Motif ID: POU1F1.p2

Z-value: 1.021


Transcription factors associated with POU1F1.p2:

Gene SymbolEntrez IDGene Name
POU1F1 5449 POU class 1 homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
POU1F1chr3_-_873256110.374.6e-02Click!


Activity profile for motif POU1F1.p2.

activity profile for motif POU1F1.p2


Sorted Z-values histogram for motif POU1F1.p2

Sorted Z-values for motif POU1F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU1F1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_20110884 7.257 NM_001141968
NM_130785
NM_199254
TPTE2


transmembrane phosphoinositide 3-phosphatase and tensin homolog 2


chr20_+_31870940 6.807 NM_033197
BPIFB1
BPI fold containing family B, member 1
chr5_+_140220811 4.091 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr16_-_21314371 3.284 NM_001014444
NM_001888
CRYM

crystallin, mu

chr16_+_82068910 2.813 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr16_+_82068830 2.640 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr4_-_16077740 2.413 NM_001145849
NM_001145850
NM_001145851
NM_001145852
NM_006017
PROM1




prominin 1




chr4_-_100273831 2.405 NM_000669
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr4_-_110723334 2.182 NM_000204
CFI
complement factor I
chr14_-_106774311 2.059 IGHA1
immunoglobulin heavy constant alpha 1
chr3_+_361365 1.894 NM_001253388
CHL1
cell adhesion molecule with homology to L1CAM (close homolog of L1)
chr6_+_32407618 1.854 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr3_+_97158453 1.714 NM_173655
EPHA6
EPH receptor A6
chr19_-_9092017 1.694 NM_024690
MUC16
mucin 16, cell surface associated
chr17_-_39165343 1.427 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr8_+_39771327 1.410 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr5_+_156696351 1.410 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr5_-_41213513 1.350 NM_000065
C6
complement component 6
chr6_-_32920812 1.332 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr11_-_102401430 1.331 NM_002423
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr4_-_70080448 1.309 NM_001073
UGT2B11
UGT2B10
UDP glucuronosyltransferase 2 family, polypeptide B11
UDP glucuronosyltransferase 2 family, polypeptide B10
chr6_+_20534686 1.295 NM_017774
CDKAL1
CDK5 regulatory subunit associated protein 1-like 1
chrX_-_131261871 1.267 NM_194277
FRMD7
FERM domain containing 7
chr6_-_52628272 1.257 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr12_-_91573264 1.237 NM_133503
DCN
decorin
chr12_-_14849427 1.201 NM_004963
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr3_+_238274 1.178 NM_001253387
NM_006614
CHL1

cell adhesion molecule with homology to L1CAM (close homolog of L1)

chr12_+_55248298 1.140 NM_058173
MUCL1
mucin-like 1
chr7_+_37723378 1.134


chr6_-_52668599 1.133 NM_145740
GSTA1
glutathione S-transferase alpha 1
chr2_+_102770401 1.123 NM_000877
IL1R1
interleukin 1 receptor, type I
chr4_-_100356449 1.113 NM_000673
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr6_+_16143281 1.106 MYLIP
myosin regulatory light chain interacting protein
chr9_-_70178814 1.100 NM_001126334
FOXD4L5
forkhead box D4-like 5
chr19_+_49199227 1.093 NM_000511
NM_001097638
FUT2

fucosyltransferase 2 (secretor status included)

chr9_-_70429730 1.085 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr6_+_131958441 1.061 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr9_+_42717233 1.044 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr10_+_118187381 1.016 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chrX_-_2882288 1.010 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr11_-_114466397 0.999 FAM55D
family with sequence similarity 55, member D
chr16_-_28620648 0.987 NM_177530
NM_177534
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr2_+_115822246 0.913 NM_001178037
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr1_-_161337663 0.897 NM_001013625
C1orf192
chromosome 1 open reading frame 192
chr8_+_24151579 0.884 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr16_-_23724820 0.874 NM_033266
ERN2
endoplasmic reticulum to nucleus signaling 2
chr20_+_123230 0.827 NM_030931
DEFB126
defensin, beta 126
chr12_-_10282680 0.826 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr16_+_82068958 0.808 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr1_-_89591685 0.805 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr10_+_96443250 0.795 NM_000772
NM_001128925
CYP2C18

cytochrome P450, family 2, subfamily C, polypeptide 18

chr15_-_93632161 0.790 NM_020211
RGMA
RGM domain family, member A
chrX_+_105412297 0.786 NM_001171020
NM_152423
MUM1L1

