Motif ID: PAX2.p2

Z-value: 0.869


Transcription factors associated with PAX2.p2:

Gene SymbolEntrez IDGene Name
PAX2 5076 paired box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PAX2chr10_+_102505337-0.164.0e-01Click!


Activity profile for motif PAX2.p2.

activity profile for motif PAX2.p2


Sorted Z-values histogram for motif PAX2.p2

Sorted Z-values for motif PAX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_42921676 2.409 ZMYND12
zinc finger, MYND-type containing 12
chr9_-_115652961 1.328 NM_033051
SLC46A2
solute carrier family 46, member 2
chr11_-_119252267 1.255 USP2
ubiquitin specific peptidase 2
chr10_+_22634373 1.252 NM_001253854
NM_001253855
NM_012443
NM_172242
SPAG6



sperm associated antigen 6



chr11_+_65479685 1.209 KAT5
K(lysine) acetyltransferase 5
chr1_-_42921923 1.208 NM_001146192
NM_032257
ZMYND12

zinc finger, MYND-type containing 12

chr6_+_112408673 1.114 NM_001033564
C6orf225
chromosome 6 open reading frame 225
chr16_-_67427335 1.094 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr10_+_69644341 1.083 NM_012238
SIRT1
sirtuin 1
chr5_+_172483285 1.062 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chr11_+_65479472 1.056 NM_001206833
NM_006388
NM_182709
NM_182710
KAT5



K(lysine) acetyltransferase 5



chr3_+_63638343 0.987 NM_001080537
SNTN
sentan, cilia apical structure protein
chr1_-_207119707 0.969 NM_002644
PIGR
polymeric immunoglobulin receptor
chr3_-_197686837 0.945 NM_032263
IQCG
IQ motif containing G
chr14_+_77564570 0.941 NM_033426
KIAA1737
KIAA1737
chr11_-_26593667 0.925 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr16_-_88923233 0.898 GALNS
galactosamine (N-acetyl)-6-sulfate sulfatase
chr11_+_73358593 0.898 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr15_+_43809805 0.876 NM_002373
MAP1A
microtubule-associated protein 1A
chrY_+_21729214 0.861 TXLNG2P
taxilin gamma 2, pseudogene
chr11_-_119252364 0.858 NM_001243759
NM_004205
USP2

ubiquitin specific peptidase 2

chr11_+_67159421 0.854 NM_004584
RAD9A
RAD9 homolog A (S. pombe)
chr5_-_35938736 0.843 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chrY_+_15016698 0.838 NM_004660
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr2_-_160654668 0.831 CD302
CD302 molecule
chrX_+_119029799 0.823 NM_001008534
NM_001008535
NM_178813
AKAP14


A kinase (PRKA) anchor protein 14


chr22_-_50970542 0.808 ODF3B
outer dense fiber of sperm tails 3B
chr9_-_90589360 0.792 CDK20
cyclin-dependent kinase 20
chr19_-_45681454 0.789 NM_024108
TRAPPC6A
trafficking protein particle complex 6A
chr14_+_24584009 0.755 DCAF11
DDB1 and CUL4 associated factor 11
chr19_-_3047632 0.753 NM_001144761
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr17_-_42200957 0.752 HDAC5
histone deacetylase 5
chr8_+_75896707 0.747 NM_031461
CRISPLD1
cysteine-rich secretory protein LCCL domain containing 1
chr19_+_45504686 0.746 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chrX_+_30671456 0.736 NM_000167
NM_001128127
NM_001205019
NM_203391
GK



