Motif ID: KLF4.p3

Z-value: 2.071


Transcription factors associated with KLF4.p3:

Gene SymbolEntrez IDGene Name
KLF4 9314 Kruppel-like factor 4 (gut)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
KLF4chr9_-_1102507070.291.2e-01Click!


Activity profile for motif KLF4.p3.

activity profile for motif KLF4.p3


Sorted Z-values histogram for motif KLF4.p3

Sorted Z-values for motif KLF4.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF4.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_4135701 11.991 NM_001166010
NM_006117
NM_206836
ECI2


enoyl-CoA delta isomerase 2


chr8_-_144650998 9.815 C8orf73
chromosome 8 open reading frame 73
chr6_+_37137882 8.108 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chrX_-_153599581 6.877 FLNA
filamin A, alpha
chr9_-_139890984 6.572 NM_004669
CLIC3
chloride intracellular channel 3
chr19_-_15343767 6.418 NM_001142886
EPHX3
epoxide hydrolase 3
chr11_-_568419 6.213 MIR210HG
MIR210 host gene (non-protein coding)
chr22_+_31477231 6.029 NM_006932
NM_134269
NM_134270
SMTN


smoothelin


chr10_-_15210610 5.784 NM_004808
NMT2
N-myristoyltransferase 2
chr8_+_26371461 5.753 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr19_-_50143350 5.428 NM_006270
RRAS
related RAS viral (r-ras) oncogene homolog
chr17_-_26903854 5.386 ALDOC
aldolase C, fructose-bisphosphate
chr21_-_47648618 5.364 LSS
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chr17_-_26903926 5.325 NM_005165
ALDOC
aldolase C, fructose-bisphosphate
chr21_-_47648685 5.019 LSS
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chrX_-_153599719 4.787 FLNA
filamin A, alpha
chr22_-_36783851 4.753 MYH9
myosin, heavy chain 9, non-muscle
chr22_-_36784001 4.661 MYH9
myosin, heavy chain 9, non-muscle
chr11_-_66725790 4.618 NM_000920
NM_001040716
PC

pyruvate carboxylase

chr19_+_54371150 4.491 MYADM
myeloid-associated differentiation marker
chr2_+_173420873 4.457 PDK1
pyruvate dehydrogenase kinase, isozyme 1
chr19_+_54371125 4.338 NM_001020819
NM_138373
MYADM

myeloid-associated differentiation marker

chr19_+_2096930 4.263 IZUMO4
IZUMO family member 4
chr22_-_36783977 4.247 MYH9
myosin, heavy chain 9, non-muscle
chr14_+_105941061 4.233 NM_001312
CRIP2
cysteine-rich protein 2
chr20_+_42295708 4.230 NM_002466
MYBL2
v-myb myeloblastosis viral oncogene homolog (avian)-like 2
chr9_+_131183225 4.196 CERCAM
cerebral endothelial cell adhesion molecule
chr19_+_54371170 4.180 MYADM
myeloid-associated differentiation marker
chr6_+_31126340 4.076 TCF19
transcription factor 19
chr18_-_28681885 3.968 NM_004949
NM_024422
DSC2

desmocollin 2

chr19_-_41196419 3.887 NM_004756
NUMBL
numb homolog (Drosophila)-like
chr10_+_11784355 3.822 NM_024693
ECHDC3
enoyl CoA hydratase domain containing 3
chr20_+_42295747 3.793 MYBL2
v-myb myeloblastosis viral oncogene homolog (avian)-like 2
chr12_-_47473424 3.766 NM_001143668
NM_181847
AMIGO2

adhesion molecule with Ig-like domain 2

chr11_+_65686908 3.723 DRAP1
DR1-associated protein 1 (negative cofactor 2 alpha)
chr21_-_47648672 3.715 LSS
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chr11_-_65667858 3.710 FOSL1
FOS-like antigen 1
chr1_-_143913118 3.686 NM_207418
FAM72D
family with sequence similarity 72, member D
chr19_+_48828820 3.643 EMP3
epithelial membrane protein 3
chr18_+_33877630 3.622 NM_025135
FHOD3
formin homology 2 domain containing 3
chr7_-_73133917 3.522 NM_001165903
NM_004603
STX1A

