Motif ID: NFE2.p2

Z-value: 1.227


Transcription factors associated with NFE2.p2:

Gene SymbolEntrez IDGene Name
NFE2 4778 nuclear factor (erythroid-derived 2), 45kDa

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFE2chr12_-_54694717,
chr12_-_54689536,
chr12_-_54694647
0.202.8e-01Click!


Activity profile for motif NFE2.p2.

activity profile for motif NFE2.p2


Sorted Z-values histogram for motif NFE2.p2

Sorted Z-values for motif NFE2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_150480584 7.037 ECM1
extracellular matrix protein 1
chr1_+_150480486 6.974 NM_001202858
NM_004425
NM_022664
ECM1


extracellular matrix protein 1


chr18_+_21452981 6.685 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr17_-_39768939 5.442 NM_005557
KRT16
keratin 16
chr1_+_152881022 4.915 NM_005547
IVL
involucrin
chr2_-_216259197 4.900 FN1
fibronectin 1
chr21_+_41029253 4.356 NM_006057
NM_033170
NM_033171
NM_033172
NM_033173
B3GALT5




UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5




chr8_+_7752198 3.838 NM_004942
DEFB4A
defensin, beta 4A
chr1_+_183155173 3.794 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr2_+_113875469 3.670 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr11_-_65667858 3.598 FOSL1
FOS-like antigen 1
chr1_-_153029987 3.491 NM_005988
SPRR2A
small proline-rich protein 2A
chr1_-_153348057 3.485 NM_005621
S100A12
S100 calcium binding protein A12
chr1_+_32043745 3.471 NM_001204415
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr8_-_7274353 3.410 NM_001205266
DEFB4B
defensin, beta 4B
chr6_+_74405764 3.335 CD109
CD109 molecule
chr1_+_183155393 3.052 LAMC2
laminin, gamma 2
chr14_-_24732344 3.042 NM_000359
TGM1
transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)
chr6_+_74405505 2.899 NM_001159587
NM_001159588
NM_133493
CD109


CD109 molecule


chr1_+_17531619 2.880 NM_013358
PADI1
peptidyl arginine deiminase, type I
chr1_+_183155361 2.872 LAMC2
laminin, gamma 2
chrX_+_99899162 2.849 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr17_-_76921205 2.817 TIMP2
TIMP metallopeptidase inhibitor 2
chr6_+_74405933 2.770 CD109
CD109 molecule
chr11_-_65667860 2.742 NM_005438
FOSL1
FOS-like antigen 1
chrX_+_99899388 2.737 SRPX2
sushi-repeat containing protein, X-linked 2
chr6_+_74405909 2.725 CD109
CD109 molecule
chr11_-_65667809 2.612 FOSL1
FOS-like antigen 1
chr4_-_159093523 2.605 FAM198B
family with sequence similarity 198, member B
chr17_-_76921453 2.398 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr6_-_35696359 2.388 NM_001145775
FKBP5
FK506 binding protein 5
chr5_+_148520985 2.335 NM_014945
ABLIM3
actin binding LIM protein family, member 3
chr4_-_159092509 2.305 FAM198B
family with sequence similarity 198, member B
chr18_+_61442611 2.277 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr18_+_61254533 2.252 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr13_+_78109808 2.220 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr7_-_1199822 2.169 NM_182491
ZFAND2A
zinc finger, AN1-type domain 2A
chr19_-_36019194 2.152 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr21_+_30517897 2.067 C21orf7
chromosome 21 open reading frame 7
chr10_-_90611675 2.033 NM_144590
ANKRD22
ankyrin repeat domain 22
chr7_-_1199813 1.932 ZFAND2A
zinc finger, AN1-type domain 2A
chr7_-_1199785 1.918 ZFAND2A
zinc finger, AN1-type domain 2A
chr1_-_154943001 1.898 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr6_+_74405856 1.885 CD109
CD109 molecule
chr11_+_62649160 1.849 SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr3_-_48632592 1.764 NM_000094
COL7A1
collagen, type VII, alpha 1
chr1_-_153013593 1.750 NM_006945
SPRR2D
small proline-rich protein 2D
chr6_+_34206567 1.716 NM_145905
HMGA1
high mobility group AT-hook 1
chr1_+_152956563 1.693 NM_001199828
NM_005987
SPRR1A

