Motif ID: PDX1.p2

Z-value: 0.420


Transcription factors associated with PDX1.p2:

Gene SymbolEntrez IDGene Name
PDX1 3651 pancreatic and duodenal homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PDX1chr13_+_284941360.579.5e-04Click!


Activity profile for motif PDX1.p2.

activity profile for motif PDX1.p2


Sorted Z-values histogram for motif PDX1.p2

Sorted Z-values for motif PDX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PDX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_113735595 1.806 NM_019618
IL36G
interleukin 36, gamma
chr12_+_47610244 1.007 FAM113B
family with sequence similarity 113, member B
chr1_+_63063186 1.000 NM_014495
ANGPTL3
angiopoietin-like 3
chr12_+_47610051 0.980 NM_138371
FAM113B
family with sequence similarity 113, member B
chr6_+_130339715 0.956 NM_001007102
NM_032438
L3MBTL3

l(3)mbt-like 3 (Drosophila)

chr3_+_100238063 0.852 TMEM45A
transmembrane protein 45A
chr11_+_5410606 0.816 NM_001004756
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr17_-_39637351 0.725 NM_002280
KRT35
keratin 35
chr7_+_80267972 0.649 CD36
CD36 molecule (thrombospondin receptor)
chr6_-_131291480 0.635 NM_001199389
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr17_-_38859976 0.604 NM_019016
KRT24
keratin 24
chr1_+_159175048 0.544 NM_001122951
DARC
Duffy blood group, chemokine receptor
chr2_-_216259197 0.518 FN1
fibronectin 1
chr19_-_36019194 0.512 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr10_+_118187381 0.472 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chrX_+_99899388 0.423 SRPX2
sushi-repeat containing protein, X-linked 2
chr6_-_43423785 0.398 NM_206539
DLK2
delta-like 2 homolog (Drosophila)
chr16_+_70557688 0.386 NM_012426
SF3B3
splicing factor 3b, subunit 3, 130kDa
chr2_-_158300517 0.368 NM_004288
CYTIP
cytohesin 1 interacting protein
chr4_+_169013687 0.344 NM_007193
ANXA10
annexin A10
chr17_+_7482938 0.329 CD68
CD68 molecule
chr14_-_81864726 0.323 NM_033104
STON2
stonin 2
chr6_-_31107110 0.322 NM_014069
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr7_-_44228880 0.322 NM_000162
GCK
glucokinase (hexokinase 4)
chr1_-_204135420 0.321 NM_000537
REN
renin
chr8_+_32579350 0.319 NM_001159996
NRG1
neuregulin 1
chr5_+_147648374 0.315 NM_001040129
SPINK13
serine peptidase inhibitor, Kazal type 13 (putative)
chr12_+_119616594 0.310 NM_014365
HSPB8
heat shock 22kDa protein 8
chr6_-_41254392 0.294 NM_001242589
NM_001242590
NM_018643
TREM1


triggering receptor expressed on myeloid cells 1


chr5_-_119740531 0.279


chr17_+_7482980 0.279 CD68
CD68 molecule
chr17_-_9694613 0.276 NM_001105571
NM_001220493
DHRS7C

dehydrogenase/reductase (SDR family) member 7C

chr3_-_45017600 0.257 NM_001135179
NM_016598
ZDHHC3

zinc finger, DHHC-type containing 3

chr15_+_67841341 0.257 NM_001206804
MAP2K5
mitogen-activated protein kinase kinase 5
chr2_-_166060552 0.254 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr2_+_185463235 0.250 ZNF804A
zinc finger protein 804A
chr16_-_70557430 0.250 NM_001195139
NM_015386
COG4

component of oligomeric golgi complex 4

chr1_+_36636690 0.243 MAP7D1
MAP7 domain containing 1
chr4_-_10023094 0.243 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr6_-_131321868 0.221 NM_001252660
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr5_+_34684611 0.221 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr2_+_169921298 0.220 NM_005771
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr12_+_15475190 0.218 NM_002848
NM_030667
PTPRO

