Motif ID: NRF1.p2

Z-value: 3.456


Transcription factors associated with NRF1.p2:

Gene SymbolEntrez IDGene Name
NRF1 4899 nuclear respiratory factor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NRF1chr7_+_1292515290.752.0e-06Click!


Activity profile for motif NRF1.p2.

activity profile for motif NRF1.p2


Sorted Z-values histogram for motif NRF1.p2

Sorted Z-values for motif NRF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NRF1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_260092 34.441 NM_001013672
 C17orf97
chromosome 17 open reading frame 97
chr2_-_99758034 17.770 NM_182911
 TSGA10
testis specific, 10
chr4_-_7044664 15.444 NM_153376
 CCDC96
coiled-coil domain containing 96
chr3_+_49449753 14.975 TCTA
T-cell leukemia translocation altered gene
chr3_+_49449638 12.850 NM_022171
 TCTA
T-cell leukemia translocation altered gene
chr5_+_10441973 12.525 NM_001201466
NM_031916
 ROPN1L

rhophilin associated tail protein 1-like

chr9_+_124922189 11.327 NM_198469
 MORN5
MORN repeat containing 5
chr17_-_6735007 10.919 NM_053285
 TEKT1
tektin 1
chr16_+_80574853 10.453 NM_130897
 DYNLRB2
dynein, light chain, roadblock-type 2
chr14_+_75536298 9.486 NM_001042430
NM_024643
 FAM164C

family with sequence similarity 164, member C

chr20_-_35580109 7.715 SAMHD1
SAM domain and HD domain 1
chr20_-_35580175 7.291 SAMHD1
SAM domain and HD domain 1
chr20_-_35580045 7.272 SAMHD1
SAM domain and HD domain 1
chr1_+_231473681 7.132 NM_001010984
NM_032018
 C1orf124

chromosome 1 open reading frame 124

chr20_-_35580186 6.714 NM_015474
 SAMHD1
SAM domain and HD domain 1
chr22_+_24666749 6.553 NM_001145468
NM_015330
 SPECC1L

sperm antigen with calponin homology and coiled-coil domains 1-like

chr4_-_177116713 6.160 NM_144644
 SPATA4
spermatogenesis associated 4
chr16_+_84178864 6.153 NM_178452
 DNAAF1
dynein, axonemal, assembly factor 1
chr19_+_36236460 6.127 NM_172341
 PSENEN
presenilin enhancer 2 homolog (C. elegans)
chr2_-_207630009 5.976 NM_001039845
 MDH1B
malate dehydrogenase 1B, NAD (soluble)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 62 entries
enrichment   p-value GO term description
3.26 6.63e-04 GO:0006406 mRNA export from nucleus
3.18 3.31e-04 GO:0006405 RNA export from nucleus
3.09 3.42e-02 GO:0000723 telomere maintenance
3.03 4.68e-02 GO:0032200 telomere organization
2.99 1.18e-03 GO:0006302 double-strand break repair
2.83 1.06e-02 GO:0006200 ATP catabolic process
2.77 2.24e-03 GO:0051168 nuclear export
2.55 5.64e-03 GO:0043414 macromolecule methylation
2.53 6.94e-08 GO:0000375 RNA splicing, via transesterification reactions
2.51 2.39e-07 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.51 2.39e-07 GO:0000398 nuclear mRNA splicing, via spliceosome
2.28 1.64e-08 GO:0008380 RNA splicing
2.21 2.52e-09 GO:0016568 chromatin modification
2.17 4.30e-08 GO:0006281 DNA repair
2.13 9.12e-15 GO:0051276 chromosome organization
2.13 1.22e-12 GO:0016071 mRNA metabolic process
2.13 4.93e-02 GO:0006310 DNA recombination
2.12 1.38e-10 GO:0006325 chromatin organization
2.12 1.45e-08 GO:0006397 mRNA processing
2.08 1.34e-02 GO:0016570 histone modification

Gene overrepresentation in compartment category:

Showing 1 to 20 of 40 entries
enrichment   p-value GO term description
3.30 3.24e-04 GO:0034708 methyltransferase complex
3.30 3.24e-04 GO:0035097 histone methyltransferase complex
2.54 8.11e-03 GO:0031461 cullin-RING ubiquitin ligase complex
2.26 4.68e-03 GO:0016607 nuclear speck
2.14 6.38e-03 GO:0000151 ubiquitin ligase complex
2.09 1.88e-02 GO:0005681 spliceosomal complex
2.01 2.21e-04 GO:0000785 chromatin
2.00 7.76e-03 GO:0044454 nuclear chromosome part
1.97 1.19e-10 GO:0005694 chromosome
1.95 1.24e-13 GO:0044451 nucleoplasm part
1.95 2.27e-03 GO:0000228 nuclear chromosome
1.91 1.55e-24 GO:0005654 nucleoplasm
1.89 2.61e-07 GO:0044427 chromosomal part
1.87 7.37e-03 GO:0016604 nuclear body
1.78 8.86e-27 GO:0031981 nuclear lumen
1.75 8.68e-30 GO:0044428 nuclear part
1.71 6.01e-28 GO:0070013 intracellular organelle lumen
1.71 3.71e-05 GO:0030529 ribonucleoprotein complex
1.70 8.52e-03 GO:0005815 microtubule organizing center
1.67 2.57e-26 GO:0031974 membrane-enclosed lumen

Gene overrepresentation in function category:

Showing 1 to 20 of 34 entries
enrichment   p-value GO term description
4.99 3.26e-02 GO:0031593 polyubiquitin binding
3.27 1.27e-02 GO:0003899 DNA-directed RNA polymerase activity
3.27 1.27e-02 GO:0034062 RNA polymerase activity
2.91 4.40e-03 GO:0008276 protein methyltransferase activity
2.72 1.93e-05 GO:0016779 nucleotidyltransferase activity
2.42 9.41e-03 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
2.01 1.31e-02 GO:0008168 methyltransferase activity
1.97 8.18e-03 GO:0003682 chromatin binding
1.95 2.65e-02 GO:0016741 transferase activity, transferring one-carbon groups
1.89 3.73e-02 GO:0043566 structure-specific DNA binding
1.82 1.88e-02 GO:0019787 small conjugating protein ligase activity
1.77 1.64e-02 GO:0016881 acid-amino acid ligase activity
1.75 1.11e-02 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.64 3.87e-02 GO:0016887 ATPase activity
1.63 3.99e-03 GO:0016874 ligase activity
1.63 2.25e-02 GO:0003712 transcription cofactor activity
1.63 2.47e-02 GO:0000988 protein binding transcription factor activity
1.63 2.47e-02 GO:0000989 transcription factor binding transcription factor activity
1.61 2.07e-06 GO:0003723 RNA binding
1.48 4.02e-21 GO:0003676 nucleic acid binding