small proline-rich protein 1A

chr16_-_72206348 1.689 NM_001160213
PMFBP1
polyamine modulated factor 1 binding protein 1
chr4_-_39033981 1.666 NM_024943
TMEM156
transmembrane protein 156
chr1_+_154377847 1.639 IL6R
interleukin 6 receptor
chr1_+_24649529 1.624 NM_021180
GRHL3
grainyhead-like 3 (Drosophila)
chr4_-_76944585 1.611 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr4_-_159093717 1.602 NM_016613
FAM198B
family with sequence similarity 198, member B
chr2_-_85641128 1.591 CAPG
capping protein (actin filament), gelsolin-like
chr2_-_85641153 1.564 CAPG
capping protein (actin filament), gelsolin-like
chr15_-_74494851 1.557 STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr15_-_40630272 1.554 C15orf52
chromosome 15 open reading frame 52
chr15_-_74494780 1.531 STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr5_-_149535309 1.499 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr20_-_633844 1.495 NM_080725
SRXN1
sulfiredoxin 1
chr19_-_39264144 1.480 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr6_+_106546736 1.443 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr19_+_39279849 1.430 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr19_-_39235113 1.428 NM_144691
CAPN12
calpain 12
chr20_+_44637539 1.420 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr1_+_154377668 1.391 NM_000565
NM_001206866
NM_181359
IL6R


interleukin 6 receptor


chr12_-_54813002 1.376 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr16_+_58534045 1.355 NM_001242833
NM_001242834
NM_001242835
NM_001242836
NDRG4



NDRG family member 4



chr12_-_91573264 1.354 NM_133503
DCN
decorin
chr1_+_154378044 1.342 IL6R
interleukin 6 receptor
chr1_-_17308072 1.340 NM_001135247
NM_017459
MFAP2

microfibrillar-associated protein 2

chr17_+_60704747 1.336 NM_006039
MRC2
mannose receptor, C type 2
chr7_+_100770378 1.334 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr20_-_1309809 1.324 NM_080489
SDCBP2
syndecan binding protein (syntenin) 2
chr20_+_33759773 1.321 NM_006404
PROCR
protein C receptor, endothelial
chr1_-_153521717 1.271 NM_002960
S100A3
S100 calcium binding protein A3
chr19_-_51568323 1.269 NM_015596
KLK13
kallikrein-related peptidase 13
chr16_-_72206023 1.265 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chrX_+_135278912 1.239 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr5_+_179247841 1.225 NM_003900
SQSTM1
sequestosome 1
chr11_-_6341708 1.221 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr19_-_36004553 1.219 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine






chr3_-_98241357 1.196 CLDND1
claudin domain containing 1
chr8_-_125580745 1.196 MTSS1
metastasis suppressor 1
chr4_+_41258941 1.196 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr4_+_74606222 1.185 NM_000584
IL8
interleukin 8
chr10_+_118187381 1.165 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr4_-_139163222 1.144 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr19_-_41859253 1.143 TGFB1
transforming growth factor, beta 1
chr14_-_65409445 1.134 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr17_-_38657814 1.091 NM_032865
TNS4
tensin 4
chr2_+_87755059 1.086 LINC00152
long intergenic non-protein coding RNA 152
chr8_-_145025043 1.068 NM_201380
PLEC
plectin
chr15_+_44829373 1.049 EIF3J
eukaryotic translation initiation factor 3, subunit J
chr4_+_156587861 1.038 NM_000856
NM_001130682
NM_001130686
NM_001130687
NM_001130683
NM_001130685
GUCY1A3





guanylate cyclase 1, soluble, alpha 3





chr3_-_98241683 1.028 CLDND1
claudin domain containing 1
chr17_+_60705042 1.027 MRC2
mannose receptor, C type 2
chr9_-_123688352 1.021 TRAF1
TNF receptor-associated factor 1
chr17_-_7493389 1.020 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr6_-_35888889 1.017 SRPK1
SRSF protein kinase 1
chr11_-_58343308 1.017 NM_004811
LPXN
leupaxin
chr19_+_49055421 1.003 NM_177973
SULT2B1
sulfotransferase family, cytosolic, 2B, member 1
chr8_+_87111132 0.999 NM_152565
ATP6V0D2
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
chr16_+_31494438 0.997 NM_003041
SLC5A2
solute carrier family 5 (sodium/glucose cotransporter), member 2
chrX_-_15683153 0.991 NM_020665
TMEM27
transmembrane protein 27
chr20_+_6748744 0.991 NM_001200
BMP2
bone morphogenetic protein 2
chr2_+_87754991 0.987 LINC00152
long intergenic non-protein coding RNA 152
chr7_+_139528951 0.984 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr9_+_131191206 0.974 CERCAM
cerebral endothelial cell adhesion molecule
chr12_+_21679190 0.967 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr15_+_59904090 0.965 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr11_+_35160385 0.964 NM_000610
NM_001001389
NM_001001390
NM_001001391
NM_001001392
NM_001202555
NM_001202556
NM_001202557
CD44