protein tyrosine phosphatase, receptor type, O

chr7_-_41742666 0.214 NM_002192
INHBA
inhibin, beta A
chr16_-_67517715 0.206 NM_001138
AGRP
agouti related protein homolog (mouse)
chr2_-_188419185 0.202 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr3_-_51909599 0.201 NM_001145059
IQCF5
IQ motif containing F5
chr2_-_188419049 0.196 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr3_-_167191808 0.194 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr16_+_8814567 0.190 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr19_+_48828627 0.177 NM_001425
EMP3
epithelial membrane protein 3
chr4_+_74606222 0.177 NM_000584
IL8
interleukin 8
chr1_+_10057254 0.176 NM_052960
RBP7
retinol binding protein 7, cellular
chr3_-_51813202 0.175 NM_001143833
IQCF6
IQ motif containing F6
chr14_+_21510384 0.174 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chrX_+_99899162 0.163 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chrX_+_49091926 0.162 NM_014008
CCDC22
coiled-coil domain containing 22
chr2_+_158114109 0.159 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr12_+_105153258 0.159 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr4_-_176733413 0.158 GPM6A
glycoprotein M6A
chr19_-_14785626 0.157 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chrX_+_123234462 0.153 STAG2
stromal antigen 2
chr17_+_7482804 0.151 NM_001251
NM_001040059
CD68

CD68 molecule

chr1_+_84609941 0.150 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr17_+_7960201 0.150


chr10_+_115310589 0.148 NM_001177660
HABP2
hyaluronan binding protein 2
chr12_-_54019633 0.147 NM_001206683
ATF7
activating transcription factor 7
chr10_+_88730497 0.147 NM_133447
AGAP11
ankyrin repeat and GTPase domain Arf GTPase activating protein 11
chr15_+_25281105 0.144 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr18_-_51690988 0.143 MBD2
methyl-CpG binding domain protein 2
chr7_+_26400503 0.142 NM_001199837
SNX10
sorting nexin 10
chr4_-_139163222 0.138 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr4_+_88896801 0.128 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr17_-_7082654 0.128 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr4_+_95376396 0.127 PDLIM5
PDZ and LIM domain 5
chrX_+_49091931 0.127 CCDC22
coiled-coil domain containing 22
chrX_-_132095422 0.121 NM_001077188
NM_147175
HS6ST2

heparan sulfate 6-O-sulfotransferase 2

chr16_+_70557724 0.120 SF3B3
splicing factor 3b, subunit 3, 130kDa
chr14_+_51955854 0.120 NM_001042481
FRMD6
FERM domain containing 6
chr9_+_33624214 0.120 ANXA2P2
annexin A2 pseudogene 2
chr7_+_80275967 0.119 CD36
CD36 molecule (thrombospondin receptor)
chr17_-_15554809 0.116 TRIM16
tripartite motif containing 16
chr17_+_47923271 0.115 NM_001242791
FLJ45513
uncharacterized LOC729220
chr19_-_50847957 0.112 NAPSB
napsin B aspartic peptidase pseudogene
chr4_-_48136245 0.111 NM_003328
TXK
TXK tyrosine kinase
chr9_+_136501484 0.110 NM_000787
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr12_-_14849427 0.110 NM_004963
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr5_-_16738346 0.109 MYO10
myosin X
chr4_+_187187342 0.109 F11
coagulation factor XI
chr17_-_39156106 0.108 NM_031959
KRTAP3-2
keratin associated protein 3-2
chr14_+_101295409 0.106 MEG3
maternally expressed 3 (non-protein coding)
chr18_+_616671 0.105 NM_199167
CLUL1
clusterin-like 1 (retinal)
chr1_-_33841142 0.105 NM_198040
PHC2
polyhomeotic homolog 2 (Drosophila)
chr17_-_39150384 0.102 NM_033185
KRTAP3-3
keratin associated protein 3-3
chr2_-_200213802 0.101 SATB2
SATB homeobox 2
chr3_+_45017729 0.100 NM_015004
EXOSC7
exosome component 7
chr15_+_80364902 0.100 NM_001242915
NM_001242916
ZFAND6

zinc finger, AN1-type domain 6

chr2_-_47134945 0.099 MCFD2
multiple coagulation factor deficiency 2
chr5_-_77844975 0.098 LHFPL2
lipoma HMGIC fusion partner-like 2
chr6_+_35310399 0.097 PPARD
peroxisome proliferator-activated receptor delta
chr14_-_47812394 0.095 NM_182830
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr6_-_133035180 0.093 NM_004666
VNN1
vanin 1
chr12_-_53012332 0.092 NM_175068
KRT73
keratin 73
chrX_+_110366304 0.090 NM_001128168
NM_001128172
NM_001128173
PAK3


