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• Activity deltas table
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Motif ID: REST.p3

Z-value: 1.001

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chrX_-_153141284	2.404		L1CAM	L1 cell adhesion molecule
chr3_+_9745509	1.835	NM_153635	CPNE9	copine family member IX
chr20_+_62328068	1.677		TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy
chr6_+_35773070	1.598	NM_182548	LHFPL5	lipoma HMGIC fusion partner-like 5
chr8_-_91094924	1.564	NM_004929	CALB1	calbindin 1, 28kDa
chr12_-_29936685	1.453	NM_001193451	TMTC1	transmembrane and tetratricopeptide repeat containing 1
chr5_+_33936490	1.415	NM_016568	RXFP3	relaxin/insulin-like family peptide receptor 3
chr7_+_145813452	1.380	NM_014141	CNTNAP2	contactin associated protein-like 2
chr20_+_62328002	1.351	NM_003823	TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy
chr4_+_8582216	1.323	NM_080819	GPR78	G protein-coupled receptor 78
chr12_-_29937691	1.204	NM_175861	TMTC1	transmembrane and tetratricopeptide repeat containing 1
chr9_+_135457974	1.167	NM_020064	BARHL1	BarH-like homeobox 1
chr5_-_151304322	1.105	NM_000171 NM_001146040	GLRA1	glycine receptor, alpha 1
chr2_+_115199898	1.005	NM_020868	DPP10	dipeptidyl-peptidase 10 (non-functional)
chr1_-_241520467	0.884	NM_002924	RGS7	regulator of G-protein signaling 7
chr2_-_51259239	0.863		NRXN1	neurexin 1
chr15_-_27018917	0.821	NM_021912	GABRB3	gamma-aminobutyric acid (GABA) A receptor, beta 3
chr4_+_158141735	0.818	NM_000826 NM_001083619 NM_001083620	GRIA2	glutamate receptor, ionotropic, AMPA 2
chr11_+_62380212	0.798	NM_000327	ROM1	retinal outer segment membrane protein 1
chr4_-_175750377	0.791	NM_001042543 NM_006529	GLRA3	glycine receptor, alpha 3
chr10_-_50970321	0.779	NM_001143996 NM_001143997 NM_018245	OGDHL	oxoglutarate dehydrogenase-like
chrX_-_47479229	0.777	NM_006950 NM_133499	SYN1	synapsin I
chr10_+_99609994	0.766	NM_001010917	GOLGA7B	golgin A7 family, member B
chr3_-_131753757	0.756	NM_130808	CPNE4	copine IV
chrX_-_47479095	0.752
chr6_+_25652373	0.746	NM_006998	SCGN	secretagogin, EF-hand calcium binding protein
chr14_+_93389444	0.745	NM_001275	CHGA	chromogranin A (parathyroid secretory protein 1)
chr9_-_74061819	0.730		TRPM3	transient receptor potential cation channel, subfamily M, member 3
chr7_-_100808832	0.728	NM_003378	VGF	VGF nerve growth factor inducible
chr1_+_33352071	0.727	NM_002143	HPCA	hippocalcin
chr12_+_113229548	0.726	NM_001143854 NM_014954	RPH3A	rabphilin 3A homolog (mouse)
chr5_+_175298604	0.708		CPLX2	complexin 2
chr7_-_19812403	0.678	NM_152774	TMEM196	transmembrane protein 196
chr19_+_34175433	0.675	NM_022467	CHST8	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr15_-_32162778	0.666		OTUD7A	OTU domain containing 7A
chr17_+_30813928	0.652	NM_003885	CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr10_+_73555527	0.642	NM_001171933 NM_001171934	CDH23	cadherin-related 23
chr16_+_67686813	0.639		RLTPR	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr3_-_48700317	0.620	NM_001407	CELSR3	cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr1_-_151689246	0.609	NM_007185	CELF3	CUGBP, Elav-like family member 3
chr9_+_140033588	0.583	NM_000832 NM_001185090 NM_001185091 NM_007327 NM_021569	GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1
chr5_+_71014989	0.576	NM_004291	CARTPT	CART prepropeptide
chr19_+_41036367	0.558	NM_025213	SPTBN4	spectrin, beta, non-erythrocytic 4
chr19_-_3971089	0.555		DAPK3	death-associated protein kinase 3
chr19_-_3971032	0.552		DAPK3	death-associated protein kinase 3
chr1_-_102462371	0.528		OLFM3	olfactomedin 3
chr12_+_113796370	0.520	NM_001159727 NM_173542	PLBD2	phospholipase B domain containing 2