glycerol kinase



chr16_+_84178864 0.732 NM_178452
DNAAF1
dynein, axonemal, assembly factor 1
chr11_-_108093262 0.724 NPAT
nuclear protein, ataxia-telangiectasia locus
chr1_+_222885895 0.723 NM_144695
BROX
BRO1 domain and CAAX motif containing
chr1_-_6052481 0.712 NM_015102
NPHP4
nephronophthisis 4
chr1_-_6052410 0.707 NPHP4
nephronophthisis 4
chr12_+_50355278 0.702 NM_001651
AQP5
aquaporin 5
chr14_+_74486049 0.696 NM_025057
C14orf45
chromosome 14 open reading frame 45
chrX_+_30671602 0.693 GK
glycerol kinase
chr19_+_14544100 0.691 NM_002741
PKN1
protein kinase N1
chr17_-_42201009 0.688 NM_001015053
NM_005474
HDAC5

histone deacetylase 5

chrY_+_2803409 0.685 NM_001145275
NM_003411
ZFY

zinc finger protein, Y-linked

chr21_-_43430448 0.684 NM_001098402
NM_001098403
NM_020727
ZNF295


zinc finger protein 295


chr2_-_99771186 0.682 NM_025244
TSGA10
testis specific, 10
chr9_-_90589593 0.682 NM_001039803
NM_001170639
NM_001170640
NM_012119
NM_178432
CDK20




cyclin-dependent kinase 20




chr15_-_40401041 0.679 NM_001003940
BMF
Bcl2 modifying factor
chr7_-_73184535 0.667 NM_001306
CLDN3
claudin 3
chr9_-_97356007 0.659 NM_003837
FBP2
fructose-1,6-bisphosphatase 2
chr14_+_24584321 0.648 DCAF11
DDB1 and CUL4 associated factor 11
chr2_-_160654736 0.646 NM_001198763
NM_001198764
NM_014880
CD302


CD302 molecule


chr7_+_150065330 0.645 REPIN1
replication initiator 1
chr11_-_119066583 0.645 NM_001145018
CCDC153
coiled-coil domain containing 153
chr10_+_69644708 0.642 SIRT1
sirtuin 1
chr9_+_135754284 0.641 NM_018956
C9orf9
chromosome 9 open reading frame 9
chr14_+_24583979 0.636 NM_025230
DCAF11
DDB1 and CUL4 associated factor 11
chr14_+_24584467 0.636 NM_181357
DCAF11
DDB1 and CUL4 associated factor 11
chr17_-_7137675 0.633 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr12_-_122107559 0.623 NM_173855
MORN3
MORN repeat containing 3
chr19_-_10764449 0.621 LOC147727
uncharacterized LOC147727
chr17_-_7137722 0.618 NM_004422
DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr3_-_45883562 0.614 NM_020347
LZTFL1
leucine zipper transcription factor-like 1
chr14_+_45431333 0.612 NM_015091
FAM179B
family with sequence similarity 179, member B
chr1_+_183605207 0.612 NM_015149
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr17_-_7137580 0.605 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr9_-_99382073 0.600 NM_003671
NM_033331
CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

chr6_+_43612766 0.598 NM_001193341
NM_152732
RSPH9

radial spoke head 9 homolog (Chlamydomonas)

chr14_+_24583905 0.594 NM_001163484
DCAF11
DDB1 and CUL4 associated factor 11
chr20_+_33146500 0.594 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr5_+_139927182 0.587 NM_003732
EIF4EBP3
eukaryotic translation initiation factor 4E binding protein 3
chr11_-_108093328 0.587 NM_002519
NPAT
nuclear protein, ataxia-telangiectasia locus
chr18_+_9136742 0.581 NM_001083625
NM_015208
ANKRD12

ankyrin repeat domain 12

chr19_+_14544216 0.578 PKN1
protein kinase N1
chr10_-_123357503 0.571 NM_000141
NM_001144917
NM_001144918
NM_001144919
NM_022970
FGFR2




fibroblast growth factor receptor 2




chr15_-_50978921 0.567 TRPM7
transient receptor potential cation channel, subfamily M, member 7
chr12_+_20963637 0.567 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr15_+_44084039 0.565 NM_001018108
NM_001199875
NM_001199876
SERF2


small EDRK-rich factor 2


chr5_-_126366068 0.563 MARCH3
membrane-associated ring finger (C3HC4) 3
chr5_-_80597362 0.561 LOC100131067
uncharacterized LOC100131067
chr22_-_41593466 0.560


chr22_+_35777051 0.559 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr5_-_100238870 0.552 NM_175052
NM_005668
ST8SIA4

