Motif ID: REST.p3

Z-value: 1.001


Transcription factors associated with REST.p3:

Gene SymbolEntrez IDGene Name
REST 5978 RE1-silencing transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RESTchr4_+_57775064,
chr4_+_57774035		-0.587.5e-04Click!


Activity profile for motif REST.p3.

activity profile for motif REST.p3


Sorted Z-values histogram for motif REST.p3

Sorted Z-values for motif REST.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of REST.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 148 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_153141284 2.404 L1CAM
L1 cell adhesion molecule
chr3_+_9745509 1.835 NM_153635
 CPNE9
copine family member IX
chr20_+_62328068 1.677 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr6_+_35773070 1.598 NM_182548
 LHFPL5
lipoma HMGIC fusion partner-like 5
chr8_-_91094924 1.564 NM_004929
 CALB1
calbindin 1, 28kDa
chr12_-_29936685 1.453 NM_001193451
 TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr5_+_33936490 1.415 NM_016568
 RXFP3
relaxin/insulin-like family peptide receptor 3
chr7_+_145813452 1.380 NM_014141
 CNTNAP2
contactin associated protein-like 2
chr20_+_62328002 1.351 NM_003823
 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr4_+_8582216 1.323 NM_080819
 GPR78
G protein-coupled receptor 78
chr12_-_29937691 1.204 NM_175861
 TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr9_+_135457974 1.167 NM_020064
 BARHL1
BarH-like homeobox 1
chr5_-_151304322 1.105 NM_000171
NM_001146040
 GLRA1

glycine receptor, alpha 1

chr2_+_115199898 1.005 NM_020868
 DPP10
dipeptidyl-peptidase 10 (non-functional)
chr1_-_241520467 0.884 NM_002924
 RGS7
regulator of G-protein signaling 7
chr2_-_51259239 0.863 NRXN1
neurexin 1
chr15_-_27018917 0.821 NM_021912
 GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr4_+_158141735 0.818 NM_000826
NM_001083619
NM_001083620
 GRIA2


glutamate receptor, ionotropic, AMPA 2


chr11_+_62380212 0.798 NM_000327
 ROM1
retinal outer segment membrane protein 1
chr4_-_175750377 0.791 NM_001042543
NM_006529
 GLRA3

glycine receptor, alpha 3


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 22 entries
enrichment   p-value GO term description
37.12 3.14e-02 GO:0051954 positive regulation of amine transport
17.40 3.90e-02 GO:0051952 regulation of amine transport
12.77 2.18e-02 GO:0007269 neurotransmitter secretion
10.98 8.74e-03 GO:0001505 regulation of neurotransmitter levels
10.63 2.10e-03 GO:0003001 generation of a signal involved in cell-cell signaling
10.63 2.10e-03 GO:0023061 signal release
10.39 5.02e-04 GO:0051969 regulation of transmission of nerve impulse
9.47 2.03e-02 GO:0006836 neurotransmitter transport
9.40 1.07e-03 GO:0031644 regulation of neurological system process
8.63 3.42e-02 GO:0050804 regulation of synaptic transmission
6.86 1.83e-07 GO:0007268 synaptic transmission
6.47 1.36e-07 GO:0019226 transmission of nerve impulse
6.47 1.36e-07 GO:0035637 multicellular organismal signaling
5.59 5.95e-03 GO:0007610 behavior
4.84 2.13e-04 GO:0007186 G-protein coupled receptor protein signaling pathway
4.80 3.67e-03 GO:0046903 secretion
4.33 2.29e-02 GO:0055082 cellular chemical homeostasis
4.23 1.00e-04 GO:0007267 cell-cell signaling
3.51 2.69e-06 GO:0050877 neurological system process
3.37 1.39e-03 GO:0007154 cell communication

Gene overrepresentation in compartment category:

Showing 1 to 20 of 30 entries
enrichment   p-value GO term description
21.45 3.95e-05 GO:0030672 synaptic vesicle membrane
14.80 7.79e-06 GO:0008021 synaptic vesicle
13.25 1.15e-04 GO:0030665 clathrin coated vesicle membrane
11.92 4.17e-02 GO:0034707 chloride channel complex
9.80 8.74e-04 GO:0030662 coated vesicle membrane
9.00 8.38e-05 GO:0030136 clathrin-coated vesicle
8.13 4.50e-02 GO:0019717 synaptosome
7.83 3.39e-07 GO:0044456 synapse part
7.62 4.51e-03 GO:0045211 postsynaptic membrane
7.49 8.06e-06 GO:0030659 cytoplasmic vesicle membrane
7.36 4.47e-04 GO:0030135 coated vesicle
7.24 1.17e-05 GO:0012506 vesicle membrane
6.64 2.47e-07 GO:0045202 synapse
6.22 6.05e-05 GO:0044433 cytoplasmic vesicle part
6.00 2.03e-02 GO:0030425 dendrite
5.42 3.76e-02 GO:0034702 ion channel complex
5.05 5.31e-04 GO:0043005 neuron projection
4.55 4.79e-05 GO:0030054 cell junction
3.77 5.52e-04 GO:0016023 cytoplasmic membrane-bounded vesicle
3.70 7.01e-04 GO:0031988 membrane-bounded vesicle

Gene overrepresentation in function category:

Showing 1 to 17 of 17 entries
enrichment   p-value GO term description
80.42 2.90e-02 GO:0016933 extracellular-glycine-gated ion channel activity
80.42 2.90e-02 GO:0016934 extracellular-glycine-gated chloride channel activity
64.34 4.82e-02 GO:0022824 transmitter-gated ion channel activity
64.34 4.82e-02 GO:0022835 transmitter-gated channel activity
37.12 8.11e-03 GO:0016594 glycine binding
22.99 3.64e-02 GO:0005184 neuropeptide hormone activity
20.54 5.50e-05 GO:0005231 excitatory extracellular ligand-gated ion channel activity
15.65 3.90e-05 GO:0005230 extracellular ligand-gated ion channel activity
9.02 1.61e-03 GO:0015276 ligand-gated ion channel activity
9.02 1.61e-03 GO:0022834 ligand-gated channel activity
4.82 1.36e-02 GO:0022836 gated channel activity
4.23 1.63e-02 GO:0005216 ion channel activity
4.17 1.85e-02 GO:0022838 substrate-specific channel activity
4.11 1.96e-04 GO:0005509 calcium ion binding
4.04 2.37e-02 GO:0015267 channel activity
4.03 2.42e-02 GO:0022803 passive transmembrane transporter activity
2.70 8.12e-03 GO:0005215 transporter activity