Motif ID: MSX1,2.p2

Z-value: 0.420


Transcription factors associated with MSX1,2.p2:

Gene SymbolEntrez IDGene Name
MSX1 4487 msh homeobox 1
MSX2 4488 msh homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MSX1chr4_+_48613710.291.2e-01Click!
MSX2chr5_+_174151531-0.271.5e-01Click!


Activity profile for motif MSX1,2.p2.

activity profile for motif MSX1,2.p2


Sorted Z-values histogram for motif MSX1,2.p2

Sorted Z-values for motif MSX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MSX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_68071386 1.017 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr5_-_160279045 0.920 NM_025153
ATP10B
ATPase, class V, type 10B
chr3_-_165555252 0.725 NM_000055
BCHE
butyrylcholinesterase
chr3_-_165555167 0.668 BCHE
butyrylcholinesterase
chr6_+_16129285 0.596 NM_013262
MYLIP
myosin regulatory light chain interacting protein
chr12_-_71551564 0.415 TSPAN8
tetraspanin 8
chr3_-_151102536 0.405 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr8_-_27115935 0.379 STMN4
stathmin-like 4
chr16_-_21289571 0.376 CRYM
crystallin, mu
chr12_+_53818864 0.375 AMHR2
anti-Mullerian hormone receptor, type II
chr8_-_27115897 0.368 NM_030795
STMN4
stathmin-like 4
chr10_+_115511212 0.366 NM_001193434
NM_001193435
NM_024889
C10orf81


chromosome 10 open reading frame 81


chr3_-_148939784 0.329 NM_000096
CP
ceruloplasmin (ferroxidase)
chr6_+_16129321 0.325 MYLIP
myosin regulatory light chain interacting protein
chr11_+_7618416 0.314 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr1_-_108231122 0.307 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr1_+_84767288 0.293 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chrX_-_15620191 0.266 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr12_-_15114495 0.265 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr8_-_110620220 0.241 SYBU
syntabulin (syntaxin-interacting)
chr9_+_1050333 0.227 NM_006557
NM_001130865
DMRT2

doublesex and mab-3 related transcription factor 2

chr15_-_43594452 0.203 NM_052955
TGM7
transglutaminase 7
chr4_+_88896838 0.188 SPP1
secreted phosphoprotein 1
chr4_+_88896801 0.186 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr4_+_88896868 0.182 SPP1
secreted phosphoprotein 1
chr5_-_35938736 0.182 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr12_+_54891539 0.182 NCKAP1L
NCK-associated protein 1-like
chr6_-_32920812 0.175 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr2_-_69098502 0.170 NM_014482
BMP10
bone morphogenetic protein 10
chr4_+_88896899 0.168 SPP1
secreted phosphoprotein 1
chr9_+_1050367 0.166 DMRT2
doublesex and mab-3 related transcription factor 2
chr1_+_151763174 0.166


chr12_+_54891522 0.158 NCKAP1L
NCK-associated protein 1-like
chr4_-_156787377 0.157 NM_017419
ACCN5
amiloride-sensitive cation channel 5, intestinal
chr6_-_154677868 0.154 NM_001130700
NM_015553
IPCEF1

interaction protein for cytohesin exchange factors 1

chr15_-_40398573 0.154 NM_033503
BMF
Bcl2 modifying factor
chr10_+_7745354 0.151 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr13_-_86373328 0.147 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr11_-_40315663 0.139 NM_020929
LRRC4C
leucine rich repeat containing 4C
chr4_-_41884568 0.137


chr12_+_54891491 0.126 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr17_-_19651586 0.125 NM_000691
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr19_+_6772705 0.125 NM_005428
VAV1
vav 1 guanine nucleotide exchange factor
chr11_-_64727608 0.123 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr1_-_104239071 0.123 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr12_+_86268072 0.121 NM_006183
NTS
neurotensin
chr1_-_242612757 0.119 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr12_+_51318743 0.117 METTL7A
methyltransferase like 7A
chr19_+_50016500 0.116 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr9_-_97356007 0.115 NM_003837
FBP2
fructose-1,6-bisphosphatase 2
chr6_-_55740387 0.114 BMP5
bone morphogenetic protein 5
chr11_+_15133969 0.112 NM_001031853
INSC
inscuteable homolog (Drosophila)
chr1_+_196621007 0.110 NM_000186
NM_001014975
CFH

