Motif ID: HAND1,2.p2

Z-value: 1.349


Transcription factors associated with HAND1,2.p2:

Gene SymbolEntrez IDGene Name
HAND1 9421 heart and neural crest derivatives expressed 1
HAND2 9464 heart and neural crest derivatives expressed 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HAND2chr4_-_1744505290.613.4e-04Click!
HAND1chr5_-_1538578200.115.8e-01Click!


Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_51472003 10.529 NM_001012964
NM_001012965
KLK6

kallikrein-related peptidase 6

chr16_+_82660390 7.307 NM_001220488
NM_001220489
NM_001220490
NM_001220491
NM_001220492
NM_001257
CDH13





cadherin 13, H-cadherin (heart)





chr2_-_31637598 6.286 NM_000379
XDH
xanthine dehydrogenase
chr19_-_51456159 5.787 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr6_-_30652434 5.292 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr2_-_31440378 5.161 NM_001145122
CAPN14
calpain 14
chr2_+_210444364 4.850 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr12_-_57630867 4.570 NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr11_+_118827007 4.130 NM_006760
UPK2
uroplakin 2
chr12_+_41086189 4.029 NM_001843
NM_175038
CNTN1

contactin 1

chr22_+_31478845 3.982 NM_001207017
SMTN
smoothelin
chr12_-_91505541 3.834 NM_002345
LUM
lumican
chr19_-_51504799 3.665 NM_007196
NM_144505
NM_144506
NM_144507
KLK8



kallikrein-related peptidase 8



chrX_-_48328601 3.531 NM_033518
SLC38A5
solute carrier family 38, member 5
chr2_-_31637553 3.394 XDH
xanthine dehydrogenase
chr2_-_27718059 3.162 FNDC4
fibronectin type III domain containing 4
chr2_+_210444154 3.028 MAP2
microtubule-associated protein 2
chr22_+_25003610 2.976 NM_001032365
GGT1
gamma-glutamyltransferase 1
chrX_-_48328564 2.939 SLC38A5
solute carrier family 38, member 5
chr2_-_27718098 2.837 NM_022823
FNDC4
fibronectin type III domain containing 4
chr10_+_102123420 2.645


chr18_+_61420276 2.625 NM_001040147
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr9_+_125137600 2.625 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr2_+_228678556 2.545 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr1_-_149908759 2.506 NM_001145862
MTMR11
myotubularin related protein 11
chr1_-_149908721 2.468 MTMR11
myotubularin related protein 11
chr6_-_112194430 2.296 FYN
FYN oncogene related to SRC, FGR, YES
chr2_-_113542970 2.205 NM_000575
IL1A
interleukin 1, alpha
chr21_+_30517897 2.183 C21orf7
chromosome 21 open reading frame 7
chr10_-_121296044 2.071 NM_002925
RGS10
regulator of G-protein signaling 10
chr22_+_24999113 2.049 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr13_-_60587298 1.967 NM_030932
DIAPH3
diaphanous homolog 3 (Drosophila)
chr19_-_51472816 1.875 NM_002774
KLK6
kallikrein-related peptidase 6
chr8_-_125580745 1.815 MTSS1
metastasis suppressor 1
chr2_+_113816684 1.772 NM_012275
IL36RN
interleukin 36 receptor antagonist
chr11_+_124933197 1.754 SLC37A2
solute carrier family 37 (glycerol-3-phosphate transporter), member 2
chr11_-_2158510 1.742 IGF2
insulin-like growth factor 2 (somatomedin A)
chr12_+_49716970 1.710 NM_001100620
NM_005480
TROAP

trophinin associated protein (tastin)

chr6_-_112194648 1.700 NM_002037
FYN
FYN oncogene related to SRC, FGR, YES
chr20_-_1306512 1.675 NM_001199784
SDCBP2
syndecan binding protein (syntenin) 2
chr2_-_165478357 1.659 NM_004490
GRB14
growth factor receptor-bound protein 14
chr2_+_113875469 1.659 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr20_-_56285576 1.655 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chrX_-_153599581 1.655 FLNA
filamin A, alpha
chr18_+_61254533 1.643 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr1_+_152486977 1.620 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr17_-_39092714 1.614 KRT23
keratin 23 (histone deacetylase inducible)
chr17_-_56358118 1.570 MPO
myeloperoxidase
chr7_+_110731061 1.544 NM_001099658
NM_001099660
NM_018334
LRRN3


leucine rich repeat neuronal 3


chr10_-_76859247 1.465 NM_016364
DUSP13
dual specificity phosphatase 13
chr4_+_69313166 1.456 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr22_+_31063914 1.441


chr10_-_90712510 1.408 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr11_-_5537815 1.388 NM_145053
UBQLNL
ubiquilin-like
chr2_+_204732509 1.360 NM_001037631
NM_005214
CTLA4