chr5_+_175298492	0.513	NM_001008220	CPLX2	complexin 2
chr10_-_102790877	0.509	NM_001195263 NM_024895	PDZD7	PDZ domain containing 7
chr11_+_22359666	0.496	NM_020346	SLC17A6	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chrX_-_153141398	0.477	NM_000425 NM_001143963 NM_024003	L1CAM	L1 cell adhesion molecule
chrX_-_49056638	0.468	NM_003179	SYP	synaptophysin
chr20_+_44657812	0.456	NM_020708	SLC12A5	solute carrier family 12 (potassium/chloride transporter), member 5
chr20_-_62284701	0.450	NM_015894	STMN3	stathmin-like 3
chr8_+_57358361	0.436
chr2_-_27531113	0.434	NM_003353	UCN	urocortin
chr6_+_110300197	0.434	NM_005284	GPR6	G protein-coupled receptor 6
chr14_+_93389491	0.425		CHGA	chromogranin A (parathyroid secretory protein 1)
chr1_+_154540250	0.421	NM_000748	CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)
chr10_-_102790850	0.412		PDZD7	PDZ domain containing 7
chr15_-_72612497	0.398	NM_052840	CELF6	CUGBP, Elav-like family member 6
chr12_+_113796374	0.367		PLBD2	phospholipase B domain containing 2
chr1_-_241520384	0.361		RGS7	regulator of G-protein signaling 7
chr1_-_102462789	0.358	NM_058170	OLFM3	olfactomedin 3
chr20_-_60795270	0.334	NM_007232	HRH3	histamine receptor H3
chr9_-_104357202	0.323	NM_147180	PPP3R2	protein phosphatase 3, regulatory subunit B, beta
chr16_+_24267474	0.323		CACNG3	calcium channel, voltage-dependent, gamma subunit 3
chr16_+_5008317	0.320	NM_014692	SEC14L5	SEC14-like 5 (S. cerevisiae)
chr5_-_176037091	0.311	NM_052899	GPRIN1	G protein regulated inducer of neurite outgrowth 1
chr14_-_74892804	0.298	NM_001105579	SYNDIG1L	synapse differentiation inducing 1-like
chr19_-_40724272	0.297	NM_152479	TTC9B	tetratricopeptide repeat domain 9B
chr2_-_51259536	0.290	NM_001135659 NM_004801	NRXN1	neurexin 1
chr11_-_75141210	0.282		KLHL35	kelch-like 35 (Drosophila)
chr1_+_210111537	0.273	NM_001146261 NM_001146262 NM_001146264 NM_153262	SYT14	synaptotagmin XIV
chr11_-_75141015	0.272		KLHL35	kelch-like 35 (Drosophila)
chr12_+_119419299	0.272	NM_194286	SRRM4	serine/arginine repetitive matrix 4
chr15_-_72612247	0.271	NM_001172684	CELF6	CUGBP, Elav-like family member 6
chr15_-_83378488	0.266	NM_004644	AP3B2	adaptor-related protein complex 3, beta 2 subunit
chr11_-_75141517	0.262	NM_001039548	KLHL35	kelch-like 35 (Drosophila)
chr19_+_4769144	0.241		MIR7-3HG	MIR7-3 host gene (non-protein coding)
chr16_+_24267672	0.229		CACNG3	calcium channel, voltage-dependent, gamma subunit 3
chr14_-_51561657	0.223		TRIM9	tripartite motif containing 9
chr10_+_26505235	0.223	NM_000818 NM_001134366	GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr20_+_44657858	0.215		SLC12A5	solute carrier family 12 (potassium/chloride transporter), member 5
chr17_+_42385780	0.201	NM_001144825 NM_001144826 NM_006695	RUNDC3A	RUN domain containing 3A
chr17_-_3337134	0.200	NM_003554	OR1E2	olfactory receptor, family 1, subfamily E, member 2
chr11_-_66115016	0.196	NM_006876	B3GNT1	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr6_+_153071931	0.188	NM_003381 NM_194435	VIP	vasoactive intestinal peptide
chr15_-_72612127	0.187		CELF6	CUGBP, Elav-like family member 6
chr1_-_13184325	0.180	NM_001136561	LOC440563	heterogeneous nuclear ribonucleoprotein C-like
chr17_-_27332888	0.178	NM_001098635 NM_178860	SEZ6	seizure related 6 homolog (mouse)
chr6_+_138725314	0.175	NM_014320	HEBP2	heme binding protein 2
chr17_+_80332152	0.168	NM_018949	UTS2R	urotensin 2 receptor
chr11_+_637268	0.160	NM_000797	DRD4	dopamine receptor D4
chr6_+_43149925	0.158		CUL9	cullin 9
chr10_+_26505593	0.155		GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr8_-_145559831	0.154	NM_031309	SCRT1	scratch homolog 1, zinc finger protein (Drosophila)
chr1_-_153123426	0.152	NM_001014291	SPRR2G	small proline-rich protein 2G