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

chr14_+_55738102 0.545 FBXO34
F-box protein 34
chr6_+_87865261 0.536 NM_015021
ZNF292
zinc finger protein 292
chr19_-_11545900 0.527 NM_145045
CCDC151
coiled-coil domain containing 151
chr6_-_90121966 0.526 NM_021244
RRAGD
Ras-related GTP binding D
chr9_+_135753711 0.525 C9orf9
chromosome 9 open reading frame 9
chr16_+_4784320 0.524 C16orf71
chromosome 16 open reading frame 71
chrX_-_13835187 0.519 GPM6B
glycoprotein M6B
chr15_-_50978726 0.518 TRPM7
transient receptor potential cation channel, subfamily M, member 7
chr10_+_76586299 0.516 NM_012330
KAT6B
K(lysine) acetyltransferase 6B
chrY_+_2803111 0.512 NM_001145276
ZFY
zinc finger protein, Y-linked
chr17_+_42977141 0.511 NM_213607
CCDC103
coiled-coil domain containing 103
chrX_+_53449804 0.510 NM_144968
NM_001031745
RIBC1

RIB43A domain with coiled-coils 1

chr11_+_101785720 0.510 NM_020802
KIAA1377
KIAA1377
chr1_+_9599546 0.509 SLC25A33
solute carrier family 25, member 33
chrX_-_13835012 0.507 GPM6B
glycoprotein M6B
chr20_+_32077780 0.504 CBFA2T2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr22_+_35777087 0.503 HMOX1
heme oxygenase (decycling) 1
chr6_+_52285804 0.497 NM_001172420
EFHC1
EF-hand domain (C-terminal) containing 1
chr12_-_63328663 0.497 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr21_+_33784751 0.496 NM_058187
C21orf63
chromosome 21 open reading frame 63
chr11_+_7618416 0.487 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr5_+_122424840 0.486 NM_001136239
PRDM6
PR domain containing 6
chr3_-_122512526 0.484 NM_024610
HSPBAP1
HSPB (heat shock 27kDa) associated protein 1
chr4_-_149363498 0.483 NM_000901
NM_001166104
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr4_+_39184023 0.472 NM_025132
WDR19
WD repeat domain 19
chr12_-_64616032 0.472 NM_152440
C12orf66
chromosome 12 open reading frame 66
chr6_-_32920812 0.471 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr17_-_46688279 0.471 HOXB7
homeobox B7
chr11_+_60197061 0.462 NM_023945
MS4A5
membrane-spanning 4-domains, subfamily A, member 5
chr14_-_88459459 0.461 GALC
galactosylceramidase
chr16_-_88923348 0.458 NM_000512
GALNS
galactosamine (N-acetyl)-6-sulfate sulfatase
chr1_+_85527992 0.457 NM_145172
WDR63
WD repeat domain 63
chr16_+_4784261 0.454 NM_139170
C16orf71
chromosome 16 open reading frame 71
chr11_+_7535213 0.447 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr4_+_25657434 0.447 NM_001177998
NM_006424
SLC34A2

solute carrier family 34 (sodium phosphate), member 2

chr3_-_36986535 0.446 NM_014831
TRANK1
tetratricopeptide repeat and ankyrin repeat containing 1
chr16_-_46782104 0.446 NM_182493
MYLK3
myosin light chain kinase 3
chr6_-_84937313 0.439 NM_014895
KIAA1009
KIAA1009
chr2_-_60780404 0.438 NM_018014
NM_022893
NM_138559
BCL11A