CD44 molecule (Indian blood group)







chr16_+_83986826 0.961 NM_182981
OSGIN1
oxidative stress induced growth inhibitor 1
chr9_-_99064385 0.958 NM_000197
HSD17B3
hydroxysteroid (17-beta) dehydrogenase 3
chr15_+_59903980 0.957 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr5_-_149535138 0.943 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chrX_-_15511710 0.940 NM_001018109
NM_003662
PIR

pirin (iron-binding nuclear protein)

chr7_+_143058794 0.940 ZYX
zyxin
chrX_-_106960268 0.918 NM_004089
TSC22D3
TSC22 domain family, member 3
chr17_+_60705051 0.913 MRC2
mannose receptor, C type 2
chr12_+_56522043 0.905 ESYT1
extended synaptotagmin-like protein 1
chr1_+_35246789 0.901 NM_024009
GJB3
gap junction protein, beta 3, 31kDa
chr12_+_56521953 0.899 NM_001184796
NM_015292
ESYT1

extended synaptotagmin-like protein 1

chr8_-_145016691 0.898 NM_201383
PLEC
plectin
chr9_+_4985082 0.886 JAK2
Janus kinase 2
chr2_-_172016904 0.882 TLK1
tousled-like kinase 1
chr2_+_28615771 0.881 NM_005253
FOSL2
FOS-like antigen 2
chr17_+_9745847 0.876 GLP2R
glucagon-like peptide 2 receptor
chr3_-_98241748 0.870 CLDND1
claudin domain containing 1
chrX_-_153285262 0.865 IRAK1
interleukin-1 receptor-associated kinase 1
chr6_-_35888816 0.858 SRPK1
SRSF protein kinase 1
chr19_-_44285012 0.852 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr5_-_175843531 0.849 NM_001834
NM_007097
CLTB

clathrin, light chain B

chr12_+_56522202 0.846 ESYT1
extended synaptotagmin-like protein 1
chr4_+_110834039 0.841 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr12_+_56522049 0.837 ESYT1
extended synaptotagmin-like protein 1
chr6_+_32121228 0.829 NM_138717
PPT2
palmitoyl-protein thioesterase 2
chr2_+_28615695 0.829 FOSL2
FOS-like antigen 2
chr6_-_35888937 0.827 NM_003137
SRPK1
SRSF protein kinase 1
chr3_-_98241722 0.826 CLDND1
claudin domain containing 1
chr11_+_35160666 0.824 CD44
CD44 molecule (Indian blood group)
chr11_-_62314199 0.820 AHNAK
AHNAK nucleoprotein
chr5_-_149535420 0.820 NM_002609
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr12_-_54812936 0.817 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr2_+_33359607 0.815 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr9_-_35111534 0.803 FAM214B
family with sequence similarity 214, member B
chr14_+_79745653 0.797 NM_001105250
NM_138970
NRXN3

neurexin 3

chr7_+_143078444 0.796 ZYX
zyxin
chr9_+_140119643 0.793 NM_199001
C9orf169
chromosome 9 open reading frame 169
chr7_+_143078447 0.786 ZYX
zyxin
chr2_-_190044330 0.785 NM_000393
COL5A2
collagen, type V, alpha 2
chr8_+_32504250 0.784 NM_013959
NRG1
neuregulin 1
chr8_-_143823823 0.783 NM_020427
SLURP1
secreted LY6/PLAUR domain containing 1
chr20_-_633808 0.778 SRXN1
sulfiredoxin 1
chr9_-_130341265 0.776 NM_001035534
FAM129B
family with sequence similarity 129, member B
chr6_+_64231626 0.765 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr1_+_40627066 0.758 RLF
rearranged L-myc fusion
chr19_+_56347943 0.757 NM_134444
NLRP4
NLR family, pyrin domain containing 4
chr3_+_160394946 0.756 NM_025047
ARL14
ADP-ribosylation factor-like 14
chr12_-_49259549 0.755 NM_014470
RND1
Rho family GTPase 1
chr1_+_84647342 0.750 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr14_-_25078818 0.748 NM_033423
GZMH
granzyme H (cathepsin G-like 2, protein h-CCPX)
chr10_+_17270257 0.745 NM_003380
VIM
vimentin
chr7_+_143078457 0.737 ZYX
zyxin
chr10_-_76868853 0.735 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr20_-_34195409 0.733 FER1L4
fer-1-like 4 (C. elegans) pseudogene
chr22_-_37584254 0.725 NM_031910
NM_182486
C1QTNF6

