Motif ID: IKZF2.p2

Z-value: 1.296


Transcription factors associated with IKZF2.p2:

Gene SymbolEntrez IDGene Name
IKZF2 22807 IKAROS family zinc finger 2 (Helios)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IKZF2chr2_-_214015053-0.355.6e-02Click!


Activity profile for motif IKZF2.p2.

activity profile for motif IKZF2.p2


Sorted Z-values histogram for motif IKZF2.p2

Sorted Z-values for motif IKZF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_9198036 5.255 NM_182797
PLCB4
phospholipase C, beta 4
chr1_-_161337663 5.147 NM_001013625
C1orf192
chromosome 1 open reading frame 192
chr1_+_111889194 4.314 NM_181643
C1orf88
chromosome 1 open reading frame 88
chr5_+_140602914 4.258 NM_018934
PCDHB14
protocadherin beta 14
chr16_-_52581713 3.890 NM_001146188
TOX3
TOX high mobility group box family member 3
chr13_+_36050885 3.871 NM_001204197
NBEA
neurobeachin
chr12_-_71551564 3.546 TSPAN8
tetraspanin 8
chr10_+_63422718 3.543 NM_173554
C10orf107
chromosome 10 open reading frame 107
chr18_-_53089722 3.446 NM_001243233
TCF4
transcription factor 4
chr11_+_60467046 3.423 NM_031457
MS4A8B
membrane-spanning 4-domains, subfamily A, member 8B
chr8_-_72268720 3.423 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr10_-_21435487 3.271 NM_001010896
NM_001177483
C10orf113

chromosome 10 open reading frame 113

chr4_+_70861647 3.228 NM_001009181
NM_003154
STATH

statherin

chr11_-_62472901 3.205


chr2_-_135782246 3.168 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr4_+_15471488 3.109 NM_001080522
NM_001164720
NM_020785
CC2D2A


coiled-coil and C2 domain containing 2A


chr4_-_100356290 3.092 NM_001166504
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr5_+_43609261 3.000 NNT
nicotinamide nucleotide transhydrogenase
chr3_+_238274 2.867 NM_001253387
NM_006614
CHL1

cell adhesion molecule with homology to L1CAM (close homolog of L1)

chr1_-_57045235 2.822 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr1_-_150738292 2.731 NM_001199739
NM_004079
CTSS

cathepsin S

chr1_+_47489239 2.726 NM_178033
CYP4X1
cytochrome P450, family 4, subfamily X, polypeptide 1
chr11_+_101918168 2.715 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr14_-_21270537 2.574 NM_198232
RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr7_+_106685007 2.567 NM_002736
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr11_+_71903172 2.532 NM_016729
FOLR1
folate receptor 1 (adult)
chr15_+_82555101 2.528 NM_001008226
FAM154B
family with sequence similarity 154, member B
chr1_-_46089638 2.378 NM_001114938
NM_001190182
CCDC17

coiled-coil domain containing 17

chr8_+_75896707 2.338 NM_031461
CRISPLD1
cysteine-rich secretory protein LCCL domain containing 1
chr18_-_24722757 2.324 NM_001243848
CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr8_-_133772808 2.317 NM_001145153
NM_144649
TMEM71

transmembrane protein 71

chr4_-_100273831 2.285 NM_000669
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr12_+_69742130 2.266 NM_000239
LYZ
lysozyme
chrX_-_117119282 2.251 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr7_+_142829169 2.247 NM_002652
PIP
prolactin-induced protein
chr5_-_35938736 2.221 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr2_+_191301020 2.168 MFSD6
major facilitator superfamily domain containing 6
chr9_-_117156684 2.154 NM_030767
AKNA
AT-hook transcription factor
chr11_-_62475060 2.151 NM_001122955
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr6_+_163148163 2.114 NM_001080378
NM_152410
PACRG

PARK2 co-regulated

chr1_+_228871109 2.108 RHOU
ras homolog gene family, member U
chr8_-_110655418 2.105 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr1_-_104238785 2.091 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr3_+_16974581 2.086 NM_015184
PLCL2
phospholipase C-like 2
chr11_-_33890931 2.085 LMO2
LIM domain only 2 (rhombotin-like 1)
chr6_-_33041266 2.081 NM_033554
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr1_+_104198301 2.071 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr6_-_32557431 2.060 NM_001243965
NM_002124
HLA-DRB1

HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1

major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr22_-_37164073 2.055 NM_001177702
IFT27
intraflagellar transport 27 homolog (Chlamydomonas)
chr1_+_79115476 2.031 NM_006417
IFI44
interferon-induced protein 44
chr2_+_98330030 2.026 NM_001079
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr13_+_24144402 2.013 NM_001204459
NM_148957
TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr1_+_104159953 2.003 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr13_+_50589389 1.960 NM_173605
NM_199464
TRIM13
KCNRG

tripartite motif containing 13
potassium channel regulator

chr1_-_57045214 1.957 PPAP2B
phosphatidic acid phosphatase type 2B
chr3_+_361365 1.922 NM_001253388
CHL1
cell adhesion molecule with homology to L1CAM (close homolog of L1)
chr21_-_35828038 1.922 NM_001127670
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr1_+_162351519 1.885 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chr7_+_94297448 1.878 PEG10
paternally expressed 10
chr3_-_167371701 1.863 WDR49
WD repeat domain 49
chr5_-_121412805 1.843 NM_001178102
LOX
lysyl oxidase
chr18_-_53071225 1.824 NM_001243232
TCF4
transcription factor 4
chr11_+_36422546 1.809 NM_001160169
PRR5L
proline rich 5 like
chr13_-_39564857 1.789 NM_001144033
NM_145286
STOML3

stomatin (EPB72)-like 3

chr1_+_171060017 1.789 NM_001002294
NM_006894
FMO3

flavin containing monooxygenase 3

chr6_-_29012951 1.777 NM_030903
OR2W1
olfactory receptor, family 2, subfamily W, member 1
chr11_+_27062508 1.774 NM_003986
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr20_-_62436855 1.770 NM_025224
ZBTB46
zinc finger and BTB domain containing 46
chr11_-_115088628 1.769 CADM1
cell adhesion molecule 1
chr19_+_58152331 1.762 ZNF211
zinc finger protein 211
chrX_-_135863104 1.746 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr1_-_41627045 1.726 NM_001031694
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr12_+_69742140 1.718 LYZ
lysozyme
chr1_+_170904611 1.718 NM_001163629
NM_025063
C1orf129

chromosome 1 open reading frame 129

chr5_-_42811959 1.715 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr5_+_140247767 1.707 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr10_+_115511212 1.706 NM_001193434
NM_001193435
NM_024889
C10orf81


chromosome 10 open reading frame 81


chr4_-_70518964 1.705 NM_001252274
NM_001252275
NM_006798
UGT2A1


UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus


chr5_+_42565963 1.689 NM_001242460
NM_001242461
NM_001242462
GHR


growth hormone receptor


chr6_+_131958441 1.682 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr10_-_116444374 1.675 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr5_+_42565562 1.647 NM_001242406
GHR
growth hormone receptor
chr10_+_95848811 1.636 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr4_+_25658085 1.613 NM_001177999
SLC34A2
solute carrier family 34 (sodium phosphate), member 2
chr3_+_69812620 1.607 NM_001184967
MITF
microphthalmia-associated transcription factor
chr1_+_61869699 1.598 NFIA
nuclear factor I/A
chr1_-_207119707 1.589 NM_002644
PIGR
polymeric immunoglobulin receptor
chr9_-_97356007 1.552 NM_003837
FBP2
fructose-1,6-bisphosphatase 2
chr18_-_71814948 1.546 NM_152676
NM_001142958
FBXO15

F-box protein 15

chr4_+_130017281 1.539 NM_001099783
C4orf33
chromosome 4 open reading frame 33
chr1_-_150738232 1.538 CTSS
cathepsin S
chr2_-_217540722 1.535 IGFBP5
insulin-like growth factor binding protein 5
chr1_-_162838550 1.460 NM_178550
C1orf110
chromosome 1 open reading frame 110
chr5_+_42550181 1.453 NM_001242405
GHR
growth hormone receptor
chr6_-_46825942 1.429 GPR116
G protein-coupled receptor 116
chr9_+_123850573 1.418 NM_007018
CNTRL
centriolin
chr6_-_165723074 1.416 NM_144980
C6orf118
chromosome 6 open reading frame 118
chr8_-_110661007 1.405 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr4_-_100212085 1.391 NM_000667
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr3_-_187452669 1.364 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr1_+_244216506 1.352 NM_006352
ZNF238
zinc finger protein 238
chr2_-_178483677 1.352 NM_152275
TTC30A
tetratricopeptide repeat domain 30A
chr14_-_54423448 1.340 NM_001202
NM_130850
BMP4