syntaxin 1A (brain)

chr12_-_54813002 3.522 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr12_+_57610577 3.498 NM_007224
NXPH4
neurexophilin 4
chr16_+_2479387 3.465 NM_001761
CCNF
cyclin F
chr11_+_65686727 3.446 NM_006442
DRAP1
DR1-associated protein 1 (negative cofactor 2 alpha)
chr20_+_33464404 3.441 ACSS2
acyl-CoA synthetase short-chain family member 2
chr12_-_125348266 3.435 SCARB1
scavenger receptor class B, member 1
chr2_-_165477986 3.380 GRB14
growth factor receptor-bound protein 14
chrX_+_64887510 3.356 NM_002444
MSN
moesin
chrX_+_64887534 3.328 MSN
moesin
chr20_+_56884749 3.324 NM_020673
RAB22A
RAB22A, member RAS oncogene family
chr22_+_45098091 3.317 NM_181334
PRR5-ARHGAP8
PRR5
PRR5-ARHGAP8 readthrough
proline rich 5 (renal)
chr19_+_2096792 3.314 NM_001031735
NM_001039846
IZUMO4

IZUMO family member 4

chr10_-_75634219 3.303 NM_001204492
NM_001222
NM_172169
NM_172170
NM_172171
NM_172173
CAMK2G





calcium/calmodulin-dependent protein kinase II gamma





chr20_+_33464327 3.297 NM_001076552
NM_018677
ACSS2

acyl-CoA synthetase short-chain family member 2

chr12_-_122231554 3.264 NM_019034
RHOF
ras homolog gene family, member F (in filopodia)
chr5_-_180018465 3.261 NM_052863
SCGB3A1
secretoglobin, family 3A, member 1
chr6_-_30654978 3.255 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr21_-_47648715 3.243 NM_001001438
NM_001145436
NM_001145437
NM_002340
LSS



lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)



chr12_+_53491448 3.237 IGFBP6
insulin-like growth factor binding protein 6
chr22_-_36784055 3.178 NM_002473
MYH9
myosin, heavy chain 9, non-muscle
chr9_-_130331350 3.176 NM_022833
FAM129B
family with sequence similarity 129, member B
chr8_+_144816287 3.153 LOC100128338
uncharacterized LOC100128338
chr12_-_125348422 3.149 NM_001082959
NM_005505
SCARB1

scavenger receptor class B, member 1

chr12_+_53491417 3.146 NM_002178
IGFBP6
insulin-like growth factor binding protein 6
chr18_+_56338783 3.124 MALT1
mucosa associated lymphoid tissue lymphoma translocation gene 1
chr7_-_128050006 3.084 NM_000883
NM_001102605
NM_001142576
NM_183243
IMPDH1