B-cell CLL/lymphoma 11A (zinc finger protein)


chr19_-_36545646 0.437 NM_152658
THAP8
THAP domain containing 8
chr11_-_8739398 0.436 ST5
suppression of tumorigenicity 5
chr7_+_23719743 0.430 NM_001127364
NM_001127365
NM_199136
C7orf46


chromosome 7 open reading frame 46


chr4_+_37455551 0.424 NM_001104629
C4orf19
chromosome 4 open reading frame 19
chr22_+_35695872 0.422 TOM1
target of myb1 (chicken)
chrX_+_101975641 0.422 NM_001142524
NM_001142525
NM_001142526
NM_001142527
NM_001142528
NM_030639
BHLHB9





basic helix-loop-helix domain containing, class B, 9





chr14_+_93651295 0.419 NM_015676
NM_001098621
C14orf109

chromosome 14 open reading frame 109

chr17_+_14204326 0.419 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr2_-_197036301 0.418 NM_004226
STK17B
serine/threonine kinase 17b
chr9_-_124990949 0.416 NM_014368
NM_199160
LHX6

LIM homeobox 6

chr4_-_8442427 0.416 NM_001101667
NM_003501
ACOX3

acyl-CoA oxidase 3, pristanoyl

chr15_-_40398573 0.410 NM_033503
BMF
Bcl2 modifying factor
chr9_+_6757919 0.406 KDM4C
lysine (K)-specific demethylase 4C
chr5_-_121412805 0.405 NM_001178102
LOX
lysyl oxidase
chr7_-_36429695 0.405 NM_001100425
KIAA0895
KIAA0895
chr11_-_2016743 0.405 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chrX_-_34675366 0.403 NM_031442
TMEM47
transmembrane protein 47
chr2_-_178257380 0.403 LOC100130691
uncharacterized LOC100130691
chr16_+_4784446 0.401 C16orf71
chromosome 16 open reading frame 71
chrX_-_8700170 0.399 NM_000216
KAL1
Kallmann syndrome 1 sequence
chrY_+_15016775 0.397 DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr16_+_699277 0.394 NM_145294
WDR90
WD repeat domain 90
chr6_-_31745048 0.393 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr17_+_4402128 0.392 NM_001124758
SPNS2
spinster homolog 2 (Drosophila)
chr7_+_150068252 0.392 NM_014374
REPIN1
replication initiator 1
chr17_+_79609298 0.392 NM_031945
TSPAN10
tetraspanin 10
chr12_+_12764755 0.387 NM_001310
CREBL2
cAMP responsive element binding protein-like 2
chr11_-_8892909 0.387 ST5
suppression of tumorigenicity 5
chr20_-_44519629 0.385 NM_080749
NEURL2
neuralized homolog 2 (Drosophila)
chr9_-_139922595 0.385 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr2_+_120302024 0.385 NM_001029996
PCDP1
primary ciliary dyskinesia protein 1
chr12_-_65153182 0.384 GNS
glucosamine (N-acetyl)-6-sulfatase
chr1_+_154193294 0.384 NM_014847
UBAP2L
ubiquitin associated protein 2-like
chr15_+_44084493 0.383 SERF2
small EDRK-rich factor 2
chr17_+_73472578 0.383 KIAA0195
KIAA0195
chr11_-_6640645 0.381 TPP1
tripeptidyl peptidase I
chr1_+_151483861 0.381 NM_020770
CGN
cingulin
chr11_+_61522860 0.379 NM_013279
C11orf9
chromosome 11 open reading frame 9
chr9_-_139922705 0.377 NM_001606
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr4_+_36285643 0.376 NM_001170700
DTHD1
death domain containing 1
chr6_+_43027368 0.375 NM_138343
NM_201521
KLC4

kinesin light chain 4

chr2_-_220083699 0.374 NM_005689
ABCB6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr6_+_139456240 0.374 NM_016217
HECA
headcase homolog (Drosophila)
chr22_-_38349533 0.374 NM_032561
NM_001207062
C22orf23

