Motif ID: HIF1A.p2

Z-value: 1.247


Transcription factors associated with HIF1A.p2:

Gene SymbolEntrez IDGene Name
HIF1A 3091 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIF1Achr14_+_62162042,
chr14_+_62164339
0.057.9e-01Click!


Activity profile for motif HIF1A.p2.

activity profile for motif HIF1A.p2


Sorted Z-values histogram for motif HIF1A.p2

Sorted Z-values for motif HIF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIF1A.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_23261626 3.138 LOXL2
lysyl oxidase-like 2
chr8_-_23261632 2.801 LOXL2
lysyl oxidase-like 2
chr13_-_20806533 2.684 NM_001110219
NM_001110220
NM_001110221
GJB6


gap junction protein, beta 6, 30kDa


chr1_+_193091283 2.631 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr8_-_23261675 2.560 NM_002318
LOXL2
lysyl oxidase-like 2
chr6_+_43738757 2.523 VEGFA
vascular endothelial growth factor A
chrX_+_69509878 2.365 NM_012310
KIF4A
kinesin family member 4A
chr12_-_57634474 2.291 NM_020142
NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr16_-_87903028 2.226 NM_003486
SLC7A5
solute carrier family 7 (amino acid transporter light chain, L system), member 5
chr5_-_59995938 2.223 NM_001145208
NM_018369
DEPDC1B

DEP domain containing 1B

chr15_-_90039776 2.219 NM_016321
RHCG
Rh family, C glycoprotein
chr22_+_40390935 2.194 NM_138435
FAM83F
family with sequence similarity 83, member F
chrX_+_135229536 2.092 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr7_-_102920665 2.051 DPY19L2P2
dpy-19-like 2 pseudogene 2 (C. elegans)
chr5_+_154393259 2.030 NM_001099293
KIF4B
kinesin family member 4B
chr11_+_69924407 1.966 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr7_-_102920840 1.958 DPY19L2P2
dpy-19-like 2 pseudogene 2 (C. elegans)
chr1_-_26233367 1.907 NM_203399
STMN1
stathmin 1
chr8_-_23261591 1.900 LOXL2
lysyl oxidase-like 2
chr19_+_4909447 1.865 NM_001048201
UHRF1
ubiquitin-like with PHD and ring finger domains 1
chr2_+_173420873 1.863 PDK1
pyruvate dehydrogenase kinase, isozyme 1
chr1_-_26232890 1.850 NM_001145454
NM_005563
STMN1

stathmin 1

chr7_-_98741605 1.802 SMURF1
SMAD specific E3 ubiquitin protein ligase 1
chr8_+_31497267 1.727 NM_013962
NRG1
neuregulin 1
chr7_-_98741681 1.632 NM_001199847
NM_020429
NM_181349
SMURF1


SMAD specific E3 ubiquitin protein ligase 1


chr10_+_3110818 1.627 NM_001242339
PFKP
phosphofructokinase, platelet
chr3_-_81810618 1.583 GBE1
glucan (1,4-alpha-), branching enzyme 1
chr13_+_41363754 1.583 SLC25A15
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
chr3_-_50336662 1.536 NM_001200016
NM_012191
NM_001200030
NM_001200031
NM_001200032
NM_003549
NAT6

HYAL3



N-acetyltransferase 6 (GCN5-related)

hyaluronoglucosaminidase 3



chr2_+_173420794 1.533 PDK1
pyruvate dehydrogenase kinase, isozyme 1
chr3_-_145879222 1.513 NM_000935
NM_182943
PLOD2