melanoma associated antigen (mutated) 1-like 1

chr19_+_50796820 0.758 MYH14
myosin, heavy chain 14, non-muscle
chr1_-_93399531 0.740


chr6_-_33041266 0.725 NM_033554
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr11_+_59807747 0.722 NM_173801
PLAC1L
placenta-specific 1-like
chrX_+_7810302 0.718 NM_013452
VCX
variable charge, X-linked
chr19_+_41515495 0.708 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr16_-_28621279 0.695 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr5_+_140602914 0.685 NM_018934
PCDHB14
protocadherin beta 14
chr18_+_59157774 0.679 NM_031891
CDH20
cadherin 20, type 2
chr15_-_45670624 0.676 GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr6_+_116832807 0.665 NM_153711
FAM26E
family with sequence similarity 26, member E
chr3_-_164796275 0.646 NM_001041
SI
sucrase-isomaltase (alpha-glucosidase)
chr13_-_46756295 0.640 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr5_-_149792276 0.640 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr14_-_20774089 0.635 TTC5
tetratricopeptide repeat domain 5
chr4_+_70894129 0.634 NM_000200
HTN3
histatin 3
chrY_-_6742028 0.623 NM_001143
AMELY
amelogenin, Y-linked
chr14_-_20774129 0.621 NM_138376
TTC5
tetratricopeptide repeat domain 5
chr14_-_106641585 0.611 IGHV4-31
IGHA1
IGHA2
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
chr22_+_39883228 0.605 NM_001098270
MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr7_+_107301079 0.604 NM_000441
SLC26A4
solute carrier family 26, member 4
chr7_+_80275967 0.603 CD36
CD36 molecule (thrombospondin receptor)
chr11_-_114466471 0.599 NM_001077639
NM_017678
FAM55D

family with sequence similarity 55, member D

chr4_-_118006731 0.593 NM_152402
TRAM1L1
translocation associated membrane protein 1-like 1
chr2_-_216241321 0.590 FN1
fibronectin 1
chr19_+_52873169 0.590 NM_001145434
ZNF880
zinc finger protein 880
chr9_-_74675498 0.577 NM_001128618
C9orf57
chromosome 9 open reading frame 57
chr12_-_91576579 0.573 DCN
decorin
chr6_-_32557431 0.571 NM_001243965
NM_002124
HLA-DRB1

HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1

major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr7_+_107110501 0.563 NM_005295
GPR22
G protein-coupled receptor 22
chrX_+_125953746 0.560 NM_001122716
CXorf64
chromosome X open reading frame 64
chr7_+_143412938 0.541 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr17_-_38978824 0.525 NM_000421
KRT10
keratin 10
chr1_+_147374945 0.519 NM_005267
GJA8
gap junction protein, alpha 8, 50kDa
chr17_-_38911524 0.514 NM_181534
KRT25
keratin 25
chr12_-_71551564 0.509 TSPAN8
tetraspanin 8
chr6_+_26368405 0.507 NM_001197246
BTN3A2
butyrophilin, subfamily 3, member A2
chr2_+_24807345 0.504 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr13_-_49110117 0.495 RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr7_-_139763520 0.495 NM_022750
PARP12
poly (ADP-ribose) polymerase family, member 12
chr1_-_1711453 0.490 NM_001198994
NADK
NAD kinase
chr19_+_46651499 0.489 NM_001135113
IGFL2
IGF-like family member 2
chr2_-_228244005 0.480 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr4_+_187148624 0.477 NM_000892
KLKB1
kallikrein B, plasma (Fletcher factor) 1
chr20_+_2276612 0.470 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr20_-_45061554 0.467 ELMO2
engulfment and cell motility 2
chrX_+_147800610 0.465 NM_001170628
AFF2
AF4/FMR2 family, member 2
chr11_-_59633942 0.462 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr2_-_88285308 0.461 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr6_+_28109611 0.455 NM_006298
ZNF192
zinc finger protein 192
chr3_-_100712248 0.452 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr11_+_124095343 0.439 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr3_+_113616317 0.436 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr16_+_57050985 0.434 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr2_-_231090443 0.427 NM_001185015
SP110
SP110 nuclear body protein
chr4_-_100212085 0.419 NM_000667
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr7_+_80275634 0.416 NM_001127443
NM_001127444
CD36

