Motif ID: HNF4A_NR2F1,2.p2

Z-value: 1.617


Transcription factors associated with HNF4A_NR2F1,2.p2:

Gene SymbolEntrez IDGene Name
HNF4A 3172 hepatocyte nuclear factor 4, alpha
NR2F1 7025 nuclear receptor subfamily 2, group F, member 1
NR2F2 7026 nuclear receptor subfamily 2, group F, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR2F1chr5_+_929189240.271.5e-01Click!
HNF4Achr20_+_430299730.241.9e-01Click!
NR2F2chr5_+_929205920.242.0e-01Click!


Activity profile for motif HNF4A_NR2F1,2.p2.

activity profile for motif HNF4A_NR2F1,2.p2


Sorted Z-values histogram for motif HNF4A_NR2F1,2.p2

Sorted Z-values for motif HNF4A_NR2F1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A_NR2F1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_96211643 3.946 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2

chr5_+_96212167 3.388 ERAP2
endoplasmic reticulum aminopeptidase 2
chr6_-_29527477 2.119 UBD
ubiquitin D
chr19_+_41594367 1.969 NM_000766
CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chr3_+_186560462 1.935 NM_001177800
NM_004797
ADIPOQ

adiponectin, C1Q and collagen domain containing

chr3_+_186560478 1.853 ADIPOQ
adiponectin, C1Q and collagen domain containing
chr16_-_55867016 1.635 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr4_-_120243257 1.576 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr16_-_55866972 1.481 CES1
carboxylesterase 1
chr7_+_107301079 1.400 NM_000441
SLC26A4
solute carrier family 26, member 4
chr4_+_69962191 1.352 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr1_-_151345156 1.325 NM_003944
SELENBP1
selenium binding protein 1
chr17_+_72732958 1.316 NM_001163989
RAB37
RAB37, member RAS oncogene family
chr11_-_3692544 1.212 NM_020402
CHRNA10
cholinergic receptor, nicotinic, alpha 10
chr20_-_52687014 1.134 BCAS1
breast carcinoma amplified sequence 1
chr6_-_29527701 1.123 NM_006398
UBD
ubiquitin D
chr19_+_36239261 1.106 NM_019104
LIN37
lin-37 homolog (C. elegans)
chr12_+_21168629 1.081 NM_001009562
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr6_-_46922533 1.055 NM_015234
GPR116
G protein-coupled receptor 116
chr4_-_69886112 1.011 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr4_-_682915 1.009 MFSD7
major facilitator superfamily domain containing 7
chr20_-_52687303 0.979 NM_003657
BCAS1
breast carcinoma amplified sequence 1
chr6_-_32557431 0.965 NM_001243965
NM_002124
HLA-DRB1

HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1

major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr2_+_95940220 0.949 PROM2
prominin 2
chr9_+_74764266 0.948 NM_001242505
NM_001242506
NM_004293
GDA


guanine deaminase


chr22_+_25003610 0.946 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr17_+_72439187 0.944 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr9_+_74764394 0.937 GDA
guanine deaminase
chr4_-_682967 0.934 NM_032219
MFSD7
major facilitator superfamily domain containing 7
chr9_+_74764382 0.932 GDA
guanine deaminase
chr20_+_31755882 0.912 NM_080574
BPIFA2
BPI fold containing family A, member 2
chr1_+_26485510 0.879 NM_024869
FAM110D
family with sequence similarity 110, member D
chr12_+_113659275 0.875 TPCN1
two pore segment channel 1
chr6_+_29691116 0.872 NM_001098478
NM_001098479
NM_018950
HLA-F


major histocompatibility complex, class I, F


chr12_+_113659216 0.855 NM_001143819
NM_017901
TPCN1

two pore segment channel 1

chr3_+_42530790 0.848 NM_001251882
VIPR1
vasoactive intestinal peptide receptor 1
chr20_-_62130390 0.845 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr3_+_9691198 0.841 MTMR14
myotubularin related protein 14
chr19_+_50016606 0.839 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr19_-_16045669 0.834 NM_001128932
NM_021187
CYP4F11

