Motif ID: HMX1.p2

Z-value: 1.184


Transcription factors associated with HMX1.p2:

Gene SymbolEntrez IDGene Name
HMX1 3166 H6 family homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HMX1chr4_-_88734530.271.5e-01Click!


Activity profile for motif HMX1.p2.

activity profile for motif HMX1.p2


Sorted Z-values histogram for motif HMX1.p2

Sorted Z-values for motif HMX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMX1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51472816 6.292 NM_002774
 KLK6
kallikrein-related peptidase 6
chr1_-_153433104 4.592 NM_002963
 S100A7
S100 calcium binding protein A7
chr3_-_111314181 3.919 NM_024508
 ZBED2
zinc finger, BED-type containing 2
chr11_+_69924407 3.039 NM_018043
 ANO1
anoctamin 1, calcium activated chloride channel
chr22_-_37640287 2.792 NM_002872
 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr12_+_4382882 2.727 NM_001759
 CCND2
cyclin D2
chr22_-_37640187 2.690 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chrX_-_107019001 2.613 NM_198057
 TSC22D3
TSC22 domain family, member 3
chr17_+_74381186 2.551 NM_001142602
 SPHK1
sphingosine kinase 1
chr2_-_192015733 2.513 STAT4
signal transducer and activator of transcription 4
chr17_+_74381419 2.427 SPHK1
sphingosine kinase 1
chr2_-_192015751 2.284 STAT4
signal transducer and activator of transcription 4
chrX_-_107018889 2.272 TSC22D3
TSC22 domain family, member 3
chr4_+_75310852 2.262 NM_001657
 AREG
amphiregulin
chr2_-_192015934 2.197 NM_003151
 STAT4
signal transducer and activator of transcription 4
chr2_-_192015706 2.151 STAT4
signal transducer and activator of transcription 4
chr10_-_135150368 2.058 CALY
calcyon neuron-specific vesicular protein
chr6_+_86159738 2.044 NT5E
5'-nucleotidase, ecto (CD73)
chrX_-_153599581 2.036 FLNA
filamin A, alpha
chr4_-_175443791 2.018 NM_000860
NM_001145816
 HPGD

hydroxyprostaglandin dehydrogenase 15-(NAD)


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 85 entries
enrichment   p-value GO term description
5.26 1.35e-02 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway
3.26 4.54e-02 GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
2.84 9.94e-03 GO:0007160 cell-matrix adhesion
2.74 7.30e-03 GO:0051216 cartilage development
2.43 2.43e-02 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
2.27 1.58e-04 GO:0048011 nerve growth factor receptor signaling pathway
1.94 4.06e-02 GO:0046578 regulation of Ras protein signal transduction
1.93 5.43e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.87 6.51e-04 GO:0016477 cell migration
1.87 8.01e-03 GO:0009894 regulation of catabolic process
1.86 2.71e-03 GO:0051056 regulation of small GTPase mediated signal transduction
1.85 1.25e-02 GO:0007411 axon guidance
1.82 7.67e-04 GO:0048870 cell motility
1.82 7.67e-04 GO:0051674 localization of cell
1.82 2.28e-03 GO:0007409 axonogenesis
1.81 5.75e-05 GO:0006928 cellular component movement
1.81 1.34e-03 GO:0051094 positive regulation of developmental process
1.80 2.91e-04 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.80 2.13e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.79 1.22e-02 GO:0007264 small GTPase mediated signal transduction

Gene overrepresentation in compartment category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
3.79 2.95e-02 GO:0008305 integrin complex
1.69 1.67e-02 GO:0031012 extracellular matrix
1.42 3.36e-07 GO:0005829 cytosol
1.38 3.25e-06 GO:0044459 plasma membrane part
1.22 3.06e-04 GO:0071944 cell periphery
1.21 7.27e-04 GO:0005886 plasma membrane
1.12 7.78e-04 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
2.87 4.91e-03 GO:0005089 Rho guanyl-nucleotide exchange factor activity
2.52 1.90e-02 GO:0005088 Ras guanyl-nucleotide exchange factor activity
2.07 3.29e-02 GO:0005085 guanyl-nucleotide exchange factor activity
1.82 1.26e-02 GO:0005083 small GTPase regulator activity
1.62 2.40e-02 GO:0030695 GTPase regulator activity
1.60 3.27e-02 GO:0060589 nucleoside-triphosphatase regulator activity
1.56 6.39e-05 GO:0030234 enzyme regulator activity
1.23 3.18e-12 GO:0005515 protein binding
1.10 4.36e-07 GO:0005488 binding