Motif ID: PRRX1,2.p2

Z-value: 1.652


Transcription factors associated with PRRX1,2.p2:

Gene SymbolEntrez IDGene Name
PRRX1 5396 paired related homeobox 1
PRRX2 51450 paired related homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PRRX1chr1_+_170633312-0.096.4e-01Click!
PRRX2chr9_+_1324279190.077.1e-01Click!


Activity profile for motif PRRX1,2.p2.

activity profile for motif PRRX1,2.p2


Sorted Z-values histogram for motif PRRX1,2.p2

Sorted Z-values for motif PRRX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PRRX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_36050885 19.993 NM_001204197
NBEA
neurobeachin
chr12_-_71551564 15.470 TSPAN8
tetraspanin 8
chr3_+_361365 13.651 NM_001253388
CHL1
cell adhesion molecule with homology to L1CAM (close homolog of L1)
chr6_+_32407618 12.921 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr7_-_16921596 10.638 NM_176813
AGR3
anterior gradient 3 homolog (Xenopus laevis)
chr20_+_9288446 10.560 NM_000933
PLCB4
phospholipase C, beta 4
chr5_-_35938736 9.421 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr20_+_31870940 9.309 NM_033197
BPIFB1
BPI fold containing family B, member 1
chr20_+_9198036 9.153 NM_182797
PLCB4
phospholipase C, beta 4
chr6_-_32557431 8.545 NM_001243965
NM_002124
HLA-DRB1

HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1

major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr5_+_140602914 8.501 NM_018934
PCDHB14
protocadherin beta 14
chr20_+_31823801 8.482 NM_001243193
NM_016583
NM_130852
BPIFA1


BPI fold containing family A, member 1


chr8_-_110661007 8.181 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr8_-_110620220 8.180 SYBU
syntabulin (syntaxin-interacting)
chr8_+_17396285 7.660 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr9_-_34397786 7.389 NM_032596
C9orf24
chromosome 9 open reading frame 24
chr9_-_14086901 7.293 NFIB
nuclear factor I/B
chr18_-_53089722 7.242 NM_001243233
TCF4
transcription factor 4
chr20_+_5987897 6.829 NM_001127458
CRLS1
cardiolipin synthase 1
chr11_+_101918168 6.824 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr1_+_244216506 6.689 NM_006352
ZNF238
zinc finger protein 238
chr16_-_21314371 6.595 NM_001014444
NM_001888
CRYM

crystallin, mu

chr4_-_70505359 6.421 NM_001105677
UGT2A2
UDP glucuronosyltransferase 2 family, polypeptide A2
chr4_+_70861647 6.420 NM_001009181
NM_003154
STATH

statherin

chr3_-_167098070 6.200 NM_001199202
NM_001199201
NM_024687
ZBBX


zinc finger, B-box domain containing


chr7_+_114055048 6.145 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr13_+_43355685 6.009 NM_182508
C13orf30
chromosome 13 open reading frame 30
chr5_-_160279045 5.863 NM_025153
ATP10B
ATPase, class V, type 10B
chr10_+_51549552 5.713 NM_002443
NM_138634
MSMB

microseminoprotein, beta-

chr13_+_24144402 5.595 NM_001204459
NM_148957
TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr6_-_29012951 5.535 NM_030903
OR2W1
olfactory receptor, family 2, subfamily W, member 1
chr8_-_110693233 5.434 NM_001099745
NM_001099746
SYBU

syntabulin (syntaxin-interacting)

chr6_-_32908583 5.351 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr7_-_25268057 5.326 NM_022150
NPVF
neuropeptide VF precursor
chr4_-_100273831 5.190 NM_000669
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr9_-_3223007 4.996


chr4_-_100356449 4.882 NM_000673
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr9_-_75568232 4.853 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr3_+_69812961 4.806 NM_006722
MITF
microphthalmia-associated transcription factor
chrX_+_70765479 4.793 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr17_-_34328530 4.778 CCL14-CCL15
CCL15
CCL14-CCL15 readthrough
chemokine (C-C motif) ligand 15
chr18_-_24722757 4.777 NM_001243848
CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr4_+_186350543 4.777 NM_001114357
C4orf47
chromosome 4 open reading frame 47
chr4_-_41884568 4.774


