Motif ID: HIC1.p2

Z-value: 1.774


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIC1chr17_+_1958354,
chr17_+_1959512
0.775.5e-07Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_110959592 6.956 NM_001846
COL4A2
collagen, type IV, alpha 2
chr2_-_224903933 6.343 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr2_-_224903324 6.145 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr17_-_76921076 5.957 TIMP2
TIMP metallopeptidase inhibitor 2
chr6_+_34204928 5.360 HMGA1
high mobility group AT-hook 1
chr10_+_102106958 5.340 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr1_-_20812271 5.132 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr2_+_238536183 5.119 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chrX_+_135229536 4.909 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr18_-_28681885 4.678 NM_004949
NM_024422
DSC2

desmocollin 2

chr19_-_15343194 4.676 NM_024794
EPHX3
epoxide hydrolase 3
chr18_-_21242592 4.574 NM_173505
ANKRD29
ankyrin repeat domain 29
chr6_+_34205029 4.550 HMGA1
high mobility group AT-hook 1
chr19_-_41859519 4.467 TGFB1
transforming growth factor, beta 1
chr17_-_76921205 4.433 TIMP2
TIMP metallopeptidase inhibitor 2
chr11_+_94822937 4.219 NM_015036
ENDOD1
endonuclease domain containing 1
chr2_-_27718098 4.192 NM_022823
FNDC4
fibronectin type III domain containing 4
chr9_-_72287097 4.129 NM_001163
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr19_-_41859830 4.115 NM_000660
TGFB1
transforming growth factor, beta 1
chr10_+_102107001 3.860 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr2_+_11886739 3.798 NM_145693
LPIN1
lipin 1
chr8_-_23261591 3.622 LOXL2
lysyl oxidase-like 2
chr10_+_102106771 3.616 NM_005063
SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr8_-_23261626 3.600 LOXL2
lysyl oxidase-like 2
chr6_-_112194430 3.568 FYN
FYN oncogene related to SRC, FGR, YES
chr2_+_102314162 3.468 NM_001242560
NM_004834
NM_145686
NM_001242559
NM_145687
MAP4K4




mitogen-activated protein kinase kinase kinase kinase 4




chr2_-_235405692 3.438 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr7_-_24797316 3.397 DFNA5
deafness, autosomal dominant 5
chr6_+_34204690 3.393 HMGA1
high mobility group AT-hook 1
chr2_-_27718059 3.381 FNDC4
fibronectin type III domain containing 4
chr12_-_99038705 3.358 IKBIP
IKBKB interacting protein
chr8_-_23261632 3.271 LOXL2
lysyl oxidase-like 2
chr20_-_23030141 3.237 NM_000361
THBD
thrombomodulin
chr18_+_33877630 3.224 NM_025135
FHOD3
formin homology 2 domain containing 3
chr16_+_31483066 3.211 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr6_-_131384387 3.207 NM_001135554
NM_001135555
NM_001199388
NM_001431
EPB41L2



erythrocyte membrane protein band 4.1-like 2



chr1_+_10270680 3.196 NM_015074
NM_183416
KIF1B

kinesin family member 1B

chr2_-_1748240 3.186 PXDN
peroxidasin homolog (Drosophila)
chr7_-_24797031 3.140 DFNA5
deafness, autosomal dominant 5
chr14_+_65171149 3.112 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr12_+_96588000 3.110 NM_005230
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr14_-_105487421 3.081 NM_017955
NM_145701
CDCA4

cell division cycle associated 4

chr10_+_11784355 3.078 NM_024693
ECHDC3
enoyl CoA hydratase domain containing 3
chr17_+_15848230 3.076 NM_000676
ADORA2B
adenosine A2b receptor
chr6_-_4135701 3.070 NM_001166010
NM_006117
NM_206836
ECI2


