Motif ID: HNF1A.p2

Z-value: 0.788


Transcription factors associated with HNF1A.p2:

Gene SymbolEntrez IDGene Name
HNF1A 6927 HNF1 homeobox A

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HNF1Achr12_+_121416294-0.441.5e-02Click!


Activity profile for motif HNF1A.p2.

activity profile for motif HNF1A.p2


Sorted Z-values histogram for motif HNF1A.p2

Sorted Z-values for motif HNF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF1A.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_32497925 3.502 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr6_-_32557431 3.229 NM_001243965
NM_002124
HLA-DRB1

HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1

major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr4_-_110723127 2.303 CFI
complement factor I
chr10_+_114154522 2.273 ACSL5
acyl-CoA synthetase long-chain family member 5
chr14_-_94854910 2.107 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr4_-_110723334 2.067 NM_000204
CFI
complement factor I
chr11_+_71900958 1.853 NM_000802
FOLR1
folate receptor 1 (adult)
chr12_+_20963637 1.671 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr7_+_141695678 1.592 NM_004668
MGAM
maltase-glucoamylase (alpha-glucosidase)
chr20_+_9288446 1.550 NM_000933
PLCB4
phospholipase C, beta 4
chr14_-_94855120 1.540 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr1_+_18807423 1.504 NM_152375
KLHDC7A
kelch domain containing 7A
chr7_-_50633042 1.500 NM_001082971
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr17_+_4692226 1.428 NM_001014985
GLTPD2
glycolipid transfer protein domain containing 2
chr12_-_71551564 1.405 TSPAN8
tetraspanin 8
chr15_-_90349819 1.347 ANPEP
alanyl (membrane) aminopeptidase
chr4_+_25658085 1.317 NM_001177999
SLC34A2
solute carrier family 34 (sodium phosphate), member 2
chr4_-_100273831 1.312 NM_000669
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr4_+_69962191 1.309 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr14_+_21156922 1.191 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr11_+_71900601 1.190 NM_016724
NM_016725
FOLR1

folate receptor 1 (adult)

chr1_+_162351519 1.182 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chr6_+_126070724 1.079 NM_012259
HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr17_+_73553883 1.034 LLGL2
lethal giant larvae homolog 2 (Drosophila)
chr13_+_43355685 1.028 NM_182508
C13orf30
chromosome 13 open reading frame 30
chr1_+_104159953 1.015 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr3_-_161089747 0.922 NM_001040100
SPTSSB
serine palmitoyltransferase, small subunit B
chr8_-_95220769 0.893 NM_004063
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr6_+_126070813 0.870 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr13_+_96085852 0.858 NM_001160100
NM_182848
CLDN10

claudin 10

chr8_-_108510094 0.822 NM_001146
NM_001199859
ANGPT1

angiopoietin 1

chr14_-_92333856 0.809 NM_001128596
TC2N
tandem C2 domains, nuclear
chrX_-_105282714 0.795 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr9_-_21305311 0.767 NM_002169
IFNA5
interferon, alpha 5
chr3_-_137834450 0.765 NM_173543
DZIP1L
DAZ interacting protein 1-like
chr1_+_211519705 0.727 NM_145759
TRAF5
TNF receptor-associated factor 5
chr8_+_21911062 0.697 NM_001114137
EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr6_+_126070738 0.692 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr22_-_32651317 0.678 NM_014227
SLC5A4
solute carrier family 5 (low affinity glucose cotransporter), member 4
chr17_+_73642645 0.677 NM_001162997
C17orf110
chromosome 17 open reading frame 110
chr17_-_202557 0.668 RPH3AL
rabphilin 3A-like (without C2 domains)
chr1_+_47264669 0.660 NM_000779
NM_001099772
CYP4B1

cytochrome P450, family 4, subfamily B, polypeptide 1

chr12_-_71551778 0.656 NM_004616
TSPAN8
tetraspanin 8
chr6_-_31681845 0.646


chr2_-_228244005 0.639 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr11_-_117695408 0.622 NM_001680
FXYD2
FXYD domain containing ion transport regulator 2
chr5_-_147211235 0.619 NM_003122
SPINK1
serine peptidase inhibitor, Kazal type 1
chr6_-_24383519 0.618 NM_001195610
DCDC2
doublecortin domain containing 2
chr7_-_87856282 0.606 NM_198901
SRI
sorcin
chr8_-_17555158 0.601 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr6_-_29012951 0.601 NM_030903
OR2W1
olfactory receptor, family 2, subfamily W, member 1
chr16_-_3085541 0.597 NM_001103175
CCDC64B
coiled-coil domain containing 64B
chr14_+_78870092 0.558 NM_004796
NRXN3
neurexin 3
chr16_+_21245015 0.546 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr3_-_157221362 0.540 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr4_-_100212085 0.539 NM_000667
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr5_-_147211141 0.538 SPINK1
serine peptidase inhibitor, Kazal type 1
chr16_+_89696674 0.536 DPEP1
dipeptidase 1 (renal)
chr5_+_88185090 0.532


