Motif ID: NANOG.p2

Z-value: 0.738


Transcription factors associated with NANOG.p2:

Gene SymbolEntrez IDGene Name
NANOG 79923 Nanog homeobox

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NANOGchr12_+_79419940.301.1e-01Click!


Activity profile for motif NANOG.p2.

activity profile for motif NANOG.p2


Sorted Z-values histogram for motif NANOG.p2

Sorted Z-values for motif NANOG.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NANOG.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_34206567 2.110 NM_145905
HMGA1
high mobility group AT-hook 1
chr1_-_152386727 1.706 NM_016190
CRNN
cornulin
chr7_+_94297448 1.303 PEG10
paternally expressed 10
chr12_-_52779362 1.239 NM_033045
KRT84
keratin 84
chr3_-_74570262 1.234 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr1_+_209878135 1.233 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr13_+_109281569 1.201 NM_001198950
MYO16
myosin XVI
chr6_+_34204647 1.173 NM_145901
NM_145902
HMGA1

high mobility group AT-hook 1

chr2_+_158114109 1.149 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr4_-_57547845 1.139 NM_001145460
NM_032495
NM_139212
HOPX


HOP homeobox


chr3_+_159557649 1.106 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr6_+_34204928 1.102 HMGA1
high mobility group AT-hook 1
chr10_+_118187381 1.072 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr2_+_210444154 1.040 MAP2
microtubule-associated protein 2
chr3_+_159557745 1.031 SCHIP1
schwannomin interacting protein 1
chrX_+_37892786 1.018 NM_001163334
SYTL5
synaptotagmin-like 5
chr2_+_210444364 0.970 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr6_+_34204690 0.936 HMGA1
high mobility group AT-hook 1
chr9_-_124984018 0.898 NM_001242335
LHX6
LIM homeobox 6
chr6_-_131291480 0.861 NM_001199389
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr12_-_89745997 0.859 DUSP6
dual specificity phosphatase 6
chr9_+_6215785 0.851 NM_001199640
NM_001199641
NM_033439
IL33


interleukin 33


chr4_+_169013687 0.839 NM_007193
ANXA10
annexin A10
chr11_-_115088628 0.781 CADM1
cell adhesion molecule 1
chr12_-_89746244 0.768 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr17_-_9694613 0.764 NM_001105571
NM_001220493
DHRS7C

dehydrogenase/reductase (SDR family) member 7C

chr6_+_34205029 0.753 HMGA1
high mobility group AT-hook 1
chr2_-_113594325 0.753 NM_000576
IL1B
interleukin 1, beta
chr10_-_105845619 0.752 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr10_-_105845556 0.744 COL17A1
collagen, type XVII, alpha 1
chr3_-_71778268 0.737 NM_001134650
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr9_-_124989755 0.728 NM_001242334
LHX6
LIM homeobox 6
chr12_-_89746238 0.723 DUSP6
dual specificity phosphatase 6
chr7_-_14025826 0.711 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr22_+_38071612 0.704 NM_002305
LGALS1
lectin, galactoside-binding, soluble, 1
chr12_-_16760935 0.688 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr7_-_41742666 0.684 NM_002192
INHBA
inhibin, beta A
chr3_+_121796695 0.660 NM_006889
NM_176892
CD86

CD86 molecule

chr7_+_18535351 0.626 NM_001204145
NM_001204146
NM_014707
NM_178423
HDAC9



histone deacetylase 9



chr10_-_14372807 0.617 NM_018027
FRMD4A
FERM domain containing 4A
chr10_+_102123420 0.595


chr5_-_148758787 0.588 NM_014443
IL17B
interleukin 17B
chr10_-_56560947 0.587 NM_001142763
NM_001142764
NM_001142765
NM_001142766
NM_001142767
NM_001142768
NM_001142769
NM_001142770
NM_001142771
NM_001142772
NM_001142773
NM_033056
PCDH15











protocadherin-related 15











chr5_-_112630301 0.570 MCC
mutated in colorectal cancers
chr3_+_111717585 0.558 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr8_-_7287651 0.553 NM_018661
DEFB103B
defensin, beta 103B
chr8_+_32504250 0.550 NM_013959
NRG1
neuregulin 1
chr14_+_23305816 0.531 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr12_+_47610244 0.530 FAM113B
family with sequence similarity 113, member B
chr10_+_11206928 0.516 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr8_+_32579350 0.499 NM_001159996
NRG1
neuregulin 1
chr14_-_57272344 0.499 NM_172337
OTX2
orthodenticle homeobox 2
chr12_-_16759939 0.493 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chr5_-_112630557 0.488 NM_002387
MCC
mutated in colorectal cancers
chr14_-_81864726 0.488 NM_033104
STON2
stonin 2
chr16_+_8814567 0.486 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr12_+_105153258 0.483 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr12_-_57328044 0.482 NM_148897
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chr7_+_129906702 0.473 NM_001869
CPA2
carboxypeptidase A2 (pancreatic)
chr10_+_17270257 0.470 NM_003380
VIM
vimentin
chr1_+_84647342 0.470 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr7_+_150690838 0.466 NM_001160109
NM_001160110
NM_001160111
NOS3