bone morphogenetic protein 4

chr20_+_9458460 1.340 PLCB4
phospholipase C, beta 4
chr7_-_99680170 1.337


chrX_+_57313109 1.335 NM_174912
FAAH2
fatty acid amide hydrolase 2
chr11_+_65271145 1.325


chr5_+_140180782 1.311 NM_018906
NM_031497
PCDHA3

protocadherin alpha 3

chr4_+_74702272 1.310 NM_002993
CXCL6
chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
chr14_-_106926393 1.307 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chrX_-_135863033 1.306 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr9_+_92219926 1.304 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr3_-_120401401 1.304 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr4_+_15480833 1.303 CC2D2A
coiled-coil and C2 domain containing 2A
chr6_+_112408673 1.293 NM_001033564
C6orf225
chromosome 6 open reading frame 225
chrY_+_16634487 1.272 NM_001206850
NLGN4Y
neuroligin 4, Y-linked
chr16_+_57769667 1.264 KATNB1
katanin p80 (WD repeat containing) subunit B 1
chr1_-_150738255 1.258 CTSS
cathepsin S
chr9_-_125941304 1.256 STRBP
spermatid perinuclear RNA binding protein
chr14_+_39734475 1.247 NM_203354
CTAGE5
CTAGE family, member 5
chr12_-_86229981 1.246 RASSF9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr4_+_170581212 1.244 NM_001243374
CLCN3
chloride channel 3
chr19_-_14992166 1.243 NM_030901
OR7A17
olfactory receptor, family 7, subfamily A, member 17
chr11_-_119066583 1.243 NM_001145018
CCDC153
coiled-coil domain containing 153
chr12_-_52867521 1.240 NM_173086
KRT6C
keratin 6C
chr5_-_160279045 1.234 NM_025153
ATP10B
ATPase, class V, type 10B
chr7_-_64023454 1.227 NM_001130022
NM_178558
ZNF680

zinc finger protein 680

chr1_-_173962050 1.223 NM_172071
RC3H1
ring finger and CCCH-type domains 1
chr4_-_38806410 1.219 NM_003263
TLR1
toll-like receptor 1
chr14_+_45431333 1.201 NM_015091
FAM179B
family with sequence similarity 179, member B
chr4_-_168155576 1.200 NM_001204353
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr5_-_146833150 1.197 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr20_+_51588945 1.197 NM_173485
TSHZ2
teashirt zinc finger homeobox 2
chr5_+_140254930 1.196 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chr17_+_26369935 1.194 NLK
nemo-like kinase
chr6_-_32634287 1.193 NM_001243961
NM_002123
HLA-DQB1

major histocompatibility complex, class II, DQ beta 1

chr3_-_151058439 1.180 NM_176876
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr11_-_33891258 1.180 LMO2
LIM domain only 2 (rhombotin-like 1)
chr3_+_69915374 1.179 NM_198177
MITF
microphthalmia-associated transcription factor
chrX_-_114252132 1.177 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr6_+_32605182 1.172 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr2_+_98703594 1.168 NM_144992
VWA3B
von Willebrand factor A domain containing 3B
chr14_+_64680858 1.163 NM_182913
SYNE2
spectrin repeat containing, nuclear envelope 2
chr14_-_35591652 1.156 PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr15_-_55652777 1.143 CCPG1
cell cycle progression 1
chr16_+_19467771 1.142 NM_024780
TMC5
transmembrane channel-like 5
chr16_-_21289637 1.137 CRYM
crystallin, mu
chr4_+_187070326 1.132 NM_001006655
FAM149A
family with sequence similarity 149, member A
chr3_-_137893718 1.128 DBR1
debranching enzyme homolog 1 (S. cerevisiae)
chr1_+_228870801 1.124 NM_021205
RHOU
ras homolog gene family, member U
chr8_+_42552561 1.123 NM_000749
CHRNB3
cholinergic receptor, nicotinic, beta 3
chr8_+_17396285 1.121 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr6_-_154677868 1.119 NM_001130700
NM_015553
IPCEF1

interaction protein for cytohesin exchange factors 1

chr19_+_9361605 1.111 NM_001079935
OR7E24
olfactory receptor, family 7, subfamily E, member 24
chr5_+_140261792 1.105 NM_018904
NM_031865
PCDHA13

