Motif ID: HIC1.p2

Z-value: 1.774


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIC1chr17_+_1958354,
chr17_+_1959512		0.775.5e-07Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_110959592 6.956 NM_001846
 COL4A2
collagen, type IV, alpha 2
chr2_-_224903933 6.343 NM_001136528
NM_006216
 SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr2_-_224903324 6.145 NM_001136530
 SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr17_-_76921076 5.957 TIMP2
TIMP metallopeptidase inhibitor 2
chr6_+_34204928 5.360 HMGA1
high mobility group AT-hook 1
chr10_+_102106958 5.340 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr1_-_20812271 5.132 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr2_+_238536183 5.119 NM_001137550
 LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chrX_+_135229536 4.909 NM_001159702
NM_001159703
NM_001449
 FHL1


four and a half LIM domains 1


chr18_-_28681885 4.678 NM_004949
NM_024422
 DSC2

desmocollin 2

chr19_-_15343194 4.676 NM_024794
 EPHX3
epoxide hydrolase 3
chr18_-_21242592 4.574 NM_173505
 ANKRD29
ankyrin repeat domain 29
chr6_+_34205029 4.550 HMGA1
high mobility group AT-hook 1
chr19_-_41859519 4.467 TGFB1
transforming growth factor, beta 1
chr17_-_76921205 4.433 TIMP2
TIMP metallopeptidase inhibitor 2
chr11_+_94822937 4.219 NM_015036
 ENDOD1
endonuclease domain containing 1
chr2_-_27718098 4.192 NM_022823
 FNDC4
fibronectin type III domain containing 4
chr9_-_72287097 4.129 NM_001163
 APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr19_-_41859830 4.115 NM_000660
 TGFB1
transforming growth factor, beta 1
chr10_+_102107001 3.860 SCD
stearoyl-CoA desaturase (delta-9-desaturase)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 152 entries
enrichment   p-value GO term description
2.00 1.93e-02 GO:0050770 regulation of axonogenesis
1.98 9.44e-06 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.96 1.44e-05 GO:0022604 regulation of cell morphogenesis
1.96 4.54e-03 GO:0060828 regulation of canonical Wnt receptor signaling pathway
1.94 4.52e-02 GO:0010721 negative regulation of cell development
1.91 3.01e-02 GO:0030178 negative regulation of Wnt receptor signaling pathway
1.88 6.84e-04 GO:0007265 Ras protein signal transduction
1.87 4.44e-03 GO:0032956 regulation of actin cytoskeleton organization
1.82 1.32e-02 GO:0032970 regulation of actin filament-based process
1.75 1.42e-02 GO:0010975 regulation of neuron projection development
1.69 7.32e-05 GO:0048011 nerve growth factor receptor signaling pathway
1.68 5.43e-08 GO:0007411 axon guidance
1.67 1.96e-02 GO:0031344 regulation of cell projection organization
1.66 4.27e-02 GO:0034330 cell junction organization
1.65 7.03e-10 GO:0048667 cell morphogenesis involved in neuron differentiation
1.65 1.12e-04 GO:0050767 regulation of neurogenesis
1.65 1.51e-03 GO:0045664 regulation of neuron differentiation
1.65 1.31e-02 GO:0051493 regulation of cytoskeleton organization
1.64 9.47e-10 GO:0048812 neuron projection morphogenesis
1.64 4.00e-09 GO:0007409 axonogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 47 entries
enrichment   p-value GO term description
2.93 1.52e-02 GO:0032589 neuron projection membrane
2.15 2.52e-04 GO:0031256 leading edge membrane
2.03 3.13e-02 GO:0005905 coated pit
1.97 5.07e-05 GO:0005925 focal adhesion
1.93 1.93e-07 GO:0005912 adherens junction
1.88 2.88e-08 GO:0031252 cell leading edge
1.88 3.75e-04 GO:0005924 cell-substrate adherens junction
1.86 5.08e-07 GO:0070161 anchoring junction
1.84 6.00e-04 GO:0030055 cell-substrate junction
1.82 1.47e-02 GO:0030027 lamellipodium
1.76 3.09e-02 GO:0001726 ruffle
1.74 2.04e-02 GO:0019717 synaptosome
1.63 3.50e-02 GO:0031253 cell projection membrane
1.57 1.09e-02 GO:0030424 axon
1.54 1.96e-03 GO:0016323 basolateral plasma membrane
1.49 1.43e-03 GO:0015629 actin cytoskeleton
1.45 2.42e-04 GO:0043005 neuron projection
1.44 9.78e-07 GO:0030054 cell junction
1.37 1.06e-06 GO:0005626 insoluble fraction
1.35 1.10e-03 GO:0044431 Golgi apparatus part

Gene overrepresentation in function category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
1.77 5.91e-03 GO:0017124 SH3 domain binding
1.77 4.56e-02 GO:0005088 Ras guanyl-nucleotide exchange factor activity
1.60 2.10e-02 GO:0004721 phosphoprotein phosphatase activity
1.59 4.25e-09 GO:0019904 protein domain specific binding
1.58 6.05e-04 GO:0019787 small conjugating protein ligase activity
1.55 3.66e-04 GO:0016881 acid-amino acid ligase activity
1.55 3.91e-03 GO:0004842 ubiquitin-protein ligase activity
1.53 2.67e-04 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.48 1.92e-02 GO:0016791 phosphatase activity
1.46 2.69e-03 GO:0003779 actin binding
1.45 4.54e-06 GO:0008092 cytoskeletal protein binding
1.43 8.54e-03 GO:0042578 phosphoric ester hydrolase activity
1.42 2.67e-04 GO:0060589 nucleoside-triphosphatase regulator activity
1.42 3.03e-04 GO:0030695 GTPase regulator activity
1.27 3.53e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.26 3.54e-02 GO:0019899 enzyme binding
1.25 1.92e-02 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.25 4.98e-02 GO:0016301 kinase activity
1.24 3.26e-02 GO:0030234 enzyme regulator activity
1.22 1.81e-04 GO:0016740 transferase activity