Motif ID: RFX1..5_RFXANK_RFXAP.p2

Z-value: 15.688


Transcription factors associated with RFX1..5_RFXANK_RFXAP.p2:

Gene SymbolEntrez IDGene Name
RFX1 5989 regulatory factor X, 1 (influences HLA class II expression)
RFX2 5990 regulatory factor X, 2 (influences HLA class II expression)
RFX3 5991 regulatory factor X, 3 (influences HLA class II expression)
RFX4 5992 regulatory factor X, 4 (influences HLA class II expression)
RFX5 5993 regulatory factor X, 5 (influences HLA class II expression)
RFXANK 8625 regulatory factor X-associated ankyrin-containing protein
RFXAP 5994 regulatory factor X-associated protein

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RFX2chr19_-_61105610.993.7e-26Click!
RFX3chr9_-_35257210.961.7e-16Click!
RFXAPchr13_+_373933060.632.2e-04Click!
RFX1chr19_-_14116875-0.441.4e-02Click!
RFX4chr12_+_1069949140.356.2e-02Click!
RFX5chr1_-_1513196740.281.3e-01Click!
RFXANKchr19_+_19303732-0.057.9e-01Click!


Activity profile for motif RFX1..5_RFXANK_RFXAP.p2.

activity profile for motif RFX1..5_RFXANK_RFXAP.p2


Sorted Z-values histogram for motif RFX1..5_RFXANK_RFXAP.p2

Sorted Z-values for motif RFX1..5_RFXANK_RFXAP.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RFX1..5_RFXANK_RFXAP.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_23487512 194.236 NM_004914
RAB36
RAB36, member RAS oncogene family
chr21_-_43916298 193.525 NM_080860
RSPH1
radial spoke head 1 homolog (Chlamydomonas)
chr17_-_74137370 167.329 NM_001454
FOXJ1
forkhead box J1
chr1_-_109656478 165.076 NM_001122961
C1orf194
chromosome 1 open reading frame 194
chr16_-_67427335 154.861 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr1_-_159869897 132.868 NM_012337
CCDC19
coiled-coil domain containing 19
chr3_-_197676755 128.550 NM_001134435
IQCG
IQ motif containing G
chr15_+_71184781 110.112 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chrX_-_48693934 109.756 NM_013271
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chrX_+_106449861 103.397 NM_001169154
NM_173494
CXorf41

chromosome X open reading frame 41

chr1_+_111889194 103.314 NM_181643
C1orf88
chromosome 1 open reading frame 88
chr9_+_127615695 100.863 NM_001045476
WDR38
WD repeat domain 38
chr11_+_94245694 100.740 NM_001190462
LOC643037
uncharacterized LOC643037
chr17_-_6735007 99.342 NM_053285
TEKT1
tektin 1
chr6_+_88117689 96.984 NM_001031743
C6orf165
chromosome 6 open reading frame 165
chr2_+_228736326 95.595 NM_178821
WDR69
WD repeat domain 69
chr10_+_63422718 92.434 NM_173554
C10orf107
chromosome 10 open reading frame 107
chr11_+_111385509 91.175 NM_001100388
NM_207430
C11orf88

chromosome 11 open reading frame 88

chr6_+_43612766 88.839 NM_001193341
NM_152732
RSPH9

radial spoke head 9 homolog (Chlamydomonas)

chr3_-_50383009 88.790 NM_015896
ZMYND10
zinc finger, MYND-type containing 10
chr1_+_38022514 86.969 NM_003462
DNALI1
dynein, axonemal, light intermediate chain 1
chr1_+_161068150 84.617 NM_001007255
NM_152366
KLHDC9

kelch domain containing 9

chr3_-_169530306 83.513 LRRC34
leucine rich repeat containing 34
chr16_+_67840976 82.112 NM_018430
TSNAXIP1
translin-associated factor X interacting protein 1
chr11_+_101918168 81.708 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr2_+_132285469 81.358 NM_138770
CCDC74A
coiled-coil domain containing 74A
chr10_+_22634373 81.284 NM_001253854
NM_001253855
NM_012443
NM_172242
SPAG6