protocadherin alpha 13

chr3_-_183273407 1.097 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr1_-_216978708 1.097 NM_001243514
ESRRG
estrogen-related receptor gamma
chr5_+_140186658 1.094 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr19_-_14260728 1.094 LPHN1
latrophilin 1
chr12_-_10282680 1.094 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr8_-_17942304 1.088 ASAH1
N-acylsphingosine amidohydrolase (acid ceramidase) 1
chr5_+_32173481 1.084 LOC153546
uncharacterized LOC153546
chr1_-_173886401 1.083 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr3_-_121740968 1.081 NM_001199799
NM_001199800
NM_175924
ILDR1


immunoglobulin-like domain containing receptor 1


chr14_-_24777184 1.073 CIDEB
cell death-inducing DFFA-like effector b
chr2_-_217560247 1.067 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr6_-_97345760 1.065 NM_014165
NDUFAF4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4
chr14_-_24777160 1.062 CIDEB
cell death-inducing DFFA-like effector b
chr1_+_36387788 1.059 EIF2C1
eukaryotic translation initiation factor 2C, 1
chr16_+_10522724 1.054 NM_024997
ATF7IP2
activating transcription factor 7 interacting protein 2
chr6_-_56258891 1.052 COL21A1
collagen, type XXI, alpha 1
chr7_+_23286386 1.052 GPNMB
glycoprotein (transmembrane) nmb
chr4_-_168155691 1.044 SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr11_+_63137260 1.042 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr1_-_57045129 1.024 PPAP2B
phosphatidic acid phosphatase type 2B
chrX_+_35937850 1.013 NM_152632
CXorf22
chromosome X open reading frame 22
chr8_+_7353367 0.997 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr15_+_71184781 0.985 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr8_-_145838887 0.985 NM_025251
ARHGAP39
Rho GTPase activating protein 39
chr7_+_23286384 0.984 GPNMB
glycoprotein (transmembrane) nmb
chr4_-_146859568 0.983 NM_178835
ZNF827
zinc finger protein 827
chr17_-_10633645 0.979 NM_001004313
TMEM220
transmembrane protein 220
chr3_+_69812961 0.974 NM_006722
MITF
microphthalmia-associated transcription factor
chr7_+_73442486 0.972 ELN
elastin
chr11_-_62474869 0.972 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr1_+_40862471 0.971 NM_001198980
SMAP2
small ArfGAP2
chr9_-_124989755 0.969 NM_001242334
LHX6
LIM homeobox 6
chr11_-_47736896 0.964 NM_024783
AGBL2
ATP/GTP binding protein-like 2
chr6_+_123109970 0.962 NM_006714
SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr1_+_226016428 0.962 EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr1_-_57044980 0.961 PPAP2B
phosphatidic acid phosphatase type 2B
chr7_+_48211054 0.953 NM_152701
ABCA13
ATP-binding cassette, sub-family A (ABC1), member 13
chr3_-_161089747 0.948 NM_001040100
SPTSSB
serine palmitoyltransferase, small subunit B
chr16_+_57728711 0.945 NM_032269
CCDC135
coiled-coil domain containing 135
chr19_+_9434447 0.945 NM_001202406
NM_001202407
NM_001202408
NM_001202409
NM_001202410
NM_001202411
NM_032497
ZNF559






zinc finger protein 559






chr12_+_20963637 0.942 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr5_+_149151502 0.941 NM_001172699
PPARGC1B
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr1_-_117746457 0.939 NM_001253849
VTCN1
V-set domain containing T cell activation inhibitor 1
chr6_+_16129321 0.933 MYLIP
myosin regulatory light chain interacting protein
chr5_-_96478438 0.932 LIX1
Lix1 homolog (chicken)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.28 1.25e-02 GO:0007156 homophilic cell adhesion

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.15 1.02e-03 GO:0005634 nucleus
1.09 1.12e-02 GO:0043227 membrane-bounded organelle
1.09 1.12e-02 GO:0043231 intracellular membrane-bounded organelle
5.17 1.56e-02 GO:0042613 MHC class II protein complex
1.06 3.11e-02 GO:0005622 intracellular
1.06 4.01e-02 GO:0044424 intracellular part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.16 4.30e-02 GO:0046872 metal ion binding