enoyl-CoA delta isomerase 2


chr12_-_47473424 3.050 NM_001143668
NM_181847
AMIGO2

adhesion molecule with Ig-like domain 2

chr12_-_122231554 3.048 NM_019034
RHOF
ras homolog gene family, member F (in filopodia)
chr15_-_83953465 3.029 NM_001717
BNC1
basonuclin 1
chr7_-_24797052 3.015 NM_001127453
DFNA5
deafness, autosomal dominant 5
chr7_+_5632435 3.009 NM_003088
FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr1_-_8086347 2.999 ERRFI1
ERBB receptor feedback inhibitor 1
chr22_+_33197744 2.998 TIMP3
TIMP metallopeptidase inhibitor 3
chr19_+_35646006 2.964 FXYD5
FXYD domain containing ion transport regulator 5
chr16_+_2570322 2.959 NM_001145815
NM_015944
AMDHD2

amidohydrolase domain containing 2

chr17_-_80009649 2.931 NM_002917
RFNG
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr3_-_52567809 2.928 NT5DC2
5'-nucleotidase domain containing 2
chr18_+_21269528 2.902 NM_001127717
NM_198129
LAMA3

laminin, alpha 3

chr14_-_105487365 2.889 CDCA4
cell division cycle associated 4
chr2_+_241375235 2.883 GPC1
glypican 1
chr17_-_76921453 2.879 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr19_-_41859253 2.879 TGFB1
transforming growth factor, beta 1
chr7_+_5632453 2.863 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr6_-_131384321 2.856 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr22_+_33197678 2.850 TIMP3
TIMP metallopeptidase inhibitor 3
chr7_+_128578246 2.848 NM_032643
IRF5
interferon regulatory factor 5
chr19_-_41859332 2.816 TGFB1
transforming growth factor, beta 1
chr1_+_230202966 2.808 GALNT2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
chr19_+_35645640 2.789 NM_144779
NM_001164605
FXYD5

FXYD domain containing ion transport regulator 5

chr14_-_53162370 2.784 ERO1L
ERO1-like (S. cerevisiae)
chr8_-_23261675 2.752 NM_002318
LOXL2
lysyl oxidase-like 2
chr7_+_128577990 2.684 NM_001098629
NM_001098630
NM_001242452
IRF5


interferon regulatory factor 5


chr12_+_130647002 2.675 NM_007197
FZD10
frizzled family receptor 10
chr2_+_239756672 2.633 NM_057179
TWIST2
twist homolog 2 (Drosophila)
chr16_-_85784628 2.599 NM_206967
C16orf74
chromosome 16 open reading frame 74
chr1_-_8086392 2.578 NM_018948
ERRFI1
ERBB receptor feedback inhibitor 1
chr6_+_159590428 2.573 NM_032532
FNDC1
fibronectin type III domain containing 1
chr18_+_21269404 2.568 LAMA3
laminin, alpha 3
chr17_-_74581881 2.536 ST6GALNAC2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr1_+_230202928 2.526 NM_004481
GALNT2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
chr6_-_30654978 2.515 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr19_+_16187047 2.514 NM_003290
TPM4
tropomyosin 4
chr1_-_113498828 2.502 NM_003051
SLC16A1
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
chr1_-_6479880 2.488 NM_019089
HES2
hairy and enhancer of split 2 (Drosophila)
chr16_+_58497548 2.477 NM_020465
NDRG4
NDRG family member 4
chr1_-_20812727 2.465 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr7_-_28220146 2.465 JAZF1
JAZF zinc finger 1
chr6_+_34205369 2.455 HMGA1
high mobility group AT-hook 1
chrX_-_153602998 2.433 NM_001110556
NM_001456
FLNA

filamin A, alpha

chr10_+_17271341 2.426 VIM
vimentin
chr20_-_5591487 2.421 NM_019593
GPCPD1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chr2_-_10220321 2.412 NM_001037160
CYS1
cystin 1
chr5_-_171881355 2.400 SH3PXD2B
SH3 and PX domains 2B
chr11_-_2162340 2.396 NM_001127598
IGF2
insulin-like growth factor 2 (somatomedin A)
chr14_-_53162418 2.395 NM_014584
ERO1L
ERO1-like (S. cerevisiae)
chr16_+_58497628 2.391 NDRG4
NDRG family member 4
chr19_+_54926721 2.387 TTYH1
tweety homolog 1 (Drosophila)
chr14_+_55034633 2.370 SAMD4A
sterile alpha motif domain containing 4A
chr12_-_69326946 2.363 NM_001005502
NM_198320
CPM