sperm associated antigen 6



chr2_-_130902568 80.600 NM_207310
CCDC74B
coiled-coil domain containing 74B
chr1_+_217804665 80.009 NM_138796
SPATA17
spermatogenesis associated 17
chr3_-_167098070 79.823 NM_001199202
NM_001199201
NM_024687
ZBBX


zinc finger, B-box domain containing


chr7_+_48075107 78.842 NM_001100159
C7orf57
chromosome 7 open reading frame 57
chr13_+_31506809 78.130 NM_152325
C13orf26
chromosome 13 open reading frame 26
chr19_-_55677919 77.951 NM_178837
C19orf51
chromosome 19 open reading frame 51
chr6_+_116937641 77.112 NM_001010892
NM_001161664
RSPH4A

radial spoke head 4 homolog A (Chlamydomonas)

chr6_-_43477980 76.749 LRRC73
leucine rich repeat containing 73
chr17_+_9479943 76.215 NM_001080556
NM_145054
WDR16

WD repeat domain 16

chr4_-_177116713 73.273 NM_144644
SPATA4
spermatogenesis associated 4
chr1_-_169396654 73.262 NM_021179
C1orf114
chromosome 1 open reading frame 114
chr16_-_75590107 71.911 NM_001077416
NM_001077418
NM_001077419
TMEM231


transmembrane protein 231


chr2_+_74648856 68.566 NM_032118
WDR54
WD repeat domain 54
chr7_+_76751933 67.377 NM_020879
CCDC146
coiled-coil domain containing 146
chr15_+_82555101 66.460 NM_001008226
FAM154B
family with sequence similarity 154, member B
chr1_-_118727780 65.654 NM_206996
SPAG17
sperm associated antigen 17
chrX_+_119029799 65.200 NM_001008534
NM_001008535
NM_178813
AKAP14


A kinase (PRKA) anchor protein 14


chr19_-_7990974 65.023 NM_206833
CTXN1
cortexin 1
chr11_-_8615412 64.546 NM_030906
STK33
serine/threonine kinase 33
chr4_-_147866963 64.433 NM_031956
TTC29
tetratricopeptide repeat domain 29
chr3_-_129147331 63.708 NM_207307
C3orf25
chromosome 3 open reading frame 25
chr6_+_112408673 63.492 NM_001033564
C6orf225
chromosome 6 open reading frame 225
chr15_+_81426605 61.997 NM_173528
C15orf26
chromosome 15 open reading frame 26
chr8_-_49647717 61.844 NM_001142857
NM_024593
EFCAB1

EF-hand calcium binding domain 1

chr1_+_151694012 61.835 NM_001144956
RIIAD1
regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1
chr7_+_138818489 61.769 NM_001144920
NM_001144923
NM_024926
TTC26


tetratricopeptide repeat domain 26


chr5_-_7851255 60.839 NM_001089584
C5orf49
chromosome 5 open reading frame 49
chr10_-_25304865 60.064 NM_145010
ENKUR
enkurin, TRPC channel interacting protein
chr11_+_86085777 59.839 NM_001156474
NM_021827
CCDC81

coiled-coil domain containing 81

chr9_+_135754284 59.784 NM_018956
C9orf9
chromosome 9 open reading frame 9
chr11_-_111944757 58.488 NM_001082619
NM_138789
PIH1D2