IMP (inosine 5'-monophosphate) dehydrogenase 1



chr1_+_150521786 3.067 NM_019032
NM_025008
ADAMTSL4

ADAMTS-like 4

chr7_-_128049959 3.059 IMPDH1
IMP (inosine 5'-monophosphate) dehydrogenase 1
chr12_-_54812936 3.057 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr19_-_51568323 3.034 NM_015596
KLK13
kallikrein-related peptidase 13
chr8_-_23261626 3.032 LOXL2
lysyl oxidase-like 2
chr9_+_131183122 3.029 CERCAM
cerebral endothelial cell adhesion molecule
chr2_-_235405692 3.025 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr8_-_23261591 3.021 LOXL2
lysyl oxidase-like 2
chr9_+_131182690 3.019 NM_016174
CERCAM
cerebral endothelial cell adhesion molecule
chr11_-_575848 3.010 LOC143666
uncharacterized LOC143666
chr20_+_34203746 3.007 NM_003116
SPAG4
sperm associated antigen 4
chr12_-_125348346 2.990 SCARB1
scavenger receptor class B, member 1
chr16_+_31483066 2.980 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr9_-_130331133 2.979 FAM129B
family with sequence similarity 129, member B
chr2_-_215674292 2.934 NM_000465
BARD1
BRCA1 associated RING domain 1
chr3_-_48594209 2.907 NM_004567
PFKFB4
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
chr18_+_56338818 2.900 MALT1
mucosa associated lymphoid tissue lymphoma translocation gene 1
chr19_+_48828627 2.894 NM_001425
EMP3
epithelial membrane protein 3
chr20_+_56884839 2.886 RAB22A
RAB22A, member RAS oncogene family
chr16_+_66638652 2.877 CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr8_-_23261632 2.848 LOXL2
lysyl oxidase-like 2
chrX_-_153775427 2.833 G6PD
glucose-6-phosphate dehydrogenase
chr1_+_120839004 2.818 NM_001100910
FAM72B
family with sequence similarity 72, member B
chr19_-_10679328 2.814 CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr11_-_64645925 2.814 EHD1
EH-domain containing 1
chr13_+_52158483 2.801 NM_052950
WDFY2
WD repeat and FYVE domain containing 2
chr8_+_26149080 2.785 PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr22_-_43583058 2.761 TTLL12
tubulin tyrosine ligase-like family, member 12
chr18_+_56338678 2.745 MALT1
mucosa associated lymphoid tissue lymphoma translocation gene 1
chr22_-_43583132 2.732 NM_015140
TTLL12
tubulin tyrosine ligase-like family, member 12
chr17_-_17726855 2.721 SREBF1
sterol regulatory element binding transcription factor 1
chr13_+_52158639 2.676 WDFY2
WD repeat and FYVE domain containing 2
chr1_-_6321034 2.672 NM_207370
GPR153
G protein-coupled receptor 153
chr17_+_42081913 2.656 NM_153006
NAGS
N-acetylglutamate synthase
chr11_-_19263144 2.655 E2F8
E2F transcription factor 8
chr12_-_57630867 2.646 NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr6_+_34204928 2.643 HMGA1
high mobility group AT-hook 1
chr14_+_94640648 2.637 NM_020958
NM_058237
PPP4R4

protein phosphatase 4, regulatory subunit 4

chr7_+_130131921 2.629 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chr17_-_882905 2.626 NM_022463
NXN
nucleoredoxin
chr7_-_102257135 2.621 RASA4
RAS p21 protein activator 4
chr12_-_109125275 2.578 CORO1C
coronin, actin binding protein, 1C
chr19_-_10679620 2.573 NM_001800
NM_079421
CDKN2D

cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

chr22_-_37640187 2.571 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr17_+_48133331 2.569 NM_002204
NM_005501
ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr2_+_11886739 2.559 NM_145693
LPIN1
lipin 1
chr6_+_31126114 2.557 NM_001077511
NM_007109
TCF19

transcription factor 19

chr3_-_48130283 2.550 MAP4
microtubule-associated protein 4
chr8_-_23261675 2.548 NM_002318
LOXL2
lysyl oxidase-like 2
chr15_+_63481788 2.532 RAB8B
RAB8B, member RAS oncogene family
chr2_-_165477818 2.525 GRB14
growth factor receptor-bound protein 14
chr7_-_98741375 2.508 SMURF1
SMAD specific E3 ubiquitin protein ligase 1
chr5_-_149682447 2.486 NM_001012301
ARSI
arylsulfatase family, member I
chr17_-_41623246 2.483 NM_001986
ETV4
ets variant 4
chrX_+_64887593 2.461 MSN
moesin
chr22_+_38071612 2.459 NM_002305
LGALS1
lectin, galactoside-binding, soluble, 1
chr5_+_95998170 2.451 CAST
calpastatin
chr1_-_204120909 2.425 ETNK2
ethanolamine kinase 2
chr19_-_51456159 2.421 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr20_+_56885027 2.410 RAB22A
RAB22A, member RAS oncogene family
chr19_+_8429010 2.400 NM_001039667
NM_139314
ANGPTL4

angiopoietin-like 4

chr16_-_75529278 2.388


chr11_-_19262424 2.374 NM_024680
E2F8
E2F transcription factor 8
chr10_+_112257624 2.364 NM_004419
DUSP5
dual specificity phosphatase 5
chr1_+_90098643 2.360 NM_032270
LRRC8C
leucine rich repeat containing 8 family, member C
chr9_-_123639566 2.357 NM_001009936
NM_015651
PHF19