chromosome 22 open reading frame 23

chr5_-_137368682 0.373 FAM13B
family with sequence similarity 13, member B
chr6_+_32821924 0.373 NM_002800
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr4_+_175204827 0.372 NM_001040157
CEP44
centrosomal protein 44kDa
chr11_+_120894756 0.371 NM_001130047
NM_152715
TBCEL

tubulin folding cofactor E-like

chr17_-_57184116 0.369 TRIM37
tripartite motif containing 37
chr4_+_106068009 0.369 TET2
tet methylcytosine dioxygenase 2
chr13_+_48877950 0.367 RB1
retinoblastoma 1
chr20_+_47538211 0.366 NM_006420
ARFGEF2
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr6_+_89791510 0.366 PNRC1
proline-rich nuclear receptor coactivator 1
chr6_-_90121911 0.364 RRAGD
Ras-related GTP binding D
chr1_-_204329043 0.363 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr6_+_127587984 0.362 RNF146
ring finger protein 146
chr17_+_55333843 0.362 NM_138962
MSI2
musashi homolog 2 (Drosophila)
chr14_-_45431090 0.360 KLHL28
kelch-like 28 (Drosophila)
chr2_-_197036262 0.360 STK17B
serine/threonine kinase 17b
chr16_+_28875181 0.357 NM_001145812
NM_015503
SH2B1

SH2B adaptor protein 1

chr12_+_38710556 0.356 NM_001013620
ALG10B
asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog B (yeast)
chr3_+_113616317 0.356 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr2_-_99224868 0.355 NM_001008215
COA5
cytochrome C oxidase assembly factor 5
chr2_+_46926049 0.355 NM_014011
SOCS5
suppressor of cytokine signaling 5
chr11_+_67776016 0.354 NM_001161473
ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr14_+_74035762 0.354 NM_006821
ACOT2
acyl-CoA thioesterase 2
chr1_-_202896368 0.354 NM_021633
KLHL12
kelch-like 12 (Drosophila)
chr1_+_40839368 0.350 NM_022733
SMAP2
small ArfGAP2
chr7_+_150065968 0.347 REPIN1
replication initiator 1
chr14_+_55738020 0.347 NM_017943
FBXO34
F-box protein 34
chr12_-_7245048 0.346 C1R
complement component 1, r subcomponent
chr22_+_45809541 0.346 NM_015653
RIBC2
RIB43A domain with coiled-coils 2
chr21_-_47743753 0.345 NM_058180
C21orf58
chromosome 21 open reading frame 58
chr3_-_107941168 0.344 NM_018010
IFT57
intraflagellar transport 57 homolog (Chlamydomonas)
chr3_-_187463474 0.344 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr5_-_137368778 0.343 NM_001101800
NM_001101801
NM_016603
FAM13B


family with sequence similarity 13, member B



Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.11 2.72e-14 GO:0005622 intracellular
1.12 6.44e-14 GO:0044424 intracellular part
1.14 7.52e-10 GO:0043227 membrane-bounded organelle
1.14 9.48e-10 GO:0043231 intracellular membrane-bounded organelle
1.11 5.98e-08 GO:0043226 organelle
1.11 7.50e-08 GO:0043229 intracellular organelle
1.12 4.74e-07 GO:0005737 cytoplasm
1.16 2.43e-05 GO:0005634 nucleus
1.12 1.55e-03 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.09 9.46e-09 GO:0005488 binding
1.13 1.50e-05 GO:0005515 protein binding
1.73 8.46e-05 GO:0000988 protein binding transcription factor activity
1.73 8.46e-05 GO:0000989 transcription factor binding transcription factor activity
1.71 1.50e-04 GO:0003712 transcription cofactor activity
1.20 2.93e-02 GO:0003677 DNA binding
1.90 3.35e-02 GO:0003714 transcription corepressor activity
7.08 4.88e-02 GO:0030306 ADP-ribosylation factor binding