PIH1 domain containing 2

chr22_-_38349533 57.440 NM_032561
NM_001207062
C22orf23

chromosome 22 open reading frame 23

chr1_-_67390413 56.995 NM_024763
NM_207014
WDR78

WD repeat domain 78

chr16_+_84178864 56.838 NM_178452
DNAAF1
dynein, axonemal, assembly factor 1
chr16_+_58283819 56.039 NM_001142302
NM_014157
CCDC113

coiled-coil domain containing 113

chr1_-_183622447 55.992 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr20_-_3762060 55.058 NM_015417
SPEF1
sperm flagellar 1
chr16_+_57728711 55.027 NM_032269
CCDC135
coiled-coil domain containing 135
chr2_-_110962577 54.523 NM_000272
NM_001128178
NM_001128179
NM_207181
NPHP1



nephronophthisis 1 (juvenile)



chr14_+_100259445 54.507 NM_001008707
NM_004434
EML1

echinoderm microtubule associated protein like 1

chr1_-_48937791 53.248 NM_019073
SPATA6
spermatogenesis associated 6
chr1_-_36915969 52.759 NM_145047
NM_206837
OSCP1

organic solute carrier partner 1

chr9_+_124922189 52.563 NM_198469
MORN5
MORN repeat containing 5
chr11_-_62473502 52.146 NM_001130702
NM_032667
BSCL2

Berardinelli-Seip congenital lipodystrophy 2 (seipin)

chr17_+_11501747 51.947 NM_001372
DNAH9
dynein, axonemal, heavy chain 9
chr17_+_62075710 51.386 NM_001164257
NM_001191029
NM_001191030
NM_001191031
C17orf72



chromosome 17 open reading frame 72



chr6_+_52284948 51.282 NM_018100
EFHC1
EF-hand domain (C-terminal) containing 1
chr11_-_75379113 50.578 MAP6
microtubule-associated protein 6
chr11_-_75379651 50.507 MAP6
microtubule-associated protein 6
chr14_+_74486049 50.186 NM_025057
C14orf45
chromosome 14 open reading frame 45
chr2_+_120302024 49.896 NM_001029996
PCDP1
primary ciliary dyskinesia protein 1
chr2_+_39103102 48.397 NM_001145450
MORN2
MORN repeat containing 2
chr1_+_245133283 48.071 EFCAB2
EF-hand calcium binding domain 2
chr3_+_97483563 47.706 NM_032146
NM_177976
ARL6

ADP-ribosylation factor-like 6

chr19_-_55690717 47.395 SYT5
synaptotagmin V
chr10_-_75118502 47.380 NM_145170
TTC18
tetratricopeptide repeat domain 18
chr22_-_31063786 46.899 NM_152511
DUSP18
dual specificity phosphatase 18
chr6_-_165723074 46.597 NM_144980
C6orf118
chromosome 6 open reading frame 118
chr19_-_55791428 45.832 HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr7_-_102715171 45.790 NM_001111038
FBXL13
F-box and leucine-rich repeat protein 13
chr3_+_158288952 45.387 NM_001130156
NM_001130157
NM_001195432
NM_001195433
NM_001195434
NM_022443
MLF1





myeloid leukemia factor 1





chr1_+_245133067 44.817 NM_032328
EFCAB2
EF-hand calcium binding domain 2
chr3_-_113160318 44.811 NM_001164496
NM_018338
WDR52

WD repeat domain 52

chr3_-_196439067 44.612 NM_032898
CEP19
centrosomal protein 19kDa
chr6_+_109169587 44.473 NM_032131
ARMC2
armadillo repeat containing 2
chr2_-_178417434 44.196 NM_152517
TTC30B
tetratricopeptide repeat domain 30B
chr2_+_170335948 43.649 NM_152384
BBS5
Bardet-Biedl syndrome 5
chr2_-_178483677 43.564 NM_152275
TTC30A
tetratricopeptide repeat domain 30A
chr19_-_55791446 43.427 HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr15_-_68497601 43.307 CALML4
calmodulin-like 4
chr3_-_169530451 43.057 NM_001172779
NM_001172780
NM_153353
LRRC34


leucine rich repeat containing 34


chr3_-_107941168 41.644 NM_018010
IFT57
intraflagellar transport 57 homolog (Chlamydomonas)
chr19_-_55791727 41.625 NM_001130106
NM_012267
HSPBP1

HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1

chr17_-_5404304 41.502 NM_001162371
LOC728392
uncharacterized LOC728392
chr12_-_25706177 41.234 NM_152590
NM_001145728
NM_001145729
IFLTD1


intermediate filament tail domain containing 1


chr17_+_260092 40.788 NM_001013672
C17orf97
chromosome 17 open reading frame 97
chr16_-_53737713 40.747 NM_001127897
NM_015272
RPGRIP1L

RPGRIP1-like

chr3_-_47324255 39.072 NM_001134878
NM_022342
NM_182902
KIF9


kinesin family member 9


chr18_-_47792773 38.585 NM_145020
CCDC11
coiled-coil domain containing 11
chr9_-_140024159 38.080


chr2_-_207630009 37.987 NM_001039845
MDH1B
malate dehydrogenase 1B, NAD (soluble)
chr6_-_43478423 37.831 NM_001012974
LRRC73
leucine rich repeat containing 73
chr1_-_114301753 37.745 NM_006608
PHTF1
putative homeodomain transcription factor 1
chr11_-_119252267 37.573 USP2
ubiquitin specific peptidase 2
chr11_-_75379414 37.224 NM_033063
NM_207577
MAP6

microtubule-associated protein 6

chr1_-_114302093 37.193 PHTF1
putative homeodomain transcription factor 1
chr12_+_122356446 36.965 NM_001178003
NM_144668
WDR66

WD repeat domain 66

chr16_-_776366 36.778 NM_001031737
CCDC78
coiled-coil domain containing 78
chr22_-_38240246 36.643 ANKRD54
ankyrin repeat domain 54
chr13_+_37006408 36.613 NM_001111045
NM_003914
CCNA1

cyclin A1

chr1_-_24740155 36.268 NM_001199013
NM_001199014
NM_178122
C1orf201


chromosome 1 open reading frame 201


chr8_-_133687761 35.652 NM_012472
LRRC6
leucine rich repeat containing 6
chr9_-_135754163 35.601 NM_152572
AK8
adenylate kinase 8
chr10_+_127585107 35.471 NM_145235
FANK1
fibronectin type III and ankyrin repeat domains 1
chr4_-_156297973 35.459 MAP9
microtubule-associated protein 9
chr1_-_173638970 34.721 NM_198493
ANKRD45
ankyrin repeat domain 45
chr4_-_156297944 34.459 MAP9
microtubule-associated protein 9
chr7_+_102073953 34.437 NM_001126340
NM_032831
ORAI2

ORAI calcium release-activated calcium modulator 2

chr2_+_27193448 34.266 NM_012326
MAPRE3
microtubule-associated protein, RP/EB family, member 3
chr1_+_63989012 34.241 NM_032437
EFCAB7
EF-hand calcium binding domain 7
chr16_-_30773303 34.211 NM_001014979
NM_001195620
C16orf93

chromosome 16 open reading frame 93

chr3_-_57530067 34.062 NM_178504
NM_198564
DNAH12

dynein, axonemal, heavy chain 12

chr1_+_109656570 34.023 NM_020775
KIAA1324
KIAA1324
chr1_+_109656724 33.903 KIAA1324
KIAA1324
chr3_+_113666544 33.678 NM_173570
ZDHHC23
zinc finger, DHHC-type containing 23
chr2_-_241497367 33.526 ANKMY1
ankyrin repeat and MYND domain containing 1
chr2_-_241497404 33.419 NM_016552
NM_017844
ANKMY1

ankyrin repeat and MYND domain containing 1

chr8_+_144798494 32.961 NM_139021
MAPK15
mitogen-activated protein kinase 15
chr16_+_89724175 32.926 NM_153025
C16orf55
chromosome 16 open reading frame 55
chr16_+_3550916 32.797 NM_015041
CLUAP1
clusterin associated protein 1
chr5_-_54529424 32.759 NM_021147
CCNO
cyclin O
chr3_+_130745693 32.621 NM_001146003
NM_024800
NM_145910
NEK11