nitric oxide synthase 3 (endothelial cell)


chr1_-_42384370 0.464 NM_001127714
NM_024503
HIVEP3

human immunodeficiency virus type I enhancer binding protein 3

chr18_-_51880942 0.454 NM_139171
STARD6
StAR-related lipid transfer (START) domain containing 6
chr6_+_34204663 0.454 HMGA1
high mobility group AT-hook 1
chr2_-_165424993 0.454 GRB14
growth factor receptor-bound protein 14
chr10_-_29923900 0.449 NM_021738
SVIL
supervillin
chr8_-_7274353 0.448 NM_001205266
DEFB4B
defensin, beta 4B
chr12_-_16759733 0.434 NM_001243610
LMO3
LIM domain only 3 (rhombotin-like 2)
chr14_+_51955854 0.431 NM_001042481
FRMD6
FERM domain containing 6
chr1_-_205391180 0.430 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr20_+_2276612 0.428 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr17_-_39150384 0.426 NM_033185
KRTAP3-3
keratin associated protein 3-3
chr3_-_123339423 0.420 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr6_+_43968303 0.420 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chr7_-_121944485 0.414 NM_001024613
NM_001160264
FEZF1

FEZ family zinc finger 1

chr6_-_31107110 0.412 NM_014069
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr6_+_34204576 0.405 NM_002131
NM_145899
NM_145903
HMGA1


high mobility group AT-hook 1


chr17_-_39324423 0.403 NM_033187
KRTAP4-3
keratin associated protein 4-3
chr18_+_29027731 0.402 NM_001944
DSG3
desmoglein 3
chr10_+_11207053 0.401 CELF2
CUGBP, Elav-like family member 2
chr3_+_156394452 0.399 NM_001184718
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr14_+_23305792 0.385 NM_004995
MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr1_-_200377488 0.382 ZNF281
zinc finger protein 281
chr13_-_60325073 0.381


chrX_-_21676416 0.378 NM_153270
KLHL34
kelch-like 34 (Drosophila)
chr11_-_83393436 0.377 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr4_-_159956332 0.371 NM_152543
C4orf45
chromosome 4 open reading frame 45
chr7_-_14029641 0.368 NM_001163147
NM_004956
ETV1

ets variant 1

chr17_-_41739261 0.367 NM_001040002
MEOX1
mesenchyme homeobox 1
chr19_-_33360641 0.365 NM_001126335
NM_001243036
NM_014270
SLC7A9


solute carrier family 7 (glycoprotein-associated amino acid transporter light chain, bo,+ system), member 9


chrX_-_153602928 0.360 FLNA
filamin A, alpha
chr17_-_39211462 0.359 NM_033032
KRTAP2-2
keratin associated protein 2-2
chr21_-_39956823 0.356 NM_001243429
ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chrX_+_41306686 0.346 NM_022567
NYX
nyctalopin
chr19_-_51456159 0.338 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr2_-_163008913 0.335 NM_002054
GCG
glucagon
chr12_+_47610051 0.335 NM_138371
FAM113B
family with sequence similarity 113, member B
chr9_+_118916069 0.335 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr3_-_123339178 0.330 MYLK
myosin light chain kinase
chr12_-_14849427 0.330 NM_004963
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr19_+_45409003 0.330 NM_000041
APOE
apolipoprotein E
chr15_+_58430394 0.327 NM_020980
AQP9
aquaporin 9
chr11_-_58980321 0.322 NM_001039396
MPEG1
macrophage expressed 1
chr22_+_40322609 0.321 GRAP2
GRB2-related adaptor protein 2
chr6_+_131571298 0.317 NM_004842
NM_138633
AKAP7

A kinase (PRKA) anchor protein 7

chr12_-_11062160 0.300 NM_023920
TAS2R13
taste receptor, type 2, member 13
chr4_+_71587674 0.296 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr19_-_14785626 0.291 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr8_+_26150731 0.288 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr16_+_87984948 0.283 NM_001173539
NM_001173540
NM_001173541
NM_017869
NM_079837
BANP