chr1_-_183622447 4.762 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr1_-_150738255 4.732 CTSS
cathepsin S
chr3_+_113616317 4.728 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr12_-_71551778 4.726 NM_004616
TSPAN8
tetraspanin 8
chr3_+_69812620 4.661 NM_001184967
MITF
microphthalmia-associated transcription factor
chr12_+_41831484 4.580 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr17_+_68071386 4.476 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr12_+_113587547 4.446 NM_001144872
CCDC42B
coiled-coil domain containing 42B
chr16_+_53133063 4.386 CHD9
chromodomain helicase DNA binding protein 9
chr10_+_7745354 4.363 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr18_-_45663667 4.348 NM_001039360
ZBTB7C
zinc finger and BTB domain containing 7C
chr12_+_20963637 4.257 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr6_-_29527477 4.251 UBD
ubiquitin D
chr7_+_116660291 4.178 ST7
suppression of tumorigenicity 7
chr1_-_150738232 4.129 CTSS
cathepsin S
chr4_-_100356290 4.126 NM_001166504
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr4_+_81256873 4.111 NM_001206997
NM_152770
C4orf22

chromosome 4 open reading frame 22

chr8_-_72268720 4.084 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr17_-_34328607 4.040 CCL14-CCL15
CCL14-CCL15 readthrough
chr5_-_137475076 4.033 NM_003551
NME5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chr8_-_110655418 3.953 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr16_+_82068958 3.953 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr16_+_82068910 3.896 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chrX_+_37892786 3.883 NM_001163334
SYTL5
synaptotagmin-like 5
chr16_+_82068830 3.857 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr10_+_94594469 3.812 NM_001013848
EXOC6
exocyst complex component 6
chr3_-_151058439 3.760 NM_176876
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr20_+_9458460 3.749 PLCB4
phospholipase C, beta 4
chr13_+_50589389 3.621 NM_173605
NM_199464
TRIM13
KCNRG

tripartite motif containing 13
potassium channel regulator

chr17_+_9479943 3.614 NM_001080556
NM_145054
WDR16

WD repeat domain 16

chr6_+_16143281 3.606 MYLIP
myosin regulatory light chain interacting protein
chr10_-_32667543 3.571 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr11_+_71900958 3.556 NM_000802
FOLR1
folate receptor 1 (adult)
chr6_-_79675672 3.548 PHIP
pleckstrin homology domain interacting protein
chrX_-_44202834 3.546 NM_025184
EFHC2
EF-hand domain (C-terminal) containing 2
chr4_+_71108304 3.528 NM_005212
CSN3
casein kappa
chr9_-_75567915 3.526 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr3_-_114478117 3.516 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr5_+_36606667 3.477 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr19_+_13134782 3.469 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr12_-_10282680 3.464 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr13_-_36429798 3.277 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr11_+_71900601 3.224 NM_016724
NM_016725
FOLR1

folate receptor 1 (adult)

chr8_-_17555158 3.160 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr2_-_99279935 3.158 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr3_-_114790221 3.147 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr14_-_92413738 2.983 FBLN5
fibulin 5
chr5_-_13944588 2.973 NM_001369
DNAH5
dynein, axonemal, heavy chain 5
chr5_+_140207562 2.912 NM_018909
NM_031848
NM_031849
PCDHA6


protocadherin alpha 6


chr5_+_36606456 2.860 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr1_+_61547625 2.836 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr10_-_116418056 2.827 NM_002313
ABLIM1
actin binding LIM protein 1
chr3_-_151102536 2.805 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr4_+_77356252 2.802 NM_020859
SHROOM3
shroom family member 3
chr5_+_94727047 2.782 NM_152548
FAM81B
family with sequence similarity 81, member B
chr21_+_30400229 2.775 USP16
ubiquitin specific peptidase 16
chr4_-_70518964 2.744 NM_001252274
NM_001252275
NM_006798
UGT2A1


UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus


chr11_-_26593667 2.737 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr2_+_8822112 2.732 NM_002166
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr1_+_167298382 2.703 POU2F1
POU class 2 homeobox 1
chr14_-_20774129 2.699 NM_138376
TTC5
tetratricopeptide repeat domain 5
chr17_+_48821106 2.694 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr16_-_21289571 2.682 CRYM
crystallin, mu
chr6_-_55740358 2.666 NM_021073
BMP5
bone morphogenetic protein 5
chr4_-_110723334 2.647 NM_000204
CFI
complement factor I
chr5_+_140213968 2.602 NM_018910
NM_031852
PCDHA7

protocadherin alpha 7

chr6_-_130031278 2.577 NM_033515
ARHGAP18
Rho GTPase activating protein 18
chr2_+_24807345 2.572 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr14_-_20774089 2.564 TTC5
tetratricopeptide repeat domain 5
chr17_-_10421858 2.560 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr14_-_54423448 2.547 NM_001202
NM_130850
BMP4