p21 protein (Cdc42/Rac)-activated kinase 3


chr3_+_183770834 0.087 NM_130770
HTR3C
5-hydroxytryptamine (serotonin) receptor 3, family member C
chr6_+_167704802 0.084 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr17_-_42144986 0.084 NM_152344
LSM12
LSM12 homolog (S. cerevisiae)
chr7_-_87342569 0.081 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr7_+_93535819 0.080 NM_021955
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr12_-_50616425 0.079 NM_001113547
LIMA1
LIM domain and actin binding 1
chr4_+_74281884 0.078 ALB
albumin
chr12_+_4699243 0.077 NM_003845
DYRK4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr1_+_186265404 0.077 NM_001127708
NM_001127709
NM_001127710
NM_005807
PRG4



proteoglycan 4



chr14_-_77889231 0.075 NM_001113475
NOXRED1
NADP-dependent oxidoreductase domain containing 1
chr16_+_70557726 0.073 SF3B3
splicing factor 3b, subunit 3, 130kDa
chr9_-_21228132 0.071 NM_021268
IFNA17
interferon, alpha 17
chr19_-_14952688 0.071 NM_001005190
OR7A10
olfactory receptor, family 7, subfamily A, member 10
chr7_+_120965420 0.071 NM_016087
WNT16
wingless-type MMTV integration site family, member 16
chr7_-_113559048 0.070 NM_002711
PPP1R3A
protein phosphatase 1, regulatory subunit 3A
chr3_+_45017749 0.070 EXOSC7
exosome component 7
chr3_+_35722428 0.069 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr10_+_70980058 0.069 NM_025130
HKDC1
hexokinase domain containing 1
chr2_-_100046262 0.068 REV1
REV1 homolog (S. cerevisiae)
chr4_+_88720701 0.066 NM_004967
IBSP
integrin-binding sialoprotein
chr11_-_66488712 0.066 NM_006946
SPTBN2
spectrin, beta, non-erythrocytic 2
chr8_-_80993009 0.066 NM_001025252
TPD52
tumor protein D52
chr7_+_129984629 0.065 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr3_+_52813936 0.064 NM_001166435
NM_001166436
ITIH1

inter-alpha-trypsin inhibitor heavy chain 1

chr5_+_140227356 0.063 NM_014005
NM_031857
PCDHA9

protocadherin alpha 9

chr7_-_128543379 0.063 KCP
kielin/chordin-like protein
chr15_+_40509628 0.063 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr9_-_34620483 0.062 DCTN3
dynactin 3 (p22)
chr17_+_35732927 0.061 NM_173625
C17orf78
chromosome 17 open reading frame 78
chr10_+_63808968 0.061 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr9_+_125376947 0.061 NM_012364
OR1Q1
olfactory receptor, family 1, subfamily Q, member 1
chr11_+_22696318 0.059 NM_005256
GAS2
growth arrest-specific 2
chr10_+_116697914 0.059 NM_139169
TRUB1
TruB pseudouridine (psi) synthase homolog 1 (E. coli)
chr6_+_149887542 0.058 C6orf72
chromosome 6 open reading frame 72
chr12_-_10962673 0.057 NM_023917
TAS2R9
taste receptor, type 2, member 9
chr12_+_21525801 0.057 NM_000415
IAPP
islet amyloid polypeptide
chr12_-_9885859 0.055 NM_001253748
NM_001253750
NM_172004
CLECL1


C-type lectin-like 1


chr2_+_169926084 0.055 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr17_+_39555993 0.054 GAST
gastrin
chr1_+_28764660 0.054 NM_023923
PHACTR4
phosphatase and actin regulator 4
chr5_+_140718353 0.053 NM_018915
NM_032009
PCDHGA2

protocadherin gamma subfamily A, 2

chr11_-_5323174 0.052 NM_033179
OR51B4
olfactory receptor, family 51, subfamily B, member 4
chr3_-_143567163 0.052 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr1_-_20250051 0.052 NM_014589
PLA2G2E
phospholipase A2, group IIE
chr10_+_32856650 0.049 NM_024688
C10orf68
chromosome 10 open reading frame 68
chr7_-_44580857 0.048 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr12_-_54020081 0.048 NM_001130060
NM_001206682
NM_006856
ATF7