cytotoxic T-lymphocyte-associated protein 4

chr11_+_69924407 1.347 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr5_-_176836488 1.345 F12
coagulation factor XII (Hageman factor)
chr19_-_8642232 1.301 MYO1F
myosin IF
chr19_+_40146533 1.290 NM_001190441
LGALS16
lectin, galactoside-binding, soluble, 16
chr13_+_31309690 1.286 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr1_+_11249344 1.235 NM_021146
ANGPTL7
angiopoietin-like 7
chr7_+_76139744 1.222 NM_030570
NM_182684
UPK3B

uroplakin 3B

chr17_+_37894161 1.215 NM_005310
GRB7
growth factor receptor-bound protein 7
chr5_-_176836535 1.202 NM_000505
F12
coagulation factor XII (Hageman factor)
chr1_+_84630014 1.193 NM_001242857
NM_001242858
NM_001242859
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr2_-_85637486 1.188 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr11_+_33037397 1.184 NM_001077242
DEPDC7
DEP domain containing 7
chr11_-_89650877 1.182 NM_001206627
LOC399939
ring finger protein 18-like
chr17_+_6347733 1.181 NM_001195228
NM_019013
FAM64A

family with sequence similarity 64, member A

chr14_-_65409445 1.161 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr5_-_176831183 1.160 F12
coagulation factor XII (Hageman factor)
chr1_+_150245182 1.159 NM_024579
C1orf54
chromosome 1 open reading frame 54
chr7_+_143079925 1.151 ZYX
zyxin
chr14_+_96722546 1.145 NM_000710
BDKRB1
bradykinin receptor B1
chr11_+_69061599 1.144 NM_138768
MYEOV
myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas)
chr11_+_89659929 1.135 NM_001206627
LOC399939
ring finger protein 18-like
chr19_-_42931500 1.133 NM_005357
LIPE
lipase, hormone-sensitive
chr7_-_100858312 1.125 PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr2_+_113735595 1.123 NM_019618
IL36G
interleukin 36, gamma
chr12_+_27485767 1.123 NM_001248002
NM_001248003
NM_001248004
NM_001248005
NM_020183
ARNTL2




aryl hydrocarbon receptor nuclear translocator-like 2




chr14_-_107078578 1.118


chr9_+_72658496 1.113 NM_153267
MAMDC2
MAM domain containing 2
chr17_+_73720775 1.104 NM_001005619
ITGB4
integrin, beta 4
chr2_+_238475216 1.095 NM_015893
PRLH
prolactin releasing hormone
chr19_-_51845377 1.056 NM_001163922
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr1_+_22979681 1.053 NM_000491
C1QB
complement component 1, q subcomponent, B chain
chr6_-_31088195 1.041 NM_001264
CDSN
corneodesmosin
chr12_-_110271205 1.036 NM_021625
TRPV4
transient receptor potential cation channel, subfamily V, member 4
chr17_+_37894212 1.024 GRB7
growth factor receptor-bound protein 7
chr12_-_110271182 1.020 TRPV4
transient receptor potential cation channel, subfamily V, member 4
chr17_-_27402626 1.016 NM_004740
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr7_+_26403944 1.013 NM_001199838
SNX10
sorting nexin 10
chr12_-_53601051 1.005 ITGB7
integrin, beta 7
chrX_-_153599719 1.005 FLNA
filamin A, alpha
chr2_+_113885145 0.992 IL1RN
interleukin 1 receptor antagonist
chr11_-_64527369 0.983 PYGM
phosphorylase, glycogen, muscle
chr5_+_150399980 0.982 NM_002084
GPX3
glutathione peroxidase 3 (plasma)
chr13_+_31309644 0.979 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr7_+_63774378 0.970 ZNF736
zinc finger protein 736
chr8_-_93029864 0.964 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr10_+_72972268 0.960 NM_001244889
NM_170744
UNC5B

unc-5 homolog B (C. elegans)

chr1_-_26680620 0.960 NM_001039775
AIM1L
absent in melanoma 1-like
chr11_-_55703875 0.957 NM_006637
OR5I1
olfactory receptor, family 5, subfamily I, member 1
chr16_-_10788729 0.934 NM_144674
TEKT5
tektin 5
chr15_-_90222572 0.934 NM_001145311
NM_002666
PLIN1

perilipin 1

chr6_+_146348781 0.934 NM_000838
NM_001114329
GRM1

glutamate receptor, metabotropic 1

chr6_+_167525294 0.932 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr15_-_56209305 0.929 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr20_+_123230 0.927 NM_030931
DEFB126
defensin, beta 126
chr10_-_75401492 0.922 NM_021245
MYOZ1
myozenin 1
chr19_-_54604070 0.919 NM_130771
NM_133168
NM_133169
NM_206818
OSCAR