bone morphogenetic protein 4

chr4_+_72204769 2.526 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr1_-_161337663 2.525 NM_001013625
C1orf192
chromosome 1 open reading frame 192
chr2_-_216946463 2.525 NM_018441
PECR
peroxisomal trans-2-enoyl-CoA reductase
chr16_+_69680959 2.524 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr6_+_131958441 2.520 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr22_-_36013303 2.513 NM_005368
NM_203378
MB

myoglobin

chr11_-_46867788 2.499 CKAP5
cytoskeleton associated protein 5
chr17_+_72667255 2.496 NM_175738
RAB37
RAB37, member RAS oncogene family
chr10_-_21435487 2.496 NM_001010896
NM_001177483
C10orf113

chromosome 10 open reading frame 113

chr2_-_133429069 2.467 NM_001077427
LYPD1
LY6/PLAUR domain containing 1
chr10_-_69597768 2.456 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr6_-_55740387 2.447 BMP5
bone morphogenetic protein 5
chr3_+_151488214 2.440 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr10_+_695887 2.435 C10orf108
chromosome 10 open reading frame 108
chr6_-_119252887 2.433 NM_017696
MCM9
minichromosome maintenance complex component 9
chr16_-_21289637 2.410 CRYM
crystallin, mu
chr10_+_69869249 2.404 NM_032578
MYPN
myopalladin
chr3_-_187452669 2.402 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chrX_-_13835012 2.397 GPM6B
glycoprotein M6B
chr3_-_187463227 2.394 BCL6
B-cell CLL/lymphoma 6
chr3_+_171561138 2.378 NM_001164436
TMEM212
transmembrane protein 212
chr12_+_74931550 2.361 NM_001136262
ATXN7L3B
ataxin 7-like 3B
chr1_-_217250230 2.351 NM_001243507
NM_001243509
ESRRG

estrogen-related receptor gamma

chr7_+_141695678 2.334 NM_004668
MGAM
maltase-glucoamylase (alpha-glucosidase)
chr5_+_140220811 2.333 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr1_+_196621007 2.330 NM_000186
NM_001014975
CFH

complement factor H

chr3_+_63638343 2.330 NM_001080537
SNTN
sentan, cilia apical structure protein
chr9_-_5968367 2.320


chr1_+_183774214 2.318 RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr13_+_99058147 2.299


chr8_-_102803196 2.294 NCALD
neurocalcin delta
chr3_-_114102488 2.267 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr3_+_108541544 2.262 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr5_+_36608430 2.256 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr12_-_105322056 2.242 NM_032148
SLC41A2
solute carrier family 41, member 2
chrX_+_36254050 2.214 NM_001098843
CXorf30
chromosome X open reading frame 30
chr1_+_61547388 2.212 NM_001145512
NFIA
nuclear factor I/A
chr5_-_54468833 2.210 NM_001145734
NM_001170402
NM_152623
CDC20B


cell division cycle 20 homolog B (S. cerevisiae)


chr1_-_150738292 2.208 NM_001199739
NM_004079
CTSS

cathepsin S

chr17_-_39165343 2.206 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr4_+_41700736 2.180 LIMCH1
LIM and calponin homology domains 1
chr7_-_130080823 2.173 NM_018718
CEP41
centrosomal protein 41kDa
chr7_+_90339146 2.173 CDK14
cyclin-dependent kinase 14
chr7_+_23286386 2.161 GPNMB
glycoprotein (transmembrane) nmb
chr4_-_16077740 2.159 NM_001145849
NM_001145850
NM_001145851
NM_001145852
NM_006017
PROM1




prominin 1




chr7_+_23286384 2.155 GPNMB
glycoprotein (transmembrane) nmb
chr11_-_108464344 2.142 NM_015065
EXPH5
exophilin 5
chr6_-_32497925 2.140 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr10_+_114133838 2.132 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr9_-_86584079 2.117 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr2_-_44586854 2.106 NM_001042385
NM_001042386
PREPL

prolyl endopeptidase-like

chr6_+_32709162 2.082 NM_020056
HLA-DQA1
HLA-DQA2
major histocompatibility complex, class II, DQ alpha 1
major histocompatibility complex, class II, DQ alpha 2
chr10_+_114133775 2.077 ACSL5
acyl-CoA synthetase long-chain family member 5
chr8_-_17579729 2.076 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr11_-_85425790 2.075 NM_032379
SYTL2
synaptotagmin-like 2
chr6_-_76203256 2.066 NM_015687
FILIP1
filamin A interacting protein 1
chr2_-_135782246 2.048 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr22_+_23487512 2.036 NM_004914
RAB36
RAB36, member RAS oncogene family
chr6_-_87804773 2.036 NM_000735
NM_001252383
CGA