PHD finger protein 19

chr7_-_158497432 2.346 NM_017760
NCAPG2
non-SMC condensin II complex, subunit G2
chr12_-_30907447 2.345 NM_001002259
NM_001206856
NM_023925
NM_032156
CAPRIN2



caprin family member 2



chr1_-_204121144 2.342 NM_018208
ETNK2
ethanolamine kinase 2
chr2_-_27718059 2.341 FNDC4
fibronectin type III domain containing 4
chr1_-_27816667 2.333 WASF2
WAS protein family, member 2
chr22_-_19166296 2.330 NM_005984
SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr1_-_109825767 2.330 NM_001005290
NM_001032291
NM_032636
PSRC1


proline/serine-rich coiled-coil 1


chr1_-_109825683 2.325 PSRC1
proline/serine-rich coiled-coil 1
chr19_-_41356193 2.316 NM_000762
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr8_-_144654921 2.291 NM_001100878
C8orf73
chromosome 8 open reading frame 73
chr12_-_54813010 2.277 NM_002205
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr3_+_50192420 2.271 SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr17_+_33914357 2.255 AP2B1
adaptor-related protein complex 2, beta 1 subunit
chr16_-_87903028 2.255 NM_003486
SLC7A5
solute carrier family 7 (amino acid transporter light chain, L system), member 5
chr13_+_98086315 2.249 NM_021033
RAP2A
RAP2A, member of RAS oncogene family
chr3_-_52090090 2.249 NM_001947
DUSP7
dual specificity phosphatase 7
chr1_-_154155594 2.228 TPM3
tropomyosin 3
chr18_+_21452981 2.227 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr2_+_24272583 2.222 NM_004116
NM_054033
FKBP1B

FK506 binding protein 1B, 12.6 kDa

chr22_+_37956404 2.218 NM_152243
CDC42EP1
CDC42 effector protein (Rho GTPase binding) 1
chr8_-_145013628 2.213 NM_201384
PLEC
plectin
chr20_+_62371218 2.213 SLC2A4RG
SLC2A4 regulator
chrX_-_153775064 2.209 NM_000402
G6PD
glucose-6-phosphate dehydrogenase
chr16_+_15737123 2.205 NM_001143979
NDE1
nudE nuclear distribution gene E homolog 1 (A. nidulans)
chr16_-_67217825 2.198 NM_001040715
KIAA0895L
KIAA0895-like
chr6_-_45345574 2.197 NM_003599
NM_181356
SUPT3H

suppressor of Ty 3 homolog (S. cerevisiae)

chr12_+_57522247 2.192 NM_002332
LRP1
low density lipoprotein receptor-related protein 1
chr2_-_27718098 2.191 NM_022823
FNDC4
fibronectin type III domain containing 4
chr14_-_75422466 2.187 NM_001207012
NM_002632
PGF

placental growth factor

chr8_-_143867931 2.184 NM_003695
LY6D
lymphocyte antigen 6 complex, locus D
chr22_-_30685485 2.159 NM_001037666
GATSL3
GATS protein-like 3
chrX_+_118533257 2.157 NM_145305
SLC25A43
solute carrier family 25, member 43
chr19_+_6739697 2.149 NM_004240
TRIP10
thyroid hormone receptor interactor 10
chr7_-_128045995 2.144 NM_001142573
NM_001142574
NM_001142575
IMPDH1


IMP (inosine 5'-monophosphate) dehydrogenase 1


chr2_+_110371887 2.116 NM_023016
ANKRD57
ankyrin repeat domain 57
chr8_-_144650884 2.103 C8orf73
chromosome 8 open reading frame 73
chr6_-_31869768 2.099 NM_181842
ZBTB12
zinc finger and BTB domain containing 12
chr2_-_110371669 2.097 NM_144710
NM_178584
SEPT10

septin 10

chr22_-_19166276 2.095 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr19_-_46283281 2.090


chr13_+_98086681 2.073 RAP2A
RAP2A, member of RAS oncogene family
chr3_-_50336662 2.063 NM_001200016
NM_012191
NM_001200030
NM_001200031
NM_001200032
NM_003549
NAT6