carboxypeptidase M

chr10_-_43762366 2.353 NM_145313
RASGEF1A
RasGEF domain family, member 1A
chr21_-_44846927 2.348 NM_173354
SIK1
salt-inducible kinase 1
chr7_-_50860665 2.341 GRB10
growth factor receptor-bound protein 10
chr12_+_70759974 2.330 NM_014505
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr8_-_125740378 2.328 MTSS1
metastasis suppressor 1
chr10_+_76871345 2.327 NM_001174156
NM_144660
SAMD8

sterile alpha motif domain containing 8

chr10_+_102107074 2.324 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr18_+_56338783 2.312 MALT1
mucosa associated lymphoid tissue lymphoma translocation gene 1
chr7_+_155089614 2.285 INSIG1
insulin induced gene 1
chr7_+_130131921 2.282 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chr12_+_96588254 2.273 ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr12_-_124018066 2.264 NM_178314
RILPL1
Rab interacting lysosomal protein-like 1
chr12_-_124018428 2.255 RILPL1
Rab interacting lysosomal protein-like 1
chr19_+_531737 2.252 CDC34
cell division cycle 34 homolog (S. cerevisiae)
chr17_-_74581934 2.252 ST6GALNAC2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr4_-_57522469 2.250 NM_001145459
NM_139211
HOPX

HOP homeobox

chr2_+_23608297 2.236 NM_052920
KLHL29
kelch-like 29 (Drosophila)
chr15_-_73661141 2.231 HCN4
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chr17_-_80056104 2.228 NM_004104
FASN
fatty acid synthase
chr11_+_33061291 2.228 TCP11L1
t-complex 11 (mouse)-like 1
chr2_-_31361284 2.225 GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr6_+_37137882 2.223 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chr17_+_30813928 2.207 NM_003885
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr3_+_136537860 2.207 NM_001097599
NM_001097600
NM_025246
TMEM22


transmembrane protein 22


chr1_-_85358851 2.205 NM_012152
LPAR3
lysophosphatidic acid receptor 3
chr5_+_92920592 2.198 NR2F1
NR2F2
nuclear receptor subfamily 2, group F, member 1
nuclear receptor subfamily 2, group F, member 2
chr3_-_52567708 2.197 NM_001134231
NT5DC2
5'-nucleotidase domain containing 2
chr22_+_37956404 2.196 NM_152243
CDC42EP1
CDC42 effector protein (Rho GTPase binding) 1
chr14_-_105487413 2.194 CDCA4
cell division cycle associated 4
chr7_-_1199822 2.190 NM_182491
ZFAND2A
zinc finger, AN1-type domain 2A
chr2_+_173420873 2.188 PDK1
pyruvate dehydrogenase kinase, isozyme 1
chr2_-_1748285 2.186 NM_012293
PXDN
peroxidasin homolog (Drosophila)
chr3_-_52090090 2.181 NM_001947
DUSP7
dual specificity phosphatase 7
chr8_-_145050896 2.162 NM_000445
PLEC
plectin
chr7_-_50861114 2.161 NM_001001555
GRB10
growth factor receptor-bound protein 10
chr15_+_90744506 2.157 NM_198925
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr7_-_128045995 2.150 NM_001142573
NM_001142574
NM_001142575
IMPDH1


IMP (inosine 5'-monophosphate) dehydrogenase 1


chr19_+_16187306 2.142 TPM4
tropomyosin 4
chr16_-_58231641 2.142 NM_001896
CSNK2A2
casein kinase 2, alpha prime polypeptide
chr1_+_182992329 2.136 NM_002293
LAMC1
laminin, gamma 1 (formerly LAMB2)
chr3_-_53290099 2.128 NM_001064
NM_001135055
TKT

transketolase

chr22_+_46692637 2.114 NM_016426
GTSE1
G-2 and S-phase expressed 1
chrX_-_109561427 2.113 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr4_-_174450529 2.113 HAND2
heart and neural crest derivatives expressed 2
chr18_-_28681429 2.110 DSC2
desmocollin 2
chr10_+_102107256 2.110


