Motif ID: NFKB1_REL_RELA.p2

Z-value: 2.149


Transcription factors associated with NFKB1_REL_RELA.p2:

Gene SymbolEntrez IDGene Name
NFKB1 4790 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
REL 5966 v-rel reticuloendotheliosis viral oncogene homolog (avian)
RELA 5970 v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RELAchr11_-_654304270.613.5e-04Click!
RELchr2_+_611087020.422.2e-02Click!
NFKB1chr4_+_103422822,
chr4_+_103422553		0.115.6e-01Click!


Activity profile for motif NFKB1_REL_RELA.p2.

activity profile for motif NFKB1_REL_RELA.p2


Sorted Z-values histogram for motif NFKB1_REL_RELA.p2

Sorted Z-values for motif NFKB1_REL_RELA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFKB1_REL_RELA.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_47655603 6.631 PDZK1IP1
PDZK1 interacting protein 1
chr1_-_47655723 6.366 NM_005764
 PDZK1IP1
PDZK1 interacting protein 1
chr12_-_76425375 5.708 NM_007350
 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr2_+_228678556 5.271 NM_001130046
NM_004591
 CCL20

chemokine (C-C motif) ligand 20

chr12_-_76425207 4.926 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr19_-_41859332 4.333 TGFB1
transforming growth factor, beta 1
chr19_-_41859830 4.066 NM_000660
 TGFB1
transforming growth factor, beta 1
chr4_-_74864296 3.933 NM_002994
 CXCL5
chemokine (C-X-C motif) ligand 5
chr19_-_41859519 3.694 TGFB1
transforming growth factor, beta 1
chr12_+_53491448 3.502 IGFBP6
insulin-like growth factor binding protein 6
chr12_+_53491417 3.501 NM_002178
 IGFBP6
insulin-like growth factor binding protein 6
chr13_-_20806533 3.345 NM_001110219
NM_001110220
NM_001110221
 GJB6


gap junction protein, beta 6, 30kDa


chr22_-_37640187 3.147 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr22_-_37640287 3.031 NM_002872
 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr9_+_131183225 2.994 CERCAM
cerebral endothelial cell adhesion molecule
chr19_-_41859253 2.990 TGFB1
transforming growth factor, beta 1
chr9_-_136344182 2.966 NM_001145099
NM_017585
 SLC2A6

solute carrier family 2 (facilitated glucose transporter), member 6

chr12_-_54813002 2.932 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr15_-_75017710 2.910 NM_000499
 CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chr2_+_113993082 2.883 LOC654433
uncharacterized LOC654433

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 61 entries
enrichment   p-value GO term description
3.42 1.93e-02 GO:0045621 positive regulation of lymphocyte differentiation
2.93 3.65e-02 GO:0045619 regulation of lymphocyte differentiation
2.19 3.89e-02 GO:0034762 regulation of transmembrane transport
2.14 8.77e-03 GO:0002696 positive regulation of leukocyte activation
2.12 2.45e-02 GO:0051251 positive regulation of lymphocyte activation
2.10 1.37e-02 GO:0050867 positive regulation of cell activation
2.05 7.79e-03 GO:0051249 regulation of lymphocyte activation
2.02 4.02e-03 GO:0002694 regulation of leukocyte activation
1.99 5.56e-03 GO:0050865 regulation of cell activation
1.88 3.99e-03 GO:0031347 regulation of defense response
1.78 1.33e-03 GO:0002684 positive regulation of immune system process
1.70 2.80e-02 GO:0007243 intracellular protein kinase cascade
1.70 2.80e-02 GO:0023014 signal transduction via phosphorylation event
1.69 3.24e-03 GO:0006935 chemotaxis
1.69 3.24e-03 GO:0042330 taxis
1.67 1.06e-04 GO:0002682 regulation of immune system process
1.66 2.23e-02 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.62 3.27e-04 GO:0006955 immune response
1.62 3.21e-02 GO:0008284 positive regulation of cell proliferation
1.57 1.46e-05 GO:0010646 regulation of cell communication

Gene overrepresentation in compartment category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
2.35 1.22e-02 GO:0005924 cell-substrate adherens junction
2.28 4.18e-02 GO:0005925 focal adhesion
2.27 2.45e-02 GO:0030055 cell-substrate junction
2.08 1.63e-02 GO:0005912 adherens junction
1.97 9.51e-05 GO:0015629 actin cytoskeleton
1.37 3.47e-06 GO:0005829 cytosol
1.31 2.34e-04 GO:0044459 plasma membrane part
1.18 8.24e-03 GO:0071944 cell periphery
1.17 1.26e-02 GO:0005886 plasma membrane
1.13 5.61e-05 GO:0005737 cytoplasm
1.13 3.36e-02 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
3.29 2.98e-02 GO:0003823 antigen binding
2.14 1.53e-03 GO:0005126 cytokine receptor binding
1.22 6.82e-13 GO:0005515 protein binding
1.07 3.24e-03 GO:0005488 binding