Motif ID: HAND1,2.p2

Z-value: 1.349


Transcription factors associated with HAND1,2.p2:

Gene SymbolEntrez IDGene Name
HAND1 9421 heart and neural crest derivatives expressed 1
HAND2 9464 heart and neural crest derivatives expressed 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HAND2chr4_-_1744505290.613.4e-04Click!
HAND1chr5_-_1538578200.115.8e-01Click!


Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51472003 10.529 NM_001012964
NM_001012965
 KLK6

kallikrein-related peptidase 6

chr16_+_82660390 7.307 NM_001220488
NM_001220489
NM_001220490
NM_001220491
NM_001220492
NM_001257
 CDH13





cadherin 13, H-cadherin (heart)





chr2_-_31637598 6.286 NM_000379
 XDH
xanthine dehydrogenase
chr19_-_51456159 5.787 NM_001077491
NM_001077492
NM_012427
 KLK5


kallikrein-related peptidase 5


chr6_-_30652434 5.292 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr2_-_31440378 5.161 NM_001145122
 CAPN14
calpain 14
chr2_+_210444364 4.850 NM_002374
NM_031845
NM_031847
 MAP2


microtubule-associated protein 2


chr12_-_57630867 4.570 NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr11_+_118827007 4.130 NM_006760
 UPK2
uroplakin 2
chr12_+_41086189 4.029 NM_001843
NM_175038
 CNTN1

contactin 1

chr22_+_31478845 3.982 NM_001207017
 SMTN
smoothelin
chr12_-_91505541 3.834 NM_002345
 LUM
lumican
chr19_-_51504799 3.665 NM_007196
NM_144505
NM_144506
NM_144507
 KLK8



kallikrein-related peptidase 8



chrX_-_48328601 3.531 NM_033518
 SLC38A5
solute carrier family 38, member 5
chr2_-_31637553 3.394 XDH
xanthine dehydrogenase
chr2_-_27718059 3.162 FNDC4
fibronectin type III domain containing 4
chr2_+_210444154 3.028 MAP2
microtubule-associated protein 2
chr22_+_25003610 2.976 NM_001032365
 GGT1
gamma-glutamyltransferase 1
chrX_-_48328564 2.939 SLC38A5
solute carrier family 38, member 5
chr2_-_27718098 2.837 NM_022823
 FNDC4
fibronectin type III domain containing 4

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
7.97 5.62e-03 GO:0006693 prostaglandin metabolic process
2.46 9.18e-04 GO:0030029 actin filament-based process
2.39 1.47e-02 GO:0030036 actin cytoskeleton organization
1.65 2.86e-02 GO:0009611 response to wounding
1.60 4.51e-02 GO:0007154 cell communication
1.25 1.69e-03 GO:0032501 multicellular organismal process
1.20 2.79e-02 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
1.85 3.80e-05 GO:0005615 extracellular space
1.73 8.12e-12 GO:0005576 extracellular region
1.65 6.75e-04 GO:0044421 extracellular region part
1.62 1.82e-02 GO:0005624 membrane fraction
1.59 1.98e-03 GO:0000267 cell fraction
1.57 4.81e-02 GO:0005626 insoluble fraction
1.37 6.72e-03 GO:0044459 plasma membrane part
1.26 2.93e-03 GO:0071944 cell periphery
1.25 5.06e-03 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
4.48 2.53e-02 GO:0003823 antigen binding
3.26 4.03e-03 GO:0005179 hormone activity
2.74 7.86e-03 GO:0004252 serine-type endopeptidase activity
2.47 2.76e-02 GO:0008236 serine-type peptidase activity
2.43 3.66e-02 GO:0017171 serine hydrolase activity
2.11 7.15e-03 GO:0003779 actin binding
2.02 9.42e-03 GO:0004175 endopeptidase activity