chr17_+_15848422 2.099 ADORA2B
adenosine A2b receptor
chr10_+_112257624 2.099 NM_004419
DUSP5
dual specificity phosphatase 5
chr1_-_236030170 2.094


chr13_-_40177304 2.083 LHFP
lipoma HMGIC fusion partner
chr2_+_208576446 2.077 CCNYL1
cyclin Y-like 1
chr14_+_105155724 2.064 NM_001031714
NM_022489
NM_032714
INF2


inverted formin, FH2 and WH2 domain containing


chr7_+_45614179 2.043 ADCY1
adenylate cyclase 1 (brain)
chr11_-_12030882 2.043 NM_013253
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr1_+_220701523 2.037 MARK1
MAP/microtubule affinity-regulating kinase 1
chr7_-_1199785 2.036 ZFAND2A
zinc finger, AN1-type domain 2A
chr3_+_50192420 2.017 SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr7_-_1199813 2.016 ZFAND2A
zinc finger, AN1-type domain 2A
chr7_-_752083 2.008 PRKAR1B
protein kinase, cAMP-dependent, regulatory, type I, beta
chr12_-_123635284 2.007 PITPNM2
phosphatidylinositol transfer protein, membrane-associated 2
chr14_-_75422466 2.005 NM_001207012
NM_002632
PGF

placental growth factor

chr4_+_1873035 2.004 NM_001042424
WHSC1
Wolf-Hirschhorn syndrome candidate 1
chrX_-_8700132 1.996 KAL1
Kallmann syndrome 1 sequence
chr11_+_94501503 1.983 NM_130847
AMOTL1
angiomotin like 1
chr22_+_50609159 1.976 NM_001160300
NM_052839
PANX2

pannexin 2

chr6_-_53213699 1.968 ELOVL5
ELOVL fatty acid elongase 5
chr13_-_110959441 1.963 NM_001845
COL4A1
collagen, type IV, alpha 1
chr7_+_40174594 1.963 C7orf10
chromosome 7 open reading frame 10
chr14_-_53162198 1.960 ERO1L
ERO1-like (S. cerevisiae)
chr1_-_21044202 1.956 NM_001122819
NM_020816
KIF17

kinesin family member 17

chr8_+_86376130 1.950 NM_000067
CA2
carbonic anhydrase II
chr20_+_61340165 1.941 NM_002531
NTSR1
neurotensin receptor 1 (high affinity)
chr5_+_38845959 1.939 NM_001168355
OSMR
oncostatin M receptor
chr8_+_145734445 1.938 NM_138431
MFSD3
major facilitator superfamily domain containing 3
chrX_-_153602928 1.931 FLNA
filamin A, alpha
chr4_+_1723233 1.928 TACC3
transforming, acidic coiled-coil containing protein 3
chr22_-_37915209 1.927 NM_014550
CARD10
caspase recruitment domain family, member 10
chr2_+_9346909 1.927 ASAP2
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
chr9_+_137218324 1.918 RXRA
retinoid X receptor, alpha
chr22_-_26986071 1.905 NM_003595
TPST2
tyrosylprotein sulfotransferase 2
chr16_-_88851371 1.894 NM_001142864
PIEZO1
piezo-type mechanosensitive ion channel component 1
chr12_+_53491448 1.894 IGFBP6
insulin-like growth factor binding protein 6
chr2_+_9346876 1.886 NM_001135191
NM_003887
ASAP2

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

chr19_+_2096930 1.877 IZUMO4
IZUMO family member 4
chr14_-_91282760 1.877 NM_001010854
TTC7B
tetratricopeptide repeat domain 7B
chr6_+_163835668 1.869 NM_006775
NM_206853
NM_206854
NM_206855
QKI



QKI, KH domain containing, RNA binding



chr9_+_124461365 1.867 DAB2IP
DAB2 interacting protein
chr6_-_53213747 1.863 NM_001242828
NM_001242830
NM_001242831
NM_021814
ELOVL5