cytochrome P450, family 4, subfamily F, polypeptide 11

chr1_+_59775749 0.833 NM_001244714
FGGY
FGGY carbohydrate kinase domain containing
chr4_-_683107 0.830 MFSD7
major facilitator superfamily domain containing 7
chr2_-_238499317 0.827 RAB17
RAB17, member RAS oncogene family
chr22_-_20104695 0.823 TRMT2A
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
chr8_+_21916858 0.815 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr6_+_31913763 0.812 CFB
complement factor B
chr15_+_74165967 0.798 NM_153356
TBC1D21
TBC1 domain family, member 21
chr19_-_45822841 0.788 CKM
creatine kinase, muscle
chr8_-_143999255 0.786 NM_000498
CYP11B2
cytochrome P450, family 11, subfamily B, polypeptide 2
chr5_-_149792276 0.778 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr19_+_50016490 0.772 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr2_-_238499713 0.769 NM_022449
RAB17
RAB17, member RAS oncogene family
chr19_+_50016500 0.767 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr9_+_17578952 0.758 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr17_+_73585552 0.754 MYO15B
myosin XVB pseudogene
chr20_-_32031425 0.752 NM_003098
SNTA1
syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)
chr22_+_31003069 0.747 NM_000355
NM_001184726
TCN2

transcobalamin II

chr1_+_47264669 0.734 NM_000779
NM_001099772
CYP4B1

cytochrome P450, family 4, subfamily B, polypeptide 1

chr9_-_127269689 0.731 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr19_+_18111923 0.725 NM_001025604
ARRDC2
arrestin domain containing 2
chr20_-_57425957 0.724 GNAS-AS1
GNAS antisense RNA 1 (non-protein coding)
chr6_+_31913852 0.712 CFB
complement factor B
chr22_-_24640850 0.701 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chr3_+_13590624 0.701 NM_001004019
NM_001998
FBLN2

fibulin 2

chrX_-_153191710 0.695 NM_001164741
NM_001666
ARHGAP4

Rho GTPase activating protein 4

chr2_-_19558371 0.684 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr1_+_6052357 0.682 NM_001199861
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr15_+_75105152 0.679 NM_021819
LMAN1L
lectin, mannose-binding, 1 like
chr3_+_9691184 0.675 MTMR14
myotubularin related protein 14
chr22_+_23229959 0.675 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr3_+_51976274 0.668 NM_001003931
NM_005485
PARP3

poly (ADP-ribose) polymerase family, member 3

chr2_+_95940195 0.666 NM_001165977
NM_001165978
NM_144707
PROM2


prominin 2


chr15_+_67000929 0.662 NM_001142861
SMAD6
SMAD family member 6
chr13_+_52586516 0.658 NM_001004127
ALG11
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
chr19_-_633526 0.658 POLRMT
polymerase (RNA) mitochondrial (DNA directed)
chr2_+_27719702 0.649 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr7_+_193112 0.644 FAM20C
family with sequence similarity 20, member C
chr1_-_20126368 0.642 NM_181719
TMCO4
transmembrane and coiled-coil domains 4
chr1_+_222988324 0.641 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chr19_-_18335302 0.640 NM_001098819
PDE4C
phosphodiesterase 4C, cAMP-specific
chr1_-_60392461 0.639 CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr22_-_43089856 0.634 A4GALT
alpha 1,4-galactosyltransferase
chr1_-_60392324 0.634 NM_000775
CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr11_+_45943171 0.632 NM_152312
GYLTL1B
glycosyltransferase-like 1B
chr17_+_7812703 0.630 CHD3
chromodomain helicase DNA binding protein 3
chr22_-_31686707 0.621 PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr22_+_38453478 0.619 PICK1
protein interacting with PRKCA 1
chr7_+_192968 0.616 NM_020223
FAM20C
family with sequence similarity 20, member C
chr16_+_3115312 0.612 NM_001012631
NM_001012633
NM_001012718
NM_004221
IL32



