Motif ID: IRF1,2,7.p3

Z-value: 3.185


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IRF1chr5_-_1318264260.914.9e-12Click!
IRF7chr11_-_6159200.144.6e-01Click!
IRF2chr4_-_1853956160.077.3e-01Click!


Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_39771327 21.538 NM_002164
 IDO1
indoleamine 2,3-dioxygenase 1
chr6_-_29527701 19.663 NM_006398
 UBD
ubiquitin D
chr1_-_27998719 19.152 NM_002038
NM_022872
NM_022873
 IFI6


interferon, alpha-inducible protein 6


chr4_+_70861647 18.846 NM_001009181
NM_003154
 STATH

statherin

chr1_-_27998658 18.824 IFI6
interferon, alpha-inducible protein 6
chr1_-_27998700 18.585 IFI6
interferon, alpha-inducible protein 6
chr6_-_29527477 18.292 UBD
ubiquitin D
chr2_-_7005764 16.124 NM_207315
 CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr5_-_149792276 15.873 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr21_+_42733916 15.846 NM_002463
 LOC100131190
MX2
uncharacterized LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr5_-_149792370 12.495 NM_001025158
NM_001025159
NM_004355
 CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr16_-_21289637 12.453 CRYM
crystallin, mu
chr8_-_110655418 12.195 NM_001099756
 SYBU
syntabulin (syntaxin-interacting)
chr10_+_91152321 11.487 NM_001548
 IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr1_+_79086087 11.459 NM_006820
 IFI44L
interferon-induced protein 44-like
chr4_-_169239816 10.971 NM_017631
 DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr7_+_142829169 10.654 NM_002652
 PIP
prolactin-induced protein
chr1_+_948846 10.640 NM_005101
 ISG15
ISG15 ubiquitin-like modifier
chr9_-_32526164 10.386 NM_014314
 DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr1_+_79115476 10.009 NM_006417
 IFI44
interferon-induced protein 44

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 26 entries
enrichment   p-value GO term description
18.64 9.03e-04 GO:0002483 antigen processing and presentation of endogenous peptide antigen
18.64 9.03e-04 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
15.98 3.23e-04 GO:0019883 antigen processing and presentation of endogenous antigen
11.47 1.39e-04 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
8.39 7.20e-04 GO:0048002 antigen processing and presentation of peptide antigen
7.10 1.09e-11 GO:0034340 response to type I interferon
6.92 7.91e-11 GO:0060337 type I interferon-mediated signaling pathway
6.92 7.91e-11 GO:0071357 cellular response to type I interferon
5.59 3.77e-02 GO:0032480 negative regulation of type I interferon production
5.05 1.95e-03 GO:0032479 regulation of type I interferon production
3.90 5.20e-08 GO:0009615 response to virus
3.65 2.32e-08 GO:0019221 cytokine-mediated signaling pathway
3.50 4.09e-02 GO:0034341 response to interferon-gamma
3.29 4.97e-07 GO:0071345 cellular response to cytokine stimulus
3.04 1.49e-10 GO:0045087 innate immune response
2.96 2.54e-02 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
2.90 3.81e-07 GO:0034097 response to cytokine stimulus
2.87 4.08e-02 GO:0001819 positive regulation of cytokine production
2.41 2.29e-11 GO:0006955 immune response
2.31 1.57e-04 GO:0051707 response to other organism

Nothing significant found in compartment category.

Nothing significant found in function category.