ELOVL fatty acid elongase 5



chrX_+_21958714 1.860 NM_004595
SMS
spermine synthase
chr7_-_98741375 1.859 SMURF1
SMAD specific E3 ubiquitin protein ligase 1
chr16_+_66638530 1.857 NM_181553
CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr6_+_160769365 1.854 NM_021977
SLC22A3
solute carrier family 22 (extraneuronal monoamine transporter), member 3
chr2_+_9614636 1.838 NM_001039613
IAH1
isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae)
chr17_+_16945766 1.836 NM_015134
NM_201274
MPRIP

myosin phosphatase Rho interacting protein

chr10_-_3827418 1.832 NM_001160124
NM_001160125
NM_001300
KLF6


Kruppel-like factor 6


chr4_-_177713664 1.828 NM_005429
VEGFC
vascular endothelial growth factor C
chr22_-_26986041 1.826 TPST2
tyrosylprotein sulfotransferase 2
chr7_+_27135672 1.825 HOTAIRM1
HOXA transcript antisense RNA, myeloid-specific 1 (non-protein coding)
chr15_+_68570038 1.824 NM_015322
FEM1B
fem-1 homolog b (C. elegans)
chr11_-_12030838 1.815 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr9_-_123639462 1.814 PHF19
PHD finger protein 19
chr1_-_6557448 1.813 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.13 1.98e-30 GO:0009987 cellular process
1.17 6.09e-18 GO:0050794 regulation of cellular process
1.15 3.22e-17 GO:0065007 biological regulation
1.15 6.77e-17 GO:0050789 regulation of biological process
1.40 7.55e-16 GO:0023051 regulation of signaling
1.41 2.41e-14 GO:0009966 regulation of signal transduction
1.40 4.04e-14 GO:0007399 nervous system development
1.23 9.41e-14 GO:0032502 developmental process
1.51 1.01e-13 GO:0022008 neurogenesis
1.32 1.09e-12 GO:0030154 cell differentiation
1.51 1.19e-12 GO:0048699 generation of neurons
1.22 2.50e-12 GO:0023052 signaling
1.29 4.01e-12 GO:0048519 negative regulation of biological process
1.30 6.49e-12 GO:0048869 cellular developmental process
1.22 7.20e-12 GO:0051179 localization
1.22 1.57e-11 GO:0007275 multicellular organismal development
1.29 2.44e-11 GO:0048523 negative regulation of cellular process
1.36 4.58e-11 GO:0009653 anatomical structure morphogenesis
1.23 6.66e-11 GO:0048856 anatomical structure development
1.22 7.85e-11 GO:0007165 signal transduction
1.63 8.99e-11 GO:0000904 cell morphogenesis involved in differentiation
1.24 1.65e-10 GO:0048731 system development
1.22 2.31e-10 GO:0016043 cellular component organization
1.36 6.64e-10 GO:0035556 intracellular signal transduction
1.65 7.03e-10 GO:0048667 cell morphogenesis involved in neuron differentiation
1.64 9.47e-10 GO:0048812 neuron projection morphogenesis
1.19 1.12e-09 GO:0051716 cellular response to stimulus
1.14 2.53e-09 GO:0044238 primary metabolic process
1.64 4.00e-09 GO:0007409 axonogenesis
1.20 5.90e-09 GO:0071840 cellular component organization or biogenesis
1.28 8.15e-09 GO:0048583 regulation of response to stimulus
1.23 9.30e-09 GO:0071842 cellular component organization at cellular level
1.13 9.51e-09 GO:0044237 cellular metabolic process
1.57 1.93e-08 GO:0031175 neuron projection development
1.53 2.40e-08 GO:0048666 neuron development
1.21 3.07e-08 GO:0051234 establishment of localization
1.51 3.30e-08 GO:0000902 cell morphogenesis
1.47 4.72e-08 GO:0030182 neuron differentiation
1.68 5.43e-08 GO:0007411 axon guidance
1.40 7.23e-08 GO:0048468 cell development
1.55 7.40e-08 GO:0032990 cell part morphogenesis