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

chr21_-_44495894 1.510 NM_000071
CBS
cystathionine-beta-synthase
chr7_+_27135672 1.503 HOTAIRM1
HOXA transcript antisense RNA, myeloid-specific 1 (non-protein coding)
chr3_-_81810914 1.501 NM_000158
GBE1
glucan (1,4-alpha-), branching enzyme 1
chr15_-_83953465 1.496 NM_001717
BNC1
basonuclin 1
chr7_+_156931663 1.479 UBE3C
ubiquitin protein ligase E3C
chr11_-_568419 1.444 MIR210HG
MIR210 host gene (non-protein coding)
chr11_-_125366048 1.444 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr2_-_224903933 1.443 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr3_-_50336258 1.432 NM_001200018
NM_001200029
NAT6
HYAL3
N-acetyltransferase 6 (GCN5-related)
hyaluronoglucosaminidase 3
chr7_+_128095881 1.420 NM_001098786
NM_013332
HILPDA

hypoxia inducible lipid droplet-associated

chr7_+_130126035 1.412 NM_177524
MEST
mesoderm specific transcript homolog (mouse)
chr20_+_42086533 1.405 SRSF6
serine/arginine-rich splicing factor 6
chr6_+_34204690 1.358 HMGA1
high mobility group AT-hook 1
chr11_-_66725790 1.356 NM_000920
NM_001040716
PC

pyruvate carboxylase

chr6_+_34205029 1.347 HMGA1
high mobility group AT-hook 1
chr3_-_81810816 1.324 GBE1
glucan (1,4-alpha-), branching enzyme 1
chr1_+_65613211 1.302 NM_203464
NM_001005353
AK4

adenylate kinase 4

chr1_-_26232643 1.291 NM_203401
STMN1
stathmin 1
chr3_-_50374795 1.270 RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chrX_+_64887534 1.267 MSN
moesin
chr14_+_65171243 1.263 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chrX_+_64887510 1.263 NM_002444
MSN
moesin
chr5_-_131563481 1.240 NM_001017974
NM_001142598
NM_001142599
P4HA2


prolyl 4-hydroxylase, alpha polypeptide II


chr6_+_151187310 1.234 NM_001242768
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr7_+_156931631 1.223 NM_014671
UBE3C
ubiquitin protein ligase E3C
chr19_+_38810540 1.204 KCNK6
potassium channel, subfamily K, member 6
chr19_+_35646006 1.203 FXYD5
FXYD domain containing ion transport regulator 5
chr18_+_33877630 1.202 NM_025135
FHOD3
formin homology 2 domain containing 3
chr11_+_13690246 1.200 FAR1
fatty acyl CoA reductase 1
chr6_+_151187064 1.196 MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr1_+_65613971 1.193 AK4
adenylate kinase 4
chr2_+_113403433 1.174 NM_005415
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr3_-_52090090 1.169 NM_001947
DUSP7
dual specificity phosphatase 7
chr22_+_45148437 1.165 NM_001017526
NM_001198726
NM_181335
ARHGAP8


Rho GTPase activating protein 8


chr6_+_34204928 1.162 HMGA1
high mobility group AT-hook 1
chr4_-_143767603 1.159 NM_001101669
NM_003866
INPP4B