chr12_+_71833518	0.149		LGR5	leucine-rich repeat containing G protein-coupled receptor 5
chr9_-_139096954	0.147	NM_178138	LHX3	LIM homeobox 3
chr1_+_210111575	0.147		SYT14	synaptotagmin XIV
chr14_-_94759594	0.142	NM_001100607	SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr19_-_45737466	0.130	NM_138568	EXOC3L2	exocyst complex component 3-like 2
chr9_-_131038196	0.126	NM_004486	GOLGA2	golgin A2
chr6_+_138725458	0.118		HEBP2	heme binding protein 2
chr2_-_42720476	0.115		KCNG3	potassium voltage-gated channel, subfamily G, member 3
chr12_-_99288502	0.107	NM_001204065 NM_001204079 NM_001204080 NM_001204081	ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B
chr1_-_33336289	0.098	NM_001171940 NM_153756	FNDC5	fibronectin type III domain containing 5
chr20_+_33814538	0.096	NM_006690	MMP24	matrix metallopeptidase 24 (membrane-inserted)
chr5_+_175298538	0.094		CPLX2	complexin 2
chr6_-_71666740	0.084	NM_080742	B3GAT2	beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)
chr3_+_120627026	0.084	NM_014980	STXBP5L	syntaxin binding protein 5-like
chr11_-_125773086	0.084	NM_031307	PUS3	pseudouridylate synthase 3
chr2_+_131513782	0.081	NM_001105194 NM_001105195	FAM123C	family with sequence similarity 123C
chr17_-_3599487	0.070	NM_001204519 NM_001204520 NM_002561 NM_175080	P2RX5-TAX1BP3 P2RX5	P2RX5-TAX1BP3 readthrough purinergic receptor P2X, ligand-gated ion channel, 5
chr16_+_69345250	0.060	NM_013245	VPS4A	vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr6_+_44238479	0.058	NM_001137560	TMEM151B	transmembrane protein 151B
chr14_-_58332591	0.057	NM_001206920	SLC35F4	solute carrier family 35, member F4
chr15_-_60884615	0.057	NM_134262	RORA	RAR-related orphan receptor A
chr16_+_2510080	0.057	NM_025108	C16orf59	chromosome 16 open reading frame 59
chr11_+_134123406	0.056	NM_014384	ACAD8	acyl-CoA dehydrogenase family, member 8
chr18_-_40857245	0.054	NM_020783	SYT4	synaptotagmin IV
chr5_+_141303366	0.053	NM_001142603 NM_014773	KIAA0141	KIAA0141
chr3_+_52812438	0.052	NM_001166434	ITIH1	inter-alpha-trypsin inhibitor heavy chain 1
chrX_+_153237990	0.051	NM_003492	TMEM187	transmembrane protein 187
chr19_+_15197790	0.046	NM_001004713	OR1I1	olfactory receptor, family 1, subfamily I, member 1
chr6_+_43149905	0.045	NM_015089	CUL9	cullin 9
chr9_-_123812535	0.045	NM_001735	C5	complement component 5
chr1_-_209825797	0.042	NM_000228	LAMB3	laminin, beta 3
chr6_+_43603554	0.039	NM_014628	MAD2L1BP	MAD2L1 binding protein
chr1_+_25071906	0.038		CLIC4	chloride intracellular channel 4
chr17_-_3301703	0.037	NM_003553	OR1E1	olfactory receptor, family 1, subfamily E, member 1
chr11_-_1769086	0.028		IFITM10	interferon induced transmembrane protein 10
chr1_+_212606194	0.026	NM_013349	NENF	neudesin neurotrophic factor
chr11_+_32112607	0.022		RCN1	reticulocalbin 1, EF-hand calcium binding domain
chr8_+_68864341	0.015		PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr11_-_6676851	0.014	NM_003737	DCHS1	dachsous 1 (Drosophila)
chr16_+_70147528	0.012	NM_017990	PDPR	pyruvate dehydrogenase phosphatase regulatory subunit
chr22_-_18256748	0.012	NM_001244572 NM_197966	BID	BH3 interacting domain death agonist
chr6_+_43603588	0.011		MAD2L1BP	MAD2L1 binding protein
chr1_-_20834609	0.011	NM_024544	MUL1	mitochondrial E3 ubiquitin protein ligase 1
chr22_+_20008633	0.010		C22orf25	chromosome 22 open reading frame 25
chr1_-_20834516	0.009		MUL1	mitochondrial E3 ubiquitin protein ligase 1
chr3_+_193853937	0.007		HES1	hairy and enhancer of split 1, (Drosophila)
chr1_-_241683011	0.005		FH	fumarate hydratase
chr10_+_102790984	0.004	NM_030971	SFXN3	sideroflexin 3
chr8_+_68864589	0.002	NM_024870 NM_025170	PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr15_+_94774763	0.000		MCTP2	multiple C2 domains, transmembrane 2