C1q and tumor necrosis factor related protein 6

chr9_+_116356407 0.720 RGS3
regulator of G-protein signaling 3
chr19_-_44285407 0.719 NM_002250
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr7_-_86688944 0.714 NM_001142749
KIAA1324L
KIAA1324-like
chr5_-_175843360 0.700 CLTB
clathrin, light chain B
chr19_-_51537996 0.697 NM_019598
NM_145894
NM_145895
KLK12


kallikrein-related peptidase 12


chr2_-_65593866 0.693 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr17_+_74381186 0.691 NM_001142602
SPHK1
sphingosine kinase 1
chr19_-_41858948 0.691 TGFB1
transforming growth factor, beta 1
chr11_+_128563993 0.685 FLI1
Friend leukemia virus integration 1
chr1_+_36621751 0.680 NM_018067
MAP7D1
MAP7 domain containing 1
chr9_+_4985243 0.671 NM_004972
JAK2
Janus kinase 2
chr7_-_93519990 0.670 NM_006528
TFPI2
tissue factor pathway inhibitor 2
chr7_+_134212343 0.669 NM_020299
AKR1B10
aldo-keto reductase family 1, member B10 (aldose reductase)
chr2_-_69870705 0.668 AAK1
AP2 associated kinase 1
chr12_-_48152860 0.651 NM_001098531
RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chr3_-_87040246 0.648 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr7_+_143078358 0.641 NM_001010972
NM_003461
ZYX

zyxin

chr7_+_143078399 0.636 ZYX
zyxin
chr21_-_35986744 0.634 NM_203417
RCAN1
regulator of calcineurin 1
chr3_+_49208979 0.634 NM_173546
KLHDC8B
kelch domain containing 8B
chr1_-_24469571 0.634 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr12_-_53242716 0.632 NM_173352
KRT78
keratin 78
chr2_+_74057969 0.632 STAMBP
STAM binding protein
chr2_-_190927321 0.631 NM_005259
MSTN
myostatin
chr5_-_158636489 0.630 NM_001199383
RNF145
ring finger protein 145
chr4_+_77953942 0.628 SEPT11
septin 11
chr8_+_11946846 0.626 NM_001039615
ZNF705D
zinc finger protein 705D
chr4_-_80329354 0.625 NM_033214
GK2
glycerol kinase 2
chr19_+_6531009 0.623 NM_003811
TNFSF9
tumor necrosis factor (ligand) superfamily, member 9
chr16_+_56642477 0.621 NM_005953
MT2A
metallothionein 2A
chr12_-_10324675 0.620 NM_001172632
NM_001172633
NM_002543
OLR1


