Motif ID: HBP1_HMGB_SSRP1_UBTF.p2

Z-value: 1.304


Transcription factors associated with HBP1_HMGB_SSRP1_UBTF.p2:

Gene SymbolEntrez IDGene Name
HBP1 26959 HMG-box transcription factor 1
HMGB2 3148 high-mobility group box 2
HMGB3 3149 high-mobility group box 3
SSRP1 6749 structure specific recognition protein 1
UBTF 7343 upstream binding transcription factor, RNA polymerase I

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
UBTFchr17_-_42297037,
chr17_-_42298228		0.431.7e-02Click!
HMGB2chr4_-_174254730-0.346.2e-02Click!
SSRP1chr11_-_571033240.241.9e-01Click!
HMGB3chrX_+_150151757-0.115.8e-01Click!
HBP1chr7_+_1068094050.058.1e-01Click!


Activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2.

activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2


Sorted Z-values histogram for motif HBP1_HMGB_SSRP1_UBTF.p2

Sorted Z-values for motif HBP1_HMGB_SSRP1_UBTF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HBP1_HMGB_SSRP1_UBTF.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_135782246 10.671 NM_001018046
NM_025052
 YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr13_+_24144402 5.786 NM_001204459
NM_148957
 TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr17_+_36861398 5.761 MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr19_+_55888203 5.708 NM_139172
 TMEM190
transmembrane protein 190
chr3_+_63638343 5.474 NM_001080537
 SNTN
sentan, cilia apical structure protein
chr3_-_148939784 5.468 NM_000096
 CP
ceruloplasmin (ferroxidase)
chr7_+_114055048 5.201 NM_001172766
NM_014491
NM_148898
NM_148900
 FOXP2



forkhead box P2



chr4_-_16085666 4.859 PROM1
prominin 1
chr7_-_16921596 4.852 NM_176813
 AGR3
anterior gradient 3 homolog (Xenopus laevis)
chr5_+_94727047 4.847 NM_152548
 FAM81B
family with sequence similarity 81, member B
chr3_+_186648515 4.721 ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr11_+_36317724 4.297 NM_001160167
 PRR5L
proline rich 5 like
chr5_+_121465214 4.192 NM_207317
 ZNF474
zinc finger protein 474
chrX_+_106449861 4.181 NM_001169154
NM_173494
 CXorf41

chromosome X open reading frame 41

chr18_-_53071225 4.160 NM_001243232
 TCF4
transcription factor 4
chr3_+_171561138 4.102 NM_001164436
 TMEM212
transmembrane protein 212
chr4_-_16085593 4.041 NM_001145847
NM_001145848
 PROM1

prominin 1

chr6_-_139613114 4.000 NM_153235
 TXLNB
taxilin beta
chr18_-_45663667 3.911 NM_001039360
 ZBTB7C
zinc finger and BTB domain containing 7C
chr6_-_32557431 3.846 NM_001243965
NM_002124
 HLA-DRB1

HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1

major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 46 entries
enrichment   p-value GO term description
2.60 6.04e-05 GO:0007156 homophilic cell adhesion
2.03 3.79e-06 GO:0016568 chromatin modification
1.92 5.17e-09 GO:0010629 negative regulation of gene expression
1.90 2.96e-03 GO:0016337 cell-cell adhesion
1.84 3.19e-05 GO:0006325 chromatin organization
1.83 5.01e-06 GO:0045892 negative regulation of transcription, DNA-dependent
1.80 1.11e-06 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.79 1.54e-05 GO:0051253 negative regulation of RNA metabolic process
1.77 2.93e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.73 8.49e-06 GO:0010558 negative regulation of macromolecule biosynthetic process
1.68 4.97e-05 GO:0031327 negative regulation of cellular biosynthetic process
1.67 3.45e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.65 6.52e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
1.64 1.62e-04 GO:0009890 negative regulation of biosynthetic process
1.62 1.87e-03 GO:0051276 chromosome organization
1.61 2.62e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.58 4.14e-03 GO:0051254 positive regulation of RNA metabolic process
1.55 3.37e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
1.55 1.15e-02 GO:0010628 positive regulation of gene expression
1.54 3.12e-04 GO:0010605 negative regulation of macromolecule metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 20 entries
enrichment   p-value GO term description
4.78 3.31e-02 GO:0016514 SWI/SNF complex
4.27 1.45e-02 GO:0070603 SWI/SNF-type complex
3.88 3.47e-03 GO:0000932 cytoplasmic mRNA processing body
2.93 1.31e-02 GO:0035770 RNA granule
2.41 3.02e-02 GO:0000790 nuclear chromatin
2.36 1.95e-02 GO:0016585 chromatin remodeling complex
2.17 1.96e-02 GO:0016607 nuclear speck
1.92 3.48e-03 GO:0016604 nuclear body
1.63 1.39e-05 GO:0044451 nucleoplasm part
1.37 1.90e-05 GO:0031981 nuclear lumen
1.34 1.80e-05 GO:0044428 nuclear part
1.34 1.00e-02 GO:0005654 nucleoplasm
1.28 2.44e-14 GO:0005634 nucleus
1.23 4.00e-02 GO:0043233 organelle lumen
1.13 1.26e-06 GO:0043231 intracellular membrane-bounded organelle
1.13 1.69e-06 GO:0043227 membrane-bounded organelle
1.12 4.46e-06 GO:0043229 intracellular organelle
1.11 5.55e-06 GO:0043226 organelle
1.10 2.53e-08 GO:0005622 intracellular
1.10 8.64e-08 GO:0044424 intracellular part

Gene overrepresentation in function category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
1.79 3.69e-04 GO:0000988 protein binding transcription factor activity
1.79 3.69e-04 GO:0000989 transcription factor binding transcription factor activity
1.77 6.78e-04 GO:0003712 transcription cofactor activity
1.70 2.98e-02 GO:0016564 transcription repressor activity
1.69 3.33e-02 GO:0016563 transcription activator activity
1.51 6.56e-05 GO:0001071 nucleic acid binding transcription factor activity
1.51 6.56e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.51 6.49e-03 GO:0043565 sequence-specific DNA binding
1.50 7.02e-05 GO:0030528 transcription regulator activity
1.40 1.30e-08 GO:0003677 DNA binding
1.38 1.33e-06 GO:0008270 zinc ion binding
1.32 6.71e-09 GO:0003676 nucleic acid binding
1.29 3.66e-04 GO:0046914 transition metal ion binding
1.19 5.46e-03 GO:0046872 metal ion binding
1.18 8.82e-03 GO:0043169 cation binding
1.18 1.15e-02 GO:0043167 ion binding
1.14 6.92e-05 GO:0005515 protein binding
1.09 5.86e-07 GO:0005488 binding