Motif ID: KLF4.p3

Z-value: 2.071


Transcription factors associated with KLF4.p3:

Gene SymbolEntrez IDGene Name
KLF4 9314 Kruppel-like factor 4 (gut)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
KLF4chr9_-_1102507070.291.2e-01Click!


Activity profile for motif KLF4.p3.

activity profile for motif KLF4.p3


Sorted Z-values histogram for motif KLF4.p3

Sorted Z-values for motif KLF4.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF4.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_4135701 11.991 NM_001166010
NM_006117
NM_206836
 ECI2


enoyl-CoA delta isomerase 2


chr8_-_144650998 9.815 C8orf73
chromosome 8 open reading frame 73
chr6_+_37137882 8.108 NM_001243186
NM_002648
 PIM1

pim-1 oncogene

chrX_-_153599581 6.877 FLNA
filamin A, alpha
chr9_-_139890984 6.572 NM_004669
 CLIC3
chloride intracellular channel 3
chr19_-_15343767 6.418 NM_001142886
 EPHX3
epoxide hydrolase 3
chr11_-_568419 6.213 MIR210HG
MIR210 host gene (non-protein coding)
chr22_+_31477231 6.029 NM_006932
NM_134269
NM_134270
 SMTN


smoothelin


chr10_-_15210610 5.784 NM_004808
 NMT2
N-myristoyltransferase 2
chr8_+_26371461 5.753 NM_001197293
 DPYSL2
dihydropyrimidinase-like 2
chr19_-_50143350 5.428 NM_006270
 RRAS
related RAS viral (r-ras) oncogene homolog
chr17_-_26903854 5.386 ALDOC
aldolase C, fructose-bisphosphate
chr21_-_47648618 5.364 LSS
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chr17_-_26903926 5.325 NM_005165
 ALDOC
aldolase C, fructose-bisphosphate
chr21_-_47648685 5.019 LSS
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chrX_-_153599719 4.787 FLNA
filamin A, alpha
chr22_-_36783851 4.753 MYH9
myosin, heavy chain 9, non-muscle
chr22_-_36784001 4.661 MYH9
myosin, heavy chain 9, non-muscle
chr11_-_66725790 4.618 NM_000920
NM_001040716
 PC

pyruvate carboxylase

chr19_+_54371150 4.491 MYADM
myeloid-associated differentiation marker

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 123 entries
enrichment   p-value GO term description
1.69 8.11e-06 GO:0007265 Ras protein signal transduction
1.59 2.17e-02 GO:0006487 protein N-linked glycosylation
1.46 2.92e-02 GO:0031344 regulation of cell projection organization
1.42 2.93e-03 GO:0048011 nerve growth factor receptor signaling pathway
1.42 1.00e-02 GO:0009101 glycoprotein biosynthetic process
1.41 5.36e-06 GO:0018193 peptidyl-amino acid modification
1.40 1.84e-06 GO:0007264 small GTPase mediated signal transduction
1.40 2.29e-03 GO:0009100 glycoprotein metabolic process
1.39 2.35e-02 GO:0005996 monosaccharide metabolic process
1.38 8.75e-03 GO:0030036 actin cytoskeleton organization
1.38 3.29e-02 GO:0045786 negative regulation of cell cycle
1.37 3.34e-06 GO:0061024 membrane organization
1.36 6.40e-06 GO:0016044 cellular membrane organization
1.35 1.27e-02 GO:0030029 actin filament-based process
1.32 2.87e-04 GO:0044262 cellular carbohydrate metabolic process
1.32 2.10e-03 GO:0009968 negative regulation of signal transduction
1.32 1.10e-02 GO:0051301 cell division
1.31 1.01e-04 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.31 3.60e-02 GO:0032535 regulation of cellular component size
1.29 9.28e-03 GO:0010648 negative regulation of cell communication

Gene overrepresentation in compartment category:

Showing 1 to 20 of 46 entries
enrichment   p-value GO term description
2.05 3.03e-03 GO:0005720 nuclear heterochromatin
1.85 2.80e-03 GO:0000792 heterochromatin
1.53 3.15e-02 GO:0001726 ruffle
1.52 1.39e-02 GO:0005925 focal adhesion
1.51 4.69e-05 GO:0070161 anchoring junction
1.51 2.41e-04 GO:0005912 adherens junction
1.44 5.00e-07 GO:0015629 actin cytoskeleton
1.41 4.67e-03 GO:0031252 cell leading edge
1.28 2.62e-05 GO:0030054 cell junction
1.24 6.27e-17 GO:0005829 cytosol
1.23 2.66e-02 GO:0000139 Golgi membrane
1.22 3.00e-10 GO:0012505 endomembrane system
1.22 6.75e-06 GO:0005794 Golgi apparatus
1.22 1.13e-02 GO:0044431 Golgi apparatus part
1.21 3.61e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
1.20 4.09e-05 GO:0005783 endoplasmic reticulum
1.20 4.61e-03 GO:0031982 vesicle
1.20 4.76e-03 GO:0031988 membrane-bounded vesicle
1.20 5.27e-03 GO:0031410 cytoplasmic vesicle
1.19 2.14e-05 GO:0005654 nucleoplasm

Gene overrepresentation in function category:

Showing 1 to 20 of 34 entries
enrichment   p-value GO term description
1.83 7.16e-03 GO:0001948 glycoprotein binding
1.53 5.49e-03 GO:0051020 GTPase binding
1.53 8.23e-03 GO:0017124 SH3 domain binding
1.44 1.75e-10 GO:0019904 protein domain specific binding
1.39 1.89e-03 GO:0019900 kinase binding
1.37 2.05e-02 GO:0019901 protein kinase binding
1.36 3.39e-02 GO:0003924 GTPase activity
1.35 5.68e-04 GO:0003779 actin binding
1.33 1.83e-04 GO:0000988 protein binding transcription factor activity
1.33 1.83e-04 GO:0000989 transcription factor binding transcription factor activity
1.33 2.46e-04 GO:0003712 transcription cofactor activity
1.30 8.17e-08 GO:0019899 enzyme binding
1.29 5.65e-05 GO:0008092 cytoskeletal protein binding
1.26 1.12e-05 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.25 1.21e-05 GO:0016301 kinase activity
1.25 3.96e-02 GO:0004674 protein serine/threonine kinase activity
1.24 2.94e-02 GO:0030695 GTPase regulator activity
1.23 7.51e-03 GO:0004672 protein kinase activity
1.22 1.19e-04 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.21 2.37e-03 GO:0042802 identical protein binding