interleukin 32



chr10_+_96443250 0.609 NM_000772
NM_001128925
CYP2C18

cytochrome P450, family 2, subfamily C, polypeptide 18

chr13_-_86373328 0.609 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr10_-_50970321 0.609 NM_001143996
NM_001143997
NM_018245
OGDHL


oxoglutarate dehydrogenase-like


chrX_+_65382627 0.606 HEPH
hephaestin
chrX_-_153191686 0.605 ARHGAP4
Rho GTPase activating protein 4
chr11_-_46867788 0.604 CKAP5
cytoskeleton associated protein 5
chr6_+_29691203 0.600 HLA-F
major histocompatibility complex, class I, F
chr19_-_4540078 0.597 LRG1
leucine-rich alpha-2-glycoprotein 1
chr3_-_58652469 0.594 NM_138805
FAM3D
family with sequence similarity 3, member D
chr19_+_4153593 0.593 NM_032607
CREB3L3
cAMP responsive element binding protein 3-like 3
chr2_-_222436996 0.591 NM_004438
EPHA4
EPH receptor A4
chr2_+_113763448 0.589 NM_014440
IL36A
interleukin 36, alpha
chr8_+_70405080 0.587 SULF1
sulfatase 1
chr1_+_156785470 0.586 NM_001007792
NTRK1
neurotrophic tyrosine kinase, receptor, type 1
chr9_+_88897112 0.583


chr12_+_113659287 0.579 TPCN1
two pore segment channel 1
chr8_+_21916685 0.575 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr19_-_49339667 0.574 HSD17B14
hydroxysteroid (17-beta) dehydrogenase 14
chr5_-_149792370 0.572 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr12_+_10365415 0.571 NM_031412
GABARAPL1
GABA(A) receptor-associated protein like 1
chr19_-_4342718 0.571 STAP2
signal transducing adaptor family member 2
chr16_+_21245015 0.569 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr19_+_45504686 0.560 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr16_+_19467771 0.559 NM_024780
TMC5
transmembrane channel-like 5
chr9_-_33167084 0.557 B4GALT1
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
chr17_+_1665342 0.554 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr6_-_30523933 0.554 GNL1
guanine nucleotide binding protein-like 1
chr10_+_114133838 0.552 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr8_-_140715234 0.552 NM_016601
KCNK9
potassium channel, subfamily K, member 9
chr16_-_70719693 0.551 MTSS1L
metastasis suppressor 1-like
chr19_-_36545646 0.549 NM_152658
THAP8
THAP domain containing 8
chr22_-_20104745 0.547 NM_022727
NM_182984
TRMT2A

TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)

chr16_+_67700704 0.543 NM_001012984
C16orf86
chromosome 16 open reading frame 86
chr19_+_41430123 0.543 CYP2B7P1
cytochrome P450, family 2, subfamily B, polypeptide 7 pseudogene 1
chr19_-_35719578 0.542 NM_152481
FAM187B
family with sequence similarity 187, member B
chr20_-_20693122 0.542 NM_020343
RALGAPA2
Ral GTPase activating protein, alpha subunit 2 (catalytic)
chr1_+_25944610 0.541 MAN1C1
mannosidase, alpha, class 1C, member 1
chr1_-_247335251 0.540 NM_001243740
NM_003431
ZNF124

zinc finger protein 124

chr10_-_135379082 0.537 NM_001143763
NM_001143764
SYCE1

synaptonemal complex central element protein 1

chr12_+_121163570 0.533 NM_000017
ACADS
acyl-CoA dehydrogenase, C-2 to C-3 short chain
chr6_+_30227335 0.533 HLA-L
major histocompatibility complex, class I, L, pseudogene
chr12_+_6561176 0.532 NM_018009
TAPBPL
TAP binding protein-like
chr12_-_51420097 0.530 NM_000617
NM_001174126
NM_001174127
NM_001174128
SLC11A2



solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2



chr12_-_48213567 0.530 NM_001098416
NM_015401
HDAC7

histone deacetylase 7

chr21_+_44073650 0.529 NM_001001567
NM_001001568
NM_001001569
NM_001001570
NM_001001571
NM_001001572
NM_001001573
NM_001001574
NM_001001575
NM_001001576
NM_001001577
NM_001001578
NM_001001579
NM_001001580
NM_001001581
NM_001001582
NM_001001583
NM_001001584
NM_001001585
NM_002606
PDE9A



















phosphodiesterase 9A



















chr11_+_66742747 0.529 NM_001136485
C11orf86
chromosome 11 open reading frame 86
chr10_-_129691202 0.528 NM_152311
CLRN3
clarin 3
chr15_+_45021218 0.527 TRIM69
tripartite motif containing 69
chr4_-_4543747 0.526 NM_016930
STX18
syntaxin 18
chr6_-_73935174 0.519 NM_001126063
KHDC1L
KH homology domain containing 1-like
chr11_+_111169965 0.519 NM_001136105
C11orf93
chromosome 11 open reading frame 93
chr19_-_50432672 0.518 IL4I1
interleukin 4 induced 1
chr6_+_125475334 0.517 NM_001003395
TPD52L1
tumor protein D52-like 1
chr7_+_23286390 0.516 GPNMB
glycoprotein (transmembrane) nmb
chr1_+_1567556 0.513 NM_006983
MMP23B
matrix metallopeptidase 23B
chr19_-_41388656 0.507 NM_000764
NM_030589
CYP2A7

cytochrome P450, family 2, subfamily A, polypeptide 7

chr1_+_78956727 0.507 NM_000959
NM_001039585
PTGFR

prostaglandin F receptor (FP)

chr5_-_42811959 0.506 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr3_-_49170490 0.504 NM_002292
LAMB2
laminin, beta 2 (laminin S)
chr12_-_51419923 0.497 NM_001174129
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr17_+_68100994 0.496 NM_170742
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr7_+_80275967 0.494 CD36
CD36 molecule (thrombospondin receptor)
chr1_-_2564428 0.490 NM_033467
MMEL1
membrane metallo-endopeptidase-like 1
chr8_-_110704019 0.489 NM_001099743
NM_001099744
SYBU

syntabulin (syntaxin-interacting)

chr10_+_114133775 0.489 ACSL5
acyl-CoA synthetase long-chain family member 5
chr7_-_44180911 0.485 NM_021223
MYL7
myosin, light chain 7, regulatory
chr12_+_56114150 0.485 NM_001199771
NM_002905
RDH5

retinol dehydrogenase 5 (11-cis/9-cis)

chr19_-_50432647 0.484 IL4I1
interleukin 4 induced 1
chr6_+_31913708 0.483 NM_001710
CFB
complement factor B
chr19_+_50016435 0.483 NM_004107
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr11_+_827584 0.483 NM_173584
EFCAB4A
EF-hand calcium binding domain 4A
chr8_+_70405027 0.482 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr7_-_150780571 0.482 NM_001136044
TMUB1
transmembrane and ubiquitin-like domain containing 1
chr19_-_17014407 0.480 CPAMD8
C3 and PZP-like, alpha-2-macroglobulin domain containing 8
chr3_-_139195300 0.479 NM_004164
RBP2
retinol binding protein 2, cellular
chr14_-_92333856 0.477 NM_001128596
TC2N
tandem C2 domains, nuclear
chr8_-_22089850 0.476 NM_001099335
NM_014759
PHYHIP

phytanoyl-CoA 2-hydroxylase interacting protein

chr17_-_80291639 0.475 SECTM1
secreted and transmembrane 1
chr2_+_95963026 0.473 NM_013434
KCNIP3
Kv channel interacting protein 3, calsenilin
chr7_-_155604815 0.472 NM_000193
SHH
sonic hedgehog
chr9_+_100615406 0.471 NM_004473
FOXE1
forkhead box E1 (thyroid transcription factor 2)
chr4_+_55523906 0.467 NM_000222
NM_001093772
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr5_-_138725544 0.466 NM_016459
MZB1
marginal zone B and B1 cell-specific protein
chr17_+_4692226 0.466 NM_001014985
GLTPD2
glycolipid transfer protein domain containing 2
chr14_+_39735500 0.465 NM_001247988
NM_203356
CTAGE5

