Motif ID: NFE2.p2

Z-value: 1.227


Transcription factors associated with NFE2.p2:

Gene SymbolEntrez IDGene Name
NFE2 4778 nuclear factor (erythroid-derived 2), 45kDa

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFE2chr12_-_54694717,
chr12_-_54689536,
chr12_-_54694647		0.202.8e-01Click!


Activity profile for motif NFE2.p2.

activity profile for motif NFE2.p2


Sorted Z-values histogram for motif NFE2.p2

Sorted Z-values for motif NFE2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_150480584 7.037 ECM1
extracellular matrix protein 1
chr1_+_150480486 6.974 NM_001202858
NM_004425
NM_022664
 ECM1


extracellular matrix protein 1


chr18_+_21452981 6.685 NM_000227
NM_001127718
 LAMA3

laminin, alpha 3

chr17_-_39768939 5.442 NM_005557
 KRT16
keratin 16
chr1_+_152881022 4.915 NM_005547
 IVL
involucrin
chr2_-_216259197 4.900 FN1
fibronectin 1
chr21_+_41029253 4.356 NM_006057
NM_033170
NM_033171
NM_033172
NM_033173
 B3GALT5




UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5




chr8_+_7752198 3.838 NM_004942
 DEFB4A
defensin, beta 4A
chr1_+_183155173 3.794 NM_005562
NM_018891
 LAMC2

laminin, gamma 2

chr2_+_113875469 3.670 NM_000577
NM_173841
NM_173843
 IL1RN


interleukin 1 receptor antagonist


chr11_-_65667858 3.598 FOSL1
FOS-like antigen 1
chr1_-_153029987 3.491 NM_005988
 SPRR2A
small proline-rich protein 2A
chr1_-_153348057 3.485 NM_005621
 S100A12
S100 calcium binding protein A12
chr1_+_32043745 3.471 NM_001204415
 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr8_-_7274353 3.410 NM_001205266
 DEFB4B
defensin, beta 4B
chr6_+_74405764 3.335 CD109
CD109 molecule
chr1_+_183155393 3.052 LAMC2
laminin, gamma 2
chr14_-_24732344 3.042 NM_000359
 TGM1
transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)
chr6_+_74405505 2.899 NM_001159587
NM_001159588
NM_133493
 CD109


CD109 molecule


chr1_+_17531619 2.880 NM_013358
 PADI1
peptidyl arginine deiminase, type I

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 68 entries
enrichment   p-value GO term description
10.21 2.00e-02 GO:0060600 dichotomous subdivision of an epithelial terminal unit
6.02 2.24e-02 GO:0007044 cell-substrate junction assembly
4.58 4.35e-02 GO:0050921 positive regulation of chemotaxis
4.32 3.44e-02 GO:0048520 positive regulation of behavior
4.24 4.23e-02 GO:0006521 regulation of cellular amino acid metabolic process
4.10 1.32e-02 GO:0071158 positive regulation of cell cycle arrest
3.99 3.84e-02 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
3.99 3.84e-02 GO:0072395 signal transduction involved in cell cycle checkpoint
3.99 3.84e-02 GO:0072401 signal transduction involved in DNA integrity checkpoint
3.99 3.84e-02 GO:0072404 signal transduction involved in G1/S transition checkpoint
3.99 3.84e-02 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
3.99 3.84e-02 GO:0072422 signal transduction involved in DNA damage checkpoint
3.99 3.84e-02 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
3.99 3.84e-02 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
3.55 5.81e-03 GO:0048754 branching morphogenesis of a tube
3.37 5.96e-05 GO:0040017 positive regulation of locomotion
3.36 1.17e-04 GO:0030335 positive regulation of cell migration
3.36 1.17e-04 GO:2000147 positive regulation of cell motility
3.26 1.22e-04 GO:0051272 positive regulation of cellular component movement
2.40 1.40e-02 GO:0030334 regulation of cell migration

Gene overrepresentation in compartment category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
10.40 1.41e-02 GO:0005838 proteasome regulatory particle
9.36 5.01e-03 GO:0022624 proteasome accessory complex
4.46 2.56e-04 GO:0000502 proteasome complex
1.68 6.38e-03 GO:0005615 extracellular space
1.66 3.10e-04 GO:0000267 cell fraction
1.66 6.76e-04 GO:0044421 extracellular region part
1.66 6.77e-03 GO:0005626 insoluble fraction
1.64 1.46e-02 GO:0005624 membrane fraction
1.42 1.36e-03 GO:0044459 plasma membrane part
1.41 3.09e-03 GO:0005576 extracellular region

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
5.44 1.29e-02 GO:0015036 disulfide oxidoreductase activity
3.12 1.45e-05 GO:0005126 cytokine receptor binding
2.59 3.28e-02 GO:0061135 endopeptidase regulator activity
1.67 2.68e-02 GO:0019899 enzyme binding
1.59 1.24e-02 GO:0005102 receptor binding
1.18 2.96e-03 GO:0005515 protein binding