CD36 molecule (thrombospondin receptor)

chr9_-_21142143 0.409 NM_002177
IFNW1
interferon, omega 1
chr1_+_160336856 0.404 NM_005598
NHLH1
nescient helix loop helix 1
chr3_+_180320955 0.404 TTC14
tetratricopeptide repeat domain 14
chr1_-_57045214 0.400 PPAP2B
phosphatidic acid phosphatase type 2B
chrX_-_53310748 0.398 NM_001243197
NM_015075
IQSEC2

IQ motif and Sec7 domain 2

chr2_+_87144737 0.396 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr4_-_76944585 0.395 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr19_-_44384240 0.393 NM_001033719
ZNF404
zinc finger protein 404
chr1_+_179965756 0.387 CEP350
centrosomal protein 350kDa
chrX_-_49965657 0.385 NM_003886
AKAP4
A kinase (PRKA) anchor protein 4
chr17_+_3377346 0.383 NM_001128085
ASPA
aspartoacylase
chr2_+_110551965 0.381 NM_005054
RGPD5
RANBP2-like and GRIP domain containing 5
chr4_-_100356290 0.379 NM_001166504
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr17_-_3182267 0.377 NM_002551
OR3A2
olfactory receptor, family 3, subfamily A, member 2
chr2_-_111334677 0.376 NM_005054
RGPD5
RANBP2-like and GRIP domain containing 5
chr5_-_78281688 0.373 NM_198709
ARSB
arylsulfatase B
chr2_-_88427535 0.363 NM_001443
FABP1
fatty acid binding protein 1, liver
chrX_-_33229428 0.359 NM_004006
DMD
dystrophin
chr14_-_107013474 0.357 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr4_-_70518964 0.357 NM_001252274
NM_001252275
NM_006798
UGT2A1


UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus


chr13_-_46756326 0.354 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chrX_-_49121171 0.348 NM_001114377
NM_014009
FOXP3

forkhead box P3

chr7_-_37024664 0.347 NM_001039459
ELMO1
engulfment and cell motility 1
chr3_-_138478184 0.345 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
chr4_-_103998169 0.344 NM_178833
SLC9B2
solute carrier family 9, subfamily B (cation proton antiporter 2), member 2
chr1_-_23521221 0.343 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr6_+_31539875 0.339 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr13_-_38172862 0.338 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr5_+_40909558 0.337 NM_000587
C7
complement component 7
chr15_-_42448769 0.336 NM_213600
PLA2G4F
phospholipase A2, group IVF
chr5_+_40909617 0.331 C7
complement component 7
chr7_-_45018650 0.330 MYO1G
myosin IG
chr14_+_89060729 0.328 NM_207662
ZC3H14
zinc finger CCCH-type containing 14
chr17_-_29641068 0.328 EVI2B
ecotropic viral integration site 2B
chr3_+_121613170 0.327 NM_001145998
NM_021082
SLC15A2

solute carrier family 15 (H+/peptide transporter), member 2

chr12_-_10151689 0.325 NM_001099431
NM_016509
CLEC1B

C-type lectin domain family 1, member B

chr3_-_185270258 0.323 NM_139248
LIPH
lipase, member H
chr1_+_196743929 0.323 NM_001166624
NM_021023
CFHR3

complement factor H-related 3

chrX_-_49965003 0.321 NM_139289
AKAP4
A kinase (PRKA) anchor protein 4
chr7_-_83270746 0.318 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr11_+_18194383 0.318 NM_054032
MRGPRX4
MAS-related GPR, member X4
chr4_-_110723127 0.317 CFI
complement factor I
chr4_-_70505359 0.313 NM_001105677
UGT2A2
UDP glucuronosyltransferase 2 family, polypeptide A2
chr2_+_109204777 0.313 LIMS1
LIM and senescent cell antigen-like domains 1
chr2_-_26700909 0.311 NM_004802
NM_194322
NM_194323
OTOF


otoferlin


chr1_+_162602308 0.309 DDR2
discoidin domain receptor tyrosine kinase 2
chr11_+_67376926 0.307 NDUFV1
NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
chr1_+_152881022 0.305 NM_005547
IVL
involucrin
chr12_+_100867739 0.300 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr19_+_840963 0.300 PRTN3
proteinase 3
chr7_+_80267972 0.299 CD36
CD36 molecule (thrombospondin receptor)
chr8_-_95229530 0.298 NM_001144663
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr9_-_123812535 0.297 NM_001735
C5
complement component 5
chr4_+_100432160 0.296 NM_032149
C4orf17
chromosome 4 open reading frame 17
chr6_+_29913400 0.296