osteoclast associated, immunoglobulin-like receptor



chr12_+_75874512 0.916 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr11_+_67171379 0.916 TBC1D10C
TBC1 domain family, member 10C
chr7_-_76038894 0.914 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr19_-_17958773 0.904 JAK3
Janus kinase 3
chr12_-_53600999 0.895 NM_000889
ITGB7
integrin, beta 7
chr12_-_117742856 0.895 NM_001204213
NOS1
nitric oxide synthase 1 (neuronal)
chr9_-_14910992 0.889 NM_144966
FREM1
FRAS1 related extracellular matrix 1
chrX_+_2670092 0.889 NM_001141919
NM_001141920
NM_175569
XGPY2
XG


Xg pseudogene, Y-linked 2
Xg blood group


chr1_+_228337414 0.881 NM_020435
GJC2
gap junction protein, gamma 2, 47kDa
chr10_-_75410778 0.881 NM_024875
SYNPO2L
synaptopodin 2-like
chr7_-_141957846 0.879 NM_001001317
PRSS58
protease, serine, 58
chr2_+_75059781 0.877 NM_000189
HK2
hexokinase 2
chrX_-_55057408 0.877 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr19_+_41883168 0.868 NM_001042595
TMEM91
transmembrane protein 91
chr1_+_45478420 0.836 UROD
uroporphyrinogen decarboxylase
chr3_+_50304989 0.835 NM_001005914
NM_004636
SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

chr7_+_141490016 0.831 NM_018980
TAS2R5
taste receptor, type 2, member 5
chrX_-_100872926 0.830 NM_001009584
NM_001184768
NM_019007
ARMCX6


armadillo repeat containing, X-linked 6


chr12_-_10955168 0.817 NM_023919
TAS2R7
taste receptor, type 2, member 7
chr12_+_15475190 0.812 NM_002848
NM_030667
PTPRO

protein tyrosine phosphatase, receptor type, O

chr19_+_10397642 0.808 NM_001039132
NM_001544
NM_022377
ICAM4


intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)


chr3_+_44916097 0.802 NM_003241
TGM4
transglutaminase 4 (prostate)
chr1_+_202091971 0.790 NM_004767
GPR37L1
G protein-coupled receptor 37 like 1
chr11_+_67171400 0.783 NM_198517
TBC1D10C
TBC1 domain family, member 10C
chr6_-_34524083 0.775 NM_001252294
NM_012391
SPDEF

SAM pointed domain containing ets transcription factor

chr5_+_34656482 0.773 RAI14
retinoic acid induced 14
chr19_+_55587220 0.771 NM_133180
EPS8L1
EPS8-like 1
chr6_-_127780534 0.769 NM_014702
KIAA0408
KIAA0408
chr20_+_816710 0.767 NM_207121
FAM110A
family with sequence similarity 110, member A
chr19_-_51537996 0.767 NM_019598
NM_145894
NM_145895
KLK12


kallikrein-related peptidase 12


chr7_-_142583260 0.761 NM_018646
TRPV6
transient receptor potential cation channel, subfamily V, member 6
chr1_+_36772696 0.759 NM_024676
SH3D21
SH3 domain containing 21
chr4_+_74281884 0.757 ALB
albumin
chr21_+_37507209 0.750 NM_001236
CBR3
carbonyl reductase 3
chr16_-_3149252 0.748 ZSCAN10
zinc finger and SCAN domain containing 10
chr2_-_85637473 0.745 CAPG
capping protein (actin filament), gelsolin-like
chr5_-_147286064 0.743 NM_206966
C5orf46
chromosome 5 open reading frame 46
chr20_+_37209837 0.740 NM_001018082
ADIG
adipogenin
chr12_-_117799410 0.730 NM_000620
NM_001204218
NOS1

nitric oxide synthase 1 (neuronal)

chr1_+_116654375 0.722 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr6_-_30654978 0.712 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr2_-_219696511 0.711 NM_017431
PRKAG3
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
chr17_+_16945766 0.709 NM_015134
NM_201274
MPRIP

myosin phosphatase Rho interacting protein

chr1_+_17531619 0.701 NM_013358
PADI1
peptidyl arginine deiminase, type I
chr9_+_131191206 0.698 CERCAM
cerebral endothelial cell adhesion molecule
chr10_-_5045967 0.692 NM_001135241
AKR1C2
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr5_-_150467220 0.692 NM_001252390
TNIP1
TNFAIP3 interacting protein 1
chr17_-_56358161 0.690 MPO
myeloperoxidase
chr14_+_105391150 0.689 PLD4
phospholipase D family, member 4
chr19_-_49520346 0.678 NM_000894
LHB
luteinizing hormone beta polypeptide
chr4_-_155312448 0.677 NM_017639
DCHS2
dachsous 2 (Drosophila)
chr16_+_16326507 0.671


