Motif ID: NKX2-3_NKX2-5.p2

Z-value: 1.163


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-5chr5_-_172662085-0.106.0e-01Click!
NKX2-3chr10_+_1012926890.057.8e-01Click!


Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_69313166 7.369 NM_014058
 TMPRSS11E
transmembrane protease, serine 11E
chr1_+_84630575 5.439 NM_001242860
NM_001242861
 PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr2_+_102953716 4.879 NM_003856
 IL1RL1
interleukin 1 receptor-like 1
chr2_+_210444364 4.556 NM_002374
NM_031845
NM_031847
 MAP2


microtubule-associated protein 2


chr4_+_169013687 4.474 NM_007193
 ANXA10
annexin A10
chr1_-_153044083 4.177 NM_001017418
 SPRR2B
small proline-rich protein 2B
chr2_-_31352489 4.112 NM_001253827
 GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr10_-_105845619 4.009 NM_000494
 COL17A1
collagen, type XVII, alpha 1
chr7_-_14025826 3.933 NM_001163150
NM_001163151
NM_001163152
 ETV1


ets variant 1


chr10_+_102123420 3.871


chr10_-_105845556 3.700 COL17A1
collagen, type XVII, alpha 1
chr12_+_8975149 3.673 NM_144670
 A2ML1
alpha-2-macroglobulin-like 1
chr4_-_39033981 3.651 NM_024943
 TMEM156
transmembrane protein 156
chr1_+_151032866 3.574 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr4_-_68749698 3.439 NM_004262
 TMPRSS11D
transmembrane protease, serine 11D
chr12_-_91505541 3.374 NM_002345
 LUM
lumican
chr12_-_91505215 3.317 LUM
lumican
chr12_+_15699277 3.301 NM_030668
NM_030669
NM_030670
NM_030671
 PTPRO



protein tyrosine phosphatase, receptor type, O



chr1_+_209878135 3.240 NM_005525
 HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr15_+_93443559 3.137 CHD2
chromodomain helicase DNA binding protein 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 26 entries
enrichment   p-value GO term description
2.85 4.54e-02 GO:0034329 cell junction assembly
2.74 6.04e-03 GO:0003012 muscle system process
2.64 4.20e-02 GO:0006936 muscle contraction
2.53 2.59e-02 GO:0072503 cellular divalent inorganic cation homeostasis
2.51 4.24e-02 GO:0006874 cellular calcium ion homeostasis
2.47 1.40e-02 GO:0007601 visual perception
2.47 1.40e-02 GO:0050953 sensory perception of light stimulus
1.85 9.84e-04 GO:0007267 cell-cell signaling
1.85 3.53e-02 GO:0007186 G-protein coupled receptor protein signaling pathway
1.72 2.74e-02 GO:0007155 cell adhesion
1.72 2.74e-02 GO:0022610 biological adhesion
1.68 2.22e-02 GO:0009888 tissue development
1.63 1.53e-02 GO:0007154 cell communication
1.52 6.33e-04 GO:0007166 cell surface receptor linked signaling pathway
1.50 3.69e-03 GO:0003008 system process
1.45 1.91e-14 GO:0032501 multicellular organismal process
1.43 1.43e-06 GO:0007275 multicellular organismal development
1.42 1.24e-02 GO:0030154 cell differentiation
1.42 3.16e-02 GO:0048513 organ development
1.41 5.82e-07 GO:0032502 developmental process

Gene overrepresentation in compartment category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
7.24 3.13e-02 GO:0034706 sodium channel complex
6.03 3.10e-02 GO:0001533 cornified envelope
3.53 3.01e-03 GO:0045095 keratin filament
2.68 2.15e-03 GO:0005882 intermediate filament
2.32 2.55e-02 GO:0045111 intermediate filament cytoskeleton
1.67 4.11e-04 GO:0044421 extracellular region part
1.65 9.93e-03 GO:0005615 extracellular space
1.61 2.68e-04 GO:0005887 integral to plasma membrane
1.60 3.62e-04 GO:0031226 intrinsic to plasma membrane
1.53 4.92e-06 GO:0005576 extracellular region
1.45 1.45e-04 GO:0044459 plasma membrane part
1.32 1.40e-05 GO:0071944 cell periphery
1.31 4.10e-05 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
7.24 4.50e-02 GO:0008527 taste receptor activity
2.02 3.01e-02 GO:0003779 actin binding
1.83 9.13e-03 GO:0008092 cytoskeletal protein binding
1.38 1.21e-02 GO:0004871 signal transducer activity
1.38 1.21e-02 GO:0060089 molecular transducer activity