inositol polyphosphate-4-phosphatase, type II, 105kDa

chr6_+_34204663 1.154 HMGA1
high mobility group AT-hook 1
chrX_+_152954965 1.150 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr13_+_41363642 1.146 SLC25A15
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
chr1_+_214776494 1.141 NM_016343
CENPF
centromere protein F, 350/400kDa (mitosin)
chr13_+_41363546 1.140 NM_014252
SLC25A15
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
chr14_-_53162198 1.123 ERO1L
ERO1-like (S. cerevisiae)
chr10_-_17659365 1.117 NM_014241
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr1_-_8939150 1.111 NM_001428
ENO1
enolase 1, (alpha)
chr3_-_145878936 1.111 PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr3_-_179169180 1.107 GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr21_-_45079327 1.100 NM_007031
HSF2BP
heat shock transcription factor 2 binding protein
chr17_-_43510279 1.090 NM_174919
ARHGAP27
Rho GTPase activating protein 27
chr10_-_133795311 1.066 NM_004052
BNIP3
BCL2/adenovirus E1B 19kDa interacting protein 3
chr6_+_34205369 1.065 HMGA1
high mobility group AT-hook 1
chr14_-_53162370 1.039 ERO1L
ERO1-like (S. cerevisiae)
chr17_-_74497406 1.038 NM_024599
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chrX_+_77359665 1.028 NM_000291
PGK1
phosphoglycerate kinase 1
chr14_-_53162418 1.024 NM_014584
ERO1L
ERO1-like (S. cerevisiae)
chr16_+_610393 1.009 NM_145270
C16orf11
chromosome 16 open reading frame 11
chr11_-_19263144 1.003 E2F8
E2F transcription factor 8
chr1_+_214776582 0.998 CENPF
centromere protein F, 350/400kDa (mitosin)
chr19_+_1407750 0.994 DAZAP1
DAZ associated protein 1
chr10_-_133795447 0.993 BNIP3
BCL2/adenovirus E1B 19kDa interacting protein 3
chr11_+_33061560 0.987 NM_001145541
TCP11L1
t-complex 11 (mouse)-like 1
chr5_+_55033844 0.983 NM_001142549
NM_001166533
NM_024415
DDX4


DEAD (Asp-Glu-Ala-Asp) box polypeptide 4


chr1_-_6557448 0.970 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr8_+_95653272 0.959 ESRP1
epithelial splicing regulatory protein 1
chr10_+_101419169 0.956 NM_020354
ENTPD7
ectonucleoside triphosphate diphosphohydrolase 7
chr6_-_144385647 0.946 NM_001080951
NM_001080955
PLAGL1

pleiomorphic adenoma gene-like 1

chr15_-_70390226 0.935 TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr11_+_33061291 0.930 TCP11L1
t-complex 11 (mouse)-like 1
chr1_-_29450406 0.914 NM_001003682
TMEM200B
transmembrane protein 200B
chr17_-_8055684 0.911 NM_002616
PER1
period homolog 1 (Drosophila)
chr11_-_107729492 0.907 SLC35F2
solute carrier family 35, member F2
chr7_-_128045995 0.906 NM_001142573
NM_001142574
NM_001142575
IMPDH1


IMP (inosine 5'-monophosphate) dehydrogenase 1


chr10_+_75910908 0.895 NM_001202450
NM_006721
ADK

adenosine kinase

chr3_-_145878775 0.890 PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr12_+_7023490 0.888 NM_001975
ENO2
enolase 2 (gamma, neuronal)
chr7_-_72742084 0.886 NM_178125
TRIM50
tripartite motif containing 50
chr18_+_56338818 0.885 MALT1
mucosa associated lymphoid tissue lymphoma translocation gene 1
chr3_+_5229357 0.881 NM_014674
EDEM1
ER degradation enhancer, mannosidase alpha-like 1
chr11_-_107729523 0.876 SLC35F2
solute carrier family 35, member F2
chr18_+_56338678 0.872 MALT1
mucosa associated lymphoid tissue lymphoma translocation gene 1
chr10_+_112257624 0.872 NM_004419
DUSP5
dual specificity phosphatase 5
chr12_-_76424474 0.860 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr9_-_94185959 0.860 NFIL3
nuclear factor, interleukin 3 regulated
chr3_+_5229430 0.856 EDEM1
ER degradation enhancer, mannosidase alpha-like 1
chr1_-_20812271 0.855 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr19_-_4400470 0.854 NM_001199943
NM_003025
SH3GL1