chr9_+_72658735 0.670 MAMDC2
MAM domain containing 2
chr16_+_66638212 0.657 NM_144601
CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr10_+_131934674 0.657 GLRX3
glutaredoxin 3
chr11_-_26743545 0.655 NM_178498
SLC5A12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr4_+_119947816 0.649 SYNPO2
synaptopodin 2
chr3_-_36781351 0.649 NM_033403
DCLK3
doublecortin-like kinase 3
chr16_-_31146992 0.648 PRSS8
protease, serine, 8
chr12_-_53207843 0.647 NM_002272
KRT4
keratin 4
chr7_+_116166346 0.643 NM_001172896
NM_001172897
CAV1

caveolin 1, caveolae protein, 22kDa

chr20_+_16728997 0.641 NM_020157
OTOR
otoraplin
chr2_-_25474948 0.637 NM_153759
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr22_+_37309618 0.636 NM_000395
CSF2RB
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chrX_-_32173585 0.636 NM_004013
NM_004020
NM_004021
NM_004022
NM_004023
DMD




dystrophin




chr2_-_96150478 0.636 NM_001164464
TRIM43B
tripartite motif containing 43B
chr9_+_35829208 0.635 NM_016446
NM_001042589
TMEM8B

transmembrane protein 8B

chr4_-_176923572 0.631 NM_005277
NM_201592
GPM6A

glycoprotein M6A

chr20_+_43343523 0.630 WISP2
WNT1 inducible signaling pathway protein 2
chr1_-_209825673 0.624 NM_001127641
LAMB3
laminin, beta 3
chr3_+_111451326 0.623 NM_001134437
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr16_+_16326488 0.617 NOMO2
NODAL modulator 2
chr19_+_49259343 0.616 NM_019113
FGF21
fibroblast growth factor 21
chr15_+_42696957 0.614 NM_173089
NM_173090
CAPN3

calpain 3, (p94)

chr5_-_180632110 0.612 NM_033342
NM_203293
TRIM7

tripartite motif containing 7

chr10_-_75401199 0.611 MYOZ1
myozenin 1
chr4_-_103245468 0.609 NM_001135148
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr2_+_169921298 0.595 NM_005771
DHRS9
dehydrogenase/reductase (SDR family) member 9
chrX_-_47489243 0.592 NM_001145252
CFP
complement factor properdin
chr15_+_39542884 0.591 NM_207445
C15orf54
chromosome 15 open reading frame 54
chrX_+_129535894 0.590 NM_016024
RBMX2
RNA binding motif protein, X-linked 2
chr2_-_197791339 0.589 NM_024989
PGAP1
post-GPI attachment to proteins 1
chr2_-_133539627 0.588 NCKAP5
NCK-associated protein 5
chrX_+_70364680 0.587 NM_001166660
NM_018977
NM_181303
NLGN3


neuroligin 3


chr5_-_39394423 0.587 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr11_+_2323236 0.580 NM_139022
TSPAN32
tetraspanin 32
chr7_-_84751246 0.580 NM_152754
SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr4_-_174320616 0.573 NM_007281
SCRG1
stimulator of chondrogenesis 1
chr9_-_132515290 0.559 NM_004878
PTGES
prostaglandin E synthase

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.46 9.18e-04 GO:0030029 actin filament-based process
1.25 1.69e-03 GO:0032501 multicellular organismal process
7.97 5.62e-03 GO:0006693 prostaglandin metabolic process
2.39 1.47e-02 GO:0030036 actin cytoskeleton organization
1.20 2.79e-02 GO:0050896 response to stimulus
1.65 2.86e-02 GO:0009611 response to wounding
1.60 4.51e-02 GO:0007154 cell communication

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.73 8.12e-12 GO:0005576 extracellular region
1.85 3.80e-05 GO:0005615 extracellular space
1.65 6.75e-04 GO:0044421 extracellular region part
1.59 1.98e-03 GO:0000267 cell fraction
1.26 2.93e-03 GO:0071944 cell periphery
1.25 5.06e-03 GO:0005886 plasma membrane
1.37 6.72e-03 GO:0044459 plasma membrane part
1.62 1.82e-02 GO:0005624 membrane fraction
1.57 4.81e-02 GO:0005626 insoluble fraction

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.26 4.03e-03 GO:0005179 hormone activity
2.11 7.15e-03 GO:0003779 actin binding
2.74 7.86e-03 GO:0004252 serine-type endopeptidase activity
2.02 9.42e-03 GO:0004175 endopeptidase activity
4.48 2.53e-02 GO:0003823 antigen binding
2.47 2.76e-02 GO:0008236 serine-type peptidase activity
2.43 3.66e-02 GO:0017171 serine hydrolase activity