complement factor H

chr9_+_120466607 0.108 TLR4
toll-like receptor 4
chr8_+_76452202 0.108 NM_004133
HNF4G
hepatocyte nuclear factor 4, gamma
chr10_-_62332666 0.108 NM_001204404
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr1_-_154832187 0.107 NM_170782
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr9_+_134305476 0.107 NM_013318
PRRC2B
proline-rich coiled-coil 2B
chr16_-_3085541 0.106 NM_001103175
CCDC64B
coiled-coil domain containing 64B
chr14_-_94254765 0.105 NM_178013
PRIMA1
proline rich membrane anchor 1
chr1_+_104198140 0.103 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr19_-_14169970 0.103 NM_001145028
PALM3
paralemmin 3
chr1_-_190446701 0.101 NM_199051
FAM5C
family with sequence similarity 5, member C
chr12_-_105627182 0.101 NM_001251905
APPL2
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr14_-_65409445 0.098 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr9_+_120466625 0.095 TLR4
toll-like receptor 4
chr2_+_163200582 0.093 NM_012198
GCA
grancalcin, EF-hand calcium binding protein
chr6_-_32977312 0.092 HLA-DOA
major histocompatibility complex, class II, DO alpha
chr14_+_21756135 0.091 NM_020366
RPGRIP1
retinitis pigmentosa GTPase regulator interacting protein 1
chr9_-_116840551 0.088 AMBP
alpha-1-microglobulin/bikunin precursor
chr6_+_127898318 0.086 NM_001010905
C6orf58
chromosome 6 open reading frame 58
chr4_-_66536182 0.085 EPHA5
EPH receptor A5
chr16_+_66400524 0.083 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr5_+_139876504 0.082 ANKHD1
ankyrin repeat and KH domain containing 1
chr10_+_7745325 0.082 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr12_-_91398744 0.080 EPYC
epiphycan
chr10_+_114133838 0.080 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chrX_+_16964730 0.079 NM_001080975
NM_004726
REPS2

RALBP1 associated Eps domain containing 2

chr4_-_70725792 0.079 NM_005420
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr6_+_50786438 0.078 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr4_-_186733372 0.077 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr11_-_8832881 0.072 NM_139157
ST5
suppression of tumorigenicity 5
chr6_-_31681845 0.071


chr5_+_43602738 0.071 NM_012343
NNT
nicotinamide nucleotide transhydrogenase
chr10_-_123353771 0.071 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr12_+_54892567 0.070 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr10_+_114133775 0.069 ACSL5
acyl-CoA synthetase long-chain family member 5
chr13_+_52598678 0.068 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr9_-_116840460 0.067 AMBP
alpha-1-microglobulin/bikunin precursor
chr9_-_116840604 0.066 AMBP
alpha-1-microglobulin/bikunin precursor
chr3_-_120401401 0.065 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr6_-_39693110 0.065 NM_145027
KIF6
kinesin family member 6
chr3_-_97754147 0.064 NM_001105580
GABRR3
gamma-aminobutyric acid (GABA) receptor, rho 3
chr7_+_94539209 0.064 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr2_+_102803432 0.064 NM_003854
IL1RL2
interleukin 1 receptor-like 2
chr19_+_52264452 0.061 NM_001005738
FPR2
formyl peptide receptor 2
chr1_+_153190059 0.061 NM_001195571
PRR9
proline rich 9
chr4_+_86699846 0.059 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr10_-_62149487 0.059 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr4_-_76957139 0.059 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr17_-_78450247 0.059 NM_002522
NPTX1
neuronal pentraxin I
chr1_+_201979747 0.058 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr8_+_21900389 0.058 NM_003867
FGF17
fibroblast growth factor 17
chr6_+_132859426 0.058 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr2_-_162929928 0.057 DPP4
dipeptidyl-peptidase 4
chr21_-_37852387 0.056 NM_001146079
NM_144492
CLDN14

claudin 14

chr12_+_107078476 0.056 NM_032491
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr16_+_82068958 0.055 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr12_+_101188373 0.054 NM_178826
ANO4
anoctamin 4
chr10_+_695887 0.054 C10orf108
chromosome 10 open reading frame 108
chr2_-_162931051 0.053 NM_001935
DPP4
dipeptidyl-peptidase 4
chrX_-_135863033 0.052 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr13_-_99910548 0.052 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chrX_+_66788682 0.052 NM_001011645
AR
androgen receptor
chr12_-_53171104 0.052 NM_015848
KRT76
keratin 76
chr17_-_56618178 0.052 NM_001198713
SEPT4
septin 4
chr6_-_55740358 0.051 NM_021073
BMP5
bone morphogenetic protein 5
chr20_+_32150139 0.050 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr11_+_1889902 0.050 NM_001013253
LSP1
lymphocyte-specific protein 1
chr16_+_82068910 0.050 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr1_-_169703178 0.049 NM_000450
SELE
selectin E
chr13_+_102104941 0.049 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr7_+_114066554 0.048 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr4_-_54457723 0.048 NM_001126328
LNX1
ligand of numb-protein X 1
chr7_+_80231503 0.048 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr3_+_9944295 0.047 NM_153483
IL17RE
interleukin 17 receptor E
chr1_+_167298382 0.047 POU2F1
POU class 2 homeobox 1
chrX_+_52113157 0.046 NM_001079538
XAGE2B
XAGE2
X antigen family, member 2B
X antigen family, member 2
chr1_-_27953046 0.046 NM_001042729
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr16_-_75498582 0.046 NM_145254
TMEM170A
transmembrane protein 170A
chr19_+_36203829 0.046 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr10_-_116444374 0.046 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr6_-_51952368 0.046 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr1_+_201979689 0.045 NM_001114309
NM_004433
ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr13_-_70682458 0.043 NM_020866
KLHL1
kelch-like 1 (Drosophila)
chr3_+_42201658 0.042 NM_014965
TRAK1
trafficking protein, kinesin binding 1
chr3_+_9944511 0.042 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chrX_-_48828250 0.042 NM_004979
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr2_-_240322692 0.041 HDAC4
histone deacetylase 4
chr1_-_86043932 0.040 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr10_-_74714563 0.040 PLA2G12B
phospholipase A2, group XIIB
chr19_+_6772801 0.040


chr8_+_75736771 0.040 NM_015886
PI15
peptidase inhibitor 15
chr7_+_90338711 0.040 NM_012395
CDK14
cyclin-dependent kinase 14
chr3_+_56591237 0.040 CCDC66
coiled-coil domain containing 66
chr12_-_9760481 0.040 NM_002258
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr20_+_43835637 0.039 NM_003007
SEMG1
semenogelin I
chr14_-_50474237 0.038 NM_001012706
C14orf182
chromosome 14 open reading frame 182
chrX_+_72064875 0.038 NM_033053
NM_001080851
DMRTC1
DMRTC1B
DMRT-like family C1
DMRT-like family C1B
chr2_+_61389628 0.038 NM_001143959
C2orf74
chromosome 2 open reading frame 74
chr3_+_56591182 0.037 NM_001012506
NM_001141947
CCDC66