chr6_-_165723074 0.528 NM_144980
C6orf118
chromosome 6 open reading frame 118
chr17_+_68071386 0.525 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr9_+_82186846 0.501 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr13_+_97874704 0.497 MBNL2
muscleblind-like 2 (Drosophila)
chr6_-_116381765 0.496 NM_002031
FRK
fyn-related kinase
chr20_+_43029973 0.493 HNF4A
hepatocyte nuclear factor 4, alpha
chr3_+_119316694 0.478 NM_001206960
NM_001206961
NM_015900
PLA1A


phospholipase A1 member A


chr16_+_30210548 0.472 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr11_+_46740769 0.459 F2
coagulation factor II (thrombin)
chr9_+_130860769 0.440 SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr5_-_111093792 0.439 NM_001142477
NM_001142476
C5orf13

chromosome 5 open reading frame 13

chr17_-_202617 0.433 NM_001190411
NM_001190412
NM_001190413
NM_006987
RPH3AL



rabphilin 3A-like (without C2 domains)



chr22_-_36019363 0.432 NM_203377
MB
myoglobin
chr10_+_45406629 0.421 NM_001123376
TMEM72
transmembrane protein 72
chr2_+_98330030 0.414 NM_001079
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr16_-_55909208 0.408 NM_001143685
NM_145024
CES5A

carboxylesterase 5A

chr1_-_36789754 0.406 NM_018166
FAM176B
family with sequence similarity 176, member B
chr4_-_70080448 0.402 NM_001073
UGT2B11
UGT2B10
UDP glucuronosyltransferase 2 family, polypeptide B11
UDP glucuronosyltransferase 2 family, polypeptide B10
chr9_-_123812535 0.399 NM_001735
C5
complement component 5
chr11_+_46740736 0.394 NM_000506
F2
coagulation factor II (thrombin)
chr8_-_17752847 0.383 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr1_+_119911395 0.382 NM_001005783
NM_016527
HAO2

hydroxyacid oxidase 2 (long chain)

chr10_+_85933553 0.377 NM_207373
C10orf99
chromosome 10 open reading frame 99
chr5_-_138719018 0.371 NM_005847
NM_152685
SLC23A1

solute carrier family 23 (nucleobase transporters), member 1

chr10_-_70066594 0.369 PBLD
phenazine biosynthesis-like protein domain containing
chr17_+_1646129 0.363 NM_000934
NM_001165921
SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr8_+_76320106 0.359 HNF4G
hepatocyte nuclear factor 4, gamma
chr6_-_52628272 0.356 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr5_-_138718941 0.347 SLC23A1
solute carrier family 23 (nucleobase transporters), member 1
chr10_-_32667543 0.344 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr11_+_121461070 0.340 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr16_+_57728711 0.340 NM_032269
CCDC135
coiled-coil domain containing 135
chr5_-_111093251 0.330 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr15_+_59903980 0.322 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr5_-_135290521 0.317 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chr7_-_92777657 0.314 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr9_+_130860816 0.311 NM_052901
NM_001006643
SLC25A25

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

chr6_-_52668599 0.307 NM_145740
GSTA1
glutathione S-transferase alpha 1
chr13_-_41593405 0.304 ELF1
E74-like factor 1 (ets domain transcription factor)
chr3_-_141719188 0.304 NM_001178140
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr11_+_561449 0.299 NM_001143994
NM_003475
RASSF7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr4_-_70725792 0.298 NM_005420
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chrX_+_36254050 0.293 NM_001098843
CXorf30
chromosome X open reading frame 30
chr22_-_38506532 0.288 BAIAP2L2
BAI1-associated protein 2-like 2
chr6_-_51952368 0.286 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr15_-_44969085 0.285 NM_001145112
PATL2
protein associated with topoisomerase II homolog 2 (yeast)
chr20_+_43029865 0.284 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr11_-_121986800 0.275 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr16_-_69385656 0.272 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr9_-_27573444 0.265 NM_018325
C9orf72
chromosome 9 open reading frame 72
chr12_-_8693391 0.258 NM_014358
CLEC4E
C-type lectin domain family 4, member E
chr1_-_154578775 0.258 NM_001193495
ADAR
adenosine deaminase, RNA-specific
chr5_+_140247767 0.257 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr13_-_41593491 0.255 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr8_+_39771327 0.254 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr19_-_48389571 0.253 NM_003167
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr11_-_8739398 0.252 ST5
suppression of tumorigenicity 5
chr6_+_159070994 0.246 NM_001009991
NM_001242384
NM_001242394
NM_001242395
SYTL3