activating transcription factor 7


chr4_+_78432905 0.048 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chr3_-_123339423 0.047 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr20_+_31037447 0.047


chr11_+_28131830 0.046 METTL15
methyltransferase like 15
chr3_-_151034514 0.044 NM_023915
GPR87
G protein-coupled receptor 87
chr12_-_91398757 0.043 NM_004950
EPYC
epiphycan
chr20_+_42574535 0.043 NM_001098798
TOX2
TOX high mobility group box family member 2
chrX_-_118726852 0.043 NM_001173488
NKRF
NFKB repressing factor
chrX_+_37639306 0.042 CYBB
cytochrome b-245, beta polypeptide
chr1_+_153190059 0.042 NM_001195571
PRR9
proline rich 9
chr14_+_70918873 0.041 NM_003813
ADAM21
ADAM metallopeptidase domain 21
chr6_+_167536240 0.040 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr1_-_161519817 0.040 NM_000569
NM_001127592
FCGR3A

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

chr5_+_54398473 0.039 NM_006144
GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr5_-_147286064 0.039 NM_206966
C5orf46
chromosome 5 open reading frame 46
chr10_-_56560947 0.038 NM_001142763
NM_001142764
NM_001142765
NM_001142766
NM_001142767
NM_001142768
NM_001142769
NM_001142770
NM_001142771
NM_001142772
NM_001142773
NM_033056
PCDH15











protocadherin-related 15











chr5_-_142815076 0.038 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr17_+_18625335 0.037 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr8_-_27850368 0.036 NM_173833
SCARA5
scavenger receptor class A, member 5 (putative)
chr16_-_48269087 0.036 NM_032583
NM_145186
ABCC11

ATP-binding cassette, sub-family C (CFTR/MRP), member 11

chrX_+_123480131 0.035 NM_001114937
NM_002351
SH2D1A

SH2 domain containing 1A

chr6_-_123957941 0.034 NM_001251987
NM_006073
TRDN

triadin

chr6_-_29455678 0.033 NM_052967
MAS1L
MAS1 oncogene-like
chr1_+_84874033 0.032 NM_058248
DNASE2B
deoxyribonuclease II beta
chr6_+_158733691 0.032 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr1_-_16763887 0.031 NM_198546
SPATA21
spermatogenesis associated 21
chr3_-_69037498 0.029 C3orf64
chromosome 3 open reading frame 64
chr3_+_148447966 0.028 NM_032049
AGTR1
angiotensin II receptor, type 1
chr3_+_115342150 0.027 NM_001130064
NM_002045
GAP43

growth associated protein 43

chr5_-_75919051 0.026 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr17_-_10372875 0.025 NM_017533
MYH4
myosin, heavy chain 4, skeletal muscle
chr11_-_104905849 0.025 CASP1
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr9_-_21239975 0.025 NM_002172
IFNA14
interferon, alpha 14
chrX_+_79277741 0.024 NM_016954
TBX22
T-box 22
chr18_+_31319154 0.024 ASXL3
additional sex combs like 3 (Drosophila)
chr12_-_4488707 0.024 NM_020638
FGF23
fibroblast growth factor 23
chr6_-_138539626 0.024 NM_021635
PBOV1
prostate and breast cancer overexpressed 1
chr6_+_131571298 0.024 NM_004842
NM_138633
AKAP7

A kinase (PRKA) anchor protein 7

chr3_+_11178778 0.024 NM_001098213
HRH1
histamine receptor H1
chr14_-_23504353 0.024 NM_001144932
NM_002797
NM_001130725
PSMB5


proteasome (prosome, macropain) subunit, beta type, 5


chr18_+_28898051 0.023 NM_001942
DSG1
desmoglein 1
chr3_+_52811601 0.023 NM_002215
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chrX_+_118708540 0.023 UBE2A
ubiquitin-conjugating enzyme E2A
chr12_-_57873364 0.022 NM_001080157
ARHGAP9
Rho GTPase activating protein 9
chr4_+_113970784 0.021 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr18_+_61223392 0.021 NM_080474
SERPINB12
serpin peptidase inhibitor, clade B (ovalbumin), member 12
chr1_+_70225857 0.021 NM_020794
LRRC7
leucine rich repeat containing 7
chr18_+_55888799 0.020 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_+_17906941 0.019 NM_001011722
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.27 2.17e-06 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
28.87 2.07e-02 GO:0015643 toxin binding