1.37 7.57e-08 GO:0010646 regulation of cell communication
1.62 7.57e-08 GO:0007264 small GTPase mediated signal transduction
1.12 7.69e-08 GO:0008152 metabolic process
1.22 8.57e-08 GO:0071841 cellular component organization or biogenesis at cellular level
1.21 9.77e-08 GO:0006810 transport
1.54 1.17e-07 GO:0048858 cell projection morphogenesis
1.23 1.33e-07 GO:0048522 positive regulation of cellular process
1.48 1.41e-07 GO:0032989 cellular component morphogenesis
1.41 3.43e-07 GO:0051128 regulation of cellular component organization
1.21 3.90e-07 GO:0048518 positive regulation of biological process
1.98 9.44e-06 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.43 1.07e-05 GO:0030030 cell projection organization
1.14 1.43e-05 GO:0044260 cellular macromolecule metabolic process
1.96 1.44e-05 GO:0022604 regulation of cell morphogenesis
1.13 1.56e-05 GO:0043170 macromolecule metabolic process
1.33 1.95e-05 GO:0032268 regulation of cellular protein metabolic process
1.44 1.96e-05 GO:0042060 wound healing
1.29 1.97e-05 GO:0033036 macromolecule localization
1.24 2.37e-05 GO:0006464 protein modification process
1.36 2.65e-05 GO:0040011 locomotion
1.21 2.91e-05 GO:0042221 response to chemical stimulus
1.38 2.92e-05 GO:0016192 vesicle-mediated transport
1.31 3.54e-05 GO:0051246 regulation of protein metabolic process
1.34 3.60e-05 GO:0050793 regulation of developmental process
1.33 3.82e-05 GO:0032879 regulation of localization
1.60 3.88e-05 GO:0022603 regulation of anatomical structure morphogenesis
1.59 3.92e-05 GO:0060284 regulation of cell development
1.41 3.92e-05 GO:0007167 enzyme linked receptor protein signaling pathway
1.40 4.09e-05 GO:0045595 regulation of cell differentiation
1.46 4.52e-05 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.15 5.59e-05 GO:0019222 regulation of metabolic process
1.69 7.32e-05 GO:0048011 nerve growth factor receptor signaling pathway
1.65 1.12e-04 GO:0050767 regulation of neurogenesis
1.22 1.45e-04 GO:0043412 macromolecule modification
1.20 2.14e-04 GO:0065008 regulation of biological quality
1.15 3.25e-04 GO:0031323 regulation of cellular metabolic process
1.15 3.95e-04 GO:0080090 regulation of primary metabolic process
1.58 4.17e-04 GO:0051960 regulation of nervous system development
1.43 4.91e-04 GO:0007599 hemostasis
1.43 5.06e-04 GO:0007596 blood coagulation
1.43 5.06e-04 GO:0050817 coagulation
1.56 5.23e-04 GO:0051270 regulation of cellular component movement
1.22 6.01e-04 GO:0007166 cell surface receptor linked signaling pathway
1.88 6.84e-04 GO:0007265 Ras protein signal transduction
1.28 6.85e-04 GO:0008104 protein localization
1.42 8.16e-04 GO:0048585 negative regulation of response to stimulus
1.25 1.29e-03 GO:0051641 cellular localization
1.24 1.29e-03 GO:0065009 regulation of molecular function
1.33 1.29e-03 GO:0031399 regulation of protein modification process
1.39 1.36e-03 GO:0050878 regulation of body fluid levels
1.65 1.51e-03 GO:0045664 regulation of neuron differentiation
1.45 1.82e-03 GO:0009968 negative regulation of signal transduction
1.40 2.04e-03 GO:0006935 chemotaxis
1.40 2.04e-03 GO:0042330 taxis
1.43 2.38e-03 GO:0010648 negative regulation of cell communication
1.64 2.53e-03 GO:0044087 regulation of cellular component biogenesis
1.39 2.83e-03 GO:0023056 positive regulation of signaling