HYAL3



N-acetyltransferase 6 (GCN5-related)

hyaluronoglucosaminidase 3



chr19_-_14629227 2.057 DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr1_+_46713359 2.046 NM_001142548
NM_003579
RAD54L

RAD54-like (S. cerevisiae)

chr20_+_25228698 2.046 NM_002862
PYGB
phosphorylase, glycogen; brain
chr3_+_38207247 2.043 OXSR1
oxidative-stress responsive 1
chr3_-_123603144 2.041 NM_053025
NM_053026
NM_053027
NM_053028
MYLK



myosin light chain kinase



chr17_-_74449220 2.040 UBE2O
ubiquitin-conjugating enzyme E2O
chr7_-_102257199 2.038 NM_001079877
NM_006989
RASA4

RAS p21 protein activator 4

chr3_-_48130633 2.036 NM_001134364
NM_002375
NM_030885
MAP4


microtubule-associated protein 4


chr1_-_43424834 2.036 NM_006516
SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr19_+_41869848 2.032 NM_001098825
TMEM91
transmembrane protein 91
chr1_-_38471170 2.025 NM_001243878
NM_004468
FHL3

four and a half LIM domains 3

chr22_-_37915209 2.023 NM_014550
CARD10
caspase recruitment domain family, member 10
chr8_+_126010748 2.017 SQLE
squalene epoxidase
chr5_-_16936290 2.016 MYO10
myosin X
chr17_-_7307413 2.013 NM_152766
C17orf61-PLSCR3
C17orf61
C17orf61-PLSCR3 readthrough
chromosome 17 open reading frame 61
chrX_-_153602928 2.010 FLNA
filamin A, alpha
chr1_+_110753313 2.007 NM_001039574
NM_004978
KCNC4

potassium voltage-gated channel, Shaw-related subfamily, member 4

chr19_-_44285407 2.003 NM_002250
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr1_+_182992329 1.997 NM_002293
LAMC1
laminin, gamma 1 (formerly LAMB2)
chrX_+_56258785 1.992 NM_007250
NM_001159296
KLF8

Kruppel-like factor 8

chr12_-_109125289 1.985 NM_014325
CORO1C
coronin, actin binding protein, 1C
chr2_+_24272627 1.985 FKBP1B
FK506 binding protein 1B, 12.6 kDa
chr4_+_154387450 1.983 NM_001131007
NM_015196
KIAA0922