CTAGE family, member 5

chr8_+_22019167 0.464 NM_001172357
NM_001172410
NM_003018
SFTPC


surfactant protein C


chr20_-_43743723 0.463 NM_145652
WFDC5
WAP four-disulfide core domain 5
chr17_-_26697224 0.460 VTN
vitronectin
chr9_-_33167230 0.458 B4GALT1
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
chr6_-_35765056 0.458 NM_001252597
NM_001252598
NM_001832
CLPS


colipase, pancreatic


chr19_+_17420216 0.457 NM_024050
DDA1
DET1 and DDB1 associated 1
chr4_+_159593233 0.454 NM_004453
ETFDH
electron-transferring-flavoprotein dehydrogenase
chr22_-_37975937 0.453 NM_006498
LGALS2
lectin, galactoside-binding, soluble, 2
chr6_-_31324898 0.453 HLA-B
major histocompatibility complex, class I, B
chr15_-_43559054 0.453 NM_004245
NM_201631
TGM5

transglutaminase 5

chr2_+_219646448 0.452 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chrX_-_151903100 0.451 NM_001166386
NM_001166387
NM_005367
MAGEA12


melanoma antigen family A, 12


chr7_-_27192201 0.451


chr15_-_79382839 0.450 RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1
chr14_-_94855120 0.450 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr6_+_31913920 0.449 CFB
complement factor B
chr6_+_29855506 0.447


chr17_+_78152280 0.446 NM_024110
CARD14
caspase recruitment domain family, member 14
chr13_+_100741268 0.444 NM_000282
NM_001127692
NM_001178004
PCCA


propionyl CoA carboxylase, alpha polypeptide


chr9_-_35749209 0.444 NM_020944
GBA2
glucosidase, beta (bile acid) 2
chr17_-_80291610 0.444 SECTM1
secreted and transmembrane 1
chr3_-_100712248 0.441 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr19_-_49622278 0.439 NM_018111
C19orf73
chromosome 19 open reading frame 73
chr17_-_7123368 0.436 NM_001365
DLG4
discs, large homolog 4 (Drosophila)
chr6_-_137540551 0.436 NM_000416
IFNGR1
interferon gamma receptor 1
chr6_+_168841829 0.435 NM_001166412
NM_022138
SMOC2

SPARC related modular calcium binding 2


Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.45 4.84e-07 GO:0005783 endoplasmic reticulum
1.12 5.03e-06 GO:0016020 membrane
1.49 1.13e-05 GO:0044432 endoplasmic reticulum part
1.38 3.93e-05 GO:0000267 cell fraction
1.45 4.30e-05 GO:0005626 insoluble fraction
1.26 1.01e-04 GO:0031090 organelle membrane
1.42 3.45e-04 GO:0005624 membrane fraction
1.24 3.74e-04 GO:0044459 plasma membrane part
1.28 7.61e-04 GO:0012505 endomembrane system
1.44 1.05e-03 GO:0042175 nuclear membrane-endoplasmic reticulum network
1.44 1.14e-03 GO:0005789 endoplasmic reticulum membrane
1.11 1.67e-03 GO:0044425 membrane part
1.08 7.98e-03 GO:0005737 cytoplasm
1.11 9.79e-03 GO:0044444 cytoplasmic part
1.27 1.61e-02 GO:0031226 intrinsic to plasma membrane
1.11 1.89e-02 GO:0031224 intrinsic to membrane
1.27 2.34e-02 GO:0005887 integral to plasma membrane
1.11 2.86e-02 GO:0016021 integral to membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.72 2.10e-03 GO:0070330 aromatase activity
3.43 7.57e-03 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen