Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 1.112


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
LEF1 51176 lymphoid enhancer-binding factor 1
TCF7 6932 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 83439 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF7chr5_+_1334512970.495.6e-03Click!
LEF1chr4_-_109089444-0.479.5e-03Click!
TCF7L1chr2_+_85360373-0.374.5e-02Click!
TCF7L2chr10_+_1147107850.355.6e-02Click!


Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_31870940 7.535 NM_033197
BPIFB1
BPI fold containing family B, member 1
chr9_-_34381497 5.331 NM_001252195
NM_147168
NM_147169
C9orf24


chromosome 9 open reading frame 24


chr6_-_29527701 5.146 NM_006398
UBD
ubiquitin D
chr6_-_29527477 5.084 UBD
ubiquitin D
chr2_-_135782246 3.844 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr13_+_24144402 3.693 NM_001204459
NM_148957
TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr19_-_7990974 3.272 NM_206833
CTXN1
cortexin 1
chr19_-_41356193 3.043 NM_000762
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr19_-_3028901 2.916 NM_003260
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr14_+_74486049 2.908 NM_025057
C14orf45
chromosome 14 open reading frame 45
chr4_-_16077740 2.855 NM_001145849
NM_001145850
NM_001145851
NM_001145852
NM_006017
PROM1




prominin 1




chr2_+_172378756 2.668 CYBRD1
cytochrome b reductase 1
chr5_-_100238870 2.637 NM_175052
NM_005668
ST8SIA4

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

chr18_+_61370193 2.596 NM_080475
SERPINB11
serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)
chr13_-_39564857 2.576 NM_001144033
NM_145286
STOML3

stomatin (EPB72)-like 3

chr17_-_63557764 2.473 AXIN2
axin 2
chr17_-_63556443 2.419 AXIN2
axin 2
chr3_-_148939784 2.412 NM_000096
CP
ceruloplasmin (ferroxidase)
chr17_-_63557615 2.246 NM_004655
AXIN2
axin 2
chr14_-_21271002 2.227 NM_002933
NM_198234
NM_198235
RNASE1


ribonuclease, RNase A family, 1 (pancreatic)


chr12_-_49582800 2.203 NM_006009
TUBA1A
tubulin, alpha 1a
chrX_+_125953746 2.173 NM_001122716
CXorf64
chromosome X open reading frame 64
chr9_-_117150217 2.055 AKNA
AT-hook transcription factor
chr2_+_172378856 2.040 NM_001127383
NM_024843
CYBRD1

cytochrome b reductase 1

chr10_+_7745354 1.994 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr20_-_39317875 1.957 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr1_+_104292439 1.891 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr1_-_151345156 1.887 NM_003944
SELENBP1
selenium binding protein 1
chr3_+_151488214 1.832 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr22_+_31003069 1.809 NM_000355
NM_001184726
TCN2

transcobalamin II

chr6_-_52668599 1.757 NM_145740
GSTA1
glutathione S-transferase alpha 1
chr2_-_86564632 1.749 NM_001164731
NM_001164732
NM_022912
REEP1


receptor accessory protein 1


chr21_-_43735462 1.735 TFF3
trefoil factor 3 (intestinal)
chr2_+_98330030 1.716 NM_001079
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr10_+_114154522 1.708 ACSL5
acyl-CoA synthetase long-chain family member 5
chr14_-_21270537 1.695 NM_198232
RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr12_-_49582296 1.674 TUBA1A
tubulin, alpha 1a
chr7_+_23286386 1.638 GPNMB
glycoprotein (transmembrane) nmb
chr15_-_93632161 1.619 NM_020211
RGMA
RGM domain family, member A
chr1_-_32801606 1.583 NM_023009
MARCKSL1
MARCKS-like 1
chr20_-_25013307 1.568 NM_001252676
ACSS1
acyl-CoA synthetase short-chain family member 1
chr11_-_62474869 1.567 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr7_+_23286390 1.566 GPNMB
glycoprotein (transmembrane) nmb
chr20_+_18794369 1.561 NM_178483
C20orf79
chromosome 20 open reading frame 79
chr10_+_7745325 1.561 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr5_+_42548144 1.541 NM_001242402
GHR
growth hormone receptor
chr10_+_7745229 1.531 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr17_+_48172100 1.506 NM_001199898
PDK2
pyruvate dehydrogenase kinase, isozyme 2
chr11_-_62474666 1.505 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr11_-_62474810 1.500 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr16_+_57406398 1.472 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr11_-_62475060 1.456 NM_001122955
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr1_+_104292278 1.417 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr8_-_121824015 1.390


chr22_-_36013303 1.376 NM_005368
NM_203378
MB

myoglobin

chr20_+_9198036 1.350 NM_182797
PLCB4
phospholipase C, beta 4
chr7_-_120498128 1.345 NM_012338
TSPAN12
tetraspanin 12
chr5_+_140254930 1.315 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chr11_+_36317724 1.308 NM_001160167
PRR5L
proline rich 5 like
chr19_-_18717631 1.294 NM_004750
CRLF1
cytokine receptor-like factor 1
chr19_-_18717467 1.287 CRLF1
cytokine receptor-like factor 1
chr19_+_8274179 1.275 NM_024552
CERS4
ceramide synthase 4
chr10_-_123356158 1.274 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr5_+_42548314 1.233 NM_001242403
GHR
growth hormone receptor
chr20_-_44175995 1.233 NM_001198986
NM_020398
SPINLW1-WFDC6
SPINLW1
SPINLW1-WFDC6 readthrough
serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin)
chr1_+_87794150 1.228 NM_006769
LMO4
LIM domain only 4
chr22_+_24105207 1.180 NM_182520
C22orf15
chromosome 22 open reading frame 15
chr5_+_140220811 1.178 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr5_+_42550181 1.171 NM_001242405
GHR
growth hormone receptor
chr5_+_43602738 1.164 NM_012343
NNT
nicotinamide nucleotide transhydrogenase
chr16_-_28620648 1.156 NM_177530
NM_177534
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr5_+_36606667 1.139 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chrX_-_117119282 1.138 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr19_-_55690717 1.135 SYT5
synaptotagmin V
chr21_-_43735705 1.120 NM_003226
TFF3
trefoil factor 3 (intestinal)
chrX_-_108725284 1.120 NM_001522
GUCY2F
guanylate cyclase 2F, retinal
chr7_+_90338711 1.112 NM_012395
CDK14
cyclin-dependent kinase 14
chr1_-_177133818 1.103 ASTN1
astrotactin 1
chr1_-_177133950 1.091 NM_004319
NM_207108
ASTN1

astrotactin 1

chr16_-_49315682 1.088 NM_004352
CBLN1
cerebellin 1 precursor
chr11_-_33913835 1.084 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr15_+_50474357 1.080 NM_001159629
NM_003645
SLC27A2

solute carrier family 27 (fatty acid transporter), member 2

chr6_-_31681845 1.078


chr10_-_116392099 1.072 ABLIM1
actin binding LIM protein 1
chr9_-_35563895 1.056 NM_001099951
NM_001164310
FAM166B

family with sequence similarity 166, member B

chr2_+_69240137 1.045 NM_018153
NM_032208
NM_053034
ANTXR1


anthrax toxin receptor 1


chr15_-_89089792 1.018 NM_001144074
NM_017996
DET1

de-etiolated homolog 1 (Arabidopsis)

chrX_-_73512376 1.014 FTX
FTX transcript, XIST regulator (non-protein coding)
chr19_-_18717577 1.013 CRLF1
cytokine receptor-like factor 1
chr6_-_32557431 1.012 NM_001243965
NM_002124
HLA-DRB1

HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1

major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr17_+_55333843 0.999 NM_138962
MSI2
musashi homolog 2 (Drosophila)
chr10_-_25304865 0.997 NM_145010
ENKUR
enkurin, TRPC channel interacting protein
chr5_+_140235594 0.995 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr17_+_36861398 0.982 MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr11_+_63137260 0.974 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr19_-_6720585 0.972 NM_000064
C3
complement component 3
chr4_+_106067031 0.970 NM_017628
TET2
tet methylcytosine dioxygenase 2
chr12_+_1738411 0.960 NM_032642
WNT5B
wingless-type MMTV integration site family, member 5B
chr12_-_68726036 0.958 NM_001205028
NM_001205029
NM_017440
NM_020128
MDM1



Mdm1 nuclear protein homolog (mouse)



chr22_-_44893903 0.957 NM_032287
LDOC1L
leucine zipper, down-regulated in cancer 1-like
chr1_+_212738675 0.951 NM_001030287
ATF3
activating transcription factor 3
chr13_+_31506809 0.948 NM_152325
C13orf26
chromosome 13 open reading frame 26
chr6_+_143929316 0.941 NM_001100166
NM_014721
PHACTR2

phosphatase and actin regulator 2

chr3_-_47823377 0.936 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr19_-_44831907 0.930 ZFP112
zinc finger protein 112 homolog (mouse)
chr17_+_31254927 0.921 NM_001033504
NM_015544
TMEM98

transmembrane protein 98

chr3_-_47823368 0.911 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr4_+_39063851 0.903 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr10_+_115511212 0.897 NM_001193434
NM_001193435
NM_024889
C10orf81


chromosome 10 open reading frame 81


chr6_+_159070994 0.896 NM_001009991
NM_001242384
NM_001242394
NM_001242395
SYTL3



synaptotagmin-like 3



chr3_-_112564789 0.880 NM_001008784
NM_001199215
CD200R1L

CD200 receptor 1-like

chr19_+_13134782 0.878 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr1_-_115053677 0.873 TRIM33
tripartite motif containing 33
chr7_+_90339146 0.867 CDK14
cyclin-dependent kinase 14
chr9_-_74525846 0.867 FAM108B1
family with sequence similarity 108, member B1
chr11_+_100862719 0.864 NM_032021
TMEM133
transmembrane protein 133
chr1_-_104239071 0.859 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr7_+_73245192 0.857 NM_001305
CLDN4
claudin 4
chr15_+_65822842 0.851 PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr15_+_73344824 0.847 NM_001172623
NM_001172624
NM_002499
NEO1


neogenin 1


chr8_-_95220769 0.846 NM_004063
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr5_+_36606456 0.836 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr17_-_61518174 0.828 NM_001017917
CYB561
cytochrome b-561
chr15_-_82338348 0.825 NM_032246
MEX3B
mex-3 homolog B (C. elegans)
chr5_+_43603216 0.824 NM_182977
NNT
nicotinamide nucleotide transhydrogenase
chr1_-_20126368 0.823 NM_181719
TMCO4
transmembrane and coiled-coil domains 4
chr10_-_116444374 0.821 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr4_-_17806820 0.820 DCAF16
DDB1 and CUL4 associated factor 16
chr3_+_183353355 0.820 NM_017644
KLHL24
kelch-like 24 (Drosophila)
chr3_-_47823343 0.819 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr5_+_42549657 0.819 NM_001242404
GHR
growth hormone receptor
chr10_-_123353771 0.814 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr6_-_79787887 0.805 PHIP
pleckstrin homology domain interacting protein
chr14_-_94854910 0.801 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr7_-_137028533 0.796 NM_002825
PTN
pleiotrophin
chr20_-_32031425 0.793 NM_003098
SNTA1
syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)
chr10_+_7745341 0.789 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr3_-_151058439 0.788 NM_176876
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr18_+_55888750 0.788 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr22_+_39052671 0.786 CBY1
chibby homolog 1 (Drosophila)
chr5_+_133450353 0.785 NM_003202
TCF7
transcription factor 7 (T-cell specific, HMG-box)
chr5_+_43603312 0.771 NNT
nicotinamide nucleotide transhydrogenase
chrX_+_47092264 0.771 NM_004651
USP11
ubiquitin specific peptidase 11
chr3_-_125775609 0.770 NM_001008487
SLC41A3
solute carrier family 41, member 3
chr1_+_104198301 0.763 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr8_+_143761873 0.759 NM_005672
PSCA
prostate stem cell antigen
chr1_+_104198140 0.759 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr7_+_128828712 0.754 NM_005631
SMO
smoothened, frizzled family receptor
chr1_-_104238785 0.749 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr16_-_12897693 0.728 NM_001099455
NM_018340
CPPED1

calcineurin-like phosphoesterase domain containing 1

chr17_+_19990334 0.719 NM_001033553
NM_152904
SPECC1

sperm antigen with calponin homology and coiled-coil domains 1

chr17_-_46035109 0.711 NM_024320
PRR15L
proline rich 15-like
chr2_+_38155901 0.711 NM_001170792
FAM82A1
family with sequence similarity 82, member A1
chr12_-_25706177 0.707 NM_152590
NM_001145728
NM_001145729
IFLTD1