KIAA0922

chr7_+_155089614 1.978 INSIG1
insulin induced gene 1
chr1_-_41131113 1.976 RIMS3
regulating synaptic membrane exocytosis 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.10 7.89e-36 GO:0009987 cellular process
1.13 4.33e-18 GO:0044237 cellular metabolic process
1.18 1.11e-15 GO:0016043 cellular component organization
1.10 2.11e-15 GO:0065007 biological regulation
1.15 4.14e-15 GO:0044260 cellular macromolecule metabolic process
1.10 5.88e-15 GO:0050789 regulation of biological process
1.11 1.07e-14 GO:0008152 metabolic process
1.17 1.28e-14 GO:0071840 cellular component organization or biogenesis
1.11 1.86e-14 GO:0044238 primary metabolic process
1.11 3.76e-14 GO:0050794 regulation of cellular process
1.23 3.76e-12 GO:0006464 protein modification process
1.22 5.54e-11 GO:0043412 macromolecule modification
1.12 8.64e-11 GO:0043170 macromolecule metabolic process
1.18 3.85e-10 GO:0071842 cellular component organization at cellular level
1.18 1.39e-09 GO:0044267 cellular protein metabolic process
1.17 1.59e-09 GO:0071841 cellular component organization or biogenesis at cellular level
1.22 9.72e-09 GO:0023051 regulation of signaling
1.23 1.10e-08 GO:0009966 regulation of signal transduction
1.12 2.90e-07 GO:0019222 regulation of metabolic process
1.13 4.98e-07 GO:0031323 regulation of cellular metabolic process
1.40 1.84e-06 GO:0007264 small GTPase mediated signal transduction
1.22 2.39e-06 GO:0051641 cellular localization
1.16 2.45e-06 GO:0048523 negative regulation of cellular process
1.37 3.34e-06 GO:0061024 membrane organization
1.19 4.07e-06 GO:0006996 organelle organization
1.41 5.36e-06 GO:0018193 peptidyl-amino acid modification
1.28 5.53e-06 GO:0016192 vesicle-mediated transport
1.36 6.40e-06 GO:0016044 cellular membrane organization
1.12 6.73e-06 GO:0080090 regulation of primary metabolic process
1.69 8.11e-06 GO:0007265 Ras protein signal transduction
1.19 8.57e-06 GO:0007399 nervous system development
1.14 8.95e-06 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.11 1.03e-05 GO:0023052 signaling
1.12 1.33e-05 GO:0051179 localization
1.25 1.71e-05 GO:0008219 cell death
1.23 2.04e-05 GO:0008104 protein localization
1.15 2.06e-05 GO:0048519 negative regulation of biological process
1.12 2.24e-05 GO:0007165 signal transduction
1.13 2.26e-05 GO:0019538 protein metabolic process
1.25 2.44e-05 GO:0016265 death
1.17 2.70e-05 GO:0048583 regulation of response to stimulus
1.25 3.91e-05 GO:0045184 establishment of protein localization
1.17 4.04e-05 GO:0034645 cellular macromolecule biosynthetic process
1.22 4.53e-05 GO:0051649 establishment of localization in cell
1.20 4.69e-05 GO:0033036 macromolecule localization
1.25 5.02e-05 GO:0048699 generation of neurons
1.24 5.43e-05 GO:0022008 neurogenesis
1.14 5.98e-05 GO:0048522 positive regulation of cellular process
1.12 6.44e-05 GO:0060255 regulation of macromolecule metabolic process
1.17 7.22e-05 GO:0009059 macromolecule biosynthetic process
1.12 7.50e-05 GO:0006807 nitrogen compound metabolic process
1.25 8.00e-05 GO:0051128 regulation of cellular component organization
1.31 1.01e-04 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.21 1.18e-04 GO:0010646 regulation of cell communication
1.10 1.25e-04 GO:0032502 developmental process
1.13 1.35e-04 GO:0048518 positive regulation of biological process
1.22 1.69e-04 GO:0006793 phosphorus metabolic process
1.22 1.69e-04 GO:0006796 phosphate metabolic process
1.25 1.80e-04 GO:0046907 intracellular transport
1.26 2.29e-04 GO:0012501 programmed cell death
1.18 2.54e-04 GO:0035556 intracellular signal transduction
1.15 2.74e-04 GO:0030154 cell differentiation
1.23 2.78e-04 GO:0015031 protein transport