BTG3 associated nuclear protein




chr17_-_41276112 0.281 NM_007298
BRCA1
breast cancer 1, early onset
chr2_-_180427314 0.281 NM_001113398
ZNF385B
zinc finger protein 385B
chr12_-_10021932 0.280 CLEC2B
C-type lectin domain family 2, member B
chr5_+_92918924 0.279 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr12_-_14132920 0.278 NM_000834
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr10_-_90712510 0.276 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr5_+_31193761 0.275 NM_004932
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr11_+_64018991 0.275 NM_000932
NM_001184883
PLCB3

phospholipase C, beta 3 (phosphatidylinositol-specific)

chr1_+_16090993 0.273 NM_001024215
FBLIM1
filamin binding LIM protein 1
chr12_-_24103842 0.273 SOX5
SRY (sex determining region Y)-box 5
chr19_-_51522953 0.268 NM_145888
KLK10
kallikrein-related peptidase 10
chr12_+_15475190 0.267 NM_002848
NM_030667
PTPRO

protein tyrosine phosphatase, receptor type, O

chr4_-_26491888 0.266 NM_000730
CCKAR
cholecystokinin A receptor
chr8_+_54764367 0.265 NM_170587
RGS20
regulator of G-protein signaling 20
chr7_+_28725597 0.264 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr1_+_50574601 0.256 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr12_-_10022457 0.256 NM_005127
CLEC2B
C-type lectin domain family 2, member B
chr7_+_94285620 0.256 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr19_+_48325098 0.254 NM_000554
CRX
cone-rod homeobox
chr7_+_154002194 0.249 NM_001936
DPP6
dipeptidyl-peptidase 6
chr3_+_152880036 0.249 RAP2B
RAP2B, member of RAS oncogene family
chr12_+_81110689 0.247 NM_005593
MYF5
myogenic factor 5
chr12_-_91505215 0.242 LUM
lumican
chr14_+_78870092 0.242 NM_004796
NRXN3
neurexin 3
chr9_-_107690526 0.241 NM_005502
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr3_+_152880024 0.241 NM_002886
RAP2B
RAP2B, member of RAS oncogene family
chr10_+_82173574 0.240 NM_001243778
NM_001243782
C10orf58

chromosome 10 open reading frame 58

chr17_+_4854383 0.239 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr1_+_198608216 0.234 PTPRC
protein tyrosine phosphatase, receptor type, C
chr19_+_7030593 0.234 NM_001136507
MBD3L5
methyl-CpG binding domain protein 3-like 5
chrX_-_130423199 0.234 IGSF1
immunoglobulin superfamily, member 1
chr19_-_39235113 0.233 NM_144691
CAPN12
calpain 12
chr2_-_65593763 0.231 SPRED2
sprouty-related, EVH1 domain containing 2
chr4_-_139163222 0.231 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr15_-_70390229 0.230 NM_001105192
NM_005078
NM_020908
TLE3


transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)


chr20_+_43030005 0.228 HNF4A
hepatocyte nuclear factor 4, alpha
chr20_+_42295747 0.227 MYBL2
v-myb myeloblastosis viral oncogene homolog (avian)-like 2
chr20_+_44441334 0.227 UBE2C
ubiquitin-conjugating enzyme E2C
chr7_+_129984629 0.226 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr5_+_126984712 0.224 NM_001048252
CTXN3
cortexin 3
chr10_-_52645384 0.224 A1CF
APOBEC1 complementation factor
chr3_+_102153858 0.223 NM_175056
ZPLD1
zona pellucida-like domain containing 1
chr12_-_16757944 0.220 LMO3
LIM domain only 3 (rhombotin-like 2)
chr4_+_88529680 0.219 NM_014208
DSPP
dentin sialophosphoprotein
chr1_+_84609941 0.219 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr2_-_55199894 0.217


chr17_+_7905911 0.217 NM_000180
GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chr2_-_69098502 0.217 NM_014482
BMP10
bone morphogenetic protein 10
chr1_+_179560747 0.216 NM_001199091
NM_001199085
NM_173533
TDRD5


tudor domain containing 5


chr11_-_30601919 0.214 NM_001584
MPPED2
metallophosphoesterase domain containing 2
chr1_-_110155672 0.213 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr4_-_40936640 0.212 APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr1_+_20617411 0.211 NM_001039500
VWA5B1
von Willebrand factor A domain containing 5B1
chr14_+_76837689 0.211 NM_004452
ESRRB
estrogen-related receptor beta
chrX_+_28605558 0.208 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr4_-_69111333 0.206 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr20_+_3776385 0.205 NM_004358
NM_021872
NM_021873
CDC25B


cell division cycle 25 homolog B (S. pombe)