chr1_+_162466963 0.294 NM_001184763
UHMK1
U2AF homology motif (UHM) kinase 1
chr6_-_25930838 0.294 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr4_-_16900028 0.293 LDB2
LIM domain binding 2
chr17_+_33448597 0.292 NM_017559
FNDC8
fibronectin type III domain containing 8
chr19_-_48389514 0.287 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr14_-_106610338 0.287 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chrX_-_8139307 0.285 NM_016378
VCX2
variable charge, X-linked 2
chr7_+_39773165 0.284 LINC00265
long intergenic non-protein coding RNA 265
chr3_-_151102536 0.283 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr17_-_34313685 0.283 NM_032962
NM_032963
CCL14

chemokine (C-C motif) ligand 14

chr7_-_45018677 0.280 NM_033054
MYO1G
myosin IG
chr13_+_97874704 0.280 MBNL2
muscleblind-like 2 (Drosophila)
chr20_+_9288446 0.279 NM_000933
PLCB4
phospholipase C, beta 4
chr1_+_153003677 0.278 NM_003125
SPRR1B
small proline-rich protein 1B
chr6_+_105404922 0.278 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr3_+_88031725 0.278 NM_000866
HTR1F
5-hydroxytryptamine (serotonin) receptor 1F
chr11_+_69061599 0.275 NM_138768
MYEOV
myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas)
chr13_+_99058147 0.274


chr10_+_70502251 0.273 CCAR1
cell division cycle and apoptosis regulator 1
chr4_+_88720701 0.273 NM_004967
IBSP
integrin-binding sialoprotein
chr7_+_80231503 0.272 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr8_-_82395401 0.272 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr17_+_74463629 0.270 NM_001088
AANAT
aralkylamine N-acetyltransferase
chr4_+_74270832 0.270 ALB
albumin
chr7_-_14880954 0.267 NM_004080
NM_145695
DGKB

diacylglycerol kinase, beta 90kDa

chr7_-_45018559 0.267 MYO1G
myosin IG
chr11_+_30252562 0.266 NM_000510
NM_001018080
FSHB

follicle stimulating hormone, beta polypeptide

chr9_-_5968367 0.265


chr6_-_22297729 0.265 NM_000948
PRL
prolactin
chr3_-_195310985 0.263 NM_001647
APOD
apolipoprotein D
chr2_-_171923482 0.261 NM_001136555
TLK1
tousled-like kinase 1
chr9_-_117156684 0.260 NM_030767
AKNA
AT-hook transcription factor
chr9_+_100263461 0.255 NM_001166116
TMOD1
tropomodulin 1
chr7_+_123565908 0.255 NM_001174045
NM_001174046
SPAM1

sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)

chr19_-_46526555 0.255 NM_005091
PGLYRP1
peptidoglycan recognition protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.30 6.27e-06 GO:0006955 immune response
2.20 1.88e-05 GO:0006952 defense response
2.67 2.73e-05 GO:0050776 regulation of immune response
1.83 5.26e-04 GO:0002376 immune system process
3.10 1.49e-03 GO:0002253 activation of immune response
2.57 1.80e-03 GO:0045087 innate immune response
11.33 1.82e-03 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
5.32 3.12e-03 GO:0060333 interferon-gamma-mediated signaling pathway
4.86 8.62e-03 GO:0071346 cellular response to interferon-gamma
3.93 9.30e-03 GO:0002768 immune response-regulating cell surface receptor signaling pathway
2.01 9.75e-03 GO:0002682 regulation of immune system process
2.64 1.10e-02 GO:0050778 positive regulation of immune response
2.99 2.04e-02 GO:0019221 cytokine-mediated signaling pathway
2.23 2.62e-02 GO:0002684 positive regulation of immune system process
3.81 2.69e-02 GO:0002429 immune response-activating cell surface receptor signaling pathway
1.85 4.24e-02 GO:0048584 positive regulation of response to stimulus
4.13 4.79e-02 GO:0034341 response to interferon-gamma

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
13.75 5.20e-05 GO:0042613 MHC class II protein complex
1.53 1.21e-03 GO:0005576 extracellular region
1.32 3.25e-03 GO:0071944 cell periphery
1.43 1.99e-02 GO:0044459 plasma membrane part
6.02 2.88e-02 GO:0042611 MHC protein complex
1.28 2.98e-02 GO:0005886 plasma membrane
1.56 4.33e-02 GO:0031226 intrinsic to plasma membrane
1.57 4.35e-02 GO:0005887 integral to plasma membrane

Nothing significant found in function category.