SH3-domain GRB2-like 1

chr6_+_151646634 0.852 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chr14_+_55034633 0.852 SAMD4A
sterile alpha motif domain containing 4A
chr9_-_94186140 0.850 NM_005384
NFIL3
nuclear factor, interleukin 3 regulated
chr4_+_186317964 0.848 ANKRD37
ankyrin repeat domain 37
chr5_+_68462836 0.848 NM_031966
CCNB1
cyclin B1
chr15_-_42264687 0.848 EHD4
EH-domain containing 4
chr8_-_30515665 0.845 NM_002095
GTF2E2
general transcription factor IIE, polypeptide 2, beta 34kDa
chr17_-_74449220 0.840 UBE2O
ubiquitin-conjugating enzyme E2O
chr8_+_26435339 0.837 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr15_+_67358161 0.835 SMAD3
SMAD family member 3
chr4_+_186317837 0.831 NM_181726
ANKRD37
ankyrin repeat domain 37
chr8_-_125740650 0.831 NM_014751
MTSS1
metastasis suppressor 1
chr7_-_27135524 0.825 NM_005522
NM_153620
HOXA1

homeobox A1

chrX_+_77359768 0.825 PGK1
phosphoglycerate kinase 1
chr7_+_43622638 0.825 NM_004760
STK17A
serine/threonine kinase 17a
chr3_+_156392369 0.819 TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr13_+_48877950 0.808 RB1
retinoblastoma 1
chr11_+_94501503 0.802 NM_130847
AMOTL1
angiomotin like 1
chr1_+_65613771 0.790 NM_013410
AK4
adenylate kinase 4
chr7_-_148581377 0.784 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr17_+_25621105 0.783 NM_015626
NM_134265
WSB1

WD repeat and SOCS box containing 1

chr7_-_97601654 0.778


chr18_+_56338783 0.774 MALT1
mucosa associated lymphoid tissue lymphoma translocation gene 1
chr19_+_1407664 0.772 DAZAP1
DAZ associated protein 1
chr3_-_57113292 0.767 NM_001128615
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr18_+_56338617 0.762 NM_006785
NM_173844
MALT1

mucosa associated lymphoid tissue lymphoma translocation gene 1

chr1_-_19578030 0.758 KIAA0090
KIAA0090
chr14_-_103995336 0.755


chr1_+_1550794 0.754 NM_001170686
NM_001170687
NM_001170688
NM_080875
MIB2



mindbomb homolog 2 (Drosophila)



chr1_+_209848994 0.752 G0S2
G0/G1switch 2
chr14_+_65171149 0.751 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr11_-_76381787 0.751 NM_001128922
LRRC32
leucine rich repeat containing 32
chr1_-_8938691 0.750 ENO1
enolase 1, (alpha)
chrX_+_77359712 0.748 PGK1
phosphoglycerate kinase 1
chr22_+_45098091 0.747 NM_181334
PRR5-ARHGAP8
PRR5
PRR5-ARHGAP8 readthrough
proline rich 5 (renal)
chr7_-_87505640 0.747 SLC25A40
solute carrier family 25, member 40
chr15_+_68570402 0.744 FEM1B
fem-1 homolog b (C. elegans)
chrX_+_64887593 0.742 MSN
moesin
chr1_-_43833689 0.739 NM_022821
ELOVL1
ELOVL fatty acid elongase 1
chr16_+_88870214 0.738 CDT1
chromatin licensing and DNA replication factor 1
chr11_+_72929392 0.735 NM_176071
P2RY2
purinergic receptor P2Y, G-protein coupled, 2
chr6_-_144329342 0.733 NM_001080952
NM_001080953
NM_001080954
NM_001080956
NM_002656
NM_006718
PLAGL1





HYMAI
pleiomorphic adenoma gene-like 1





hydatidiform mole associated and imprinted (non-protein coding)
chr17_-_41622727 0.729 ETV4
ets variant 4
chrX_-_132092224 0.719 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr7_+_26331493 0.719 NM_001199835
NM_013322
SNX10

sorting nexin 10

chr19_+_11039419 0.718 NM_138358
C19orf52
chromosome 19 open reading frame 52
chr9_-_72287097 0.717 NM_001163
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chrX_-_152939256 0.717 PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr3_-_52273031 0.717 TWF2
twinfilin, actin-binding protein, homolog 2 (Drosophila)
chr19_+_4910339 0.715 NM_013282
UHRF1
ubiquitin-like with PHD and ring finger domains 1
chr11_-_71159442 0.714 NM_001163817
NM_001360
DHCR7