glycoprotein hormones, alpha polypeptide

chr1_+_61869699 2.031 NFIA
nuclear factor I/A
chr7_+_23286390 2.019 GPNMB
glycoprotein (transmembrane) nmb
chr3_-_183273407 2.018 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr6_+_90276556 2.015 NM_001242814
ANKRD6
ankyrin repeat domain 6
chr21_-_35884503 2.013 KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr1_+_236681513 2.006 NM_201545
LGALS8
lectin, galactoside-binding, soluble, 8
chr4_-_177116713 2.003 NM_144644
SPATA4
spermatogenesis associated 4
chr5_+_67586466 1.979 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr9_-_34381497 1.977 NM_001252195
NM_147168
NM_147169
C9orf24


chromosome 9 open reading frame 24


chr9_-_124989755 1.974 NM_001242334
LHX6
LIM homeobox 6
chr2_-_211018294 1.972 C2orf67
chromosome 2 open reading frame 67
chr7_+_23286277 1.966 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr6_+_159070994 1.957 NM_001009991
NM_001242384
NM_001242394
NM_001242395
SYTL3



synaptotagmin-like 3



chr1_-_216896640 1.954 NM_001243515
NM_001243518
NM_001243519
NM_001438
ESRRG



estrogen-related receptor gamma



chr1_-_23886284 1.951 NM_002167
ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr5_-_54529424 1.943 NM_021147
CCNO
cyclin O
chr3_+_69915374 1.939 NM_198177
MITF
microphthalmia-associated transcription factor
chr4_-_46996423 1.935 NM_000809
GABRA4
gamma-aminobutyric acid (GABA) A receptor, alpha 4
chr10_+_7745325 1.926 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr19_-_41356193 1.908 NM_000762
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr8_-_102803438 1.906 NM_032041
NCALD
neurocalcin delta
chr14_+_89060729 1.900 NM_207662
ZC3H14
zinc finger CCCH-type containing 14
chr2_-_234474197 1.890 NM_018218
USP40
ubiquitin specific peptidase 40
chr1_-_152131703 1.871 NM_001122965
RPTN
repetin
chr10_-_116392099 1.870 ABLIM1
actin binding LIM protein 1
chr5_-_124080773 1.864 NM_020747
ZNF608
zinc finger protein 608

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.28 6.15e-05 GO:0090304 nucleic acid metabolic process
1.30 2.21e-04 GO:0016070 RNA metabolic process
1.29 3.91e-04 GO:0010467 gene expression
1.51 4.98e-04 GO:0006396 RNA processing
1.16 1.35e-03 GO:0044260 cellular macromolecule metabolic process
1.64 3.04e-03 GO:0016568 chromatin modification
2.03 6.93e-03 GO:0007156 homophilic cell adhesion
1.20 8.24e-03 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.36 1.05e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.06 1.13e-02 GO:0009987 cellular process
1.13 1.84e-02 GO:0043170 macromolecule metabolic process
1.55 2.73e-02 GO:0006397 mRNA processing
1.17 2.81e-02 GO:0034641 cellular nitrogen compound metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.17 2.52e-08 GO:0005634 nucleus
1.08 4.75e-08 GO:0005622 intracellular
1.08 1.03e-06 GO:0044424 intracellular part
1.10 1.69e-06 GO:0043231 intracellular membrane-bounded organelle
1.32 1.88e-06 GO:0031981 nuclear lumen
1.10 1.89e-06 GO:0043227 membrane-bounded organelle
1.27 8.81e-06 GO:0044428 nuclear part
1.09 2.68e-05 GO:0043226 organelle
1.09 2.97e-05 GO:0043229 intracellular organelle
1.34 3.83e-05 GO:0005654 nucleoplasm
1.25 6.93e-05 GO:0070013 intracellular organelle lumen
1.24 8.09e-05 GO:0043233 organelle lumen
1.24 1.19e-04 GO:0031974 membrane-enclosed lumen
1.41 1.33e-03 GO:0044451 nucleoplasm part
3.97 3.59e-02 GO:0042613 MHC class II protein complex
1.41 4.46e-02 GO:0005730 nucleolus

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.18 1.03e-03 GO:0003676 nucleic acid binding
1.32 7.23e-03 GO:0030528 transcription regulator activity
1.05 1.05e-02 GO:0005488 binding
1.09 1.08e-02 GO:0005515 protein binding
1.35 1.46e-02 GO:0003723 RNA binding