1.32 2.87e-04 GO:0044262 cellular carbohydrate metabolic process
1.25 4.35e-04 GO:0006915 apoptosis
1.11 4.68e-04 GO:0034641 cellular nitrogen compound metabolic process
1.26 4.95e-04 GO:0007167 enzyme linked receptor protein signaling pathway
1.13 4.95e-04 GO:0044249 cellular biosynthetic process
1.09 5.11e-04 GO:0051716 cellular response to stimulus
1.12 5.56e-04 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.13 7.59e-04 GO:0051252 regulation of RNA metabolic process
1.14 7.86e-04 GO:0048869 cellular developmental process
1.13 8.04e-04 GO:0009058 biosynthetic process
1.10 8.07e-04 GO:0007275 multicellular organismal development
1.11 9.05e-04 GO:0051234 establishment of localization
1.25 1.11e-03 GO:0045595 regulation of cell differentiation
1.12 1.31e-03 GO:0010468 regulation of gene expression
1.21 1.86e-03 GO:0050793 regulation of developmental process
1.12 2.00e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.32 2.10e-03 GO:0009968 negative regulation of signal transduction
1.11 2.24e-03 GO:0051171 regulation of nitrogen compound metabolic process
1.40 2.29e-03 GO:0009100 glycoprotein metabolic process
1.11 2.78e-03 GO:0006810 transport
1.25 2.92e-03 GO:0030030 cell projection organization
1.42 2.93e-03 GO:0048011 nerve growth factor receptor signaling pathway
1.25 2.94e-03 GO:0005975 carbohydrate metabolic process
1.24 3.56e-03 GO:0030182 neuron differentiation
1.26 4.80e-03 GO:0048666 neuron development
1.14 5.76e-03 GO:0010467 gene expression
1.13 6.20e-03 GO:0006355 regulation of transcription, DNA-dependent
1.23 6.68e-03 GO:0019220 regulation of phosphate metabolic process
1.23 6.68e-03 GO:0051174 regulation of phosphorus metabolic process
1.11 6.91e-03 GO:0031326 regulation of cellular biosynthetic process
1.38 8.75e-03 GO:0030036 actin cytoskeleton organization
1.29 9.28e-03 GO:0010648 negative regulation of cell communication
1.11 9.43e-03 GO:0048731 system development
1.42 1.00e-02 GO:0009101 glycoprotein biosynthetic process
1.15 1.04e-02 GO:0009653 anatomical structure morphogenesis
1.32 1.10e-02 GO:0051301 cell division
1.27 1.11e-02 GO:0048585 negative regulation of response to stimulus
1.28 1.21e-02 GO:0023057 negative regulation of signaling
1.10 1.26e-02 GO:0048856 anatomical structure development
1.35 1.27e-02 GO:0030029 actin filament-based process
1.23 1.44e-02 GO:0042325 regulation of phosphorylation
1.26 1.60e-02 GO:0031175 neuron projection development
1.23 1.68e-02 GO:0001932 regulation of protein phosphorylation
1.20 1.75e-02 GO:0006351 transcription, DNA-dependent
1.26 2.05e-02 GO:0007010 cytoskeleton organization
1.59 2.17e-02 GO:0006487 protein N-linked glycosylation
1.11 2.19e-02 GO:0009889 regulation of biosynthetic process
1.39 2.35e-02 GO:0005996 monosaccharide metabolic process
1.26 2.41e-02 GO:0006753 nucleoside phosphate metabolic process
1.26 2.41e-02 GO:0009117 nucleotide metabolic process
1.11 2.76e-02 GO:0010556 regulation of macromolecule biosynthetic process
1.26 2.83e-02 GO:0000904 cell morphogenesis involved in differentiation
1.46 2.92e-02 GO:0031344 regulation of cell projection organization
1.21 2.95e-02 GO:0006468 protein phosphorylation
1.38 3.29e-02 GO:0045786 negative regulation of cell cycle
1.27 3.38e-02 GO:0048667 cell morphogenesis involved in neuron differentiation
1.31 3.60e-02 GO:0032535 regulation of cellular component size
1.27 3.70e-02 GO:0048812 neuron projection morphogenesis
1.18 4.39e-02 GO:0048468 cell development
1.27 4.89e-02 GO:0072521 purine-containing compound metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.11 5.43e-52 GO:0044424 intracellular part
1.10 1.07e-50 GO:0005622 intracellular
1.14 1.44e-41 GO:0005737 cytoplasm
1.11 1.65e-34 GO:0043226 organelle