coiled-coil domain containing 66

chr11_-_129062092 0.037 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr1_-_26644755 0.036 NM_145345
UBXN11
UBX domain protein 11
chr16_-_73092533 0.036 NM_001164766
ZFHX3
zinc finger homeobox 3
chr3_-_114790221 0.035 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr1_+_104292278 0.035 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr10_+_7745229 0.034 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr1_+_196788860 0.034 NM_002113
CFHR1
complement factor H-related 1
chr10_-_45474210 0.034 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr9_-_116840545 0.034 AMBP
alpha-1-microglobulin/bikunin precursor
chr9_-_21482311 0.033 NM_176891
IFNE
interferon, epsilon
chr3_-_79817058 0.033 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr7_-_130371305 0.033 NM_052933
TSGA13
testis specific, 13
chr6_-_119470336 0.033 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr8_+_21916858 0.032 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr5_-_138210992 0.032 CTNNA1
LRRTM2
catenin (cadherin-associated protein), alpha 1, 102kDa
leucine rich repeat transmembrane neuronal 2
chr21_+_43619798 0.032 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr16_-_12010518 0.032 NM_001130007
GSPT1
G1 to S phase transition 1
chr3_-_137851123 0.031 NM_016161
A4GNT
alpha-1,4-N-acetylglucosaminyltransferase
chrX_-_117107700 0.031 NM_033495
NM_001168300
KLHL13

kelch-like 13 (Drosophila)

chr14_+_101295409 0.031 MEG3
maternally expressed 3 (non-protein coding)
chr5_+_36608430 0.031 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr7_+_39017608 0.030 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr10_+_124320180 0.030 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr17_+_37856253 0.030 NM_004448
ERBB2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr8_+_24298442 0.030 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr17_-_47841468 0.030 FAM117A
family with sequence similarity 117, member A
chr3_+_149192367 0.030 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr12_-_113574020 0.029 NM_001193520
NM_004658
RASAL1

RAS protein activator like 1 (GAP1 like)

chr2_-_65090710 0.029


chr8_-_22089850 0.028 NM_001099335
NM_014759
PHYHIP

phytanoyl-CoA 2-hydroxylase interacting protein

chr11_+_61717355 0.028 NM_001139443
NM_004183
BEST1

bestrophin 1

chr12_-_52761254 0.028 NM_002283
KRT85
keratin 85
chr1_+_167298280 0.027 NM_001198783
POU2F1
POU class 2 homeobox 1
chr11_-_101000457 0.027 NM_000926
PGR
progesterone receptor
chr2_-_211018294 0.027 C2orf67
chromosome 2 open reading frame 67
chr14_-_68283293 0.027 NM_015346
ZFYVE26
zinc finger, FYVE domain containing 26
chr1_-_231005334 0.026 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr20_-_34543280 0.026 NM_016558
SCAND1
SCAN domain containing 1
chr5_-_138211054 0.026 NM_015564
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr11_-_85469043 0.026 NM_001162951
NM_001162953
SYTL2

synaptotagmin-like 2

chr9_+_18474078 0.025 NM_001040272
NM_052866
ADAMTSL1

ADAMTS-like 1

chr12_+_109554391 0.025 ACACB
acetyl-CoA carboxylase beta
chr11_-_27681195 0.025 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr2_-_175499275 0.025 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr2_+_88367298 0.025 NM_198274
SMYD1
SET and MYND domain containing 1
chr5_-_36301999 0.025 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chr4_+_86699858 0.025 ARHGAP24
Rho GTPase activating protein 24
chr21_-_31538970 0.024 NM_012131
CLDN17
claudin 17
chr6_-_32977351 0.024 NM_002119
HLA-DOA
major histocompatibility complex, class II, DO alpha

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.67 3.41e-03 GO:0048856 anatomical structure development
1.47 3.77e-03 GO:0032501 multicellular organismal process
1.71 4.36e-03 GO:0048731 system development
2.05 6.66e-03 GO:0007399 nervous system development
1.59 1.32e-02 GO:0007275 multicellular organismal development
1.54 2.06e-02 GO:0032502 developmental process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.77 2.86e-03 GO:0044459 plasma membrane part
1.89 8.68e-03 GO:0005856 cytoskeleton
1.46 1.31e-02 GO:0005886 plasma membrane
1.46 1.32e-02 GO:0071944 cell periphery
3.09 4.32e-02 GO:0015629 actin cytoskeleton

Nothing significant found in function category.