7-dehydrocholesterol reductase

chr19_+_45281125 0.714 NM_001130852
NM_012116
CBLC

Cas-Br-M (murine) ecotropic retroviral transforming sequence c

chr4_+_186317892 0.713 ANKRD37
ankyrin repeat domain 37
chr7_+_55086922 0.709 EGFR
epidermal growth factor receptor
chr2_-_97652300 0.709 NM_001122646
FAM178B
family with sequence similarity 178, member B
chr17_+_40610905 0.705 ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr15_-_70390229 0.702 NM_001105192
NM_005078
NM_020908
TLE3


transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)


chr12_-_99038401 0.697 NM_153687
NM_201612
NM_201613
IKBIP


IKBKB interacting protein


chr10_-_121356474 0.697 TIAL1
TIA1 cytotoxic granule-associated RNA binding protein-like 1
chr14_+_64971417 0.693 ZBTB1
zinc finger and BTB domain containing 1
chr3_-_50374749 0.693 RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr4_+_57302448 0.692 PAICS
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr3_-_50374875 0.691 NM_170713
RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr11_+_126226095 0.690 NM_006278
ST3GAL4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr1_+_230202966 0.689 GALNT2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
chr8_+_26240522 0.689 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr1_-_8938727 0.687 ENO1
enolase 1, (alpha)
chr20_+_42295708 0.686 NM_002466
MYBL2
v-myb myeloblastosis viral oncogene homolog (avian)-like 2
chr7_-_87505453 0.686 SLC25A40
solute carrier family 25, member 40
chr11_-_64014140 0.686 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr18_+_12308242 0.685 NM_032525
TUBB6
tubulin, beta 6 class V
chr3_-_179169330 0.677 NM_021629
GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr10_+_3109708 0.676 NM_002627
PFKP
phosphofructokinase, platelet
chr7_-_148581359 0.676 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr3_+_122785855 0.669 NM_006810
PDIA5
protein disulfide isomerase family A, member 5
chr19_-_14201230 0.669 NM_138352
SAMD1
sterile alpha motif domain containing 1
chr15_-_63673918 0.663 CA12
carbonic anhydrase XII
chr4_-_104119475 0.660 NM_001813
CENPE
centromere protein E, 312kDa
chr14_+_24769116 0.656


chr17_-_80056104 0.652 NM_004104
FASN
fatty acid synthase
chr13_+_114239047 0.652 NM_007111
TFDP1
transcription factor Dp-1
chr9_+_5629110 0.651 NM_001135920
NM_001206557
NM_020829
KIAA1432


KIAA1432


chr7_-_148581379 0.651 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr15_+_63481788 0.648 RAB8B
RAB8B, member RAS oncogene family