1.41 3.15e-03 GO:0045859 regulation of protein kinase activity
1.42 3.45e-03 GO:0023057 negative regulation of signaling
1.25 3.98e-03 GO:0031325 positive regulation of cellular metabolic process
1.14 4.12e-03 GO:0060255 regulation of macromolecule metabolic process
1.87 4.44e-03 GO:0032956 regulation of actin cytoskeleton organization
1.96 4.54e-03 GO:0060828 regulation of canonical Wnt receptor signaling pathway
1.40 5.05e-03 GO:0007010 cytoskeleton organization
1.45 5.19e-03 GO:0090066 regulation of anatomical structure size
1.51 5.97e-03 GO:0040012 regulation of locomotion
1.31 6.07e-03 GO:2000026 regulation of multicellular organismal development
1.27 7.60e-03 GO:0009605 response to external stimulus
1.37 7.83e-03 GO:0010647 positive regulation of cell communication
1.21 8.23e-03 GO:0006996 organelle organization
1.53 8.35e-03 GO:0030334 regulation of cell migration
1.38 9.71e-03 GO:0019226 transmission of nerve impulse
1.38 9.71e-03 GO:0035637 multicellular organismal signaling
1.34 1.16e-02 GO:0051726 regulation of cell cycle
1.23 1.20e-02 GO:0009893 positive regulation of metabolic process
1.32 1.21e-02 GO:0009719 response to endogenous stimulus
1.26 1.31e-02 GO:0007049 cell cycle
1.65 1.31e-02 GO:0051493 regulation of cytoskeleton organization
1.82 1.32e-02 GO:0032970 regulation of actin filament-based process
1.75 1.42e-02 GO:0010975 regulation of neuron projection development
1.33 1.46e-02 GO:0001932 regulation of protein phosphorylation
1.14 1.49e-02 GO:0019538 protein metabolic process
1.41 1.52e-02 GO:0016477 cell migration
1.51 1.58e-02 GO:2000145 regulation of cell motility
1.42 1.61e-02 GO:0010627 regulation of intracellular protein kinase cascade
1.27 1.62e-02 GO:0010605 negative regulation of macromolecule metabolic process
1.32 1.75e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
2.00 1.93e-02 GO:0050770 regulation of axonogenesis
1.67 1.96e-02 GO:0031344 regulation of cell projection organization
1.22 2.01e-02 GO:0051239 regulation of multicellular organismal process
1.48 2.07e-02 GO:0001944 vasculature development
1.36 2.28e-02 GO:0009967 positive regulation of signal transduction
1.31 2.36e-02 GO:0042325 regulation of phosphorylation
1.25 2.42e-02 GO:0006793 phosphorus metabolic process
1.25 2.42e-02 GO:0006796 phosphate metabolic process
1.52 2.58e-02 GO:0046578 regulation of Ras protein signal transduction
1.26 2.66e-02 GO:0009892 negative regulation of metabolic process
1.32 2.87e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.34 2.94e-02 GO:0055086 nucleobase, nucleoside and nucleotide metabolic process
1.50 2.96e-02 GO:0045596 negative regulation of cell differentiation
1.91 3.01e-02 GO:0030178 negative regulation of Wnt receptor signaling pathway
1.36 3.06e-02 GO:0043549 regulation of kinase activity
1.30 3.13e-02 GO:0009890 negative regulation of biosynthetic process
1.34 3.19e-02 GO:0006928 cellular component movement
1.27 3.71e-02 GO:0016265 death
1.44 3.92e-02 GO:0032535 regulation of cellular component size
1.66 4.27e-02 GO:0034330 cell junction organization
1.27 4.30e-02 GO:0045184 establishment of protein localization
1.94 4.52e-02 GO:0010721 negative regulation of cell development
1.35 4.62e-02 GO:0051338 regulation of transferase activity
1.26 4.98e-02 GO:0008219 cell death