1.11 2.11e-34 GO:0043229 intracellular organelle
1.12 4.14e-34 GO:0043231 intracellular membrane-bounded organelle
1.12 5.37e-34 GO:0043227 membrane-bounded organelle
1.15 1.80e-26 GO:0044444 cytoplasmic part
1.14 2.53e-19 GO:0044446 intracellular organelle part
1.14 5.76e-19 GO:0044422 organelle part
1.24 6.27e-17 GO:0005829 cytosol
1.12 8.97e-15 GO:0005634 nucleus
1.22 3.00e-10 GO:0012505 endomembrane system
1.18 3.29e-09 GO:0044428 nuclear part
1.17 1.88e-08 GO:0070013 intracellular organelle lumen
1.16 2.11e-08 GO:0031974 membrane-enclosed lumen
1.17 2.78e-08 GO:0031090 organelle membrane
1.16 9.40e-08 GO:0043233 organelle lumen
1.44 5.00e-07 GO:0015629 actin cytoskeleton
1.17 1.38e-06 GO:0031981 nuclear lumen
1.02 2.29e-06 GO:0044464 cell part
1.02 2.55e-06 GO:0005623 cell
1.22 6.75e-06 GO:0005794 Golgi apparatus
1.19 2.14e-05 GO:0005654 nucleoplasm
1.28 2.62e-05 GO:0030054 cell junction
1.12 3.13e-05 GO:0043234 protein complex
1.20 4.09e-05 GO:0005783 endoplasmic reticulum
1.51 4.69e-05 GO:0070161 anchoring junction
1.51 2.41e-04 GO:0005912 adherens junction
1.09 1.50e-03 GO:0032991 macromolecular complex
1.10 2.55e-03 GO:0043228 non-membrane-bounded organelle
1.10 2.55e-03 GO:0043232 intracellular non-membrane-bounded organelle
1.85 2.80e-03 GO:0000792 heterochromatin
2.05 3.03e-03 GO:0005720 nuclear heterochromatin
1.21 3.61e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
1.20 4.61e-03 GO:0031982 vesicle
1.41 4.67e-03 GO:0031252 cell leading edge
1.20 4.76e-03 GO:0031988 membrane-bounded vesicle
1.20 5.27e-03 GO:0031410 cytoplasmic vesicle
1.18 7.67e-03 GO:0042995 cell projection
1.22 1.13e-02 GO:0044431 Golgi apparatus part
1.52 1.39e-02 GO:0005925 focal adhesion
1.13 2.50e-02 GO:0005856 cytoskeleton
1.23 2.66e-02 GO:0000139 Golgi membrane
1.18 2.67e-02 GO:0044432 endoplasmic reticulum part
1.53 3.15e-02 GO:0001726 ruffle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.17 1.97e-45 GO:0005515 protein binding
1.09 8.05e-42 GO:0005488 binding
1.44 1.75e-10 GO:0019904 protein domain specific binding
1.17 1.55e-08 GO:0000166 nucleotide binding
1.30 8.17e-08 GO:0019899 enzyme binding
1.17 3.57e-07 GO:0017076 purine nucleotide binding
1.17 6.05e-07 GO:0032553 ribonucleotide binding
1.17 6.05e-07 GO:0032555 purine ribonucleotide binding
1.17 9.38e-07 GO:0035639 purine ribonucleoside triphosphate binding
1.17 5.31e-06 GO:0016740 transferase activity
1.26 1.12e-05 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.25 1.21e-05 GO:0016301 kinase activity
1.29 5.65e-05 GO:0008092 cytoskeletal protein binding
1.08 1.06e-04 GO:0003824 catalytic activity
1.22 1.19e-04 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.33 1.83e-04 GO:0000988 protein binding transcription factor activity
1.33 1.83e-04 GO:0000989 transcription factor binding transcription factor activity
1.33 2.46e-04 GO:0003712 transcription cofactor activity
1.16 4.23e-04 GO:0030554 adenyl nucleotide binding
1.35 5.68e-04 GO:0003779 actin binding
1.15 8.69e-04 GO:0032559 adenyl ribonucleotide binding
1.15 1.31e-03 GO:0005524 ATP binding
1.39 1.89e-03 GO:0019900 kinase binding
1.21 2.37e-03 GO:0042802 identical protein binding
1.53 5.49e-03 GO:0051020 GTPase binding
1.83 7.16e-03 GO:0001948 glycoprotein binding
1.23 7.51e-03 GO:0004672 protein kinase activity
1.53 8.23e-03 GO:0017124 SH3 domain binding
1.17 1.91e-02 GO:0001071 nucleic acid binding transcription factor activity
1.17 1.91e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.37 2.05e-02 GO:0019901 protein kinase binding
1.24 2.94e-02 GO:0030695 GTPase regulator activity
1.36 3.39e-02 GO:0003924 GTPase activity
1.25 3.96e-02 GO:0004674 protein serine/threonine kinase activity