Motif ID: MTF1.p2

Z-value: 1.266


Transcription factors associated with MTF1.p2:

Gene SymbolEntrez IDGene Name
MTF1 4520 metal-regulatory transcription factor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MTF1chr1_-_383252240.163.9e-01Click!


Activity profile for motif MTF1.p2.

activity profile for motif MTF1.p2


Sorted Z-values histogram for motif MTF1.p2

Sorted Z-values for motif MTF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MTF1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_121824268 3.058 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr19_+_708766 2.686 NM_001040134
NM_002579
 PALM

paralemmin

chr8_-_121824015 2.308


chr2_+_121103670 2.187 NM_002193
 INHBB
inhibin, beta B
chr8_-_121824287 2.123 NM_021021
 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr14_-_100625931 2.094 NM_206918
 DEGS2
delta(4)-desaturase, sphingolipid 2
chr20_-_55841090 1.936 BMP7
bone morphogenetic protein 7
chr7_+_4722091 1.866 FOXK1
forkhead box K1
chr19_-_18717467 1.844 CRLF1
cytokine receptor-like factor 1
chr22_+_39853316 1.841 NM_002409
 MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr19_-_18717631 1.816 NM_004750
 CRLF1
cytokine receptor-like factor 1
chr20_-_39317875 1.742 NM_005461
 MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr15_-_93616308 1.640 RGMA
RGM domain family, member A
chr16_-_52580805 1.633 NM_001080430
 TOX3
TOX high mobility group box family member 3
chr22_-_31741761 1.618 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr16_+_67465019 1.595 NM_000196
 HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr8_-_140715234 1.588 NM_016601
 KCNK9
potassium channel, subfamily K, member 9
chr3_+_13590624 1.579 NM_001004019
NM_001998
 FBLN2

fibulin 2

chr3_+_13590644 1.567 FBLN2
fibulin 2
chr3_-_45267804 1.527 NM_015444
 TMEM158
transmembrane protein 158 (gene/pseudogene)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 116 entries
enrichment   p-value GO term description
2.32 3.85e-04 GO:0010563 negative regulation of phosphorus metabolic process
2.32 3.85e-04 GO:0045936 negative regulation of phosphate metabolic process
2.25 3.06e-03 GO:0042326 negative regulation of phosphorylation
1.79 3.44e-02 GO:0030111 regulation of Wnt receptor signaling pathway
1.77 7.71e-03 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
1.72 1.05e-02 GO:0016570 histone modification
1.71 9.58e-03 GO:0016569 covalent chromatin modification
1.70 4.58e-02 GO:0009952 anterior/posterior pattern formation
1.69 9.17e-03 GO:0048732 gland development
1.67 1.43e-02 GO:0032582 negative regulation of gene-specific transcription
1.65 7.34e-04 GO:0045596 negative regulation of cell differentiation
1.64 4.10e-03 GO:0003002 regionalization
1.64 5.05e-03 GO:0007507 heart development
1.60 3.07e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.57 3.76e-05 GO:0008285 negative regulation of cell proliferation
1.57 1.05e-04 GO:0007264 small GTPase mediated signal transduction
1.55 1.40e-05 GO:0006325 chromatin organization
1.55 3.11e-04 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.55 2.22e-02 GO:0061061 muscle structure development
1.54 1.25e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter

Gene overrepresentation in compartment category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
1.48 4.86e-02 GO:0005667 transcription factor complex
1.33 2.91e-03 GO:0044451 nucleoplasm part
1.11 6.76e-11 GO:0043227 membrane-bounded organelle
1.11 1.17e-10 GO:0043231 intracellular membrane-bounded organelle
1.11 1.82e-04 GO:0005634 nucleus
1.09 2.85e-12 GO:0044424 intracellular part
1.09 7.78e-09 GO:0043226 organelle
1.09 1.88e-08 GO:0043229 intracellular organelle
1.08 1.09e-11 GO:0005622 intracellular
1.08 1.64e-04 GO:0005737 cytoplasm
1.03 2.12e-05 GO:0044464 cell part
1.03 2.26e-05 GO:0005623 cell

Gene overrepresentation in function category:

Showing 1 to 20 of 22 entries
enrichment   p-value GO term description
2.90 1.79e-06 GO:0046332 SMAD binding
2.17 2.86e-04 GO:0019199 transmembrane receptor protein kinase activity
1.68 3.74e-02 GO:0022843 voltage-gated cation channel activity
1.61 1.79e-02 GO:0005244 voltage-gated ion channel activity
1.61 1.79e-02 GO:0022832 voltage-gated channel activity
1.52 3.88e-03 GO:0016564 transcription repressor activity
1.43 4.53e-03 GO:0019904 protein domain specific binding
1.43 1.67e-02 GO:0000988 protein binding transcription factor activity
1.43 1.67e-02 GO:0000989 transcription factor binding transcription factor activity
1.42 2.44e-02 GO:0003712 transcription cofactor activity
1.36 2.20e-04 GO:0016301 kinase activity
1.36 3.74e-04 GO:0019899 enzyme binding
1.35 1.18e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.33 2.02e-02 GO:0004672 protein kinase activity
1.31 1.16e-03 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.29 1.41e-03 GO:0030528 transcription regulator activity
1.29 1.52e-03 GO:0001071 nucleic acid binding transcription factor activity
1.29 1.52e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.16 1.53e-02 GO:0003677 DNA binding
1.16 4.56e-02 GO:0000166 nucleotide binding