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.17 1.39e-29 GO:0005737 cytoplasm
1.11 5.21e-25 GO:0005622 intracellular
1.11 8.40e-24 GO:0044424 intracellular part
1.17 7.19e-17 GO:0044444 cytoplasmic part
1.31 2.59e-13 GO:0005829 cytosol
1.09 1.92e-09 GO:0043229 intracellular organelle
1.09 2.56e-09 GO:0043226 organelle
1.88 2.88e-08 GO:0031252 cell leading edge
1.93 1.93e-07 GO:0005912 adherens junction
1.04 2.67e-07 GO:0044464 cell part
1.04 2.90e-07 GO:0005623 cell
1.09 3.47e-07 GO:0043231 intracellular membrane-bounded organelle
1.09 3.76e-07 GO:0043227 membrane-bounded organelle
1.86 5.08e-07 GO:0070161 anchoring junction
1.44 9.78e-07 GO:0030054 cell junction
1.37 1.06e-06 GO:0005626 insoluble fraction
1.34 2.02e-05 GO:0005624 membrane fraction
1.29 2.40e-05 GO:0000267 cell fraction
1.24 2.75e-05 GO:0012505 endomembrane system
1.97 5.07e-05 GO:0005925 focal adhesion
1.29 1.54e-04 GO:0005794 Golgi apparatus
1.18 2.08e-04 GO:0044459 plasma membrane part
1.45 2.42e-04 GO:0043005 neuron projection
1.30 2.46e-04 GO:0042995 cell projection
2.15 2.52e-04 GO:0031256 leading edge membrane
1.88 3.75e-04 GO:0005924 cell-substrate adherens junction
1.10 3.76e-04 GO:0044446 intracellular organelle part
1.84 6.00e-04 GO:0030055 cell-substrate junction
1.21 6.55e-04 GO:0005856 cytoskeleton
1.10 9.96e-04 GO:0044422 organelle part
1.35 1.10e-03 GO:0044431 Golgi apparatus part
1.49 1.43e-03 GO:0015629 actin cytoskeleton
1.54 1.96e-03 GO:0016323 basolateral plasma membrane
1.29 4.01e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
1.14 5.27e-03 GO:0043234 protein complex
1.28 5.35e-03 GO:0031410 cytoplasmic vesicle
1.28 8.14e-03 GO:0031988 membrane-bounded vesicle
1.57 1.09e-02 GO:0030424 axon
1.26 1.14e-02 GO:0031982 vesicle
1.82 1.47e-02 GO:0030027 lamellipodium
2.93 1.52e-02 GO:0032589 neuron projection membrane
1.09 1.95e-02 GO:0005634 nucleus
1.74 2.04e-02 GO:0019717 synaptosome
1.76 3.09e-02 GO:0001726 ruffle
2.03 3.13e-02 GO:0005905 coated pit
1.63 3.50e-02 GO:0031253 cell projection membrane
1.31 4.88e-02 GO:0000139 Golgi membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.18 8.42e-25 GO:0005515 protein binding
1.09 1.21e-17 GO:0005488 binding
1.59 4.25e-09 GO:0019904 protein domain specific binding
1.45 4.54e-06 GO:0008092 cytoskeletal protein binding
1.11 9.60e-05 GO:0003824 catalytic activity
1.22 1.81e-04 GO:0016740 transferase activity
1.53 2.67e-04 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.42 2.67e-04 GO:0060589 nucleoside-triphosphatase regulator activity
1.42 3.03e-04 GO:0030695 GTPase regulator activity
1.55 3.66e-04 GO:0016881 acid-amino acid ligase activity
1.58 6.05e-04 GO:0019787 small conjugating protein ligase activity
1.46 2.69e-03 GO:0003779 actin binding
1.55 3.91e-03 GO:0004842 ubiquitin-protein ligase activity
1.77 5.91e-03 GO:0017124 SH3 domain binding
1.43 8.54e-03 GO:0042578 phosphoric ester hydrolase activity
1.17 1.08e-02 GO:0032553 ribonucleotide binding
1.17 1.08e-02 GO:0032555 purine ribonucleotide binding
1.17 1.69e-02 GO:0017076 purine nucleotide binding
1.48 1.92e-02 GO:0016791 phosphatase activity
1.25 1.92e-02 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.60 2.10e-02 GO:0004721 phosphoprotein phosphatase activity
1.17 2.18e-02 GO:0035639 purine ribonucleoside triphosphate binding
1.15 3.17e-02 GO:0000166 nucleotide binding
1.24 3.26e-02 GO:0030234 enzyme regulator activity
1.27 3.53e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.26 3.54e-02 GO:0019899 enzyme binding
1.77 4.56e-02 GO:0005088 Ras guanyl-nucleotide exchange factor activity
1.25 4.98e-02 GO:0016301 kinase activity