NIMA (never in mitosis gene a)- related kinase 11


chr22_-_38240341 32.136 NM_138797
ANKRD54
ankyrin repeat domain 54
chr11_-_8615745 32.129 STK33
serine/threonine kinase 33
chr11_+_537521 32.128 NM_198075
LRRC56
leucine rich repeat containing 56
chr16_-_67450149 31.954 NM_013304
ZDHHC1
zinc finger, DHHC-type containing 1
chr10_+_134973935 31.460 NM_152643
KNDC1
kinase non-catalytic C-lobe domain (KIND) containing 1
chr17_+_7761063 31.243 NM_144607
CYB5D1
cytochrome b5 domain containing 1
chr18_+_44526786 30.690 NM_031303
KATNAL2
katanin p60 subunit A-like 2
chr1_+_109656507 30.625 KIAA1324
KIAA1324
chr17_-_56406120 30.610 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr2_+_109403140 30.478 NM_144978
CCDC138
coiled-coil domain containing 138
chr4_-_156298094 29.560 NM_001039580
MAP9
microtubule-associated protein 9
chr11_+_111808017 29.551 DIXDC1
DIX domain containing 1
chr6_-_109761707 29.523 PPIL6
peptidylprolyl isomerase (cyclophilin)-like 6
chr1_-_48937676 29.484 SPATA6
spermatogenesis associated 6
chr19_-_55791490 29.289 HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr20_+_43160435 28.921 NM_007066
NM_181804
NM_181805
PKIG


protein kinase (cAMP-dependent, catalytic) inhibitor gamma


chr7_-_100964923 28.836 NM_001130820
NM_001130821
NM_001130822
NM_022777
RABL5



RAB, member RAS oncogene family-like 5



chr7_-_102715014 28.748 NM_145032
FBXL13
F-box and leucine-rich repeat protein 13
chr16_+_89724436 28.568 C16orf55
chromosome 16 open reading frame 55
chr3_+_119421865 28.184 NM_033364
C3orf15
chromosome 3 open reading frame 15
chr1_+_42928873 28.176 CCDC30
coiled-coil domain containing 30
chr6_+_109762204 27.988 SMPD2
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
chr21_-_40817658 27.926 LCA5L
Leber congenital amaurosis 5-like
chr1_-_26633110 27.920 NM_001077262
NM_183008
UBXN11

UBX domain protein 11

chr3_-_113775363 27.852 NM_020817
KIAA1407
KIAA1407
chr7_+_102074002 27.538 ORAI2
ORAI calcium release-activated calcium modulator 2
chr16_+_1386197 27.352 NM_001199096
BAIAP3
BAI1-associated protein 3
chr17_+_68100994 27.292 NM_170742
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr11_-_119211034 27.228 MFRP
membrane frizzled-related protein
chr9_+_135753711 27.155 C9orf9
chromosome 9 open reading frame 9
chr22_+_39052671 27.133 CBY1
chibby homolog 1 (Drosophila)
chr22_+_39052628 26.990 NM_001002880
NM_015373
CBY1

chibby homolog 1 (Drosophila)

chr9_-_131418931 26.529 WDR34
WD repeat domain 34
chr1_-_169336999 26.526 NM_013330
NM_197972
NME7

non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase)

chr14_-_20774089 26.512 TTC5
tetratricopeptide repeat domain 5
chr14_-_20774129 26.376 NM_138376
TTC5
tetratricopeptide repeat domain 5
chr12_-_110486275 26.353 C12orf76
chromosome 12 open reading frame 76
chr9_-_131419004 26.338 NM_052844
WDR34
WD repeat domain 34
chr9_+_100069909 26.169 NM_020893
C9orf174
chromosome 9 open reading frame 174
chr7_+_2598611 25.943 NM_001100390
NM_152558
IQCE