synaptotagmin-like 3



chr2_-_88427535 0.243 NM_001443
FABP1
fatty acid binding protein 1, liver
chr1_+_59775749 0.242 NM_001244714
FGGY
FGGY carbohydrate kinase domain containing
chr19_-_3062911 0.240 NM_198969
AES
amino-terminal enhancer of split
chr12_-_102874299 0.239 IGF1
insulin-like growth factor 1 (somatomedin C)
chr21_-_43346780 0.229 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr6_-_119470336 0.227 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr6_+_167536240 0.225 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr4_+_3443691 0.222 NM_001528
HGFAC
HGF activator
chr19_-_48389514 0.210 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr1_+_84768333 0.210 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr19_+_49199227 0.209 NM_000511
NM_001097638
FUT2

fucosyltransferase 2 (secretor status included)

chr4_+_3443659 0.208 HGFAC
HGF activator
chr17_+_1646290 0.207 NM_001165920
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr10_+_695887 0.205 C10orf108
chromosome 10 open reading frame 108
chr20_+_43029936 0.204 HNF4A
hepatocyte nuclear factor 4, alpha
chr16_+_76343734 0.201 NM_138994
CNTNAP4
contactin associated protein-like 4
chr15_-_64995459 0.199 NM_002537
OAZ2
ornithine decarboxylase antizyme 2
chr7_+_129015483 0.193 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr5_+_76435073 0.192


chr19_+_50016500 0.191 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr9_+_134378324 0.189 POMT1
protein-O-mannosyltransferase 1
chr21_-_19775958 0.187 NM_002772
TMPRSS15
transmembrane protease, serine 15
chr5_+_73109342 0.186 NM_001244364
RGNEF
190 kDa guanine nucleotide exchange factor
chr10_+_69869249 0.184 NM_032578
MYPN
myopalladin
chr9_+_123850573 0.182 NM_007018
CNTRL
centriolin
chr19_+_41509825 0.179 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr22_-_18923963 0.172 NM_001195226
NM_016335
PRODH

proline dehydrogenase (oxidase) 1

chr5_+_140571903 0.169 NM_018930
PCDHB10
protocadherin beta 10
chr7_-_156801980 0.166 NM_001165255
MNX1
motor neuron and pancreas homeobox 1
chr3_-_15839674 0.162 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr20_+_42187705 0.159 SGK2
serum/glucocorticoid regulated kinase 2
chr12_-_123834984 0.158 NM_001167856
NM_018183
SBNO1

strawberry notch homolog 1 (Drosophila)

chr2_-_158300517 0.154 NM_004288
CYTIP
cytohesin 1 interacting protein
chr6_+_131894343 0.150 NM_000045
NM_001244438
ARG1

arginase, liver

chr3_+_69812961 0.147 NM_006722
MITF
microphthalmia-associated transcription factor
chr20_+_2944918 0.145 PTPRA
protein tyrosine phosphatase, receptor type, A
chr17_+_80317122 0.143 NM_207459
TEX19
testis expressed 19
chr11_-_26743545 0.142 NM_178498
SLC5A12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr2_-_96482382 0.142 LINC00342
long intergenic non-protein coding RNA 342
chr9_-_117265452 0.142 NM_001083885
DFNB31
deafness, autosomal recessive 31
chr14_+_39735500 0.141 NM_001247988
NM_203356
CTAGE5