oxidized low density lipoprotein (lectin-like) receptor 1



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.31 6.21e-08 GO:0050896 response to stimulus
1.42 7.97e-08 GO:0051716 cellular response to stimulus
1.45 1.32e-06 GO:0007165 signal transduction
1.41 2.42e-06 GO:0023052 signaling
1.96 4.81e-06 GO:0009611 response to wounding
2.21 1.11e-05 GO:0050878 regulation of body fluid levels
1.82 2.02e-05 GO:0051246 regulation of protein metabolic process
1.53 2.60e-05 GO:0042221 response to chemical stimulus
1.54 3.15e-05 GO:0065008 regulation of biological quality
1.50 4.17e-05 GO:0006950 response to stress
2.14 4.36e-05 GO:0042060 wound healing
3.37 5.96e-05 GO:0040017 positive regulation of locomotion
2.24 6.08e-05 GO:0007599 hemostasis
3.36 1.17e-04 GO:0030335 positive regulation of cell migration
3.36 1.17e-04 GO:2000147 positive regulation of cell motility
3.26 1.22e-04 GO:0051272 positive regulation of cellular component movement
2.21 1.23e-04 GO:0007596 blood coagulation
2.21 1.23e-04 GO:0050817 coagulation
1.77 3.01e-04 GO:0032268 regulation of cellular protein metabolic process
1.42 7.05e-04 GO:0048518 positive regulation of biological process
1.81 1.11e-03 GO:0009888 tissue development
1.44 1.20e-03 GO:0048522 positive regulation of cellular process
1.64 1.29e-03 GO:0010033 response to organic substance
1.75 2.04e-03 GO:0070887 cellular response to chemical stimulus
1.63 2.70e-03 GO:0002376 immune system process
1.80 3.98e-03 GO:0031399 regulation of protein modification process
1.64 4.05e-03 GO:0050790 regulation of catalytic activity
3.55 5.81e-03 GO:0048754 branching morphogenesis of a tube
1.51 7.46e-03 GO:0023051 regulation of signaling
1.31 8.01e-03 GO:0032502 developmental process
1.57 8.17e-03 GO:0035556 intracellular signal transduction
1.71 9.75e-03 GO:0051704 multi-organism process
1.11 9.77e-03 GO:0009987 cellular process
4.10 1.32e-02 GO:0071158 positive regulation of cell cycle arrest
2.40 1.40e-02 GO:0030334 regulation of cell migration
1.46 1.40e-02 GO:0048583 regulation of response to stimulus
1.53 1.58e-02 GO:0065009 regulation of molecular function
1.17 1.71e-02 GO:0065007 biological regulation
1.53 1.74e-02 GO:0009966 regulation of signal transduction
2.37 1.80e-02 GO:2000145 regulation of cell motility
2.30 1.80e-02 GO:0051270 regulation of cellular component movement
1.33 1.89e-02 GO:0048856 anatomical structure development
10.21 2.00e-02 GO:0060600 dichotomous subdivision of an epithelial terminal unit
6.02 2.24e-02 GO:0007044 cell-substrate junction assembly
1.59 2.71e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.94 2.87e-02 GO:0001775 cell activation
1.77 2.94e-02 GO:0043085 positive regulation of catalytic activity
1.64 3.22e-02 GO:0032879 regulation of localization
4.32 3.44e-02 GO:0048520 positive regulation of behavior
1.91 3.51e-02 GO:0008284 positive regulation of cell proliferation
1.73 3.63e-02 GO:0006955 immune response
3.99 3.84e-02 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
3.99 3.84e-02 GO:0072395 signal transduction involved in cell cycle checkpoint
3.99 3.84e-02 GO:0072401 signal transduction involved in DNA integrity checkpoint
3.99 3.84e-02 GO:0072404 signal transduction involved in G1/S transition checkpoint
3.99 3.84e-02 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
3.99 3.84e-02 GO:0072422 signal transduction involved in DNA damage checkpoint
3.99 3.84e-02 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
3.99 3.84e-02 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
1.70 3.92e-02 GO:0044093 positive regulation of molecular function
2.06 3.93e-02 GO:0032270 positive regulation of cellular protein metabolic process
1.41 3.99e-02 GO:0030154 cell differentiation
1.87 4.10e-02 GO:0006928 cellular component movement
4.24 4.23e-02 GO:0006521 regulation of cellular amino acid metabolic process
2.24 4.29e-02 GO:0040012 regulation of locomotion
4.58 4.35e-02 GO:0050921 positive regulation of chemotaxis
1.56 4.65e-02 GO:0031325 positive regulation of cellular metabolic process
2.22 4.99e-02 GO:0030029 actin filament-based process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.46 2.56e-04 GO:0000502 proteasome complex
1.66 3.10e-04 GO:0000267 cell fraction
1.66 6.76e-04 GO:0044421 extracellular region part
1.42 1.36e-03 GO:0044459 plasma membrane part
1.41 3.09e-03 GO:0005576 extracellular region
9.36 5.01e-03 GO:0022624 proteasome accessory complex
1.68 6.38e-03 GO:0005615 extracellular space
1.66 6.77e-03 GO:0005626 insoluble fraction
10.40 1.41e-02 GO:0005838 proteasome regulatory particle
1.64 1.46e-02 GO:0005624 membrane fraction

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.12 1.45e-05 GO:0005126 cytokine receptor binding
1.18 2.96e-03 GO:0005515 protein binding
1.59 1.24e-02 GO:0005102 receptor binding
5.44 1.29e-02 GO:0015036 disulfide oxidoreductase activity
1.67 2.68e-02 GO:0019899 enzyme binding
2.59 3.28e-02 GO:0061135 endopeptidase regulator activity