor receptor 2




chr17_+_40439564 0.184 NM_003152
STAT5A
signal transducer and activator of transcription 5A
chr7_+_140774031 0.183 NM_001195278
LOC100507421
transmembrane protein 178-like
chr1_+_236687026 0.178 NM_201544
LGALS8
lectin, galactoside-binding, soluble, 8
chr20_-_33999780 0.173 NM_001184977
NM_018244
NM_199487
UQCC


ubiquinol-cytochrome c reductase complex chaperone


chrX_+_24167728 0.171 NM_001178086
NM_001178095
NM_001178084
NM_001178085
NM_003410
ZFX




zinc finger protein, X-linked




chr2_+_36583369 0.169 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr18_+_48494313 0.168 NM_018696
ELAC1
elaC homolog 1 (E. coli)
chr20_-_20693122 0.166 NM_020343
RALGAPA2
Ral GTPase activating protein, alpha subunit 2 (catalytic)
chr2_-_128100673 0.165 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr4_+_47487230 0.165 NM_020453
ATP10D
ATPase, class V, type 10D
chr16_+_30759619 0.163 NM_000294
NM_001172432
PHKG2

phosphorylase kinase, gamma 2 (testis)

chr10_-_94003002 0.163 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chrX_-_80457440 0.162 NM_030763
HMGN5
high mobility group nucleosome binding domain 5
chr15_-_49338496 0.161 NM_001193489
NM_014701
SECISBP2L

SECIS binding protein 2-like

chr21_+_44394634 0.161 NM_004571
PKNOX1
PBX/knotted 1 homeobox 1
chr1_+_174844655 0.161 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr3_+_45636176 0.160 NM_014240
LIMD1
LIM domains containing 1
chrX_+_122993536 0.159 NM_001204401
NM_001167
XIAP

X-linked inhibitor of apoptosis

chr9_-_14693459 0.158 NM_178566
ZDHHC21
zinc finger, DHHC-type containing 21
chr7_+_129251529 0.156 NM_005011
NRF1
nuclear respiratory factor 1
chr5_+_139493689 0.156 NM_005859
PURA
purine-rich element binding protein A
chr22_+_45064323 0.154 NM_001017528
NM_001017529
PRR5

proline rich 5 (renal)

chr16_+_22308722 0.154 NM_018119
POLR3E
polymerase (RNA) III (DNA directed) polypeptide E (80kD)
chr8_-_91657898 0.153 NM_001008495
NM_001146273
TMEM64

transmembrane protein 64

chr15_-_40401041 0.153 NM_001003940
BMF
Bcl2 modifying factor
chr22_+_45072687 0.152 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr1_+_109255555 0.151 NM_001144937
FNDC7
fibronectin type III domain containing 7
chr1_+_97187174 0.150 NM_021190
PTBP2
polypyrimidine tract binding protein 2
chrX_-_57936853 0.150 NM_007156
ZXDA
zinc finger, X-linked, duplicated A
chr10_-_21463019 0.150 NM_001173484
NM_213569
NEBL

nebulette

chr2_-_174828775 0.149 NM_001017371
SP3
Sp3 transcription factor
chr17_-_27893926 0.149 NM_198147
ABHD15
abhydrolase domain containing 15
chr19_-_23578226 0.148 NM_003430
ZNF91
zinc finger protein 91
chr15_+_41952572 0.146 NM_001080541
NM_001164273
MGA

MAX gene associated

chr6_-_86352635 0.146 NM_001159673
SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr16_-_73082169 0.146 NM_006885
ZFHX3
zinc finger homeobox 3
chr9_+_20658307 0.145 NM_017794
KIAA1797
KIAA1797
chrX_-_33357725 0.145 NM_000109
DMD
dystrophin
chr1_+_236686738 0.144 NM_006499
NM_201543
LGALS8

lectin, galactoside-binding, soluble, 8

chr5_+_140306301 0.141 NM_018898
NM_031882
PCDHAC1

protocadherin alpha subfamily C, 1

chr17_+_60556247 0.140 NM_001112707
NM_006852
TLK2

tousled-like kinase 2

chr17_+_73629513 0.140 NM_001162995
C17orf109
chromosome 17 open reading frame 109
chr1_-_108231122 0.140 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr22_+_45098046 0.139 NM_181333
PRR5
proline rich 5 (renal)
chr2_+_29117503 0.139 NM_015131
WDR43
WD repeat domain 43
chr10_-_105677986 0.138 NM_024928
OBFC1
oligonucleotide/oligosaccharide-binding fold containing 1
chr2_-_213403280 0.137 NM_001042599
NM_005235
ERBB4

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

chr10_-_101989342 0.137 NM_001278
CHUK
conserved helix-loop-helix ubiquitous kinase
chrX_-_13956644 0.137 NM_001001994
GPM6B
glycoprotein M6B

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.63 1.38e-06 GO:0007156 homophilic cell adhesion
1.59 4.20e-02 GO:0007399 nervous system development
2.95 4.58e-02 GO:0032869 cellular response to insulin stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.26 2.21e-03 GO:0005634 nucleus
1.07 4.99e-03 GO:0044464 cell part
1.07 5.08e-03 GO:0005623 cell
1.10 4.55e-02 GO:0005622 intracellular

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.44 3.00e-06 GO:0046872 metal ion binding
1.43 4.48e-06 GO:0043169 cation binding
1.43 5.48e-06 GO:0043167 ion binding
1.50 9.46e-04 GO:0046914 transition metal ion binding
1.48 7.38e-03 GO:0008270 zinc ion binding
1.11 3.00e-02 GO:0005488 binding
1.85 3.18e-02 GO:0005509 calcium ion binding