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
6.47	1.36e-07	GO:0019226	transmission of nerve impulse
6.47	1.36e-07	GO:0035637	multicellular organismal signaling
6.86	1.83e-07	GO:0007268	synaptic transmission
3.51	2.69e-06	GO:0050877	neurological system process
3.02	1.87e-05	GO:0003008	system process
4.23	1.00e-04	GO:0007267	cell-cell signaling
4.84	2.13e-04	GO:0007186	G-protein coupled receptor protein signaling pathway
10.39	5.02e-04	GO:0051969	regulation of transmission of nerve impulse
9.40	1.07e-03	GO:0031644	regulation of neurological system process
3.37	1.39e-03	GO:0007154	cell communication
10.63	2.10e-03	GO:0003001	generation of a signal involved in cell-cell signaling
10.63	2.10e-03	GO:0023061	signal release
4.80	3.67e-03	GO:0046903	secretion
5.59	5.95e-03	GO:0007610	behavior
10.98	8.74e-03	GO:0001505	regulation of neurotransmitter levels
1.88	1.33e-02	GO:0023052	signaling
9.47	2.03e-02	GO:0006836	neurotransmitter transport
12.77	2.18e-02	GO:0007269	neurotransmitter secretion
4.33	2.29e-02	GO:0055082	cellular chemical homeostasis
37.12	3.14e-02	GO:0051954	positive regulation of amine transport
8.63	3.42e-02	GO:0050804	regulation of synaptic transmission
17.40	3.90e-02	GO:0051952	regulation of amine transport

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
6.64	2.47e-07	GO:0045202	synapse
7.83	3.39e-07	GO:0044456	synapse part
14.80	7.79e-06	GO:0008021	synaptic vesicle
7.49	8.06e-06	GO:0030659	cytoplasmic vesicle membrane
7.24	1.17e-05	GO:0012506	vesicle membrane
21.45	3.95e-05	GO:0030672	synaptic vesicle membrane
4.55	4.79e-05	GO:0030054	cell junction
6.22	6.05e-05	GO:0044433	cytoplasmic vesicle part
9.00	8.38e-05	GO:0030136	clathrin-coated vesicle
13.25	1.15e-04	GO:0030665	clathrin coated vesicle membrane
7.36	4.47e-04	GO:0030135	coated vesicle
2.38	4.60e-04	GO:0044459	plasma membrane part
5.05	5.31e-04	GO:0043005	neuron projection
3.77	5.52e-04	GO:0016023	cytoplasmic membrane-bounded vesicle
3.70	7.01e-04	GO:0031988	membrane-bounded vesicle
9.80	8.74e-04	GO:0030662	coated vesicle membrane
3.55	1.19e-03	GO:0031410	cytoplasmic vesicle
1.50	1.33e-03	GO:0016020	membrane
1.60	1.34e-03	GO:0044425	membrane part
3.44	1.78e-03	GO:0031982	vesicle
7.62	4.51e-03	GO:0045211	postsynaptic membrane
1.76	6.22e-03	GO:0005886	plasma membrane
1.74	8.86e-03	GO:0071944	cell periphery
2.96	1.84e-02	GO:0042995	cell projection
6.00	2.03e-02	GO:0030425	dendrite
1.57	2.16e-02	GO:0031224	intrinsic to membrane
1.57	2.76e-02	GO:0016021	integral to membrane
5.42	3.76e-02	GO:0034702	ion channel complex
11.92	4.17e-02	GO:0034707	chloride channel complex
8.13	4.50e-02	GO:0019717	synaptosome

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
15.65	3.90e-05	GO:0005230	extracellular ligand-gated ion channel activity
20.54	5.50e-05	GO:0005231	excitatory extracellular ligand-gated ion channel activity
4.11	1.96e-04	GO:0005509	calcium ion binding
9.02	1.61e-03	GO:0015276	ligand-gated ion channel activity
9.02	1.61e-03	GO:0022834	ligand-gated channel activity
37.12	8.11e-03	GO:0016594	glycine binding
2.70	8.12e-03	GO:0005215	transporter activity
4.82	1.36e-02	GO:0022836	gated channel activity
4.23	1.63e-02	GO:0005216	ion channel activity
4.17	1.85e-02	GO:0022838	substrate-specific channel activity
4.04	2.37e-02	GO:0015267	channel activity
4.03	2.42e-02	GO:0022803	passive transmembrane transporter activity
80.42	2.90e-02	GO:0016933	extracellular-glycine-gated ion channel activity
80.42	2.90e-02	GO:0016934	extracellular-glycine-gated chloride channel activity
22.99	3.64e-02	GO:0005184	neuropeptide hormone activity
64.34	4.82e-02	GO:0022824	transmitter-gated ion channel activity
64.34	4.82e-02	GO:0022835	transmitter-gated channel activity