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.13 2.31e-09 GO:0009987 cellular process
1.22 3.75e-07 GO:0044237 cellular metabolic process
1.26 2.46e-05 GO:0044260 cellular macromolecule metabolic process
1.91 3.27e-05 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.78 6.47e-05 GO:0007167 enzyme linked receptor protein signaling pathway
1.17 2.16e-04 GO:0008152 metabolic process
1.62 3.47e-04 GO:0045184 establishment of protein localization
2.29 4.37e-04 GO:0048011 nerve growth factor receptor signaling pathway
1.18 8.91e-04 GO:0044238 primary metabolic process
1.53 1.29e-03 GO:0008104 protein localization
1.59 1.39e-03 GO:0015031 protein transport
1.28 1.97e-03 GO:0051234 establishment of localization
1.31 3.04e-03 GO:0044267 cellular protein metabolic process
1.25 4.04e-03 GO:0051179 localization
1.27 5.39e-03 GO:0006810 transport
1.44 5.84e-03 GO:0033036 macromolecule localization
1.57 8.12e-03 GO:0046907 intracellular transport
1.23 9.92e-03 GO:0023052 signaling
1.42 1.68e-02 GO:0051641 cellular localization
1.19 1.76e-02 GO:0043170 macromolecule metabolic process
1.45 2.44e-02 GO:0051649 establishment of localization in cell
1.36 2.51e-02 GO:0023051 regulation of signaling
1.78 3.46e-02 GO:0007264 small GTPase mediated signal transduction
1.80 3.90e-02 GO:0044419 interspecies interaction between organisms
1.23 4.37e-02 GO:0007165 signal transduction
1.39 4.42e-02 GO:0035556 intracellular signal transduction
1.31 4.47e-02 GO:0030154 cell differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.20 1.05e-27 GO:0044424 intracellular part
1.19 3.50e-25 GO:0005622 intracellular
1.29 4.17e-25 GO:0005737 cytoplasm
1.33 7.08e-18 GO:0044444 cytoplasmic part
1.19 3.18e-15 GO:0043229 intracellular organelle
1.19 3.87e-15 GO:0043226 organelle
1.20 6.11e-13 GO:0043231 intracellular membrane-bounded organelle
1.20 8.69e-13 GO:0043227 membrane-bounded organelle
1.51 4.47e-10 GO:0005829 cytosol
1.27 7.06e-10 GO:0044446 intracellular organelle part
1.26 2.56e-09 GO:0044422 organelle part
1.53 7.05e-08 GO:0012505 endomembrane system
1.43 4.49e-07 GO:0031090 organelle membrane
2.58 3.87e-06 GO:0031252 cell leading edge
3.21 2.57e-05 GO:0001726 ruffle
1.66 4.10e-05 GO:0044432 endoplasmic reticulum part
1.54 4.37e-05 GO:0005783 endoplasmic reticulum
1.05 1.96e-04 GO:0044464 cell part
1.05 2.03e-04 GO:0005623 cell
1.66 2.21e-04 GO:0005789 endoplasmic reticulum membrane
1.64 3.52e-04 GO:0042175 nuclear membrane-endoplasmic reticulum network
1.31 9.71e-04 GO:0031974 membrane-enclosed lumen
1.31 1.99e-03 GO:0044428 nuclear part
1.17 2.52e-03 GO:0005634 nucleus
1.30 2.93e-03 GO:0070013 intracellular organelle lumen
1.29 4.56e-03 GO:0043233 organelle lumen
1.33 5.17e-03 GO:0031981 nuclear lumen
1.92 1.87e-02 GO:0005635 nuclear envelope
1.24 2.27e-02 GO:0043228 non-membrane-bounded organelle
1.24 2.27e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.61 2.36e-02 GO:0005730 nucleolus
1.20 2.47e-02 GO:0032991 macromolecular complex
2.06 3.88e-02 GO:0070161 anchoring junction
1.22 4.77e-02 GO:0043234 protein complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.29 6.18e-19 GO:0005515 protein binding
1.12 2.33e-09 GO:0005488 binding
1.38 4.78e-06 GO:0000166 nucleotide binding
1.71 1.17e-03 GO:0008092 cytoskeletal protein binding
1.77 2.14e-03 GO:0019904 protein domain specific binding
1.71 4.14e-03 GO:0060589 nucleoside-triphosphatase regulator activity
1.17 5.96e-03 GO:0003824 catalytic activity
1.89 6.29e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.32 7.08e-03 GO:0032553 ribonucleotide binding
1.32 7.08e-03 GO:0032555 purine ribonucleotide binding
1.32 7.17e-03 GO:0017076 purine nucleotide binding
1.68 1.13e-02 GO:0030695 GTPase regulator activity
1.89 1.74e-02 GO:0016881 acid-amino acid ligase activity
1.31 2.07e-02 GO:0035639 purine ribonucleoside triphosphate binding
1.65 2.92e-02 GO:0016874 ligase activity