intermediate filament tail domain containing 1


chr4_+_25657434 0.701 NM_001177998
NM_006424
SLC34A2

solute carrier family 34 (sodium phosphate), member 2

chr4_+_170581212 0.696 NM_001243374
CLCN3
chloride channel 3
chr2_+_233734993 0.692 NM_206895
C2orf82
chromosome 2 open reading frame 82
chr7_+_105603656 0.691 NM_152750
CDHR3
cadherin-related family member 3
chr15_+_65822738 0.684 NM_016395
PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr19_+_10527448 0.680 NM_001243121
PDE4A
phosphodiesterase 4A, cAMP-specific
chr15_+_71184781 0.676 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chrX_-_100183897 0.674 NM_212559
XKRX
XK, Kell blood group complex subunit-related, X-linked
chr17_+_26698986 0.672 NM_015077
SARM1
sterile alpha and TIR motif containing 1
chr10_-_123353330 0.666 NM_001144913
NM_001144914
FGFR2

fibroblast growth factor receptor 2

chr1_+_179965756 0.650 CEP350
centrosomal protein 350kDa
chr3_+_133502876 0.650 NM_021203
SRPRB
signal recognition particle receptor, B subunit
chr20_-_20036685 0.649 NM_016652
CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr11_+_73359734 0.649 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr6_-_39072412 0.642 C6orf64
chromosome 6 open reading frame 64
chr19_+_13135368 0.629 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr6_-_32497925 0.628 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr8_-_119964059 0.628 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr7_+_30951414 0.626 NM_198098
AQP1
aquaporin 1 (Colton blood group)
chr5_+_102201526 0.622 NM_000919
NM_001177306
NM_138766
NM_138821
NM_138822
PAM




peptidylglycine alpha-amidating monooxygenase




chr5_+_43603287 0.620 NNT
nicotinamide nucleotide transhydrogenase
chr17_-_10421858 0.619 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr5_-_159827042 0.619 NM_022090
C5orf54
chromosome 5 open reading frame 54
chr4_+_1005609 0.618 NM_001004356
NM_001004358
FGFRL1

fibroblast growth factor receptor-like 1

chr10_-_93669184 0.615 NM_152429
FGFBP3
fibroblast growth factor binding protein 3
chr15_+_43809805 0.603 NM_002373
MAP1A
microtubule-associated protein 1A
chr7_-_137028370 0.601 PTN
pleiotrophin
chr1_-_183559669 0.596 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr2_+_191273012 0.585 NM_017694
MFSD6
major facilitator superfamily domain containing 6
chr15_-_64995459 0.583 NM_002537
OAZ2
ornithine decarboxylase antizyme 2
chr3_-_47823419 0.582 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr20_+_60718473 0.580 NM_198935
SS18L1
synovial sarcoma translocation gene on chromosome 18-like 1
chr5_-_139422725 0.578 NRG2
neuregulin 2
chr6_-_79787784 0.577 PHIP
pleckstrin homology domain interacting protein
chr1_-_16161279 0.577


chr16_+_30210548 0.572 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr11_+_126081618 0.571 NM_024556
FAM118B
family with sequence similarity 118, member B
chr15_-_90347534 0.571 ANPEP
alanyl (membrane) aminopeptidase
chr6_+_116850175 0.565 NM_153036
FAM26D
family with sequence similarity 26, member D
chr6_-_32908583 0.565 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr12_+_20963637 0.561 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr14_-_21572374 0.559


chr12_+_112204690 0.559 NM_000690
NM_001204889
ALDH2

aldehyde dehydrogenase 2 family (mitochondrial)

chr1_+_152758752 0.558 NM_178353
LCE1E
late cornified envelope 1E
chr5_+_121465214 0.556 NM_207317
ZNF474
zinc finger protein 474
chr15_-_82338459 0.556 MEX3B
mex-3 homolog B (C. elegans)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.64 1.60e-02 GO:0007156 homophilic cell adhesion

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.17 1.67e-02 GO:0005634 nucleus

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.32 8.17e-03 GO:0003677 DNA binding