chr5_+_126988706 0.204 NM_001127385
CTXN3
cortexin 3
chr11_+_131240370 0.203 NM_001048209
NTM
neurotrimin
chr13_+_109248499 0.202 NM_015011
MYO16
myosin XVI
chr11_-_69634191 0.201 NM_005247
FGF3
fibroblast growth factor 3
chr6_+_158438079 0.201 NM_001178088
SYNJ2
synaptojanin 2
chr4_-_80329354 0.201 NM_033214
GK2
glycerol kinase 2
chr1_-_178840079 0.200 NM_004673
ANGPTL1
angiopoietin-like 1
chr7_+_28475233 0.199 NM_004904
CREB5
cAMP responsive element binding protein 5
chr6_-_111927059 0.199 TRAF3IP2
TRAF3 interacting protein 2
chr12_-_4554779 0.199 NM_020996
FGF6
fibroblast growth factor 6
chr16_+_24740945 0.199 NM_014494
TNRC6A
trinucleotide repeat containing 6A
chr12_-_102874340 0.197 IGF1
insulin-like growth factor 1 (somatomedin C)
chr20_+_44441247 0.194 NM_007019
NM_181799
NM_181800
NM_181802
NM_181803
UBE2C




ubiquitin-conjugating enzyme E2C




chr7_-_37025696 0.194 ELMO1
engulfment and cell motility 1
chr4_-_41750936 0.194 NM_003924
PHOX2B
paired-like homeobox 2b
chr8_+_55528626 0.194 NM_006269
RP1
retinitis pigmentosa 1 (autosomal dominant)
chr8_+_32785485 0.193


chr1_+_35246789 0.193 NM_024009
GJB3
gap junction protein, beta 3, 31kDa
chr9_+_12693385 0.190 NM_000550
TYRP1
tyrosinase-related protein 1
chr19_+_45971249 0.189 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr12_-_16759531 0.188 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr2_+_33172368 0.187 NM_206943
LTBP1
latent transforming growth factor beta binding protein 1
chrX_+_22050920 0.185 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr1_-_116383692 0.185 NM_005599
NHLH2
nescient helix loop helix 2
chr3_-_123411185 0.184 MYLK
myosin light chain kinase
chr3_-_128294928 0.183 NM_007354
C3orf27
chromosome 3 open reading frame 27
chr17_-_10452939 0.183 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr15_+_49715374 0.182 NM_002009
FGF7
fibroblast growth factor 7
chr18_-_28742744 0.182 NM_004948
NM_024421
DSC1

desmocollin 1

chr12_-_52828105 0.182 NM_004693
KRT75
keratin 75
chr9_+_116263706 0.178 NM_130795
RGS3
regulator of G-protein signaling 3
chr2_+_102508377 0.178 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.50 8.69e-12 GO:0032501 multicellular organismal process
1.59 1.24e-09 GO:0032502 developmental process
1.60 1.17e-08 GO:0007275 multicellular organismal development
1.59 1.73e-07 GO:0048856 anatomical structure development
1.62 5.98e-07 GO:0048731 system development
1.51 6.42e-07 GO:0023052 signaling
1.50 1.33e-05 GO:0007165 signal transduction
1.72 1.77e-05 GO:0048513 organ development
1.26 2.81e-05 GO:0065007 biological regulation
2.08 3.89e-05 GO:0050793 regulation of developmental process
1.42 4.40e-05 GO:0051716 cellular response to stimulus
1.26 1.52e-04 GO:0050789 regulation of biological process
2.22 1.56e-04 GO:0045595 regulation of cell differentiation
1.58 1.84e-04 GO:0048519 negative regulation of biological process
1.26 2.71e-04 GO:0050794 regulation of cellular process
1.58 7.88e-04 GO:0048523 negative regulation of cellular process
2.06 9.11e-04 GO:0007267 cell-cell signaling
1.88 1.60e-03 GO:0007154 cell communication
1.64 1.70e-03 GO:0003008 system process
1.62 1.95e-03 GO:0007166 cell surface receptor linked signaling pathway
1.27 1.95e-03 GO:0050896 response to stimulus
1.69 2.21e-03 GO:0007399 nervous system development
1.92 3.86e-03 GO:0009888 tissue development
1.97 7.38e-03 GO:2000026 regulation of multicellular organismal development
2.14 2.21e-02 GO:0007417 central nervous system development
1.66 2.55e-02 GO:0051239 regulation of multicellular organismal process
1.49 4.56e-02 GO:0030154 cell differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.62 2.07e-05 GO:0005576 extracellular region
1.85 2.42e-04 GO:0044421 extracellular region part
2.14 3.00e-02 GO:0031012 extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.99 1.79e-03 GO:0043565 sequence-specific DNA binding
1.71 1.22e-02 GO:0005102 receptor binding
1.70 2.02e-02 GO:0001071 nucleic acid binding transcription factor activity
1.70 2.02e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
2.85 4.09e-02 GO:0008083 growth factor activity