IQ motif containing E

chr3_+_49027770 25.421 P4HTM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr2_-_230579198 25.414 NM_139072
DNER
delta/notch-like EGF repeat containing
chr7_+_133812051 24.555 NM_144648
LRGUK
leucine-rich repeats and guanylate kinase domain containing
chr3_+_49027281 24.525 NM_177938
NM_177939
P4HTM

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

chr7_+_129142319 24.425 NM_001195243
LOC100287482
uncharacterized LOC100287482
chr12_-_63328663 24.382 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr19_-_11545900 24.270 NM_145045
CCDC151
coiled-coil domain containing 151
chr10_+_103348040 24.172 NM_015448
DPCD
deleted in primary ciliary dyskinesia homolog (mouse)
chr19_-_41870001 23.762 NM_030578
B9D2
B9 protein domain 2
chr1_-_74663827 23.645 NM_001105659
LRRIQ3
leucine-rich repeats and IQ motif containing 3
chr6_+_109761887 23.630 NM_003080
SMPD2
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
chr10_+_12391471 23.615 NM_020397
NM_153498
CAMK1D

calcium/calmodulin-dependent protein kinase ID

chr11_+_111807857 23.549 NM_001037954
DIXDC1
DIX domain containing 1
chr4_+_123653856 23.537 NM_001178007
NM_152618
BBS12

Bardet-Biedl syndrome 12

chr1_+_109656776 23.247 KIAA1324
KIAA1324
chr4_+_40751913 23.236 NM_024677
NSUN7
NOP2/Sun domain family, member 7
chr12_+_6930689 22.968 NM_014449
NM_019858
GPR162

G protein-coupled receptor 162

chrX_-_106449543 22.798 NM_017681
NUP62CL
nucleoporin 62kDa C-terminal like
chr16_-_88923233 22.736 GALNS
galactosamine (N-acetyl)-6-sulfate sulfatase
chr1_-_86861923 22.704 NM_001007022
NM_001184765
NM_001184766
NM_020729
ODF2L



outer dense fiber of sperm tails 2-like



chr19_-_50528683 22.630 NM_001025778
NM_016440
VRK3

vaccinia related kinase 3


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
10.61 2.60e-09 GO:0042384 cilium assembly
8.15 5.48e-08 GO:0060271 cilium morphogenesis
5.91 1.06e-05 GO:0010927 cellular component assembly involved in morphogenesis
5.04 4.68e-05 GO:0030031 cell projection assembly
2.76 2.72e-03 GO:0007017 microtubule-based process
1.36 1.82e-02 GO:XXXXXXX unannotated
3.44 4.09e-02 GO:0007018 microtubule-based movement

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.06 1.31e-17 GO:0005929 cilium
8.78 7.69e-12 GO:0005930 axoneme
10.07 4.86e-11 GO:0005932 microtubule basal body
7.96 6.54e-11 GO:0044441 cilium part
2.64 1.43e-10 GO:0015630 microtubule cytoskeleton
9.32 4.95e-09 GO:0035085 cilium axoneme
3.47 6.43e-09 GO:0005874 microtubule
2.81 3.05e-07 GO:0044463 cell projection part
2.09 2.74e-06 GO:0042995 cell projection
7.78 2.21e-05 GO:0030286 dynein complex
2.60 1.72e-04 GO:0005815 microtubule organizing center
1.79 4.92e-04 GO:0044430 cytoskeletal part
1.73 6.73e-04 GO:XXXXXXX unannotated
11.76 1.36e-03 GO:0060170 cilium membrane
5.54 2.62e-03 GO:0019861 flagellum
2.68 5.22e-03 GO:0005813 centrosome
1.54 9.55e-03 GO:0005856 cytoskeleton
3.52 2.16e-02 GO:0005875 microtubule associated complex
12.74 4.06e-02 GO:0034464 BBSome

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.28 3.44e-03 GO:0003774 motor activity
4.19 8.90e-03 GO:0003777 microtubule motor activity