CTAGE family, member 5

chr3_+_149192367 0.140 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr1_+_207277577 0.133 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr22_+_32439018 0.133 NM_000343
SLC5A1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr8_-_18541441 0.131 PSD3
pleckstrin and Sec7 domain containing 3
chr19_-_42133427 0.130 NM_001817
CEACAM4
carcinoembryonic antigen-related cell adhesion molecule 4
chr3_+_149192479 0.128 TM4SF4
transmembrane 4 L six family member 4
chr10_-_52645384 0.128 A1CF
APOBEC1 complementation factor
chr1_-_42630386 0.125 NM_033553
GUCA2A
guanylate cyclase activator 2A (guanylin)
chr3_-_164796275 0.123 NM_001041
SI
sucrase-isomaltase (alpha-glucosidase)
chr1_+_54359859 0.121 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr5_+_67586466 0.120 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr7_-_107880492 0.120 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr17_+_35732927 0.118 NM_173625
C17orf78
chromosome 17 open reading frame 78
chr16_+_31404596 0.117 NM_005353
ITGAD
integrin, alpha D
chr19_+_11909360 0.117 NM_152356
ZNF491
zinc finger protein 491
chr6_+_54173202 0.116 NM_014464
TINAG
tubulointerstitial nephritis antigen
chr9_-_33395265 0.115 AQP7
aquaporin 7
chr1_-_159684274 0.115 NM_000567
CRP
C-reactive protein, pentraxin-related
chr3_+_108541544 0.114 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr12_-_51740422 0.111 NM_001971
CELA1
chymotrypsin-like elastase family, member 1
chrX_-_15332680 0.111 NM_001012428
ASB11
ankyrin repeat and SOCS box containing 11
chr15_-_64995388 0.107 OAZ2
ornithine decarboxylase antizyme 2
chr8_+_18079176 0.106 NM_001160174
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr15_+_62939509 0.099 NM_015059
TLN2
talin 2
chr13_-_99959649 0.095 NM_004951
GPR183
G protein-coupled receptor 183
chr14_-_107099379 0.095 IGHG1
IGHG3
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr10_-_101690655 0.094 DNMBP
dynamin binding protein
chr12_-_12291374 0.093 LRP6
low density lipoprotein receptor-related protein 6
chrX_-_65835845 0.092 NM_001242310
EDA2R
ectodysplasin A2 receptor
chr7_+_73275488 0.089 NM_182504
WBSCR28
Williams-Beuren syndrome chromosome region 28
chr5_+_140529619 0.086 NM_018939
PCDHB6
protocadherin beta 6
chr4_+_57036360 0.085 NM_020722
KIAA1211
KIAA1211
chr4_+_154125589 0.083 NM_015271
TRIM2
tripartite motif containing 2
chr22_+_31366662 0.083


chr11_+_17332454 0.083


chr17_+_77020229 0.082 NM_030968
NM_198594
C1QTNF1

C1q and tumor necrosis factor related protein 1

chr3_+_149530436 0.082 NM_007282
NM_183381
RNF13

ring finger protein 13

chr20_-_4990913 0.081 NM_203327
SLC23A2
solute carrier family 23 (nucleobase transporters), member 2
chr22_-_38840032 0.081 NM_004981
KCNJ4
potassium inwardly-rectifying channel, subfamily J, member 4
chr5_-_111091947 0.081 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr2_+_234627423 0.079 NM_007120
UGT1A4
UDP glucuronosyltransferase 1 family, polypeptide A4
chr15_-_85197461 0.079 WDR73
WD repeat domain 73

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
8.12 3.25e-08 GO:0006805 xenobiotic metabolic process
8.12 3.25e-08 GO:0071466 cellular response to xenobiotic stimulus
8.06 3.68e-08 GO:0009410 response to xenobiotic stimulus
28.22 7.17e-03 GO:0009812 flavonoid metabolic process
23.09 1.83e-02 GO:0009698 phenylpropanoid metabolic process
13.23 3.12e-02 GO:0017144 drug metabolic process
5.00 3.30e-02 GO:0006814 sodium ion transport
38.09 3.80e-02 GO:0044245 polysaccharide digestion
1.72 3.87e-02 GO:0042221 response to chemical stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.00 6.39e-06 GO:0044459 plasma membrane part
5.67 1.25e-05 GO:0016324 apical plasma membrane
4.82 4.40e-05 GO:0045177 apical part of cell
9.88 1.10e-03 GO:0005903 brush border
8.55 2.96e-03 GO:0031983 vesicle lumen
2.39 3.43e-03 GO:0005615 extracellular space
10.95 1.48e-02 GO:0031526 brush border membrane
8.11 1.64e-02 GO:0031093 platelet alpha granule lumen
1.32 1.79e-02 GO:0044425 membrane part
7.94 1.85e-02 GO:0034774 secretory granule lumen
7.62 2.34e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
2.04 2.48e-02 GO:0044421 extracellular region part
2.23 2.93e-02 GO:0044432 endoplasmic reticulum part
2.31 3.31e-02 GO:0005789 endoplasmic reticulum membrane
1.67 3.57e-02 GO:0005576 extracellular region
2.25 4.63e-02 GO:0042175 nuclear membrane-endoplasmic reticulum network
6.69 4.87e-02 GO:0031091 platelet alpha granule

Gene overrepresentation in function category:

enrichment   p-value GO term description
15.88 5.14e-05 GO:0015020 glucuronosyltransferase activity
27.21 3.35e-02 GO:0005436 sodium:phosphate symporter activity